KEGG ORTHOLOGY: K18125

ORTHOLOGY: K18125

Entry

K18125                      KO

Symbol

ssgdh

Name

aldose 1-dehydrogenase [NAD(P)+] [EC:1.1.1.359]

Pathway

map00030

Pentose phosphate pathway

map00052

Galactose metabolism

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

map01200

Carbon metabolism

Reaction

R01096

D-galactose:NADP+ 1-oxidoreductase

R07147

D-glucose:NADP+ 1-oxidoreductase

R08544

D-galactose:NAD+ 1-oxidoreductase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09101 Carbohydrate metabolism
   00030 Pentose phosphate pathway
    K18125  ssgdh; aldose 1-dehydrogenase [NAD(P)+]
   00052 Galactose metabolism
    K18125  ssgdh; aldose 1-dehydrogenase [NAD(P)+]
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.359  aldose 1-dehydrogenase [NAD(P)+]
     K18125  ssgdh; aldose 1-dehydrogenase [NAD(P)+]

Other DBs

COG:

COG1063

Genes

DLF:	V8247_00310

PTO:

PTO0639

FAC:	FACI_IFERC01G0109

FAI:

FAD_1034

STO:	STK_17040(gdh)

SOH:	D1869_09575

SJV:	SJAV_02960

SSO:	SSO3003(dhg-1) SSO3042(dhg-2) SSO3204(dhg-3)

SOL:	Ssol_0792 Ssol_0941

SSOA:

SULA_0783 SULA_0820 SULA_0974

SSOL:

SULB_0785 SULB_0822 SULB_0976

SSOF:

SULC_0783 SULC_0820 SULC_0975

SSHI:

J5U23_00294 J5U23_00444 J5U23_00501

SCAS:

SACC_30460 SACC_31420

SIS:	LS215_2319 LS215_2487 LS215_2525

SIA:	M1425_2156 M1425_2315 M1425_2353

SIM:	M1627_2236 M1627_2394 M1627_2431

SID:	M164_2160 M164_2317 M164_2360

SIY:	YG5714_2283 YG5714_2452 YG5714_2497

SIN:	YN1551_0407 YN1551_0458 YN1551_0633

SII:	LD85_2423 LD85_2603 LD85_2656

SIH:	SiH_2102 SiH_2256 SiH_2295

SIR:	SiRe_2034 SiRe_2200 SiRe_2243

SIC:	SiL_2009 SiL_2165 SiL_2203

SULA:

BFU36_06060 BFU36_07060 BFU36_07270

SULE:

GFS03_11745 GFS03_12475 GFS03_12660

SAI:

SACN:

SACR:

SACS:

SULO:

GFS33_03555 GFS33_04540

SULL:

MSE:

MEMJ:

MCN:

MHK:	DFR87_11970

MPRU:

DFR88_11815

MTEN:

GWK48_00425

MJN:	MjAS7_2196 MjAS7_2216 MjAS7_2369

AHO:

Ahos_2067

AMAN:

B6F84_01630 B6F84_05020

ABRI:

DFR85_11645 DFR85_12080

ASUL:

DFR86_01625 DFR86_04395

AAMB:

D1866_05350

ACIH:

HS5_08840

SACD:

HS1genome_0652 HS1genome_1599

SAZO:

CSTY:

STEP:

SMET:

SAHS:

CMA:

VSO:	Vsou_17260

CCAI:

NAS2_0753

» show all

Reference

PMID:12824170

Authors

Lamble HJ, Heyer NI, Bull SD, Hough DW, Danson MJ

Title

Metabolic pathway promiscuity in the archaeon Sulfolobus solfataricus revealed by studies on glucose dehydrogenase and 2-keto-3-deoxygluconate aldolase.

Journal

J Biol Chem 278:34066-72 (2003)
DOI:10.1074/jbc.M305818200

Sequence

[sso:SSO3003]

Reference

PMID:21265750

Authors

Haferkamp P, Kutschki S, Treichel J, Hemeda H, Sewczyk K, Hoffmann D, Zaparty M, Siebers B

Title

An additional glucose dehydrogenase from Sulfolobus solfataricus: fine-tuning of sugar degradation?

