KEGG   ORTHOLOGY: K18240
Entry
K18240                      KO                                     
Symbol
xanB2
Name
chorismate lyase / 3-hydroxybenzoate synthase [EC:4.1.3.40 4.1.3.45]
Pathway
map00130  Ubiquinone and other terpenoid-quinone biosynthesis
map00400  Phenylalanine, tyrosine and tryptophan biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01240  Biosynthesis of cofactors
Module
M00117  Ubiquinone biosynthesis, prokaryotes, chorismate (+ polyprenyl-PP) => ubiquinol
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00400 Phenylalanine, tyrosine and tryptophan biosynthesis
    K18240  xanB2; chorismate lyase / 3-hydroxybenzoate synthase
  09108 Metabolism of cofactors and vitamins
   00130 Ubiquinone and other terpenoid-quinone biosynthesis
    K18240  xanB2; chorismate lyase / 3-hydroxybenzoate synthase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.3  Oxo-acid-lyases
    4.1.3.40  chorismate lyase
     K18240  xanB2; chorismate lyase / 3-hydroxybenzoate synthase
    4.1.3.45  3-hydroxybenzoate synthase
     K18240  xanB2; chorismate lyase / 3-hydroxybenzoate synthase
Other DBs
RN: R01302 R10597
Genes
XFA: XF_0769
XFT: PD_1889(fkbO)
XFM: Xfasm12_2072
XFN: XfasM23_1994
XFF: XFLM_03915
XFL: P303_00390
XFS: D934_13290
XFH: XFHB_11425
XTW: AB672_11600
XCC: XCC4014(rapK)
XCB: XC_4103
XCP: XCR_0248
XCV: XCV4191
XAX: XACM_3971
XAC: XAC4103(rapK)
XCI: XCAW_00197(rapK)
XFU: XFF4834R_chr39700(xanB2)
XOM: XOO4072(XOO4072)
XOO: XOO4322(rapK)
XOP: PXO_03739(pigB)
XOR: XOC_0424(pigB)
XAL: XALC_0126
XPH: XppCFBP6546_13945(XppCFBP6546P_13945)
PSUW: WQ53_09330
PSD: DSC_00450
LAQ: GLA29479_4083(xanB2)
LEZ: GLE_4979
LEM: LEN_0460
LHX: LYSHEL_11580(rapK)
LCAS: LYSCAS_11580(rapK)
DKO: I596_56
CJA: CJA_0104(fkbO)
MCA: MCA1495
MMAI: sS8_2838
MISZ: MishRS11D_00380(rapK)
NOC: Noc_2127
NHL: Nhal_2765
NWA: Nwat_0961
NTT: TAO_1291
TGR: Tgr7_0320
PSE: NH8B_1247
BCN: Bcen_2143
BCJ: BCAL0847
BCEN: DM39_2849
BCEO: I35_2824
BAM: Bamb_2809
BCT: GEM_0684
BCED: DM42_2314
BCON: NL30_26875
BTEI: WS51_24135
BSEM: WJ12_13795
BPSL: WS57_32540
HYB: Q5W_08420
HPSE: HPF_20785
MPT: Mpe_A1331
HAR: HEAR2873
THI: THI_2616
RGE: RGE_38580
TBD: Tbd_2762
MEH: M301_2326
MPAU: ZMTM_13760(rapK)
SLT: Slit_0372
SEME: MIZ01_0277
SPLB: SFPGR_17920(rapK)
SNIV: SFSGTM_28320(rapK)
SLAC: SKTS_15010
APET: ToN1_47100
DAR: Daro_4196
AZO: azo3920
AOA: dqs_4064
AZA: AZKH_1770
AFR: AFE_0789
SMAL: SMALA_1276
STRM: M444_37805
SALJ: SMD11_2789
AG: AGO98693(cuv10)
 » show all
Reference
  Authors
Zhou L, Wang JY, Wu J, Wang J, Poplawsky A, Lin S, Zhu B, Chang C, Zhou T, Zhang LH, He YW
  Title
The diffusible factor synthase XanB2 is a bifunctional chorismatase that links the shikimate pathway to ubiquinone and xanthomonadins biosynthetic pathways.
  Journal
Mol Microbiol 87:80-93 (2013)
DOI:10.1111/mmi.12084
  Sequence
LinkDB

KEGG   ENZYME: 4.1.3.45
Entry
EC 4.1.3.45                 Enzyme                                 
Name
3-hydroxybenzoate synthase;
chorismatase/3-hydroxybenzoate synthase;
hyg5 (gene name);
bra8 (gene name);
XanB2
Class
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
Sysname
chorismate pyruvate-lyase (3-hydroxybenzoate-forming)
Reaction(IUBMB)
chorismate = 3-hydroxybenzoate + pyruvate [RN:R10597]
Reaction(KEGG)
R10597
Substrate
chorismate [CPD:C00251]
Product
3-hydroxybenzoate [CPD:C00587];
pyruvate [CPD:C00022]
Comment
The enzyme, found in several bacterial species is involved in biosynthesis of secondary products. The enzyme from the bacterium Xanthomonas campestris pv. campestris also has the activity of EC 4.1.3.40, chorismate lyase [3].
