KEGG   ORTHOLOGY: K18076
Entry
K18076                      KO                                     
Symbol
tphB
Name
1,2-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase [EC:1.3.1.53]
Pathway
map00624  Polycyclic aromatic hydrocarbon degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00624  Terephthalate degradation, terephthalate => 3,4-dihydroxybenzoate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00624 Polycyclic aromatic hydrocarbon degradation
    K18076  tphB; 1,2-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.53  (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase
     K18076  tphB; 1,2-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase
Dioxygenases [br01602.html]
 Dioxygenases in aromatic ring cleavage
  K18076
Other DBs
RN: R01633
GO: 0047120
Genes
VPD: VAPA_2c09680(pdxA)
CTT: CtCNB1_1495
CTES: O987_22465
RTA: Rta_16730
RTEA: HK414_12000
HYR: BSY239_2687
HYB: Q5W_19725
HTN: KI616_03575
Reference
  Authors
Sasoh M, Masai E, Ishibashi S, Hara H, Kamimura N, Miyauchi K, Fukuda M
  Title
Characterization of the terephthalate degradation genes of Comamonas sp. strain E6.
  Journal
Appl Environ Microbiol 72:1825-32 (2006)
DOI:10.1128/AEM.72.3.1825-1832.2006
  Sequence
Reference
PMID:8565920
  Authors
Wang YZ, Zhou Y, Zylstra GJ
  Title
Molecular analysis of isophthalate and terephthalate degradation by Comamonas testosteroni YZW-D.
  Journal
Environ Health Perspect 103 Suppl 5:9-12 (1995)
DOI:10.1289/ehp.95103s49
  Sequence
LinkDB

KEGG   REACTION: R01633
Entry
R01633                      Reaction                               
Name
(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate:NAD+ oxidoreductase
Definition
(3S,4R)-3,4-Dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD+ <=> 3,4-Dihydroxybenzoate + CO2 + NADH + H+
Equation
Reaction class
RC00001  C00003_C00004
RC00271  C00230_C06318
Enzyme
Pathway
rn00624  Polycyclic aromatic hydrocarbon degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Module
M00624  Terephthalate degradation, terephthalate => 3,4-dihydroxybenzoate
Orthology
K18076  1,2-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase [EC:1.3.1.53]
Other DBs
RHEA: 10747
LinkDB

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