KEGG   ORTHOLOGY: K18242
Entry
K18242                      KO                                     
Symbol
nagG
Name
salicylate 5-hydroxylase large subunit [EC:1.14.13.172]
Pathway
map00626  Naphthalene degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Module
M00638  Salicylate degradation, salicylate => gentisate
Reaction
R07709  salicylate,NADH:oxygen oxidoreductase (5-hydroxylating)
R07710  salicylate,NADPH:oxygen oxidoreductase (5-hydroxylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00626 Naphthalene degradation
    K18242  nagG; salicylate 5-hydroxylase large subunit
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.172  salicylate 5-hydroxylase
     K18242  nagG; salicylate 5-hydroxylase large subunit
Dioxygenases [br01602.html]
 Dioxygenases in aromatic ring cleavage
  K18242
Other DBs
COG: COG4638
Genes
EBT: EBL_c34270
KAS: KATP_22590
KLU: K7B04_17405
KGN: GY169_11715
PLU: plu1000
PLUM: A4R40_04995
PTT: VY86_00155
PSRR: ELR70_02780
ALT: ambt_18005
TTU: TERTU_1474
MMW: Mmwyl1_2669
MME: Marme_2404
MPC: Mar181_2357
MPRI: MP3633_2253
MARL: HH196_06885
FCE: JN531_005585
RSO: RSc1090(nagG)
RSE: F504_1061(ohbB)
RPU: CDC45_05595
RNC: GO999_11020
RSL: RPSI07_2301
RSN: RSPO_c02274
RSM: CMR15_20209
RSY: RSUY_15120
RSG: JK151_19135
RPJ: N234_28705
RMN: TK49_07930
REH: H16_A1633(nagG)
CNC: CNE_1c16410(nagG)
CUH: BJN34_29220
REU: Reut_B4719
CBW: RR42_s2751
CCUP: BKK81_31195
CUP: BKK80_25155
CUU: BKK79_30865
COX: E0W60_10145
CCAX: KZ686_18765
CUK: KB879_08295
CUPP: CTP10_R58120
BMK: DM80_1440
BCEP: APZ15_32870
BPYR: ABD05_24780
BUB: BW23_5815
BARI: NLX30_26735
BSER: R0290_17335
BGL: bglu_2g20120
BGU: KS03_3913
BUG: BC1001_0576
BUQ: AC233_10905
BURK: DM992_22165
BURT: BTHE68_44870
BURM: GJG85_21560
BURF: Bsp3421_005962
BPX: BUPH_04466
BUZ: AYM40_33045 AYM40_33155
BFN: OI25_3046
PARB: CJU94_38675
PTER: C2L65_39075
PMEG: FNZ07_23545 FNZ07_29075
PPAI: E1956_38420
POLY: PSHI2_07660 PSHI2_13350
POLN: PSHI8_07660 PSHI8_13350
PPK: U875_04295
PPNO: DA70_21370
PPNM: LV28_08950
PRB: X636_05150
PPUL: RO07_03180
PSPU: NA29_24090
PAPI: SG18_03370
PVE: UC34_19335
POX: MB84_24090
PFG: AB870_06330
PNR: AT302_02765
PAND: DRB87_17860
PFIB: PI93_008710
PCOM: NTU39_21095
PANN: PanNE5_24100
PANX: OYT13_19455
CABK: NK8_48060
BPT: Bpet2804
AXY: AXYL_00939 AXYL_06581(bphA)
AXO: NH44784_011911
AXN: AX27061_0966
AXX: ERS451415_00957(andAc_1)
ADT: APT56_05015
AIS: BUW96_21015
ASW: CVS48_01680
ACHB: DVB37_04185
ADY: HLG70_17185
ACHO: H4P35_04195
AMUI: PE062_01195
APES: FOC84_07680
AAEG: RA224_27665
ASEL: RAS12_17385
ACHM: V6V88_04515
ACHA: KYT87_04200
AVH: WHX56_09725
ACHH: ABFG95_19605
ACHJ: LN047_04805
PIG: EGT29_23980
PARK: LSG25_18565
PUD: G9Q38_01800 G9Q38_05245
RHF: EUB48_13720
POL: Bpro_0983
PNA: Pnap_2488
POS: DT070_14060
POO: F7R28_16545
AJS: Ajs_3090
ACK: C380_10000
ACIQ: ACDW_45530
ACIV: EXV95_08455
ASAH: AVXHC19_02200
AFAC: ACN9MJ_17495
AAV: Aave_0165
AAA: Acav_0196
VAP: Vapar_5349
VPE: Varpa_2933
VPD: VAPA_1c07040 VAPA_1c20410
VBO: CKY39_17845
VAM: C4F17_05695
VAZ: H7F35_31270
VAV: IG196_15115
VAE: RZE79_15700
VAW: SFB74_06675
RTA: Rta_25990
RTEA: HK414_18885
LIM: L103DPR2_01958(nagG_2)
LIH: L63ED372_02715(nagG_2)
HYR: BSY239_1027
HYB: Q5W_19155
HYL: LPB072_20445
HPSE: HPF_02890(nagG)
HYN: F9K07_14335
HTN: KI616_03135
HCZ: G9Q37_10180
HYY: JNX00_12195 JNX00_19115
HYDR: SOM08_19195
HYDA: ABSY19_04230
ATER: MW290_00175
LCH: Lcho_0797
JAJ: EKL02_16430
HEW: HBDW_22680
MASW: AM586_27630 AM586_27695 AM586_27795
UND: UNDKW_4641
AZO: azo2516(nagG)
AOA: dqs_2673
AZR: CJ010_15885
CFH: C1707_18705
BPON: IFE19_06475
BBUL: U0030_10920
BREU: FKQ52_07260
BSTA: ACETK8_15085
SWI: Swit_3056
SPHD: HY78_10295
SPJS: NUH86_23665
SLAA: EUU25_00840
BLAS: BSY18_3955
PALG: HFP57_01965
AZL: AZL_a09210
ALI: AZOLI_p20649
AHU: A6A40_17440
AZS: E6C72_28695
FER: FNB15_08990
AALU: ABWI00_09340
TMO: TMO_a0554(bphA)
AGRA: AGRA3207_001975
ACTI: UA75_12800
ACAD: UA74_12720
AHG: AHOG_11995(nagG)
LEPV: J4558_27375
VAB: WPS_05630
AG: AAD12607(nagG)
 » show all
Reference
PMID:9573207
  Authors
Fuenmayor SL, Wild M, Boyes AL, Williams PA
  Title
A gene cluster encoding steps in conversion of naphthalene to gentisate in Pseudomonas sp. strain U2.
