KEGG ORTHOLOGY: K18123

ORTHOLOGY: K18123

Entry

K18123                      KO

Symbol

HOGA1

Name

4-hydroxy-2-oxoglutarate aldolase [EC:4.1.3.16]

Pathway

map00330

Arginine and proline metabolism

map00630

Glyoxylate and dicarboxylate metabolism

map01100

Metabolic pathways

Reaction

R00470

4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)

R00471

4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)

Disease

H00117

Primary hyperoxaluria

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09101 Carbohydrate metabolism
   00630 Glyoxylate and dicarboxylate metabolism
    K18123  HOGA1; 4-hydroxy-2-oxoglutarate aldolase
  09105 Amino acid metabolism
   00330 Arginine and proline metabolism
    K18123  HOGA1; 4-hydroxy-2-oxoglutarate aldolase
Enzymes [BR:ko01000]
4. Lyases
  4.1  Carbon-carbon lyases
   4.1.3  Oxo-acid-lyases
    4.1.3.16  4-hydroxy-2-oxoglutarate aldolase
     K18123  HOGA1; 4-hydroxy-2-oxoglutarate aldolase

Other DBs

GO:

0008700

Genes

HSA:	112817(HOGA1)

PTR:	742884(HOGA1)

PPS:	103782784(HOGA1)

GGO:	101154009(HOGA1)

PON:	100171598(HOGA1)

PPYG:

129006120(HOGA1)

NLE:	100589206(HOGA1)

HMH:	116456320(HOGA1)

SSYN:

129468115(HOGA1)

MCC:	706661(HOGA1)

MCF:	102126728(HOGA1)

MTHB:

126962086

MNI:	105478444(HOGA1)

CSAB:

103216345(HOGA1)

CATY:

105581795(HOGA1)

PANU:

101014787(HOGA1)

TGE:	112631561(HOGA1)

MLEU:

105554171(HOGA1)

RRO:	104682808(HOGA1)

RBB:	108534698(HOGA1)

TFN:	117068959(HOGA1)

PTEH:

111538766(HOGA1)

CANG:

105518265(HOGA1)

CJC:	103796777(HOGA1)

SBQ:	104650492(HOGA1)

CIMI:

108285506(HOGA1)

ANAN:

105708227(HOGA1)

CSYR:

103264836(HOGA1)

MMUR:

105873085(HOGA1)

LCAT:

123650168(HOGA1)

ERUF:

138376499(HOGA1)

PCOQ:

105818494(HOGA1)

OGA:	100958797(HOGA1)

MMU:	67432(Hoga1)

MCAL:

110285310(Hoga1)

MPAH:

110333903(Hoga1)

RNO:	293949(Hoga1)

MCOC:

116103842(Hoga1)

ANU:	117715996(Hoga1)

ASYL:

127687315(Hoga1)

MUN:	110564114(Hoga1)

CGE:	100759109(Hoga1)

MAUA:

101824115(Hoga1)

PROB:

127233327(Hoga1)

PLEU:

114706886(Hoga1)

PMAV:

102917801(Hoga1)

MORG:

121454497(Hoga1)

MFOT:

126504665

AAMP:

119822156(Hoga1)

CNL:	130880382(Hoga1)

NGI:	103733196(Hoga1)

HGL:	101700602(Hoga1)

CPOC:

100720763(Hoga1)

CCAN:

109695304(Hoga1)

DORD:

105986751(Hoga1)

DSP:	122115913(Hoga1)

DMER:

138826190 138830130

PLOP:

125346195(Hoga1)

NCAR:

124984723

MMMA:

107149768(Hoga1)

ITI:	101966547(Hoga1)

OCU:

100344505

OPI:	101517296(HOGA1)

OCZ:	121164001(HOGA1)

TUP:	102486364(HOGA1)

GVR:	103590892(HOGA1)

CFA:	608755(HOGA1)

CLUD:

112672141(HOGA1)

VVP:	112914409(HOGA1)

VLG:	121483974(HOGA1)

NPO:	129493943(HOGA1)

AML:	100478059(HOGA1)

UMR:	103674087(HOGA1)

UAH:	113251791(HOGA1)

UAR:	123783886(HOGA1)

ELK:

111145298

LLV:

125084924

MPUF:

101693912(HOGA1)

MNP:	132016673(HOGA1)

MLK:	131828583(HOGA1)

NVS:	122900985(HOGA1)

ORO:	101385318(HOGA1)

EJU:	114205383(HOGA1)

ZCA:	113919122(HOGA1)

MLX:	118024504(HOGA1)

MANO:

123846728(HOGA1)

NSU:	110589086(HOGA1)

LWW:	102740193(HOGA1)

FCA:	101101417(HOGA1)

PYU:	121037065(HOGA1)

PCOO:

112854322(HOGA1)

PBG:	122493090(HOGA1)

PVIV:

125148100(HOGA1)

LRUF:

124506708

LGF:	123576898(HOGA1)

AJU:

106966929

PTG:	102965487(HOGA1)

PPAD:

109272717(HOGA1)

PUC:

125932841

PLEZ:

122202319(HOGA1)

HHV:	120230623(HOGA1)

CCRU:

144245181(HOGA1)

BTA:	506001(HOGA1)

BOM:	102265621(HOGA1)

BIU:	109552999(HOGA1)

BJV:	133239244(HOGA1)

BBUB:

102398601(HOGA1)

BKE:	129636603(HOGA1)

BBIS:

104983565(HOGA1)

CHX:	102173994(HOGA1)

OAS:	101114573(HOGA1)

OCAN:

138427988(HOGA1)

BTAX:

128067740(HOGA1)

CSUM:

138070158(HOGA1)

ODA:	120873942(HOGA1)

CCAD:

122446094(HOGA1)

MREE:

136160022(HOGA1)

OVR:	110131103(HOGA1)

MBEZ:

129555481(HOGA1)

SSC:	100153961(HOGA1)

CFR:	102512614(HOGA1)

CBAI:

105081776(HOGA1)

CDK:	105084288(HOGA1)

VPC:	102541568(HOGA1)

BACU:

103004258(HOGA1)

BMUS:

118882584(HOGA1)

LVE:	103077167 103089444(HOGA1)

OOR:	101271753(HOGA1)

LALB:

132507549(HOGA1)

GMF:	115857852(HOGA1)

DDP:	132439741(HOGA1)

DLE:	111172427(HOGA1)

PCAD:

102979032(HOGA1)

PSIU:

116741875(HOGA1)

PPHC:

136136445(HOGA1)

NASI:

112393068(HOGA1)

ECB:	100070689(HOGA1)

EPZ:	103558701(HOGA1)

EAI:	106844960(HOGA1)

MYB:	102246939(HOGA1)

MYD:	102768587(HOGA1)

MMYO:

118669893(HOGA1)

MLF:	102427524(HOGA1)

MDT:	132214200(HOGA1)

MYUM:

139021846(HOGA1)

PKL:	118719357(HOGA1)

EFUS:

103288446(HOGA1)

MNA:	107542604(HOGA1)

DRO:	112307109(HOGA1)

SHON:

118990274(HOGA1)

AJM:	119044532(HOGA1)

PDIC:

114495945(HOGA1)

PHAS:

123828952(HOGA1)

MMF:	118632358(HOGA1)

PPAM:

129077277(HOGA1)

HAI:	109379716(HOGA1)

RFQ:	117036234(HOGA1)

PALE:

102884382(HOGA1)

PGIG:

120609240(HOGA1)

PVP:	105301380(HOGA1)

RAY:	107520438(HOGA1)

MJV:	108399750(HOGA1)

TOD:	119233797(HOGA1)

SFUM:

130029477(HOGA1)

SETR:

125994794(HOGA1)

LAV:	100670230(HOGA1)

TMU:

101355404

ETF:	101646656(HOGA1)

DNM:	101419181(HOGA1)

MDO:	100021876(HOGA1)

GAS:	123238246(HOGA1)

SHR:	100929176(HOGA1)

AFZ:

127551747

PCW:	110215427(HOGA1)

TVP:	118828333(HOGA1)

PBRV:

138145523(HOGA1)

MLAO:

141521081(HOGA1)

OAA:	100088274(HOGA1)

TACU:

119925792(HOGA1)

GGA:	770036(HOGA1)

PCOC:

116231725(HOGA1)

MGP:	100548398(HOGA1)

CJO:	107316003(HOGA1)

TPAI:

128077526(HOGA1)

LMUT:

125693723(HOGA1)

NMEL:

110400352(HOGA1)

APLA:

119717295(HOGA1)

AACU:

137859296(HOGA1)

CATA:

118245260(HOGA1)

AFUL:

116491080(HOGA1)

TGU:	100231472(HOGA1)

LSR:	110473597(HOGA1)

AIB:	137478180(HOGA1)

SCAN:

103813888(HOGA1)

PMOA:

120502206(HOGA1)

OTC:	121341648(HOGA1)

PRUF:

121350021(HOGA1)

ATRC:

139599202(HOGA1)

MATE:

118688418(HOGA1)

MAEN:

136559698(HOGA1)

GFR:	102042170(HOGA1)

FAB:	101806953(HOGA1)

OMA:	130254728(HOGA1)