History
EC 4.1.3.45 created 2013
Pathway
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
Orthology
K18240  chorismate lyase / 3-hydroxybenzoate synthase
Genes
XFAXF_0769
XFTPD_1889(fkbO)
XFMXfasm12_2072
XFNXfasM23_1994
XFFXFLM_03915
XFLP303_00390
XFSD934_13290
XFHXFHB_11425
XTWAB672_11600
XCCXCC4014(rapK)
XCBXC_4103
XCAxcc-b100_4207
XCPXCR_0248
XCVXCV4191
XAXXACM_3971
XACXAC4103(rapK)
XCIXCAW_00197(rapK)
XCTJ151_04282
XCJJ158_04235
XCUJ159_04231
XCNJ169_04279
XCWJ162_04236
XCRJ163_04231
XCMJ164_04232
XCFJ172_04272
XFUXFF4834R_chr39700(xanB2)
XAOXAC29_20670
XOMXOO4072(XOO4072)
XOOXOO4322(rapK)
XOPPXO_03739(pigB)
XOYAZ54_02365
XORXOC_0424(pigB)
XOZBE73_22300
XALXALC_0126
XSASB85_11895
XTNFD63_18940
XFRBER92_01675
XVEBJD12_11200
XPEBJD13_18540
XHRXJ27_14355
XGABI317_02115
XPHXppCFBP6546_13945(XppCFBP6546P_13945)
XVAC7V42_20965
XANAC801_20370
XARXB05_15580
XHYFZ025_10110
XCZEBN15_01230
XTHG4Q83_20220
XEUXSP_003883
XHDLMG31886_42240
SACZAOT14_35850
STEKAXG53_17020
SRHBAY15_3657
SLMBIZ42_08875
PSUPsesu_2797
PSUWWQ53_09330
PSDDSC_00450
PMEXH4W19_12065
PDDMNQ95_07815
LABLA76x_0248
LAQGLA29479_4083(xanB2)
LCPLC55x_5095
LGULG3211_5064
LEZGLE_4979
LEMLEN_0460
LMBC9I47_0288
LYTDWG18_12775
LUEDCD74_10495
LYJFKV23_00765
LSOLGOY17_01120
LSXH8B22_08350
LAREHIV01_012885
LHXLYSHEL_11580(rapK)
LCASLYSCAS_11580(rapK)
LCICINQ41_00570
LUMCNR27_04035
LUSE5843_13855
LUGFPZ22_08045
THESFHQ07_09135
THEHG7079_01750
TCNH9L16_04465
TBVH9L17_07380
XBCELE36_19945
RHDR2APBS1_3770
RGLCS053_02150
RTHLRK53_02215
DJICH75_19260
DJAHY57_04105
DTXATSB10_27120
DYEEO087_10955
DCSISN74_19060
DTLH8F01_09220
DKOI596_56
LRZBJI69_05805
LPYFIV34_01550
XBAC7S18_22540
ALRDS731_16695
APELCA267_009185
SALMD0Y50_15440
CJACJA_0104(fkbO)
CEBB0D95_12335
CEKD0B88_05945
TTUTERTU_3279
MARQMARGE09_P1022
MCAMCA1495
METUGNH96_09190
MMAIsS8_2838
MMOBF6R98_00895
MISZMishRS11D_00380(rapK)
THISHZT40_23025
TUNJ9260_13960
TLOJ9253_19325
TANIJ8380_07195
NOCNoc_2127
NHLNhal_2765
NWANwat_0961
NWRE3U44_11135
TVIThivi_2245
NTTTAO_1291
TSYTHSYN_02965
NTGNSCAC_0569
THIMKFB96_13540
HHCM911_02890
EBSECTOBSL9_0369
TGRTgr7_0320
TKMTK90_1054 TK90_1999
TNITVNIR_0102
TTITHITH_00615
TVRTVD_06985 TVD_10280
APRSBI364_16220
HNAHneap_2236
HAZA9404_02390
WMAWM2015_3004
GHLGM160_05455
SDFACG33_00610
SINIGT972_11080
FCEJN531_006375
GBIPG2T_05055
ACIIC4901_07725
ATYA9R16_007130
PSENH8B_1247
AQSDKK66_12230
BURBcep18194_A6087
BCNBcen_2143
BCHBcen2424_2757
BCJBCAL0847
BCENDM39_2849
BCEOI35_2824
BAMBamb_2809
BACBamMC406_2676
BCTGEM_0684
BCEDDM42_2314
BCEPAPZ15_01650
BPYRABD05_03820
BCONNL30_26875
BDFWI26_13300
BTEIWS51_24135
BSEMWJ12_13795
BPSLWS57_32540
BSTLBBJ41_14985
BANNJFN94_14155
BYIBYI23_C009530
BUEBRPE67_CCDS01610
BURKDM992_06160
BUOBRPE64_CCDS07270
VAPVapar_2681
VPEVarpa_2705
VPDVAPA_1c28650
VAAAX767_19270
VBOCKY39_18410
VAMC4F17_06190
CSERCCO03_04245
OTKC6570_10470
HYRBSY239_3763
HYBQ5W_08420
HYLLPB072_20035