  Journal
J Bacteriol 180:2522-30 (1998)
DOI:10.1128/JB.180.9.2522-2530.1998
  Sequence
[ag:AAD12607]
LinkDB

KEGG   ORTHOLOGY: K18243
Entry
K18243                      KO                                     
Symbol
nagH
Name
salicylate 5-hydroxylase small subunit [EC:1.14.13.172]
Pathway
map00626  Naphthalene degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Module
M00638  Salicylate degradation, salicylate => gentisate
Reaction
R07709  salicylate,NADH:oxygen oxidoreductase (5-hydroxylating)
R07710  salicylate,NADPH:oxygen oxidoreductase (5-hydroxylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00626 Naphthalene degradation
    K18243  nagH; salicylate 5-hydroxylase small subunit
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.172  salicylate 5-hydroxylase
     K18243  nagH; salicylate 5-hydroxylase small subunit
Dioxygenases [br01602.html]
 Dioxygenases in aromatic ring cleavage
  K18243
Other DBs
COG: COG5517
Genes
EBT: EBL_c34280
KAS: KATP_22600
KLU: K7B04_17410
KGN: GY169_11710
PLU: plu1001
PLUM: A4R40_05000
PTT: VY86_00150
ALT: ambt_18010
TTU: TERTU_1475
CYQ: Q91_0876 Q91_2234
CZA: CYCME_2552
CYY: CPC19_01630
MMW: Mmwyl1_2670
MME: Marme_2405
MPC: Mar181_2358
MPRI: MP3633_2254
MARL: HH196_06880
FCE: JN531_005580
GBI: PG2T_03615
RSO: RSc1089(nagH)
RSE: F504_1060(ohbA)
RPU: CDC45_05590
RNC: GO999_11025
RSL: RPSI07_2302
RSN: RSPO_c02275(nagH)
RSM: CMR15_20208
RSY: RSUY_15110
RSG: JK151_19140
RPJ: N234_28710
RMN: TK49_07935
REH: H16_A1632(nagH)
CNC: CNE_1c16400(nagH)
CUH: BJN34_29225
REU: Reut_B4720
RME: Rmet_3712(nagH)
CBW: RR42_s2752
CCUP: BKK81_31200
CUP: BKK80_25150
CUU: BKK79_30860
COX: E0W60_10140
CCAX: KZ686_18770
CUK: KB879_08290
CUPP: CTP10_R58130
BMK: DM80_1441
BCEP: APZ15_32865
BPYR: ABD05_24785
BUB: BW23_5816
BARI: NLX30_26740
BSER: R0290_17330
BGL: bglu_2g20110
BGU: KS03_3914
BUG: BC1001_0577
BUQ: AC233_10900
BURK: DM992_22160
BURT: BTHE68_44880
BURM: GJG85_21555
BURF: Bsp3421_005961
BPX: BUPH_04467
BUZ: AYM40_33040 AYM40_33150
BFN: OI25_3047
PARB: CJU94_38670
PTER: C2L65_39070
PMEG: FNZ07_23540 FNZ07_29070
PPAI: E1956_38425
POLY: PSHI2_07670 PSHI2_13360
POLN: PSHI8_07670 PSHI8_13360
PPK: U875_04300
PPNO: DA70_21375
PPNM: LV28_08945
PRB: X636_05145
PPUL: RO07_03175
PSPU: NA29_24085
PAPI: SG18_03365
PVE: UC34_19330
POX: MB84_24085
PFG: AB870_06325
PNR: AT302_02760
PAND: DRB87_17855
PFIB: PI93_008715
PCOM: NTU39_21090
PANN: PanNE5_24110
PANX: OYT13_19450
CABK: NK8_48070
BPT: Bpet2805
AXY: AXYL_00938 AXYL_06578
AXO: NH44784_011921
AXN: AX27061_0965
AXX: ERS451415_00956(andAd_1)
ADT: APT56_05010
AIS: BUW96_21020
ASW: CVS48_01685
ACHR: C2U31_09370
ACHB: DVB37_04180
ADY: HLG70_17190
ACHO: H4P35_04190
AMUI: PE062_01190
APES: FOC84_07685
AAEG: RA224_27670
ASEL: RAS12_17390
ACHM: V6V88_04510
ACHA: KYT87_04195
AVH: WHX56_09720
ACHH: ABFG95_19600
ACHJ: LN047_04800