PHI:	102112987(HOGA1)

PMAJ:

107206698(HOGA1)

CCAE:

111931229(HOGA1)

CCW:	104695887(HOGA1)

CBRC:

103624537(HOGA1)

ACOE:

138112847(HOGA1)

ETL:	114070777(HOGA1)

ZAB:	102062750(HOGA1)

ZLE:	135449422(HOGA1)

ACHL:

103807138(HOGA1)

SVG:	106859028(HOGA1)

MMEA:

130582102(HOGA1)

HRT:	120755990(HOGA1)

SATI:

136364106(HOGA1)

CCIC:

134046258(HOGA1)

FPG:	101920952(HOGA1)

FCH:	102052298(HOGA1)

FRS:	119153409(HOGA1)

CCRI:

104160613(HOGA1)

NNT:	104401870(HOGA1)

SHAB:

115608256(HOGA1)

ACUN:

113481407(HOGA1)

ANOC:

141961045(HOGA1)

SURA:

141946011(HOGA1)

TALA:

116962067(HOGA1)

ACHC:

115348491(HOGA1)

HLE:	104830136(HOGA1)

AGEN:

126042830

HHAR:

128147450(HOGA1)

BBUT:

142030673(HOGA1)

CSTI:

104558098(HOGA1)

LDI:	104355014(HOGA1)

MNB:	103775287(HOGA1)

DPUB:

104307074(HOGA1)

PPUS:

135176021(HOGA1)

AVIT:

104274804(HOGA1)

BRHI:

104501654(HOGA1)

EGZ:	104132255(HOGA1)

NNI:	104012772(HOGA1)

PARX:

142063560(HOGA1)

PADL:

103916280(HOGA1)

AFOR:

103897686(HOGA1)

CBOR:

142084308(HOGA1)

CBOY:

140656049(HOGA1)

MAME:

142410899(HOGA1)

CLV:	102097409(HOGA1)

CNIC:

135990661(HOGA1)

MUI:	104544738(HOGA1)

PGUU:

104471445(HOGA1)

PLET:

104621767(HOGA1)

EHS:	104511181(HOGA1)

CMAC:

104486380(HOGA1)

CUCA:

104059789(HOGA1)

TEO:	104384160(HOGA1)

BREG:

104633603(HOGA1)

GAME:

129208621(HOGA1)

OHA:	104332280(HOGA1)

ACAR:

104531510(HOGA1)

CPEA:

104390936(HOGA1)

CVF:	104288806(HOGA1)

RTD:	128911756(HOGA1)

CRID:

134517380(HOGA1)

LMIC:

141744616(HOGA1)

NARQ:

141472235(HOGA1)

AROW:

112968046(HOGA1)

NPD:	112957175(HOGA1)

DNE:	112984791(HOGA1)

ASN:	102382587(HOGA1)

AMJ:	102563093(HOGA1)

CPOO:

109324348(HOGA1)

GGN:	109287532(HOGA1)

CIZ:	142015643(HOGA1)

CMY:	114018236(HOGA1)

CCAY:

125639699(HOGA1)

LKP:	140915111(HOGA1)

NDS:	141991244(HOGA1)

DCC:	119858528(HOGA1)

CPIC:

103307603(HOGA1)

TST:	117880415(HOGA1)

CABI:

116822802(HOGA1)

ACS:	100566929(hoga1)

ASAO:

132770857(HOGA1)

PVT:	110089167(HOGA1)

SUND:

121926128(HOGA1)

PBI:	103053263(HOGA1)

PMUR:

107295219(HOGA1)

CTIG:

120302535(HOGA1)

TSR:	106549035(HOGA1)

PGUT:

117678595(HOGA1)

PCAE:

139318350(HOGA1)

APRI:

131200355(HOGA1)

PTEX:

113436688(HOGA1)

NSS:	113416749(HOGA1)

VKO:	123026676(HOGA1)

PMUA:

114597588(HOGA1)

PRAF:

128414342(HOGA1)

ZVI:	118093538(HOGA1)

HCG:	128352167(HOGA1)

GJA:	107114457(HOGA1)

STOW:

125438115(HOGA1)

EMC:	129331742(HOGA1)

XLA:	495193(hoga1.L)

XTR:	496669(hoga1)

NPR:	108792933(HOGA1)

RTEM:

120946635(HOGA1)

ACAT:

141105211(HOGA1)

PADS:

140339864(HOGA1)

BBUF:

121004610(HOGA1)

BGAR:

122941075 122942538

DTC:	141056157(HOGA1)

PWL:	138300353(HOGA1)

MUO:	115459261 115470032(HOGA1)

GSH:	117359862(HOGA1)

DRE:	405806(hoga1)

SRX:

107706114

SANH:

107663482(hoga1)

SGH:	107551368 107588470(hoga1)

CCAR:

109069442(hoga1)

CAUA:

113039744(hoga1)

CGIB:

127988445

PTET:

122327069(hoga1)

LROH:

127162500(hoga1)

GRF:	141339230(hoga1)

OMC:	131530559(hoga1)

PPRM:

120468726 120468763(hoga1)

RKG:	130093428(hoga1)

MAMB:

125254424(hoga1)

CIDE:

127520584

CERY:

137028996(hoga1)

MASI:

127438724

TROS:

130548897(hoga1)

TDW:	130429599(hoga1)

MANU:

129454062(hoga1)

PDAB:

135740888(hoga1)

IPU:

108259603

IFU:	128602599(hoga1)

PHYP:

113546731(hoga1)

SMEO:

124379684(hoga1)

TFD:	113656985(hoga1)

TVC:	132839014(hoga1)

CGAR:

128518313(hoga1)

NGRA:

132874946(hoga1)

TRN:	134304122(hoga1)

AMEX:

103023796(hoga1)

CMAO:

118817343(hoga1)

EEE:	113577699(hoga1)

CHAR:

105892823(hoga1)

SPIL:

134101823(hoga1)

ASAD:

121677454(hoga1)

TRU:	101061435(hoga1)

TFS:	130527505(hoga1)

TNG:	GSTEN00009068G001

LCO:	104930035(hoga1)

NCC:	104953008(hoga1)

TBEN:

117482094(hoga1)

EMAC:

134864581(hoga1)

ELY:	117255225(hoga1)

EFO:	125885368(hoga1)

SLUC:

116049892(hoga1)

ECRA:

117962147(hoga1)

PFLV:

114570716(hoga1)

GAT:	120813082(hoga1)

PPUG:

119218010(hoga1)

AFB:	129095314(hoga1)

CLUM:

117733045(hoga1)

PSWI:

130190637(hoga1)

CANA:

137798769(hoga1)

CVE:	137874341 137884641

MSAM:

119898305(hoga1)

SCHU:

122873536(hoga1)

EARM:

139293419(hoga1)

CUD:	121508633(hoga1)

SPUL:

138595128(hoga1)

LMIX:

132983125(hoga1)

HTC:	141801690(hoga1)

ALAT:

119019204(hoga1)

ASTR:

137600286(hoga1)

PKLU:

139199439(hoga1)

MZE:	101479315(hoga1)

ONL:	100690946(hoga1)

OAU:	116315581(hoga1)

OLA:	101161460(hoga1)

OML:	112156927(hoga1)

CSAI:

133454314(hoga1)

XMA:	102230783(hoga1)

XCO:	114145238(hoga1)

XHE:	116720256(hoga1)

PRET:

103470116(hoga1)

PFOR:

103154489(hoga1)

PLAI:

106948744(hoga1)

PMEI:

106927085(hoga1)

GAF:	122830294(hoga1)

CVG:	107081958(hoga1)

CTUL:

119798502(hoga1)

GMU:	124869120(hoga1)

NFU:	107382406(hoga1)

KMR:	108247450(hoga1)

ALIM:

106537034(hoga1)

NWH:	119422511 119423198

AOCE:

111580411(hoga1)

EJA:	138209584(hoga1)

BFRE:

138615706(hoga1)

MCEP:

125002125(hoga1)

CSEM:

103383203(hoga1)

POV:

109645371

SSEN:

122771614(hoga1)

SSOE:

131466405(hoga1)

HHIP:

117760502(hoga1)

HSP:	118099088(hoga1)

PPLT:

128436949(hoga1)

SMAU:

118312777(hoga1)

LCF:

108880833

SDU:	111235845(hoga1)

SLAL:

111665639(hoga1)

XGL:	120800280(hoga1)

HCQ:	109511381(hoga1)

SSCV:

125969014(hoga1)

SBIA:

133506296(hoga1)

PEE:	133403755(hoga1)

PTAO:

133476783(hoga1)

BPEC:

110155940(hoga1)

ENY:	140378077(hoga1)

MALB:

109952000(hoga1)

BSPL:

114861357(hoga1)

SJO:	128381165(hoga1)

SSCO:

133998075(hoga1)

TTY:	137180182(hoga1)

GMH:	115540262(hoga1)

SASA:

106591168(hoga1) 106591313

STRU:

115178813(hoga1)

OTW:	112230192(hoga1)

OMY:	110485610 110487262

OGO:	124018276(hoga1)

ONE:	115127679(hoga1)

OKI:

109877035

OKE:	127932411(hoga1)

OMM:	135530600 135530601

OCLA:

139424364

SALP:

112079381(hoga1)

SNH:	120032829(hoga1) 120032838

SFON:

129843030(hoga1)

CCLU:

121533209(hoga1)

ELS:	105006876(hoga1)

SFM:	108924852(hoga1)

PKI:	111848362(hoga1)

AANG:

118219744(hoga1)

AROT:

135247448(hoga1)

CCOG:

133122150(hoga1)

LOC:	102687344(hoga1)

PSPA:

121321919(hoga1)

ARUT:

117415418(hoga1)

PSEX:

120542430(hoga1)

LCM:	102362318(HOGA1)

CMK:	103172525(hoga1)

RTP:	109921722(hoga1)

CPLA:

122561306(hoga1)

CPUN:

140463345(hoga1)

HOC:	132826170(hoga1)

SCAU:

119979761(hoga1)

LERI:

129704161(hoga1)

HAKA:

140715184(hoga1)

PMRN:

116947233(HOGA1)

LRJ:	133360500(HOGA1)

BFO:	118413704 118414415

BBEL:

CIN:

SCLV:

CLEP:

SPU:

LPIC:

LVG:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:

PFLL:

BCOO:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

109031207 109033146 109037695

DCI:	103507739 103520261

CLEC:

HHAL:

NLU:

LDA:

HVI:	124369256 124370050 124374619

MQU:	128987472 128998301 129004190

ZNE:

CSEC:

PAME:

SGRE:

BROR:

IEL:

HAMR:

FCD:

DPX:	DAPPUDRAFT_52277

DMK:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

SPRM:

ESN:

MNZ:

MRJ:

PORN:

HAZT:

EAF:

TCF:

PPOI:

DSV:

DALB:

RSAN:

RMP:

CSCU:

CVS:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

HRO:	HELRODRAFT_157064

LGI:	LOTGIDRAFT_211287

PVUL:

PCAN:

LSAX:

BARL:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

YBA:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:	130644187 130646181

RES:

135695854

CCLM:

134182206

NCR:	NCU04744 NCU05977

NTE:	NEUTE1DRAFT148948(NEUTE1DRAFT_148948) NEUTE1DRAFT48910(NEUTE1DRAFT_48910)

SMP:	10805247(SMAC4_03823) 10808176(SMAC4_07903)

PAN:	PODANSg09878 PODANSg3113 PODANSg3131

PBEL:

QC761_106120 QC761_407320 QC761_407500

PPSD:

QC762_106120 QC762_407320 QC762_407500

PPSP:

QC763_106120 QC763_407320 QC763_407500

PPSA:

QC764_106120 QC764_407320 QC764_407500

TTT:	THITE_2041371 THITE_2110019 THITE_2122366

MTM:	MYCTH_82456

CTHR:

CTHT_0040680 CTHT_0055950

RTHE:

98126804(VTJ83DRAFT_5548) 98129117(VTJ83DRAFT_791)

MGR:	MGG_05159 MGG_07933 MGG_08615 MGG_16966

PPEI:

PpBr36_03531 PpBr36_03838 PpBr36_03851

PGRI:

PgNI_02808 PgNI_09163 PgNI_09179 PgNI_09601

TMN:	UCRPA7_1105 UCRPA7_1858 UCRPA7_4535 UCRPA7_6686 UCRPA7_7278 UCRPA7_729 UCRPA7_7973

SSCK:

SPSK_00143 SPSK_01848 SPSK_03433 SPSK_03475 SPSK_07785

FGR:	FGSG_01813 FGSG_02063 FGSG_03069 FGSG_03647 FGSG_05048 FGSG_09521

FPU:	FPSE_01888 FPSE_02157 FPSE_03347 FPSE_04939 FPSE_05154 FPSE_11340

FPOA:

FPOAC1_002206 FPOAC1_005426 FPOAC1_007947 FPOAC1_012140

FVN:	FVRRES_02444 FVRRES_05983 FVRRES_08483 FVRRES_13215

FVR:	FVEG_04070 FVEG_06008 FVEG_07522 FVEG_07725 FVEG_08807 FVEG_10721

FOX:	FOXG_04402 FOXG_04587 FOXG_06217 FOXG_08665 FOXG_09663 FOXG_12147

NHE:	NECHADRAFT_103547 NECHADRAFT_41228 NECHADRAFT_51004 NECHADRAFT_53351 NECHADRAFT_73269 NECHADRAFT_75207 NECHADRAFT_82289 NECHADRAFT_99111

FFC:	NCS54_00134900 NCS54_00224900 NCS54_00296900 NCS54_00732200 NCS54_00892300 NCS54_01241800 NCS54_01344500 NCS54_01404400

FKR:	NCS57_00132300 NCS57_00220400 NCS57_00292100 NCS57_00772600 NCS57_01267600 NCS57_01320100 NCS57_01470900

FMU:	J7337_004076 J7337_004761 J7337_010473 J7337_013310

TRE:	TRIREDRAFT_122582 TRIREDRAFT_2036 TRIREDRAFT_3717 TRIREDRAFT_53123

TRR:	M419DRAFT_129606 M419DRAFT_131928 M419DRAFT_141790 M419DRAFT_88777

TATV:

25775279(TrAtP1_006429) 25781633(TrAtP1_008221) 25785766(TrAtP1_009982)

TASP:

36607632(TrAFT101_003156) 36608606(TrAFT101_005691) 36609779(TrAFT101_011216) 36616874(TrAFT101_006867)

MAW:	19245547(J3458_014426) 19248802(J3458_014343) 19253766(J3458_020054)

MAJ:	MAA_00627 MAA_07813 MAA_09251

MBRN:

26242821(G6M90_00g058320) 26246917(G6M90_00g112550)

PCHM:

VFPPC_05939 VFPPC_08305 VFPPC_10737

UVI:	66068414(UV8b_07637) 66068469(UV8b_07692)

CMT:	CCM_05289 CCM_07759 CCM_07861

AMUS:

LMH87_003092 LMH87_011155

PLJ:	28884668(PLICBS_005891) 28889587(PLICBS_007988) 28891153(PLICBS_004545) 28893163(PLICBS_009873) 90642997(PLICBS_005219)

PTKZ:

JDV02_004118 JDV02_005453 JDV02_008698 JDV02_009402 JDV02_010296

VAL:	VDBG_01853 VDBG_03325 VDBG_05072 VDBG_08158 VDBG_09109 VDBG_09557

VDA:	VDAG_01702 VDAG_02228 VDAG_04788 VDAG_07257 VDAG_10050 VDAG_10512

CFJ:	CFIO01_04102 CFIO01_04988 CFIO01_05142 CFIO01_05423 CFIO01_08392 CFIO01_08695 CFIO01_12712 CFIO01_13735

CLUP:

CLUP02_01428 CLUP02_01662 CLUP02_02715 CLUP02_15676 CLUP02_16425 CLUP02_16731

CHIG:

CH63R_02055 CH63R_05135 CH63R_06511 CH63R_10333 CH63R_10575 CH63R_11316 CH63R_14095

CDET:

87936785(CDEST_00282) 87942208(CDEST_05705) 87943434(CDEST_06931) 87943683(CDEST_07180) 87946067(CDEST_09564) 87947667(CDEST_11167) 87947894(CDEST_11394)

ELA:	UCREL1_1 UCREL1_10034 UCREL1_3023 UCREL1_4493 UCREL1_7875 UCREL1_8344 UCREL1_9767

PFY:	PFICI_02155 PFICI_06710 PFICI_10660 PFICI_11183 PFICI_13580 PFICI_14195

SSL:	SS1G_02917 SS1G_04053

BFU:	BCIN_01g06600 BCIN_06g05360

MBE:

MBM_05778

PSCO:

LY89DRAFT_58302 LY89DRAFT_587194 LY89DRAFT_685858 LY89DRAFT_694995 LY89DRAFT_705574

GLZ:	GLAREA_07669

ANI:	ANIA_01503 ANIA_10990

AFM:	AFUA_2G01230 AFUA_4G08690 AFUA_8G05040

ACT:	ACLA_048040 ACLA_058440 ACLA_072950 ACLA_094540

NFI:	NFIA_033530 NFIA_089760 NFIA_097850 NFIA_107490

AOR:	AO090005000638 AO090701000399

ANG:	An03g00040 An10g00330 An15g04230 An16g07700

AFV:	AFLA_003449 AFLA_004914

ALUC:

AKAW2_50024S AKAW2_70609S AKAW2_71046S

ACHE:

ACHE_40068S ACHE_60607S

APUU:

APUU_11117S APUU_21711S APUU_40056A APUU_60006S APUU_60054S APUU_80237A

PCS:	N7525_006160 N7525_006169 N7525_007792 N7525_009429

PDP:	PDIP_02670 PDIP_46650

POU:	POX_a01923 POX_h09833

PPSF:

300787636(PFLUO_LOCUS2064) 300789522(PFLUO_LOCUS3762) 300791077(PFLUO_LOCUS5162) 300792063(PFLUO_LOCUS605) 300793850(PFLUO_LOCUS7659) 300794809(PFLUO_LOCUS8521)

