Entry
Name
2-dehydro-3-deoxyglucono/galactono-kinase;
KDG kinase (ambiguous);
KDGK (ambiguous);
2-keto-3-deoxy-D-gluconate kinase (ambiguous)
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:2-dehydro-3-deoxy-D-gluconate/2-dehydro-3-deoxy-D-galactonate 6-phosphotransferase
Reaction(IUBMB)
(1) ATP + 2-dehydro-3-deoxy-D-gluconate = ADP + 2-dehydro-3-deoxy-6-phospho-D-gluconate [RN:
R01541 ];
(2) ATP + 2-dehydro-3-deoxy-D-galactonate = ADP + 2-dehydro-3-deoxy-6-phospho-D-galactonate [RN:
R03387 ]
Reaction(KEGG)
Substrate
ATP [CPD:
C00002 ];
2-dehydro-3-deoxy-D-gluconate [CPD:
C00204 ];
2-dehydro-3-deoxy-D-galactonate [CPD:
C01216 ]
Product
ADP [CPD:
C00008 ];
2-dehydro-3-deoxy-6-phospho-D-gluconate [CPD:
C04442 ];
2-dehydro-3-deoxy-6-phospho-D-galactonate [CPD:
C01286 ]
Comment
The enzyme from the archaeon Sulfolobus solfataricus is involved in glucose and galactose catabolism via the branched variant of the Entner-Doudoroff pathway. It phosphorylates 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3-deoxy-D-galactonate with similar catalytic efficiency. cf. EC
2.7.1.45 , 2-dehydro-3-deoxygluconokinase and EC
2.7.1.58 , 2-dehydro-3-deoxygalactonokinase.
History
EC 2.7.1.178 created 2013
Pathway
Orthology
K18126 2-dehydro-3-deoxygluconokinase / 2-dehydro-3-deoxygalactonokinase
Genes
» show all
Taxonomy
Reference
Authors
Lamble HJ, Theodossis A, Milburn CC, Taylor GL, Bull SD, Hough DW, Danson MJ
Title
Promiscuity in the part-phosphorylative Entner-Doudoroff pathway of the archaeon Sulfolobus solfataricus.
Journal
Sequence
Reference
Authors
Potter JA, Kerou M, Lamble HJ, Bull SD, Hough DW, Danson MJ, Taylor GL
Title
The structure of Sulfolobus solfataricus 2-keto-3-deoxygluconate kinase.
Journal
Sequence
Reference
Authors
Kim S, Lee SB
Title
Characterization of Sulfolobus solfataricus 2-keto-3-deoxy-D-gluconate kinase in the modified Entner-Doudoroff pathway.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.7.1.178
LinkDB
All DBs