PIG: EGT29_23975
PARK: LSG25_18560
NARM: N7E01_10645
PUD: G9Q38_01795 G9Q38_05250
RHF: EUB48_13715
POL: Bpro_0984
PNA: Pnap_2462 Pnap_2487
POS: DT070_14065
POO: F7R28_16540
ACK: C380_09995
ACIQ: ACDW_45540
ACIV: EXV95_08450
ASAH: AVXHC19_02210
AFAC: ACN9MJ_17490
AAV: Aave_0166
AAA: Acav_0197
VAP: Vapar_5348
VPE: Varpa_2934
VPD: VAPA_1c07030 VAPA_1c20400
VBO: CKY39_17840
VAM: C4F17_05690
VAZ: H7F35_31265
VAV: IG196_15110
VAE: RZE79_15695
VAW: SFB74_06670
RTA: Rta_25980
RTEA: HK414_18880
LIM: L103DPR2_01957(nagH)
LIH: L63ED372_02714(nagH)
HYR: BSY239_1029
HYB: Q5W_19150
HYL: LPB072_20440
HPSE: HPF_02895(nagH)
HYN: F9K07_14340
HTN: KI616_03140
HCZ: G9Q37_10175
HYY: JNX00_12200 JNX00_19110
HYDR: SOM08_19190
HYDA: ABSY19_04225
ATER: MW290_00170
LCH: Lcho_0796
JAJ: EKL02_16425
HEW: HBDW_22690
MASW: AM586_27635 AM586_27700 AM586_27790
UND: UNDKW_4640
AZO: azo2515(nagH)
AOA: dqs_2672
AZR: CJ010_15880
CFH: C1707_18700
BPON: IFE19_06480
BBUL: U0030_10915
BREU: FKQ52_07265
BSTA: ACETK8_15080
NAR: Saro_3834
NPP: PP1Y_AT15862
NOVO: IM701_20820
SWI: Swit_0895 Swit_3057
SPHD: HY78_10290 HY78_22215
SBAR: H5V43_22430
SPJS: NUH86_23670
SLAA: EUU25_00835
BLAS: BSY18_3956
PALG: HFP57_01960
AZL: AZL_a09200
ALI: AZOLI_p20648
AHU: A6A40_17435
AZS: E6C72_28690
FER: FNB15_08995
AALU: ABWI00_09345
TMO: TMO_a0553
NFR: ERS450000_00310(andAd)
RHOJ: JVH1_39340
RHZP: HYG77_33165
VAB: WPS_05620
AG: AAD12608(nagH)
 » show all
Reference
PMID:9573207
  Authors
Fuenmayor SL, Wild M, Boyes AL, Williams PA
  Title
A gene cluster encoding steps in conversion of naphthalene to gentisate in Pseudomonas sp. strain U2.
  Journal
J Bacteriol 180:2522-30 (1998)
DOI:10.1128/JB.180.9.2522-2530.1998
  Sequence
[ag:AAD12608]
LinkDB

KEGG   ORTHOLOGY: K14578
Entry
K14578                      KO                                     
Symbol
nahAb, nagAb, ndoA, nbzAb, dntAb
Name
naphthalene 1,2-dioxygenase ferredoxin component
Pathway
map00624  Polycyclic aromatic hydrocarbon degradation
map00626  Naphthalene degradation
map00627  Aminobenzoate degradation
map00633  Nitrotoluene degradation
map00642  Ethylbenzene degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00534  Naphthalene degradation, naphthalene => salicylate
M00638  Salicylate degradation, salicylate => gentisate
Reaction
R02968  naphthalene,NADH:oxygen oxidoreductase (1,2-hydroxylating)
R05422  fluorene,NADH:oxygen oxidoreductase
R05423  
R05424  
R05425  
R05426  
R05427  
R06909  naphthalene,NADH:oxygen oxidoreductase (1,2-hydroxylating)
R06930  naphthalene,NADH:oxygen oxidoreductase (1,2-hydroxylating)
R06937  naphthalene,NADH:oxygen oxidoreductase (1,2-hydroxylating)
R07704  anthracene,NADH:oxygen oxidoreductase (1,2-hydroxylating)
R07706  nitrobenzene 1,2-dioxygenase
R07709  salicylate,NADH:oxygen oxidoreductase (5-hydroxylating)