Journal

Biochem Soc Trans 39:77-81 (2011)
DOI:10.1042/BST0390077

Sequence

[sso:SSO3003]

LinkDB

ENZYME: 1.1.1.359

Entry

EC 1.1.1.359                Enzyme

Name

aldose 1-dehydrogenase [NAD(P)+]

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

an aldopyranose:NAD(P)+ 1-oxidoreductase

Reaction(IUBMB)

an aldopyranose + NAD(P)+ = an aldono-1,5-lactone + NAD(P)H + H+ [RN:R10428 R10429]

Reaction(KEGG)

R10428 > R08544;
R10429 > R01096 R07147

Substrate

aldopyranose [CPD:C20655];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]

Product

aldono-1,5-lactone [CPD:C20616];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

The enzyme from the archaeon Sulfolobus solfataricus shows broad specificity towards aldoses (D-glucose, D-galactose, D-xylose, L-arabinose, 6-deoxy-D-glucose, D-fucose) and can utilize NAD+ and NADP+ with similar catalytic efficiency. It is involved in aldose catabolism via the branched variant of the Entner-Doudoroff pathway.

History

EC 1.1.1.359 created 2013

Pathway

ec00030

Pentose phosphate pathway

ec00052

Galactose metabolism

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K18125

aldose 1-dehydrogenase [NAD(P)+]

Genes

DLF:	V8247_00310

PTO:

PTO0639

FAC:	FACI_IFERC01G0109

FAI:

FAD_1034

STO:	STK_17040(gdh)

SOH:	D1869_09575

SJV:	SJAV_02960

SSO:	SSO3003(dhg-1) SSO3042(dhg-2) SSO3204(dhg-3)

SOL:	Ssol_0792 Ssol_0941

SSOA:

SULA_0783 SULA_0820 SULA_0974

SSOL:

SULB_0785 SULB_0822 SULB_0976

SSOF:

SULC_0783 SULC_0820 SULC_0975

SSHI:

J5U23_00294 J5U23_00444 J5U23_00501

SCAS:

SACC_30460 SACC_31420

SIS:	LS215_2319 LS215_2487 LS215_2525

SIA:	M1425_2156 M1425_2315 M1425_2353

SIM:	M1627_2236 M1627_2394 M1627_2431

SID:	M164_2160 M164_2317 M164_2360

SIY:	YG5714_2283 YG5714_2452 YG5714_2497

SIN:	YN1551_0407 YN1551_0458 YN1551_0633

SII:	LD85_2423 LD85_2603 LD85_2656

SIH:	SiH_2102 SiH_2256 SiH_2295

SIR:	SiRe_2034 SiRe_2200 SiRe_2243

SIC:	SiL_2009 SiL_2165 SiL_2203

SULA:

BFU36_06060 BFU36_07060 BFU36_07270

SULE:

GFS03_11745 GFS03_12475 GFS03_12660

SAI:

Saci_1079

SACN:

SacN8_05250

SACR:

SacRon12I_05240

SACS:

SUSAZ_05025

SULO:

GFS33_03555 GFS33_04540

SULL:

EWF20_10710

MSE:

Msed_1301

MEMJ:

MJ1HA_1509

MCN:

Mcup_0902

MHK:	DFR87_11970

MPRU:

DFR88_11815

MTEN:

GWK48_00425

MJN:	MjAS7_2196 MjAS7_2216 MjAS7_2369

AHO:

Ahos_2067

AMAN:

B6F84_01630 B6F84_05020

ABRI:

DFR85_11645 DFR85_12080

ASUL:

DFR86_01625 DFR86_04395

AAMB:

D1866_05350

ACIH:

HS5_08840

SACD:

HS1genome_0652 HS1genome_1599

SAZO:

D1868_03195

CSTY:

KN1_23070

STEP:

IC006_0170

SMET:

RQ359_001431

SAHS:

HS7_05220

CMA:

Cmaq_1714

VSO:	Vsou_17260

CCAI:

NAS2_0753

» show all

Reference

1 [PMID:3827812]

Authors

Giardina P, de Biasi MG, de Rosa M, Gambacorta A, Buonocore V

Title

Glucose dehydrogenase from the thermoacidophilic archaebacterium Sulfolobus solfataricus.

Journal

Biochem J 239:517-22 (1986)
DOI:10.1042/bj2390517

Reference

2 [PMID:2803257]

Authors

Smith LD, Budgen N, Bungard SJ, Danson MJ, Hough DW

Title

Purification and characterization of glucose dehydrogenase from the thermoacidophilic archaebacterium Thermoplasma acidophilum.

Journal

Biochem J 261:973-7 (1989)
DOI:10.1042/bj2610973

Reference

3 [PMID:12824170]

Authors

Lamble HJ, Heyer NI, Bull SD, Hough DW, Danson MJ

Title

Metabolic pathway promiscuity in the archaeon Sulfolobus solfataricus revealed by studies on glucose dehydrogenase and 2-keto-3-deoxygluconate aldolase.