TMF:	EYB26_000617 EYB26_004448 EYB26_005107 EYB26_006504 EYB26_009474

TRG:	TRUGW13939_01370 TRUGW13939_02223 TRUGW13939_02289 TRUGW13939_03930 TRUGW13939_04239 TRUGW13939_07477 TRUGW13939_08086 TRUGW13939_08229 TRUGW13939_08539 TRUGW13939_09259 TRUGW13939_10146

CIM:	CIMG_00151 CIMG_06885

CPW:	9692236(D8B26_005029) 9695584(D8B26_005936)

URE:	UREG_00255 UREG_03604

ABE:	ARB_01658 ARB_05761

TVE:	TRV_00049 TRV_04481

PBL:	PAAG_03143 PAAG_03793

PBN:	PADG_03024 PADG_03296

AJE:	HCAG_01713 HCAG_07219

BGH:	BDBG_00749 BDBG_02384 BDBG_03560

PNO:	SNOG_03839 SNOG_04544 SNOG_15818

PTE:	PTT_08311 PTT_12228 PTT_17993

PTRR:

6344723(PtrM4_049530) 6346091(PtrM4_138340) 6346995(PtrM4_031640)

BZE:	COCCADRAFT_109610 COCCADRAFT_37284 COCCADRAFT_9535

BSC:	COCSADRAFT_271752 COCSADRAFT_33387 COCSADRAFT_335849

BOR:	COCMIDRAFT_23190 COCMIDRAFT_26603 COCMIDRAFT_8673

AALT:

CC77DRAFT_1017551 CC77DRAFT_1040104 CC77DRAFT_840448

ADAC:

96081372(ACET3X_001050) 96086725(ACET3X_006403) 96088492(ACET3X_008170)

ARAB:

EKO05_0002435 EKO05_0006593 EKO05_0008024 EKO05_0009845

ZTR:	MYCGRDRAFT_66153

PFJ:	MYCFIDRAFT_29231

FFU:	CLAFUR5_02034 CLAFUR5_09491

CBET:

CB0940_01575

BCOM:

BAUCODRAFT_150164 BAUCODRAFT_558779 BAUCODRAFT_573577 BAUCODRAFT_68239

NPA:	UCRNP2_1393 UCRNP2_68 UCRNP2_7892 UCRNP2_894

TML:	GSTUM_00008462001

CNE:

CNC03990

CNB:

CNBC3190

CNG:	CNAG_02781

CGI:	CGB_C6100W

CDEU:

CNBG_3436

CDEC:

89987908(IAS62_001133)

CTEG:

91988941(I308_102083)

CBAS:

91982134(I312_102086)

KMG:	30167418(I203_106328)

KNE:	92178234(IAR55_000975)

KDJ:	28964632(I303_100929)

KBI:	30207195(I302_104090)

KSH:	87953025(IL334_000894)

KER:	91106126(V865_007325)

KSN:	43588545(CI109_102434)

TMS:	TREMEDRAFT_70222

TVS:	TRAVEDRAFT_145691 TRAVEDRAFT_29711 TRAVEDRAFT_62801

DSQ:	DICSQDRAFT_129292 DICSQDRAFT_152921

PCO:	PHACADRAFT_166860 PHACADRAFT_252672 PHACADRAFT_255535 PHACADRAFT_257602

SHS:	STEHIDRAFT_119341 STEHIDRAFT_49383

HIR:	HETIRDRAFT_157267 HETIRDRAFT_412119 HETIRDRAFT_448998

PSQ:	PUNSTDRAFT_52021 PUNSTDRAFT_70957

ADL:	AURDEDRAFT_110014 AURDEDRAFT_148009

FME:	FOMMEDRAFT_131642

GTR:	GLOTRDRAFT_116882

RSX:	RhiXN_03260

LBC:	LACBIDRAFT_189233

CCI:	CC1G_04219 CC1G_06285

ABP:	AGABI1DRAFT111212(AGABI1DRAFT_111212) AGABI1DRAFT114952(AGABI1DRAFT_114952)

ABV:	AGABI2DRAFT190432(AGABI2DRAFT_190432) AGABI2DRAFT191181(AGABI2DRAFT_191181)

PCUB:

JR316_0006081

MRR:	Moror_14079 Moror_4689 Moror_8005

E1B28_006317 E1B28_007270 E1B28_008904

SCM:	SCHCO_02605035(SCHCODRAFT_02605035)

CPUT:

CONPUDRAFT_129595 CONPUDRAFT_51541

SLA:	SERLADRAFT_361556 SERLADRAFT_454235

WSE:	WALSEDRAFT_29927 WALSEDRAFT_61673

WIC:	J056_003032

UMA:	UMAG_04667

SGRA:

EX895_005464

LIP:	LI0108(dapA)

LIR:	LAW_00107(dapA_1)

STI:

Sthe_0488

LCRE:

Pla8534_42110(dapA_3)

BHC:	JFL75_14300

ABA:	Acid345_2666

ACA:

ACP_0327

ACM:	AciX9_1581

GMA:	AciX8_1331

GRW:	FTO74_12010

TRS:	Terro_1985 Terro_2351

TALB:

FTW19_14730

ABAS:

ACPOL_6664

EDA:	GWR55_03525

SUS:

Acid_1067

PFER:

IRI77_34435

ABAC:

LuPra_06084(dapA_3)

GAU:

GAU_0904

GPH:	GEMMAAP_05215

GBA:

J421_2804

DHD:

Dhaf_1978

DDL:	Desdi_0801

DOR:	Desor_3029

TFR:	BR63_09785(dapA)

TMR:

Tmar_1165

THEF:

E1B22_09485

THEP:

DYI95_005800

IBU:	IB211_03323c

TEX:	Teth514_1917

THX:

Thet_1017

TIT:

Thit_1575

TWI:	Thewi_1732

TTO:	Thethe_02138

MAS:	Mahau_1310

KME:	H0A61_00412(dapA_2)

KBS:	EPA93_24885

TRA:

Trad_0621

TTL:	TtJL18_1311

TSC:	TSC_c08910(dapA1)

THC:	TCCBUS3UF1_14710

TOS:	Theos_1413

MRB:

Mrub_2327

MRE:	K649_10895

MSV:	Mesil_2236

ACO:	Amico_1829

TLI:

Tlie_1310

AMO:	Anamo_0048

HLO:	J0X27_13620

» show all

Reference

PMID:21998747

Authors

Riedel TJ, Johnson LC, Knight J, Hantgan RR, Holmes RP, Lowther WT

Title

Structural and biochemical studies of human 4-hydroxy-2-oxoglutarate aldolase: implications for hydroxyproline metabolism in primary hyperoxaluria.

Journal

PLoS One 6:e26021 (2011)
DOI:10.1371/journal.pone.0026021

Sequence

[hsa:112817]

LinkDB

ENZYME: 4.1.3.16

Entry

EC 4.1.3.16                 Enzyme

Name

4-hydroxy-2-oxoglutarate aldolase;
2-oxo-4-hydroxyglutarate aldolase;
hydroxyketoglutaric aldolase;
4-hydroxy-2-ketoglutaric aldolase;
2-keto-4-hydroxyglutaric aldolase;
4-hydroxy-2-ketoglutarate aldolase;
2-keto-4-hydroxyglutarate aldolase;
2-oxo-4-hydroxyglutaric aldolase;
DL-4-hydroxy-2-ketoglutarate aldolase;
hydroxyketoglutarate aldolase;
2-keto-4-hydroxybutyrate aldolase;
4-hydroxy-2-oxoglutarate glyoxylate-lyase;
KHGA

Class

Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases

Sysname

4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)

Reaction(IUBMB)

4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate [RN:R00470]

Reaction(KEGG)

R00470 > R00471 R10283

Substrate

4-hydroxy-2-oxoglutarate [CPD:C01127]

Product

pyruvate [CPD:C00022];
glyoxylate [CPD:C00048]

Comment

The enzymes from rat liver and bovine liver act on both enantiomers of 4-hydroxy-2-oxoglutarate. cf. EC 4.1.3.42, (4S)-4-hydroxy-2-oxoglutarate aldolase.