R07710  salicylate,NADPH:oxygen oxidoreductase (5-hydroxylating)
R09159  
R09233  2,4-dinitrotoluene,NADH:oxygen oxidoreductase (4,5-hydroxylating, nitrite-releasing)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00627 Aminobenzoate degradation
    K14578  nahAb, nagAb, ndoA, nbzAb, dntAb; naphthalene 1,2-dioxygenase ferredoxin component
   00633 Nitrotoluene degradation
    K14578  nahAb, nagAb, ndoA, nbzAb, dntAb; naphthalene 1,2-dioxygenase ferredoxin component
   00642 Ethylbenzene degradation
    K14578  nahAb, nagAb, ndoA, nbzAb, dntAb; naphthalene 1,2-dioxygenase ferredoxin component
   00626 Naphthalene degradation
    K14578  nahAb, nagAb, ndoA, nbzAb, dntAb; naphthalene 1,2-dioxygenase ferredoxin component
   00624 Polycyclic aromatic hydrocarbon degradation
    K14578  nahAb, nagAb, ndoA, nbzAb, dntAb; naphthalene 1,2-dioxygenase ferredoxin component
Dioxygenases [br01602.html]
 Dioxygenases in aromatic ring cleavage
  K14578
Other DBs
COG: COG2146
Genes
EBT: EBL_c34290(ndoA)
KAS: KATP_22610
KLU: K7B04_17415
KGN: GY169_11705
PSD: DSC_14870
PPT: PPS_2607
PPI: ND054(nahAb)
PPUD: DW66_2865
PPJ: RK21_02167
PFK: PFAS1_28605
PMAO: PMYSY11_1632
PTAE: NCTC10697_01911(nahAb)
PSC: A458_06730
PSTU: UIB01_22620
PBM: CL52_14605
ALT: ambt_17920 ambt_18015
HARO: R50071_34990
HALC: EY643_05350
MMW: Mmwyl1_2671
MME: Marme_2406
MPC: Mar181_2359
MPRI: MP3633_2255
MARL: HH196_06875
PSE: NH8B_2003
RSO: RSc1088(nagAb)
RSE: F504_1059
RPU: CDC45_05585
RNC: GO999_11030
RSL: RPSI07_2303(doxA)
RSN: RSPO_c02276
RSM: CMR15_20207(doxA)
RSY: RSUY_15100
RSG: JK151_19145
RPJ: N234_28715
RMN: TK49_07940
REH: H16_A1631(nagI)
CNC: CNE_1c16390(ndoA) CNE_1c17590 CNE_BB1p12680(ndoA)
CUH: BJN34_29230
REU: Reut_B4721
CBW: RR42_s2753
CCUP: BKK81_31205
CUP: BKK80_25145
CUU: BKK79_30855
COX: E0W60_10135
CCAX: KZ686_18775
CUK: KB879_08285
CUPP: CTP10_R58140
BMK: DM80_1442(ndoA)
BCEP: APZ15_32860
BPYR: ABD05_24790
BUB: BW23_5817(ndoA)
BARI: NLX30_26745
BSER: R0290_17325
BGL: bglu_2g20100
BGU: KS03_3915(ndoA)
BUG: BC1001_0578
BUQ: AC233_10895
BURK: DM992_22155
BURM: GJG85_21550
BURF: Bsp3421_005960
BXE: Bxe_C0940
BXB: DR64_7510(ndoA) DR64_8472
BPX: BUPH_04468
BUZ: AYM40_33145
BFN: OI25_3048(ndoA)
PSPW: BJG93_04745
PARB: CJU94_37840 CJU94_38665
PHS: C2L64_35430
PTER: C2L65_39090
PCAF: DSC91_002388
PMEG: FNZ07_23535 FNZ07_29065
PACS: FAZ98_23225
PDIO: PDMSB3_0226(doxA)
PKF: RW095_30740
PPAI: E1956_31985 E1956_38430
POLY: PSHI2_16370(ndoA)
POLN: PSHI8_16380(ndoA)
PPK: U875_04305
PPNO: DA70_21380
PPNM: LV28_08940
PRB: X636_05140
PPUL: RO07_03170
PSPU: NA29_24080
PAPI: SG18_03360
PVE: UC34_07200 UC34_19325
POX: MB84_24080
PFG: AB870_06320
PNR: AT302_02755
PAND: DRB87_17850
PFIB: PI93_008720
PCOM: NTU39_21085
PANN: PanNE5_24120(ndoA)
PANX: OYT13_19445
TVL: FAZ95_10670
BPAR: BN117_1348(ndoA)
BPA: BPP2189(ndoA)
BBH: BN112_1870(ndoA)
