KEGG   ORTHOLOGY: K18239
Entry
K18239                      KO                                     
Symbol
fkbO, rapK
Name
chorismatase [EC:3.3.2.13]
Pathway
map00400  Phenylalanine, tyrosine and tryptophan biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00400 Phenylalanine, tyrosine and tryptophan biosynthesis
    K18239  fkbO, rapK; chorismatase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.3  Acting on ether bonds
   3.3.2  Ether hydrolases
    3.3.2.13  chorismatase
     K18239  fkbO, rapK; chorismatase
Other DBs
RN: R10583
Genes
PARZ: DTQ13_05210
SRC: M271_40655
SMAL: SMALA_8314
SSOI: I1A49_45310
SQZ: FQU76_32190
SKA: CP970_02280
STSU: B7R87_01750
SROI: IAG44_38935
SDD: D9753_34425
ACTN: L083_2967(rapK)
AG: AAF86394(fkbO)
 » show all
Reference
PMID:8635730
  Authors
Molnar I, Aparicio JF, Haydock SF, Khaw LE, Schwecke T, Konig A, Staunton J, Leadlay PF
  Title
Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase.
  Journal
Gene 169:1-7 (1996)
DOI:10.1016/0378-1119(95)00799-7
  Sequence
Reference
  Authors
Juneja P, Hubrich F, Diederichs K, Welte W, Andexer JN
  Title
Mechanistic implications for the chorismatase FkbO based on the crystal structure.
  Journal
J Mol Biol 426:105-15 (2014)
DOI:10.1016/j.jmb.2013.09.006
  Sequence
LinkDB

KEGG   ENZYME: 3.3.2.13
Entry
EC 3.3.2.13                 Enzyme                                 
Name
chorismatase;
chorismate/3,4-dihydroxycyclohexa-1,5-dienoate synthase;
fkbO (gene name);
rapK (gene name)
Class
Hydrolases;
Acting on ether bonds;
Ether hydrolases
Sysname
chorismate pyruvate-hydrolase
Reaction(IUBMB)
chorismate + H2O = (4R,5R)-4,5-dihydroxycyclohexa-1(6),2-diene-1-carboxylate + pyruvate [RN:R10583]
Reaction(KEGG)
R10583
Substrate
chorismate [CPD:C00251];
H2O [CPD:C00001]
Product
(4R,5R)-4,5-dihydroxycyclohexa-1(6),2-diene-1-carboxylate [CPD:C20710];
pyruvate [CPD:C00022]
Comment
The enzyme found in several bacterial species is involved in the biosynthesis of macrocyclic polyketides.
History
EC 3.3.2.13 created 2013
Pathway
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
Orthology
K18239  chorismatase
Genes
PARZDTQ13_05210
SRCM271_40655
SMALSMALA_8314
SSOII1A49_45310
SQZFQU76_32190
SKACP970_02280
STSUB7R87_01750
SROIIAG44_38935
SDDD9753_34425
ACTNL083_2967(rapK)
Reference
1  [PMID:21383123]
  Authors
Andexer JN, Kendrew SG, Nur-e-Alam M, Lazos O, Foster TA, Zimmermann AS, Warneck TD, Suthar D, Coates NJ, Koehn FE, Skotnicki JS, Carter GT, Gregory MA, Martin CJ, Moss SJ, Leadlay PF, Wilkinson B
  Title
Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate.
  Journal
Proc Natl Acad Sci U S A 108:4776-81 (2011)
DOI:10.1073/pnas.1015773108
  Sequence
Reference
2  [PMID:24036425]
  Authors
Juneja P, Hubrich F, Diederichs K, Welte W, Andexer JN
  Title
Mechanistic implications for the chorismatase FkbO based on the crystal structure.
  Journal
J Mol Biol 426:105-15 (2014)
DOI:10.1016/j.jmb.2013.09.006
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.3.2.13
IUBMB Enzyme Nomenclature: 3.3.2.13
ExPASy - ENZYME nomenclature database: 3.3.2.13
BRENDA, the Enzyme Database: 3.3.2.13
LinkDB

KEGG   REACTION: R10583
Entry
R10583                      Reaction                               
Name
chorismate pyruvate-hydrolase
Definition
Chorismate + H2O <=> (4R,5R)-4,5-Dihydroxycyclohexa-1(6),2-diene-1-carboxylate + Pyruvate
Equation
Reaction class
RC00350  C00251_C20710
RC02148  C00022_C00251
Enzyme
Pathway
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
Orthology
K18239  chorismatase [EC:3.3.2.13]
Other DBs
RHEA: 38322
LinkDB

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