History

EC 4.1.3.16 created 1972 (EC 4.1.2.1 created 1961, incorporated 1972, EC 4.1.2.31 created 1978, incorporated 1982)

Pathway

ec00330

Arginine and proline metabolism

ec00630

Glyoxylate and dicarboxylate metabolism

ec01100

Metabolic pathways

Orthology

K18123

4-hydroxy-2-oxoglutarate aldolase

Genes

HSA:	112817(HOGA1)

PTR:	742884(HOGA1)

PPS:	103782784(HOGA1)

GGO:	101154009(HOGA1)

PON:	100171598(HOGA1)

PPYG:

129006120(HOGA1)

NLE:	100589206(HOGA1)

HMH:	116456320(HOGA1)

SSYN:

129468115(HOGA1)

MCC:	706661(HOGA1)

MCF:	102126728(HOGA1)

MTHB:

126962086

MNI:	105478444(HOGA1)

CSAB:

103216345(HOGA1)

CATY:

105581795(HOGA1)

PANU:

101014787(HOGA1)

TGE:	112631561(HOGA1)

MLEU:

105554171(HOGA1)

RRO:	104682808(HOGA1)

RBB:	108534698(HOGA1)

TFN:	117068959(HOGA1)

PTEH:

111538766(HOGA1)

CANG:

105518265(HOGA1)

CJC:	103796777(HOGA1)

SBQ:	104650492(HOGA1)

CIMI:

108285506(HOGA1)

ANAN:

105708227(HOGA1)

CSYR:

103264836(HOGA1)

MMUR:

105873085(HOGA1)

LCAT:

123650168(HOGA1)

ERUF:

138376499(HOGA1)

PCOQ:

105818494(HOGA1)

OGA:	100958797(HOGA1)

MMU:	67432(Hoga1)

MCAL:

110285310(Hoga1)

MPAH:

110333903(Hoga1)

RNO:	293949(Hoga1)

MCOC:

116103842(Hoga1)

ANU:	117715996(Hoga1)

ASYL:

127687315(Hoga1)

MUN:	110564114(Hoga1)

CGE:	100759109(Hoga1)

MAUA:

101824115(Hoga1)

PROB:

127233327(Hoga1)

PLEU:

114706886(Hoga1)

PMAV:

102917801(Hoga1)

MORG:

121454497(Hoga1)

MFOT:

126504665

AAMP:

119822156(Hoga1)

CNL:	130880382(Hoga1)

NGI:	103733196(Hoga1)

HGL:	101700602(Hoga1)

CPOC:

100720763(Hoga1)

CCAN:

109695304(Hoga1)

DORD:

105986751(Hoga1)

DSP:	122115913(Hoga1)

DMER:

138826190 138830130

PLOP:

125346195(Hoga1)

NCAR:

124984723

MMMA:

107149768(Hoga1)

ITI:	101966547(Hoga1)

OCU:

100344505

OPI:	101517296(HOGA1)

OCZ:	121164001(HOGA1)

TUP:	102486364(HOGA1)

GVR:	103590892(HOGA1)

CFA:	608755(HOGA1)

CLUD:

112672141(HOGA1)

VVP:	112914409(HOGA1)

VLG:	121483974(HOGA1)

NPO:	129493943(HOGA1)

AML:	100478059(HOGA1)

UMR:	103674087(HOGA1)

UAH:	113251791(HOGA1)

UAR:	123783886(HOGA1)

ELK:

111145298

LLV:

125084924

MPUF:

101693912(HOGA1)

MNP:	132016673(HOGA1)

MLK:	131828583(HOGA1)

NVS:	122900985(HOGA1)

ORO:	101385318(HOGA1)

EJU:	114205383(HOGA1)

ZCA:	113919122(HOGA1)

MLX:	118024504(HOGA1)

MANO:

123846728(HOGA1)

NSU:	110589086(HOGA1)

LWW:	102740193(HOGA1)

FCA:	101101417(HOGA1)

PYU:	121037065(HOGA1)

PCOO:

112854322(HOGA1)

PBG:	122493090(HOGA1)

PVIV:

125148100(HOGA1)

LRUF:

124506708

LGF:	123576898(HOGA1)

AJU:

106966929

PTG:	102965487(HOGA1)

PPAD:

109272717(HOGA1)

PUC:

125932841

PLEZ:

122202319(HOGA1)

HHV:	120230623(HOGA1)

CCRU:

144245181(HOGA1)

BTA:	506001(HOGA1)

BOM:	102265621(HOGA1)

BIU:	109552999(HOGA1)

BJV:	133239244(HOGA1)

BBUB:

102398601(HOGA1)

BKE:	129636603(HOGA1)

BBIS:

104983565(HOGA1)

CHX:	102173994(HOGA1)

OAS:	101114573(HOGA1)

OCAN:

138427988(HOGA1)

BTAX:

128067740(HOGA1)

CSUM:

138070158(HOGA1)

ODA:	120873942(HOGA1)

CCAD:

122446094(HOGA1)

MREE:

136160022(HOGA1)

OVR:	110131103(HOGA1)

MBEZ:

129555481(HOGA1)

SSC:	100153961(HOGA1)

CFR:	102512614(HOGA1)

CBAI:

105081776(HOGA1)

CDK:	105084288(HOGA1)

VPC:	102541568(HOGA1)

BACU:

103004258(HOGA1)

BMUS:

118882584(HOGA1)

LVE:	103077167 103089444(HOGA1)

OOR:	101271753(HOGA1)

LALB:

132507549(HOGA1)

GMF:	115857852(HOGA1)

DDP:	132439741(HOGA1)

DLE:	111172427(HOGA1)

PCAD:

102979032(HOGA1)

PSIU:

116741875(HOGA1)

PPHC:

136136445(HOGA1)

NASI:

112393068(HOGA1)

ECB:	100070689(HOGA1)

EPZ:	103558701(HOGA1)

EAI:	106844960(HOGA1)

MYB:	102246939(HOGA1)

MYD:	102768587(HOGA1)

MMYO:

118669893(HOGA1)

MLF:	102427524(HOGA1)

MDT:	132214200(HOGA1)

MYUM:

139021846(HOGA1)

PKL:	118719357(HOGA1)

EFUS:

103288446(HOGA1)

MNA:	107542604(HOGA1)

DRO:	112307109(HOGA1)

SHON:

118990274(HOGA1)

AJM:	119044532(HOGA1)

PDIC:

114495945(HOGA1)

PHAS:

123828952(HOGA1)

MMF:	118632358(HOGA1)

PPAM:

129077277(HOGA1)

HAI:	109379716(HOGA1)

RFQ:	117036234(HOGA1)

PALE:

102884382(HOGA1)

PGIG:

120609240(HOGA1)

PVP:	105301380(HOGA1)

RAY:	107520438(HOGA1)

MJV:	108399750(HOGA1)

TOD:	119233797(HOGA1)

SFUM:

130029477(HOGA1)

SETR:

125994794(HOGA1)

LAV:	100670230(HOGA1)

TMU:

101355404

ETF:	101646656(HOGA1)

DNM:	101419181(HOGA1)

MDO:	100021876(HOGA1)

GAS:	123238246(HOGA1)

SHR:	100929176(HOGA1)

AFZ:

127551747

PCW:	110215427(HOGA1)

TVP:	118828333(HOGA1)

PBRV:

138145523(HOGA1)

MLAO:

141521081(HOGA1)

OAA:	100088274(HOGA1)

TACU:

119925792(HOGA1)

GGA:	770036(HOGA1)

PCOC:

116231725(HOGA1)

MGP:	100548398(HOGA1)

CJO:	107316003(HOGA1)

TPAI:

128077526(HOGA1)

LMUT:

125693723(HOGA1)

NMEL:

110400352(HOGA1)

APLA:

119717295(HOGA1)

AACU:

137859296(HOGA1)

CATA:

118245260(HOGA1)

AFUL:

116491080(HOGA1)

TGU:	100231472(HOGA1)

LSR:	110473597(HOGA1)

AIB:	137478180(HOGA1)

SCAN:

103813888(HOGA1)

PMOA:

120502206(HOGA1)

OTC:	121341648(HOGA1)

PRUF:

121350021(HOGA1)

ATRC:

139599202(HOGA1)

MATE:

118688418(HOGA1)

MAEN:

136559698(HOGA1)

GFR:	102042170(HOGA1)

FAB:	101806953(HOGA1)

OMA:	130254728(HOGA1)

PHI:	102112987(HOGA1)

PMAJ:

107206698(HOGA1)

CCAE:

111931229(HOGA1)

CCW:	104695887(HOGA1)

CBRC:

103624537(HOGA1)

ACOE:

138112847(HOGA1)

ETL:	114070777(HOGA1)

ZAB:	102062750(HOGA1)

ZLE:	135449422(HOGA1)

ACHL:

103807138(HOGA1)

SVG:	106859028(HOGA1)

MMEA:

130582102(HOGA1)

HRT:	120755990(HOGA1)

SATI:

136364106(HOGA1)

CCIC:

134046258(HOGA1)

FPG:	101920952(HOGA1)

FCH:	102052298(HOGA1)

FRS:	119153409(HOGA1)

CCRI:

104160613(HOGA1)

NNT:	104401870(HOGA1)

SHAB:

115608256(HOGA1)

ACUN:

113481407(HOGA1)

ANOC:

141961045(HOGA1)

SURA:

141946011(HOGA1)

TALA:

116962067(HOGA1)

ACHC:

115348491(HOGA1)

HLE:	104830136(HOGA1)

AGEN:

126042830

HHAR:

128147450(HOGA1)

BBUT:

142030673(HOGA1)

CSTI:

104558098(HOGA1)

LDI:	104355014(HOGA1)

MNB:	103775287(HOGA1)

DPUB:

104307074(HOGA1)

PPUS:

135176021(HOGA1)

AVIT:

104274804(HOGA1)

BRHI:

104501654(HOGA1)

EGZ:	104132255(HOGA1)

NNI:	104012772(HOGA1)

PARX:

142063560(HOGA1)

PADL:

103916280(HOGA1)

AFOR:

103897686(HOGA1)

CBOR:

142084308(HOGA1)

CBOY:

140656049(HOGA1)

MAME:

142410899(HOGA1)

CLV:	102097409(HOGA1)

CNIC:

135990661(HOGA1)

MUI:	104544738(HOGA1)

PGUU:

104471445(HOGA1)

PLET:

104621767(HOGA1)

EHS:	104511181(HOGA1)

CMAC:

104486380(HOGA1)

CUCA:

104059789(HOGA1)

TEO:	104384160(HOGA1)

BREG:

104633603(HOGA1)

GAME:

129208621(HOGA1)

OHA:	104332280(HOGA1)

ACAR:

104531510(HOGA1)

CPEA:

104390936(HOGA1)

CVF:	104288806(HOGA1)

RTD:	128911756(HOGA1)

CRID:

134517380(HOGA1)

LMIC:

141744616(HOGA1)

NARQ:

141472235(HOGA1)

AROW:

112968046(HOGA1)

NPD:	112957175(HOGA1)

DNE:	112984791(HOGA1)

ASN:	102382587(HOGA1)

AMJ:	102563093(HOGA1)

CPOO:

109324348(HOGA1)

GGN:	109287532(HOGA1)

CIZ:	142015643(HOGA1)

CMY:	114018236(HOGA1)

CCAY:

125639699(HOGA1)

LKP:	140915111(HOGA1)

NDS:	141991244(HOGA1)

DCC:	119858528(HOGA1)

CPIC:

103307603(HOGA1)

TST:	117880415(HOGA1)

CABI:

116822802(HOGA1)

ACS:	100566929(hoga1)

ASAO:

132770857(HOGA1)

PVT:	110089167(HOGA1)

SUND:

121926128(HOGA1)

PBI:	103053263(HOGA1)

PMUR:

107295219(HOGA1)

CTIG:

120302535(HOGA1)

TSR:	106549035(HOGA1)

PGUT:

117678595(HOGA1)

PCAE:

139318350(HOGA1)

APRI:

131200355(HOGA1)

PTEX:

113436688(HOGA1)

NSS:	113416749(HOGA1)

VKO:	123026676(HOGA1)

PMUA:

114597588(HOGA1)

PRAF:

128414342(HOGA1)

ZVI:	118093538(HOGA1)

HCG:	128352167(HOGA1)

GJA:	107114457(HOGA1)

STOW:

125438115(HOGA1)

EMC:	129331742(HOGA1)

XLA:	495193(hoga1.L)

XTR:	496669(hoga1)

NPR:	108792933(HOGA1)

RTEM:

120946635(HOGA1)

ACAT:

141105211(HOGA1)

PADS:

140339864(HOGA1)

BBUF:

121004610(HOGA1)

BGAR:

122941075 122942538

DTC:	141056157(HOGA1)

PWL:	138300353(HOGA1)

MUO:	115459261 115470032(HOGA1)

GSH:	117359862(HOGA1)

DRE:	405806(hoga1)

SRX:

107706114

SANH:

107663482(hoga1)

SGH:	107551368 107588470(hoga1)

CCAR:

109069442(hoga1)

CAUA:

113039744(hoga1)

CGIB:

127988445

PTET:

122327069(hoga1)

LROH:

127162500(hoga1)

GRF:	141339230(hoga1)

OMC:	131530559(hoga1)

PPRM:

120468726 120468763(hoga1)

RKG:	130093428(hoga1)

MAMB:

125254424(hoga1)

CIDE:

127520584

CERY:

137028996(hoga1)

MASI:

127438724

TROS:

130548897(hoga1)

TDW:	130429599(hoga1)

MANU:

129454062(hoga1)

PDAB:

135740888(hoga1)

IPU:

108259603

IFU:	128602599(hoga1)

PHYP:

113546731(hoga1)

SMEO:

124379684(hoga1)

TFD:	113656985(hoga1)

TVC:	132839014(hoga1)

CGAR:

128518313(hoga1)

NGRA:

132874946(hoga1)

TRN:	134304122(hoga1)

AMEX:

103023796(hoga1)

CMAO:

118817343(hoga1)

EEE:	113577699(hoga1)

CHAR:

105892823(hoga1)

SPIL:

134101823(hoga1)

ASAD:

121677454(hoga1)

TRU:	101061435(hoga1)

TFS:	130527505(hoga1)

TNG:	GSTEN00009068G001

LCO:	104930035(hoga1)

NCC:	104953008(hoga1)

TBEN:

117482094(hoga1)

EMAC:

134864581(hoga1)

ELY:	117255225(hoga1)

EFO:	125885368(hoga1)

SLUC:

116049892(hoga1)

ECRA:

117962147(hoga1)

PFLV:

114570716(hoga1)

GAT:	120813082(hoga1)

PPUG:

119218010(hoga1)

AFB:	129095314(hoga1)

CLUM:

117733045(hoga1)

PSWI:

130190637(hoga1)

CANA:

137798769(hoga1)

CVE:	137874341 137884641

MSAM:

119898305(hoga1)

SCHU:

122873536(hoga1)

EARM:

139293419(hoga1)

CUD:	121508633(hoga1)

SPUL:

138595128(hoga1)

LMIX:

132983125(hoga1)

HTC:	141801690(hoga1)

ALAT:

119019204(hoga1)

ASTR:

137600286(hoga1)

PKLU:

139199439(hoga1)

MZE:	101479315(hoga1)

ONL:	100690946(hoga1)

OAU:	116315581(hoga1)

OLA:	101161460(hoga1)

OML:	112156927(hoga1)

CSAI:

133454314(hoga1)

XMA:	102230783(hoga1)

XCO:	114145238(hoga1)

XHE:	116720256(hoga1)

PRET:

103470116(hoga1)

PFOR:

103154489(hoga1)

PLAI:

106948744(hoga1)

PMEI:

106927085(hoga1)

GAF:	122830294(hoga1)

CVG:	107081958(hoga1)

CTUL:

119798502(hoga1)

GMU:	124869120(hoga1)

NFU:	107382406(hoga1)

KMR:	108247450(hoga1)

ALIM:

106537034(hoga1)

NWH:	119422511 119423198

AOCE:

111580411(hoga1)

EJA:	138209584(hoga1)

BFRE:

138615706(hoga1)

MCEP:

125002125(hoga1)

CSEM:

103383203(hoga1)

POV:

109645371

SSEN:

122771614(hoga1)

SSOE:

131466405(hoga1)

HHIP:

117760502(hoga1)

HSP:	118099088(hoga1)

PPLT:

128436949(hoga1)

SMAU:

118312777(hoga1)

LCF:

108880833

SDU:	111235845(hoga1)

SLAL:

111665639(hoga1)

XGL:	120800280(hoga1)

HCQ:	109511381(hoga1)

SSCV:

125969014(hoga1)

SBIA:

133506296(hoga1)

PEE:	133403755(hoga1)

PTAO:

133476783(hoga1)

BPEC:

110155940(hoga1)

ENY:	140378077(hoga1)

MALB:

109952000(hoga1)

BSPL:

114861357(hoga1)

SJO:	128381165(hoga1)

SSCO:

133998075(hoga1)

TTY:	137180182(hoga1)

GMH:	115540262(hoga1)

SASA:

106591168(hoga1) 106591313

STRU:

115178813(hoga1)

OTW:	112230192(hoga1)

OMY:	110485610 110487262

OGO:	124018276(hoga1)

ONE:	115127679(hoga1)

OKI:

109877035

OKE:	127932411(hoga1)

OMM:	135530600 135530601

OCLA:

139424364

SALP:

112079381(hoga1)

SNH:	120032829(hoga1) 120032838

SFON:

129843030(hoga1)

CCLU:

121533209(hoga1)

ELS:	105006876(hoga1)

SFM:	108924852(hoga1)

PKI:	111848362(hoga1)

AANG:

118219744(hoga1)

AROT:

135247448(hoga1)

CCOG:

133122150(hoga1)

LOC:	102687344(hoga1)

PSPA:

121321919(hoga1)

ARUT:

117415418(hoga1)

PSEX:

120542430(hoga1)

LCM:	102362318(HOGA1)

CMK:	103172525(hoga1)

RTP:	109921722(hoga1)

CPLA:

122561306(hoga1)

CPUN:

140463345(hoga1)

HOC:	132826170(hoga1)

SCAU:

119979761(hoga1)

LERI:

129704161(hoga1)

HAKA:

140715184(hoga1)

PMRN:

116947233(HOGA1)

LRJ:	133360500(HOGA1)

BFO:	118413704 118414415

BBEL:

109485298

CIN:

100181036

SCLV:

120331743

CLEP:

143450056

SPU:

579934

LPIC:

129273310 129273313

LVG:

121425520

AJJ:

139968029

APLC:

110981286

ARUN:

117294569

AAMU:

139940475

AFIL:

140149244

AJC:

117105738

SKO:

100372772

PFLL:

139119689

BCOO:

119068060

API:

100570569

DNX:

107163989

AGS:

114132054

RMD:

113549091

ACOO:

126832826

DVT:

126905103

BTAB:

109031207 109033146 109037695

DCI:	103507739 103520261

CLEC:

106664885 106665585

HHAL:

106681743

NLU:

111064155

LDA:

142329826

HVI:	124369256 124370050 124374619

MQU:	128987472 128998301 129004190

ZNE:

110831450

CSEC:

111864684

PAME:

138697709

SGRE:

126355053

BROR:

134534182

IEL:

124154147

HAMR:

139687909

FCD:

110856855

DPX:	DAPPUDRAFT_52277

DMK:

116921690

PVM:

113818492

PJA:

122267255

PCHN:

125038676

PMOO:

119597868

HAME:

121871046

PCLA:

123774790

PTRU:

123517476

SPRM:

135101584

ESN:

127000337

MNZ:

135202576

MRJ:

136847432

PORN:

139750228

HAZT:

108672513

EAF:

111698923

TCF:

131887655

PPOI:

119112206

DSV:

119442461

DALB:

135911272

RSAN:

119388374

RMP:

119159482

CSCU:

111618478

CVS:

136979887

PTEP:

107438884

ABRU:

129969073

UDV:

129231927

SDM:

118202582

LPOL:

106467514

HRO:	HELRODRAFT_157064

LGI:	LOTGIDRAFT_211287

PVUL:

126816331

PCAN:

112565420

LSAX:

138981791 138981792

BARL:

143276025

BGT:

106072266

GAE:

121383851

HRF:

124138672

HRJ:

124264316

HASI:

137283817

HCRA:

139455819

CRG:

105328725

CANU:

128180636

CVN:

111132935

OED:

125657514

MYI:

110455405

PMAX:

117339557

AIRR:

138335210

YBA:

132544900

MCAF:

127733312

MMER:

123547812

RPHI:

132717755 132721141

DPOL:

127842163

MAEA:

128212036

OBI:

106884306

OSN:

115232061

LJP:

135468956

LAK:

106170963

LLON:

135489616

NVE:

5520994

EPA:

110231654

ATEN:

116307006

ADF:

107337820

AMIL:

114962597

MCAZ:

138043616 138043617

MFOO:

138006840 138006841

PDAM:

113686876

SPIS:

111324439

DGT:

114515751

XEN:

124444846

HMG:

100199549

HSY:	130644187 130646181

RES:

135695854

CCLM:

134182206

NCR:	NCU04744 NCU05977

NTE:	NEUTE1DRAFT148948(NEUTE1DRAFT_148948) NEUTE1DRAFT48910(NEUTE1DRAFT_48910)

SMP:	10805247(SMAC4_03823) 10808176(SMAC4_07903)

PAN:	PODANSg09878 PODANSg3113 PODANSg3131

PBEL:

QC761_106120 QC761_407320 QC761_407500

PPSD:

QC762_106120 QC762_407320 QC762_407500

PPSP:

QC763_106120 QC763_407320 QC763_407500

PPSA:

QC764_106120 QC764_407320 QC764_407500

TTT:	THITE_2041371 THITE_2110019 THITE_2122366

MTM:	MYCTH_82456

CTHR:

CTHT_0040680 CTHT_0055950

RTHE:

98126804(VTJ83DRAFT_5548) 98129117(VTJ83DRAFT_791)

MGR:	MGG_05159 MGG_07933 MGG_08615 MGG_16966

PPEI:

PpBr36_03531 PpBr36_03838 PpBr36_03851

PGRI:

PgNI_02808 PgNI_09163 PgNI_09179 PgNI_09601

TMN:	UCRPA7_1105 UCRPA7_1858 UCRPA7_4535 UCRPA7_6686 UCRPA7_7278 UCRPA7_729 UCRPA7_7973

SSCK:

SPSK_00143 SPSK_01848 SPSK_03433 SPSK_03475 SPSK_07785

FGR:	FGSG_01813 FGSG_02063 FGSG_03069 FGSG_03647 FGSG_05048 FGSG_09521

FPU:	FPSE_01888 FPSE_02157 FPSE_03347 FPSE_04939 FPSE_05154 FPSE_11340

FPOA:

FPOAC1_002206 FPOAC1_005426 FPOAC1_007947 FPOAC1_012140

FVN:	FVRRES_02444 FVRRES_05983 FVRRES_08483 FVRRES_13215

FVR:	FVEG_04070 FVEG_06008 FVEG_07522 FVEG_07725 FVEG_08807 FVEG_10721

FOX:	FOXG_04402 FOXG_04587 FOXG_06217 FOXG_08665 FOXG_09663 FOXG_12147

NHE:	NECHADRAFT_103547 NECHADRAFT_41228 NECHADRAFT_51004 NECHADRAFT_53351 NECHADRAFT_73269 NECHADRAFT_75207 NECHADRAFT_82289 NECHADRAFT_99111

FFC:	NCS54_00134900 NCS54_00224900 NCS54_00296900 NCS54_00732200 NCS54_00892300 NCS54_01241800 NCS54_01344500 NCS54_01404400

FKR:	NCS57_00132300 NCS57_00220400 NCS57_00292100 NCS57_00772600 NCS57_01267600 NCS57_01320100 NCS57_01470900

FMU:	J7337_004076 J7337_004761 J7337_010473 J7337_013310

TRE:	TRIREDRAFT_122582 TRIREDRAFT_2036 TRIREDRAFT_3717 TRIREDRAFT_53123

TRR:	M419DRAFT_129606 M419DRAFT_131928 M419DRAFT_141790 M419DRAFT_88777

TATV:

25775279(TrAtP1_006429) 25781633(TrAtP1_008221) 25785766(TrAtP1_009982)

TASP:

36607632(TrAFT101_003156) 36608606(TrAFT101_005691) 36609779(TrAFT101_011216) 36616874(TrAFT101_006867)

MAW:	19245547(J3458_014426) 19248802(J3458_014343) 19253766(J3458_020054)

MAJ:	MAA_00627 MAA_07813 MAA_09251

MBRN:

26242821(G6M90_00g058320) 26246917(G6M90_00g112550)

PCHM:

VFPPC_05939 VFPPC_08305 VFPPC_10737

UVI:	66068414(UV8b_07637) 66068469(UV8b_07692)

CMT:	CCM_05289 CCM_07759 CCM_07861

AMUS:

LMH87_003092 LMH87_011155

PLJ:	28884668(PLICBS_005891) 28889587(PLICBS_007988) 28891153(PLICBS_004545) 28893163(PLICBS_009873) 90642997(PLICBS_005219)

PTKZ:

JDV02_004118 JDV02_005453 JDV02_008698 JDV02_009402 JDV02_010296

VAL:	VDBG_01853 VDBG_03325 VDBG_05072 VDBG_08158 VDBG_09109 VDBG_09557

VDA:	VDAG_01702 VDAG_02228 VDAG_04788 VDAG_07257 VDAG_10050 VDAG_10512

CFJ:	CFIO01_04102 CFIO01_04988 CFIO01_05142 CFIO01_05423 CFIO01_08392 CFIO01_08695 CFIO01_12712 CFIO01_13735

CLUP:

CLUP02_01428 CLUP02_01662 CLUP02_02715 CLUP02_15676 CLUP02_16425 CLUP02_16731

CHIG:

CH63R_02055 CH63R_05135 CH63R_06511 CH63R_10333 CH63R_10575 CH63R_11316 CH63R_14095

CDET:

87936785(CDEST_00282) 87942208(CDEST_05705) 87943434(CDEST_06931) 87943683(CDEST_07180) 87946067(CDEST_09564) 87947667(CDEST_11167) 87947894(CDEST_11394)

ELA:	UCREL1_1 UCREL1_10034 UCREL1_3023 UCREL1_4493 UCREL1_7875 UCREL1_8344 UCREL1_9767

PFY:	PFICI_02155 PFICI_06710 PFICI_10660 PFICI_11183 PFICI_13580 PFICI_14195

SSL:	SS1G_02917 SS1G_04053

BFU:	BCIN_01g06600 BCIN_06g05360

MBE:

MBM_05778

PSCO:

LY89DRAFT_58302 LY89DRAFT_587194 LY89DRAFT_685858 LY89DRAFT_694995 LY89DRAFT_705574

GLZ:	GLAREA_07669

ANI:	ANIA_01503 ANIA_10990

AFM:	AFUA_2G01230 AFUA_4G08690 AFUA_8G05040

ACT:	ACLA_048040 ACLA_058440 ACLA_072950 ACLA_094540

NFI:	NFIA_033530 NFIA_089760 NFIA_097850 NFIA_107490

AOR:	AO090005000638 AO090701000399

ANG:	An03g00040 An10g00330 An15g04230 An16g07700

AFV:	AFLA_003449 AFLA_004914

ALUC:

AKAW2_50024S AKAW2_70609S AKAW2_71046S

ACHE:

ACHE_40068S ACHE_60607S

APUU:

APUU_11117S APUU_21711S APUU_40056A APUU_60006S APUU_60054S APUU_80237A

PCS:	N7525_006160 N7525_006169 N7525_007792 N7525_009429

PDP:	PDIP_02670 PDIP_46650

POU:	POX_a01923 POX_h09833

PPSF:

300787636(PFLUO_LOCUS2064) 300789522(PFLUO_LOCUS3762) 300791077(PFLUO_LOCUS5162) 300792063(PFLUO_LOCUS605) 300793850(PFLUO_LOCUS7659) 300794809(PFLUO_LOCUS8521)