BBR: BB1586(ndoA)
BBM: BN115_1540(ndoA)
BBX: BBS798_1545(ndoA)
BPT: Bpet2806
AXY: AXYL_00937 AXYL_06577
AXO: NH44784_011931
AXN: AX27061_0964
AXX: ERS451415_00955(ndoA_1) ERS451415_02890(ndoA_2)
ADT: APT56_05005
AIS: BUW96_21025
ASW: CVS48_01690
ACHR: C2U31_09365
ACHB: DVB37_04175
ADY: HLG70_17195
ACHO: H4P35_04185
AMUI: PE062_01185
APES: FOC84_07690
AAEG: RA224_13530 RA224_27675
ASEL: RAS12_17395
ACHM: V6V88_04505
ACHA: KYT87_04190
AVH: WHX56_09715
ACHH: ABFG95_19595 ABFG95_28450
ACHJ: LN047_04795
PUS: CKA81_17030
PIG: EGT29_23970
PARK: LSG25_10220 LSG25_18555
NARM: N7E01_10650
PUD: G9Q38_05255
POL: Bpro_0985
PNA: Pnap_2461 Pnap_2486
AJS: Ajs_3091
ACK: C380_09990
ACIP: CBP36_20890
ACIS: CBP35_20270
ACIQ: ACDW_45550
ACIV: EXV95_08445
ASAH: AVXHC19_02220
AFAC: ACN9MJ_17485
AAV: Aave_0167
AAA: Acav_0198
VAP: Vapar_5347
VPE: Varpa_2937
VPD: VAPA_1c07020 VAPA_1c20390
VBO: CKY39_17825
VAM: C4F17_05675
VAZ: H7F35_31250
VAV: IG196_15095
VAE: RZE79_15680
VAW: SFB74_06665
CTES: O987_21885
LIM: L103DPR2_01956(ndoA)
LIH: L63ED372_02713(ndoA)
HYB: Q5W_18510
HYL: LPB072_20435
HPSE: HPF_02900(nagAb)
HTN: KI616_03145
HYY: JNX00_11260 JNX00_12205 JNX00_19095
HYDR: SOM08_19175
DIJ: HND92_13270
DIS: I3K84_20185
ATER: MW290_00165
LCH: Lcho_0795
JAJ: EKL02_16420
HFR: G5S34_02910
HEW: HBDW_22700
MASW: AM586_27400
UND: UNDKW_4639(ndoA)
APET: ToN1_03800
AZO: azo2514(nagAb)
AOA: dqs_2671
AZA: AZKH_1938
AZR: CJ010_15875
STEG: QA637_22930
SCHP: RB548_27175
BRK: CWS35_34855
BEL: BE61_33690(hcaC)
BSEP: HAP48_0026130
BQB: J4P68_0009910
BAUT: QA635_12130
BBRA: QA636_11260
BPAH: QA639_32650
TALZ: RPMA_26285
MIND: mvi_47130
MSL: Msil_1467
CFH: C1707_18695
BPON: IFE19_06485
BBUL: U0030_10910
BREU: FKQ52_07270
BSTA: ACETK8_15075
RCON: K3740_22565
JAN: Jann_3956
ASCA: QEZ52_16380
BOO: E2K80_05850
PPAN: ESD82_07955
PFEO: E3U26_13370
CMAG: CBW24_17265
GCE: KYE46_03300
NOV: TQ38_019630
NOL: NSDW_28180
SPAN: AWL63_16080
SMAG: AN936_24260 AN936_25125
SPPH: KFK14_07995
SPJS: NUH86_23675
SHUM: STHU_47060
AZL: AZL_a09190
ALI: AZOLI_p20647
AHU: A6A40_17430
AZS: E6C72_28685
TMO: TMO_a0552(doxA)
KNV: Pan216_50810(ndoA)
ACUR: JZ785_11730
MGOR: H0P51_02440
SBAT: G4Z16_26495
AGRA: AGRA3207_001977
LEPV: J4558_26605
MELO: J7W08_00350
AG: AAA25905(nahAb) AAB09765(dntAb) AAL76201(nbzAb) AGH09225(mntAb)
 » show all
Reference
PMID:8486285
  Authors
Simon MJ, Osslund TD, Saunders R, Ensley BD, Suggs S, Harcourt A, Suen WC, Cruden DL, Gibson DT, Zylstra GJ
  Title
Sequences of genes encoding naphthalene dioxygenase in Pseudomonas putida strains G7 and NCIB 9816-4.
  Journal
Gene 127:31-7 (1993)
DOI:10.1016/0378-1119(93)90613-8
Reference
PMID:15288784
  Authors
Dennis JJ, Zylstra GJ
  Title
Complete sequence and genetic organization of pDTG1, the 83 kilobase naphthalene degradation plasmid from Pseudomonas putida strain NCIB 9816-4.
