KEGG ORTHOLOGY: K18124

ORTHOLOGY: K18124

Entry

K18124                      KO

Symbol

gdh2, gdhA

Name

glucose/galactose 1-dehydrogenase (NADP+) [EC:1.1.1.360]

Pathway

map00030

Pentose phosphate pathway

map00052

Galactose metabolism

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

map01200

Carbon metabolism

Reaction

R01096

D-galactose:NADP+ 1-oxidoreductase

R07147

D-glucose:NADP+ 1-oxidoreductase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09101 Carbohydrate metabolism
   00030 Pentose phosphate pathway
    K18124  gdh2, gdhA; glucose/galactose 1-dehydrogenase (NADP+)
   00052 Galactose metabolism
    K18124  gdh2, gdhA; glucose/galactose 1-dehydrogenase (NADP+)
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.360  glucose/galactose 1-dehydrogenase
     K18124  gdh2, gdhA; glucose/galactose 1-dehydrogenase (NADP+)

Other DBs

COG:

COG1063

Genes

TAC:

Ta0897

TVO:	TVG1073292(TVG1073292)

OMR:	OXIME_000834

PTO:

PTO1070

FAC:	FACI_IFERC01G0298

FAI:

FAD_1215

CDIV:

CPM_0706

Reference

PMID:15691337

Authors

Angelov A, Futterer O, Valerius O, Braus GH, Liebl W

Title

Properties of the recombinant glucose/galactose dehydrogenase from the extreme thermoacidophile, Picrophilus torridus.

Journal

FEBS J 272:1054-62 (2005)
DOI:10.1111/j.1742-4658.2004.04539.x

Sequence

[pto:PTO1070]

LinkDB

ENZYME: 1.1.1.360

Entry

EC 1.1.1.360                Enzyme

Name

glucose/galactose 1-dehydrogenase;
GdhA;
dual-specific glucose/galactose dehydrogenase;
glucose (galactose) dehydrogenase;
glucose/galactose dehydrogenase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

D-glucose/D-galactose 1-dehydrogenase (NADPH)

Reaction(IUBMB)

(1) D-glucopyranose + NADP+ = D-glucono-1,5-lactone + NADPH + H+ [RN:R07147];
(2) D-galactopyranose + NADP+ = D-galactono-1,5-lactone + NADPH + H+ [RN:R01096]

Reaction(KEGG)

R01096 R07147

Substrate

D-glucopyranose [CPD:C00031];
NADP+ [CPD:C00006];
D-galactopyranose [CPD:C00124]

Product

D-glucono-1,5-lactone [CPD:C00198];
NADPH [CPD:C00005];
H+ [CPD:C00080];
D-galactono-1,5-lactone [CPD:C02669]

Comment

A zinc protein. The enzyme from the archaeon Picrophilus torridus is involved in glucose and galactose catabolism via the nonphosphorylative variant of the Entner-Doudoroff pathway. It shows 20-fold higher activity with NADP+ compared to NAD+. The oxidation of D-glucose and D-galactose is catalysed at a comparable rate (cf. EC 1.1.1.119, glucose 1-dehydrogenase (NADP+) and EC 1.1.1.120, galactose 1-dehydrogenase (NADP+)).

History

EC 1.1.1.360 created 2013

Pathway

ec00030

Pentose phosphate pathway

ec00052

Galactose metabolism

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K18124

glucose/galactose 1-dehydrogenase (NADP+)

Genes

TAC:

Ta0897

TVO:	TVG1073292(TVG1073292)

OMR:	OXIME_000834

PTO:

PTO1070

FAC:	FACI_IFERC01G0298

FAI:

FAD_1215

CDIV:

CPM_0706

Reference

1 [PMID:15691337]

Authors

Angelov A, Futterer O, Valerius O, Braus GH, Liebl W

Title

Properties of the recombinant glucose/galactose dehydrogenase from the extreme thermoacidophile, Picrophilus torridus.

Journal

FEBS J 272:1054-62 (2005)
DOI:10.1111/j.1742-4658.2004.04539.x

Sequence

[pto:PTO1070]

Reference

2 [PMID:16556607]

Authors

Milburn CC, Lamble HJ, Theodossis A, Bull SD, Hough DW, Danson MJ, Taylor GL

Title

The structural basis of substrate promiscuity in glucose dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus.

Journal

J Biol Chem 281:14796-804 (2006)
DOI:10.1074/jbc.M601334200

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.360

IUBMB Enzyme Nomenclature:

1.1.1.360

ExPASy - ENZYME nomenclature database:

1.1.1.360

BRENDA, the Enzyme Database:

1.1.1.360

LinkDB

REACTION: R01096

Entry

R01096                      Reaction

Name

D-galactose:NADP+ 1-oxidoreductase

Definition

D-Galactose + NADP+ <=> D-Galactono-1,5-lactone + NADPH + H+

Equation

C00124 + C00006 <=> C02669 + C00005 + C00080

Comment

NAD+ (ec 1.1.1.48, see R08544)

Reaction class

RC00001

C00005_C00006

RC00066

C00124_C02669

Enzyme

1.1.1.48 1.1.1.120 1.1.1.359 1.1.1.360

Pathway

rn00052

Galactose metabolism

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.48
     R01096  D-Galactose + NADP+ <=> D-Galactono-1,5-lactone + NADPH + H+
    1.1.1.120
     R01096  D-Galactose + NADP+ <=> D-Galactono-1,5-lactone + NADPH + H+
    1.1.1.359
     R01096  D-Galactose + NADP+ <=> D-Galactono-1,5-lactone + NADPH + H+
    1.1.1.360
     R01096  D-Galactose + NADP+ <=> D-Galactono-1,5-lactone + NADPH + H+
IUBMB reaction hierarchy [BR:br08202]
1. Oxidoreductase reactions
  1.1.1.359
   R10429  Aldopyranose <=> Aldono-1,5-lactone
    R01096  D-Galactose <=> D-Galactono-1,5-lactone

Orthology

K18124

glucose/galactose 1-dehydrogenase (NADP+) [EC:1.1.1.360]

K18125

aldose 1-dehydrogenase [NAD(P)+] [EC:1.1.1.359]

LinkDB

DBGET integrated database retrieval system