TMF:	EYB26_000617 EYB26_004448 EYB26_005107 EYB26_006504 EYB26_009474

TRG:	TRUGW13939_01370 TRUGW13939_02223 TRUGW13939_02289 TRUGW13939_03930 TRUGW13939_04239 TRUGW13939_07477 TRUGW13939_08086 TRUGW13939_08229 TRUGW13939_08539 TRUGW13939_09259 TRUGW13939_10146

CIM:	CIMG_00151 CIMG_06885

CPW:	9692236(D8B26_005029) 9695584(D8B26_005936)

URE:	UREG_00255 UREG_03604

ABE:	ARB_01658 ARB_05761

TVE:	TRV_00049 TRV_04481

PBL:	PAAG_03143 PAAG_03793

PBN:	PADG_03024 PADG_03296

AJE:	HCAG_01713 HCAG_07219

BGH:	BDBG_00749 BDBG_02384 BDBG_03560

PNO:	SNOG_03839 SNOG_04544 SNOG_15818

PTE:	PTT_08311 PTT_12228 PTT_17993

PTRR:

6344723(PtrM4_049530) 6346091(PtrM4_138340) 6346995(PtrM4_031640)

BZE:	COCCADRAFT_109610 COCCADRAFT_37284 COCCADRAFT_9535

BSC:	COCSADRAFT_271752 COCSADRAFT_33387 COCSADRAFT_335849

BOR:	COCMIDRAFT_23190 COCMIDRAFT_26603 COCMIDRAFT_8673

AALT:

CC77DRAFT_1017551 CC77DRAFT_1040104 CC77DRAFT_840448

ADAC:

96081372(ACET3X_001050) 96086725(ACET3X_006403) 96088492(ACET3X_008170)

ARAB:

EKO05_0002435 EKO05_0006593 EKO05_0008024 EKO05_0009845

ZTR:	MYCGRDRAFT_66153

PFJ:	MYCFIDRAFT_29231

FFU:	CLAFUR5_02034 CLAFUR5_09491

CBET:

CB0940_01575

BCOM:

BAUCODRAFT_150164 BAUCODRAFT_558779 BAUCODRAFT_573577 BAUCODRAFT_68239

NPA:	UCRNP2_1393 UCRNP2_68 UCRNP2_7892 UCRNP2_894

TML:	GSTUM_00008462001

CNE:

CNC03990

CNB:

CNBC3190

CNG:	CNAG_02781

CGI:	CGB_C6100W

CDEU:

CNBG_3436

CDEC:

89987908(IAS62_001133)

CTEG:

91988941(I308_102083)

CBAS:

91982134(I312_102086)

KMG:	30167418(I203_106328)

KNE:	92178234(IAR55_000975)

KDJ:	28964632(I303_100929)

KBI:	30207195(I302_104090)

KSH:	87953025(IL334_000894)

KER:	91106126(V865_007325)

KSN:	43588545(CI109_102434)

TMS:	TREMEDRAFT_70222

TVS:	TRAVEDRAFT_145691 TRAVEDRAFT_29711 TRAVEDRAFT_62801

DSQ:	DICSQDRAFT_129292 DICSQDRAFT_152921

PCO:	PHACADRAFT_166860 PHACADRAFT_252672 PHACADRAFT_255535 PHACADRAFT_257602

SHS:	STEHIDRAFT_119341 STEHIDRAFT_49383

HIR:	HETIRDRAFT_157267 HETIRDRAFT_412119 HETIRDRAFT_448998

PSQ:	PUNSTDRAFT_52021 PUNSTDRAFT_70957

ADL:	AURDEDRAFT_110014 AURDEDRAFT_148009

FME:	FOMMEDRAFT_131642

GTR:	GLOTRDRAFT_116882

RSX:	RhiXN_03260

LBC:	LACBIDRAFT_189233

CCI:	CC1G_04219 CC1G_06285

ABP:	AGABI1DRAFT111212(AGABI1DRAFT_111212) AGABI1DRAFT114952(AGABI1DRAFT_114952)

ABV:	AGABI2DRAFT190432(AGABI2DRAFT_190432) AGABI2DRAFT191181(AGABI2DRAFT_191181)

PCUB:

JR316_0006081

MRR:	Moror_14079 Moror_4689 Moror_8005

E1B28_006317 E1B28_007270 E1B28_008904

SCM:	SCHCO_02605035(SCHCODRAFT_02605035)

CPUT:

CONPUDRAFT_129595 CONPUDRAFT_51541

SLA:	SERLADRAFT_361556 SERLADRAFT_454235

WSE:	WALSEDRAFT_29927 WALSEDRAFT_61673

WIC:	J056_003032

UMA:	UMAG_04667

SGRA:

EX895_005464

LIP:	LI0108(dapA)

LIR:	LAW_00107(dapA_1)

STI:

Sthe_0488

LCRE:

Pla8534_42110(dapA_3)

BHC:	JFL75_14300

ABA:	Acid345_2666

ACA:

ACP_0327

ACM:	AciX9_1581

GMA:	AciX8_1331

GRW:	FTO74_12010

TRS:	Terro_1985 Terro_2351

TALB:

FTW19_14730

ABAS:

ACPOL_6664

EDA:	GWR55_03525

SUS:

Acid_1067

PFER:

IRI77_34435

ABAC:

LuPra_06084(dapA_3)

GAU:

GAU_0904

GPH:	GEMMAAP_05215

GBA:

J421_2804

DHD:

Dhaf_1978

DDL:	Desdi_0801

DOR:	Desor_3029

TFR:	BR63_09785(dapA)

TMR:

Tmar_1165

THEF:

E1B22_09485

THEP:

DYI95_005800

IBU:	IB211_03323c

TEX:	Teth514_1917

THX:

Thet_1017

TIT:

Thit_1575

TWI:	Thewi_1732

TTO:	Thethe_02138

MAS:	Mahau_1310

KME:	H0A61_00412(dapA_2)

KBS:	EPA93_24885

TRA:

Trad_0621

TTL:	TtJL18_1311

TSC:	TSC_c08910(dapA1)

THC:	TCCBUS3UF1_14710

TOS:	Theos_1413

MRB:

Mrub_2327

MRE:	K649_10895

MSV:	Mesil_2236

ACO:	Amico_1829

TLI:

Tlie_1310

AMO:	Anamo_0048

HLO:	J0X27_13620

» show all

Reference

1 [PMID:14089442]

Authors

KURATOMI K, FUKUNAGA K.

Title

THE METABOLISM OF GAMMA-HYDROXYGLUTAMATE IN RAT LIVER. I. ENZYMIC SYNTHESIS OF GAMMA-HYDROXY-ALPHA-KETOGLUTARATE FROM PYRUVATE AND GLYOXYLATE.

Journal

Biochim Biophys Acta 78:617-28 (1963)
DOI:10.1016/0006-3002(63)91027-8

Reference

2 [PMID:5780845]

Authors

Kobes RD, Dekker EE

Title

2-Keto-4-hydroxyglutarate aldolase of bovine liver. Purification, criteria of purity, and general properties.

Journal

J Biol Chem 244:1919-25 (1969)

Reference

3 [PMID:5580656]

Authors

Lane RS, Shapley A, Dekker EE.

Title

2-keto-4-hydroxybutyrate aldolase. Identification as 2-keto-4-hydroxyglutarate aldolase, catalytic properties, and role in the mammalian metabolism of L-homoserine.

Journal

Biochemistry 10:1353-64 (1971)
DOI:10.1021/bi00784a013

Reference

4 [PMID:3942759]

Authors

Scholtz JM, Schuster SM

Title

Regulation of rat liver 4-hydroxy-2-ketoglutarate aldolase.

Journal

Biochim Biophys Acta 869:192-6 (1986)
DOI:10.1016/0167-4838(86)90294-3

Other DBs

ExplorEnz - The Enzyme Database:

4.1.3.16

IUBMB Enzyme Nomenclature:

4.1.3.16

ExPASy - ENZYME nomenclature database:

4.1.3.16

BRENDA, the Enzyme Database:

4.1.3.16

CAS:

9030-81-3

LinkDB

REACTION: R00470

Entry

R00470                      Reaction

Name

4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)

Definition

4-Hydroxy-2-oxoglutarate <=> Pyruvate + Glyoxylate

Equation

C01127 <=> C00022 + C00048

Reaction class

RC00307

C00022_C01127

RC00308

C00048_C01127

Enzyme

4.1.3.16 4.1.3.42

Pathway

rn00630

Glyoxylate and dicarboxylate metabolism

rn01100

Metabolic pathways

Brite

Enzymatic reactions [BR:br08201]
4. Lyase reactions
  4.1  Carbon-carbon lyases
   4.1.3  Oxo-acid-lyases
    4.1.3.16
     R00470  4-Hydroxy-2-oxoglutarate <=> Pyruvate + Glyoxylate
    4.1.3.42
     R00470  4-Hydroxy-2-oxoglutarate <=> Pyruvate + Glyoxylate
IUBMB reaction hierarchy [BR:br08202]
4. Lyase reactions
  4.1.3.16
   R00470  4-Hydroxy-2-oxoglutarate

Orthology

K01625

2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase [EC:4.1.2.14 4.1.3.42]

K18123

4-hydroxy-2-oxoglutarate aldolase [EC:4.1.3.16]

Other DBs

RHEA:

18172

LinkDB

DBGET integrated database retrieval system