  Journal
J Mol Biol 341:753-68 (2004)
DOI:10.1016/j.jmb.2004.06.034
  Sequence
[ag:AAA25905]
LinkDB

KEGG   ORTHOLOGY: K14581
Entry
K14581                      KO                                     
Symbol
nahAa, nagAa, ndoR, nbzAa, dntAa
Name
naphthalene 1,2-dioxygenase ferredoxin reductase component [EC:1.18.1.7]
Pathway
map00624  Polycyclic aromatic hydrocarbon degradation
map00626  Naphthalene degradation
map00627  Aminobenzoate degradation
map00633  Nitrotoluene degradation
map00642  Ethylbenzene degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00534  Naphthalene degradation, naphthalene => salicylate
M00638  Salicylate degradation, salicylate => gentisate
Reaction
R02968  naphthalene,NADH:oxygen oxidoreductase (1,2-hydroxylating)
R05422  fluorene,NADH:oxygen oxidoreductase
R05423  
R05424  
R05425  
R05426  
R05427  
R06909  naphthalene,NADH:oxygen oxidoreductase (1,2-hydroxylating)
R06930  naphthalene,NADH:oxygen oxidoreductase (1,2-hydroxylating)
R06937  naphthalene,NADH:oxygen oxidoreductase (1,2-hydroxylating)
R07704  anthracene,NADH:oxygen oxidoreductase (1,2-hydroxylating)
R07706  nitrobenzene 1,2-dioxygenase
R07709  salicylate,NADH:oxygen oxidoreductase (5-hydroxylating)
R07710  salicylate,NADPH:oxygen oxidoreductase (5-hydroxylating)
R09159  
R09233  2,4-dinitrotoluene,NADH:oxygen oxidoreductase (4,5-hydroxylating, nitrite-releasing)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00627 Aminobenzoate degradation
    K14581  nahAa, nagAa, ndoR, nbzAa, dntAa; naphthalene 1,2-dioxygenase ferredoxin reductase component
   00633 Nitrotoluene degradation
    K14581  nahAa, nagAa, ndoR, nbzAa, dntAa; naphthalene 1,2-dioxygenase ferredoxin reductase component
   00642 Ethylbenzene degradation
    K14581  nahAa, nagAa, ndoR, nbzAa, dntAa; naphthalene 1,2-dioxygenase ferredoxin reductase component
   00626 Naphthalene degradation
    K14581  nahAa, nagAa, ndoR, nbzAa, dntAa; naphthalene 1,2-dioxygenase ferredoxin reductase component
   00624 Polycyclic aromatic hydrocarbon degradation
    K14581  nahAa, nagAa, ndoR, nbzAa, dntAa; naphthalene 1,2-dioxygenase ferredoxin reductase component
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.18  Acting on iron-sulfur proteins as donors
   1.18.1  With NAD+ or NADP+ as acceptor
    1.18.1.7  ferredoxin---NAD(P)+ reductase (naphthalene dioxygenase ferredoxin-specific)
     K14581  nahAa, nagAa, ndoR, nbzAa, dntAa; naphthalene 1,2-dioxygenase ferredoxin reductase component
Dioxygenases [br01602.html]
 Dioxygenases in aromatic ring cleavage
  K14581
Genes
EBT: EBL_c34260(ndoR)
KAS: KATP_22580
KLU: K7B04_17400
KGN: GY169_11720
PPI: ND053(nahAa)
PFK: PFAS1_28600
PSC: A458_06735
PSTU: UIB01_22615
PBM: CL52_14600
ALT: ambt_18035
MMW: Mmwyl1_2668
MME: Marme_2403
MPC: Mar181_2356
MPRI: MP3633_2252
FCE: JN531_005600
RSO: RSc1091(nagAa)
RSE: F504_1062
RPU: CDC45_05600
RNC: GO999_11015
RSL: RPSI07_2300(ndoR)
RSN: RSPO_c02273
RSM: CMR15_20210(ndoR)
RSY: RSUY_15130
RSG: JK151_19130
RPJ: N234_28700
RMN: TK49_07925
CBW: RR42_s2750
CCUP: BKK81_31190
CUP: BKK80_25160
CUU: BKK79_30870
CCAX: KZ686_18760
BMK: DM80_1434(ndoR) DM80_1439(ndoR)
BUG: BC1001_0575
BUQ: AC233_10920
BPX: BUPH_04465
BUZ: AYM40_33160
BFN: OI25_3043(ndoR)
PARB: CJU94_38680
PTER: C2L65_39085
PPAI: E1956_38415
PPK: U875_04290
PPNO: DA70_21365
PPNM: LV28_08955
PRB: X636_05155
PPUL: RO07_03185
PSPU: NA29_24095
PAPI: SG18_03375
PVE: UC34_19340
POX: MB84_24095
PFG: AB870_06335
PNR: AT302_02770
PFIB: PI93_008705
PCOM: NTU39_21100
PANN: PanNE5_24090
PANX: OYT13_19460
AXY: AXYL_06582
PIG: EGT29_02420 EGT29_23985
POL: Bpro_0980
PNA: Pnap_2489
AJS: Ajs_3089
ACK: C380_10005
ACIQ: ACDW_45610
ACIV: EXV95_08415
ASAH: AVXHC19_02190
AFAC: ACN9MJ_17455
AAV: Aave_0164
AAA: Acav_0195
VPE: Varpa_2932
VBO: CKY39_17850
VAM: C4F17_05700
VAZ: H7F35_31275
VAV: IG196_15120
VAE: RZE79_15705
HYY: JNX00_12180
DIJ: HND92_13260
DIS: I3K84_20195
LCH: Lcho_0800
JAJ: EKL02_16445
HEW: HBDW_22650
UND: UNDKW_4644
AZO: azo2517(nagAa)
AOA: dqs_2674
AZR: CJ010_15890
SGI: SGRAN_2805(thnY)
SPJS: NUH86_23660
AG: AAA25904(nahAa) AAB09763(dntAa) AAD12606(nagAa) AAL76199(nbzAa) AGH09224(mntAa)
 » show all
Reference
PMID:8486285
  Authors
Simon MJ, Osslund TD, Saunders R, Ensley BD, Suggs S, Harcourt A, Suen WC, Cruden DL, Gibson DT, Zylstra GJ
  Title
Sequences of genes encoding naphthalene dioxygenase in Pseudomonas putida strains G7 and NCIB 9816-4.
  Journal
Gene 127:31-7 (1993)
DOI:10.1016/0378-1119(93)90613-8
Reference
PMID:15288784
  Authors
Dennis JJ, Zylstra GJ
  Title
Complete sequence and genetic organization of pDTG1, the 83 kilobase naphthalene degradation plasmid from Pseudomonas putida strain NCIB 9816-4.