HYCE5678_13820
HPSEHPF_20785
HTNKI616_23100
MELAC6568_05960
PBHAAW51_3791
MPTMpe_A1331
METPC1M51_01600
HARHEAR2873
THITHI_2616
RGERGE_38580
RBNRBXJA2T_00215
SNNEWH46_12965
TBDTbd_2762
MEHM301_2326
MPAUZMTM_13760(rapK)
SLTSlit_0372
FAMOYT1_ch1805
SEMEMIZ01_0277
SDRSCD_n02752
SPLBSFPGR_17920(rapK)
SNIVSFSGTM_28320(rapK)
SLACSKTS_15010
ARESIWH25_05135
OTROTERR_21530
APETToN1_47100
DARDaro_4196
DEYHYN24_15675
QAUKI612_19805
FLEKI610_19855
AZOazo3920
AOAdqs_4064
AZAAZKH_1770
AZIAzCIB_1917
ACOMCEW83_15875
AZDCDA09_13435
AZRCJ010_24600
AZQG3580_01750
APPCAP2UW1_0339
GBEGbCGDNIH1_0917
GBHGbCGDNIH2_0917
GBCGbCGDNIH3_0917
GBSGbCGDNIH4_0917
AOTAcetOri_orf02553
BOBGN304_00930
LCKHN018_15380
DVNHQ394_00740
AFRAFE_0789
AFELferr_0932
AFIAcife_2838
AFJAFERRID_20270
ATXGCD22_00281
AFPK1Y48_07245
TCOTheco_2590
RHEREHE19_014580
NTPCRH09_14150
SRCM271_50105
SMALSMALA_1276
SSOII1A49_09865
STRMM444_37805
SAUOBV401_10165
SALJSMD11_2789
STIRDDW44_31235
SACGFDZ84_20330 FDZ84_26815 FDZ84_28845
AMYBBKN51_40545
SSYIEKG83_20155
LEDBBK82_47075
ACTAC1701_00705
PLABC6361_34520
PLATC6W10_21680
OLEK0B96_03010
RUFIK0V07_01920
HBSIPV69_10830
NIONITINOP_0197
 » show all
Reference
1  [PMID:21383123]
  Authors
Andexer JN, Kendrew SG, Nur-e-Alam M, Lazos O, Foster TA, Zimmermann AS, Warneck TD, Suthar D, Coates NJ, Koehn FE, Skotnicki JS, Carter GT, Gregory MA, Martin CJ, Moss SJ, Leadlay PF, Wilkinson B
  Title
Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate.
  Journal
Proc Natl Acad Sci U S A 108:4776-81 (2011)
DOI:10.1073/pnas.1015773108
  Sequence
Reference
2  [PMID:23824670]
  Authors
Jiang Y, Wang H, Lu C, Ding Y, Li Y, Shen Y
  Title
Identification and characterization of the cuevaene A biosynthetic gene cluster in streptomyces sp. LZ35.
  Journal
Chembiochem 14:1468-75 (2013)
DOI:10.1002/cbic.201300316
  Sequence
Reference
3  [PMID:23113660]
  Authors
Zhou L, Wang JY, Wu J, Wang J, Poplawsky A, Lin S, Zhu B, Chang C, Zhou T, Zhang LH, He YW
  Title
The diffusible factor synthase XanB2 is a bifunctional chorismatase that links the shikimate pathway to ubiquinone and xanthomonadins biosynthetic pathways.
  Journal
Mol Microbiol 87:80-93 (2013)
DOI:10.1111/mmi.12084
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.1.3.45
IUBMB Enzyme Nomenclature: 4.1.3.45
ExPASy - ENZYME nomenclature database: 4.1.3.45
BRENDA, the Enzyme Database: 4.1.3.45
LinkDB

KEGG   REACTION: R10597
Entry
R10597                      Reaction                               
Name
chorismate pyruvate-lyase (3-hydroxybenzoate-forming)
Definition
Chorismate <=> 3-Hydroxybenzoate + Pyruvate
Equation
Reaction class
RC02148  C00022_C00251
RC03212  C00251_C00587
Enzyme
Pathway
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
Orthology
K18240  chorismate lyase / 3-hydroxybenzoate synthase [EC:4.1.3.40 4.1.3.45]
Other DBs
RHEA: 38318
LinkDB

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