Journal

J Biol Chem 278:34066-72 (2003)
DOI:10.1074/jbc.M305818200

Sequence

[sso:SSO3003]

Reference

4 [PMID:16508107]

Authors

Theodossis A, Milburn CC, Heyer NI, Lamble HJ, Hough DW, Danson MJ, Taylor GL

Title

Preliminary crystallographic studies of glucose dehydrogenase from the promiscuous Entner-Doudoroff pathway in the hyperthermophilic archaeon Sulfolobus solfataricus.

Journal

Acta Crystallogr Sect F Struct Biol Cryst Commun 61:112-5 (2005)
DOI:10.1107/S174430910403101X

Reference

5 [PMID:16556607]

Authors

Milburn CC, Lamble HJ, Theodossis A, Bull SD, Hough DW, Danson MJ, Taylor GL

Title

The structural basis of substrate promiscuity in glucose dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus.

Journal

J Biol Chem 281:14796-804 (2006)
DOI:10.1074/jbc.M601334200

Sequence

[sso:SSO3003]

Reference

6 [PMID:21265750]

Authors

Haferkamp P, Kutschki S, Treichel J, Hemeda H, Sewczyk K, Hoffmann D, Zaparty M, Siebers B

Title

An additional glucose dehydrogenase from Sulfolobus solfataricus: fine-tuning of sugar degradation?

Journal

Biochem Soc Trans 39:77-81 (2011)
DOI:10.1042/BST0390077

Sequence

[sso:SSO3003]

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.359

IUBMB Enzyme Nomenclature:

1.1.1.359

ExPASy - ENZYME nomenclature database:

1.1.1.359

BRENDA, the Enzyme Database:

1.1.1.359

LinkDB

REACTION: R01096

Entry

R01096                      Reaction

Name

D-galactose:NADP+ 1-oxidoreductase

Definition

D-Galactose + NADP+ <=> D-Galactono-1,5-lactone + NADPH + H+

Equation

C00124 + C00006 <=> C02669 + C00005 + C00080

Comment

NAD+ (ec 1.1.1.48, see R08544)

Reaction class

RC00001

C00005_C00006

RC00066

C00124_C02669

Enzyme

1.1.1.48 1.1.1.120 1.1.1.359 1.1.1.360

Pathway

rn00052

Galactose metabolism

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.48
     R01096  D-Galactose + NADP+ <=> D-Galactono-1,5-lactone + NADPH + H+
    1.1.1.120
     R01096  D-Galactose + NADP+ <=> D-Galactono-1,5-lactone + NADPH + H+
    1.1.1.359
     R01096  D-Galactose + NADP+ <=> D-Galactono-1,5-lactone + NADPH + H+
    1.1.1.360
     R01096  D-Galactose + NADP+ <=> D-Galactono-1,5-lactone + NADPH + H+
IUBMB reaction hierarchy [BR:br08202]
1. Oxidoreductase reactions
  1.1.1.359
   R10429  Aldopyranose <=> Aldono-1,5-lactone
    R01096  D-Galactose <=> D-Galactono-1,5-lactone

Orthology

K18124

glucose/galactose 1-dehydrogenase (NADP+) [EC:1.1.1.360]

K18125

aldose 1-dehydrogenase [NAD(P)+] [EC:1.1.1.359]

LinkDB

REACTION: R08544

Entry

R08544                      Reaction

Name

D-galactose:NAD+ 1-oxidoreductase

Definition

D-Galactose + NAD+ <=> D-Galactono-1,5-lactone + NADH + H+

Equation

C00124 + C00003 <=> C02669 + C00004 + C00080

Reaction class

RC00001

C00003_C00004

RC00066

C00124_C02669

Enzyme

1.1.1.48 1.1.1.121 1.1.1.359

Pathway

rn00052

Galactose metabolism

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.48
     R08544  D-Galactose + NAD+ <=> D-Galactono-1,5-lactone + NADH + H+
    1.1.1.121
     R08544  D-Galactose + NAD+ <=> D-Galactono-1,5-lactone + NADH + H+
    1.1.1.359
     R08544  D-Galactose + NAD+ <=> D-Galactono-1,5-lactone + NADH + H+
IUBMB reaction hierarchy [BR:br08202]
1. Oxidoreductase reactions
  1.1.1.121
   R02847  D-Aldose <=> D-Aldonolactone
    R08544  D-Galactose <=> D-Galactono-1,5-lactone
  1.1.1.359
   R10428  Aldopyranose <=> Aldono-1,5-lactone
    R08544  D-Galactose <=> D-Galactono-1,5-lactone

Orthology

K18125

aldose 1-dehydrogenase [NAD(P)+] [EC:1.1.1.359]

Other DBs

RHEA:

42395

LinkDB

DBGET integrated database retrieval system