  Journal
J Mol Biol 341:753-68 (2004)
DOI:10.1016/j.jmb.2004.06.034
  Sequence
[ag:AAA25904]
LinkDB

KEGG   ENZYME: 1.14.13.172
Entry
EC 1.14.13.172              Enzyme                                 
Name
salicylate 5-hydroxylase;
nagG (gene name);
nagH (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
salicylate,NADH:oxygen oxidoreductase (5-hydroxylating)
Reaction(IUBMB)
salicylate + NADH + H+ + O2 = 2,5-dihydroxybenzoate + NAD+ + H2O [RN:R07709]
Reaction(KEGG)
R07709;
(other) R07710
Substrate
salicylate [CPD:C00805];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
2,5-dihydroxybenzoate [CPD:C00628];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Comment
This enzyme, which was characterized from the bacterium Ralstonia sp. U2, comprises a multicomponent system, containing a reductase that is an iron-sulfur flavoprotein (FAD; EC 1.18.1.7, ferredoxin---NAD(P)+ reductase), an iron-sulfur oxygenase, and ferredoxin.
History
EC 1.14.13.172 created 2013
Pathway
ec00626  Naphthalene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K18242  salicylate 5-hydroxylase large subunit
K18243  salicylate 5-hydroxylase small subunit
Genes
EBT: EBL_c34270 EBL_c34280
KAS: KATP_22590 KATP_22600
KLU: K7B04_17405 K7B04_17410
KGN: GY169_11710 GY169_11715
PLU: plu1000 plu1001
PLUM: A4R40_04995 A4R40_05000
PTT: VY86_00150 VY86_00155
PSRR: ELR70_02780
ALT: ambt_18005 ambt_18010
TTU: TERTU_1474 TERTU_1475
CYQ: Q91_0876 Q91_2234
CZA: CYCME_2552
CYY: CPC19_01630
MMW: Mmwyl1_2669 Mmwyl1_2670
MME: Marme_2404 Marme_2405
MPC: Mar181_2357 Mar181_2358
MPRI: MP3633_2253 MP3633_2254
MARL: HH196_06880 HH196_06885
FCE: JN531_005580 JN531_005585
GBI: PG2T_03615
RSO: RSc1089(nagH) RSc1090(nagG)
RSE: F504_1060(ohbA) F504_1061(ohbB)
RPU: CDC45_05590 CDC45_05595
RNC: GO999_11020 GO999_11025
RSL: RPSI07_2301 RPSI07_2302
RSN: RSPO_c02274 RSPO_c02275(nagH)
RSM: CMR15_20208 CMR15_20209
RSY: RSUY_15110 RSUY_15120
RSG: JK151_19135 JK151_19140
RPJ: N234_28705 N234_28710
RMN: TK49_07930 TK49_07935
REH: H16_A1632(nagH) H16_A1633(nagG)
CNC: CNE_1c16400(nagH) CNE_1c16410(nagG)
CUH: BJN34_29220 BJN34_29225
REU: Reut_B4719 Reut_B4720
RME: Rmet_3712(nagH)
CBW: RR42_s2751 RR42_s2752
CCUP: BKK81_31195 BKK81_31200
CUP: BKK80_25150 BKK80_25155
CUU: BKK79_30860 BKK79_30865
COX: E0W60_10140 E0W60_10145
CCAX: KZ686_18765 KZ686_18770
CUK: KB879_08290 KB879_08295
CUPP: CTP10_R58120 CTP10_R58130
BMK: DM80_1440 DM80_1441
BCEP: APZ15_32865 APZ15_32870
BPYR: ABD05_24780 ABD05_24785
BUB: BW23_5815 BW23_5816
BARI: NLX30_26735 NLX30_26740
BSER: R0290_17330 R0290_17335
BGL: bglu_2g20110 bglu_2g20120
BGU: KS03_3913 KS03_3914
BUG: BC1001_0576 BC1001_0577
BUQ: AC233_10900 AC233_10905
BURK: DM992_22160 DM992_22165
BURT: BTHE68_44870 BTHE68_44880
BURM: GJG85_21555 GJG85_21560
BURF: Bsp3421_005961 Bsp3421_005962
BPX: BUPH_04466 BUPH_04467
BUZ: AYM40_33040 AYM40_33045 AYM40_33150 AYM40_33155
BFN: OI25_3046 OI25_3047
PARB: CJU94_38670 CJU94_38675
PTER: C2L65_39070 C2L65_39075
PMEG: FNZ07_23540 FNZ07_23545 FNZ07_29070 FNZ07_29075
PPAI: E1956_38420 E1956_38425
POLY: PSHI2_07660 PSHI2_07670 PSHI2_13350 PSHI2_13360
POLN: PSHI8_07660 PSHI8_07670 PSHI8_13350 PSHI8_13360
PPK: U875_04295 U875_04300
PPNO: DA70_21370 DA70_21375
PPNM: LV28_08945 LV28_08950
PRB: X636_05145 X636_05150
PPUL: RO07_03175 RO07_03180
PSPU: NA29_24085 NA29_24090
PAPI: SG18_03365 SG18_03370
PVE: UC34_19330 UC34_19335
POX: MB84_24085 MB84_24090
PFG: AB870_06325 AB870_06330
PNR: AT302_02760 AT302_02765
PAND: DRB87_17855 DRB87_17860
PFIB: PI93_008710 PI93_008715
PCOM: NTU39_21090 NTU39_21095
PANN: PanNE5_24100 PanNE5_24110
PANX: OYT13_19450 OYT13_19455
CABK: NK8_48060 NK8_48070
BPT: Bpet2804 Bpet2805
AXY: AXYL_00938 AXYL_00939 AXYL_06578 AXYL_06581(bphA)
AXO: NH44784_011911 NH44784_011921
AXN: AX27061_0965 AX27061_0966
AXX: ERS451415_00956(andAd_1) ERS451415_00957(andAc_1)
ADT: APT56_05010 APT56_05015
AIS: BUW96_21015 BUW96_21020
ASW: CVS48_01680 CVS48_01685
ACHR: C2U31_09370
ACHB: DVB37_04180 DVB37_04185
ADY: HLG70_17185 HLG70_17190
ACHO: H4P35_04190 H4P35_04195
AMUI: PE062_01190 PE062_01195
APES: FOC84_07680 FOC84_07685
AAEG: RA224_27665 RA224_27670
ASEL: RAS12_17385 RAS12_17390
ACHM: V6V88_04510 V6V88_04515
ACHA: KYT87_04195 KYT87_04200
AVH: WHX56_09720 WHX56_09725
ACHH: ABFG95_19600 ABFG95_19605
ACHJ: LN047_04800 LN047_04805
PIG: EGT29_23975 EGT29_23980
PARK: LSG25_18560 LSG25_18565
NARM: N7E01_10645
PUD: G9Q38_01795 G9Q38_01800 G9Q38_05245 G9Q38_05250
RHF: EUB48_13715 EUB48_13720
POL: Bpro_0983 Bpro_0984
PNA: Pnap_2462 Pnap_2487 Pnap_2488
POS: DT070_14060 DT070_14065
POO: F7R28_16540 F7R28_16545
AJS: Ajs_3090
ACK: C380_09995 C380_10000
ACIQ: ACDW_45530 ACDW_45540
ACIV: EXV95_08450 EXV95_08455
ASAH: AVXHC19_02200 AVXHC19_02210
AFAC: ACN9MJ_17490 ACN9MJ_17495
AAV: Aave_0165 Aave_0166
AAA: Acav_0196 Acav_0197
VAP: Vapar_5348 Vapar_5349
VPE: Varpa_2933 Varpa_2934
VPD: VAPA_1c07030 VAPA_1c07040 VAPA_1c20400 VAPA_1c20410
VBO: CKY39_17840 CKY39_17845
VAM: C4F17_05690 C4F17_05695
VAZ: H7F35_31265 H7F35_31270
VAV: IG196_15110 IG196_15115
VAE: RZE79_15695 RZE79_15700
VAW: SFB74_06670 SFB74_06675
RTA: Rta_25980 Rta_25990
RTEA: HK414_18880 HK414_18885
LIM: L103DPR2_01957(nagH) L103DPR2_01958(nagG_2)
LIH: L63ED372_02714(nagH) L63ED372_02715(nagG_2)
HYR: BSY239_1027 BSY239_1029
HYB: Q5W_19150 Q5W_19155
HYL: LPB072_20440 LPB072_20445
HPSE: HPF_02890(nagG) HPF_02895(nagH)
HYN: F9K07_14335 F9K07_14340
HTN: KI616_03135 KI616_03140
HCZ: G9Q37_10175 G9Q37_10180
HYY: JNX00_12195 JNX00_12200 JNX00_19110 JNX00_19115
HYDR: SOM08_19190 SOM08_19195
HYDA: ABSY19_04225 ABSY19_04230
ATER: MW290_00170 MW290_00175
LCH: Lcho_0796 Lcho_0797
JAJ: EKL02_16425 EKL02_16430
HEW: HBDW_22680 HBDW_22690
MASW: AM586_27630 AM586_27635 AM586_27695 AM586_27700 AM586_27790 AM586_27795
UND: UNDKW_4640 UNDKW_4641
AZO: azo2515(nagH) azo2516(nagG)
AOA: dqs_2672 dqs_2673
AZR: CJ010_15880 CJ010_15885
CFH: C1707_18700 C1707_18705
BPON: IFE19_06475 IFE19_06480
BBUL: U0030_10915 U0030_10920
BREU: FKQ52_07260 FKQ52_07265
BSTA: ACETK8_15080 ACETK8_15085
NAR: Saro_3834
NPP: PP1Y_AT15862
NOVO: IM701_20820
SWI: Swit_0895 Swit_3056 Swit_3057
SPHD: HY78_10290 HY78_10295 HY78_22215
SBAR: H5V43_22430
SPJS: NUH86_23665 NUH86_23670
SLAA: EUU25_00835 EUU25_00840
BLAS: BSY18_3955 BSY18_3956
PALG: HFP57_01960 HFP57_01965
AZL: AZL_a09200 AZL_a09210
ALI: AZOLI_p20648 AZOLI_p20649
AHU: A6A40_17435 A6A40_17440
AZS: E6C72_28690 E6C72_28695
FER: FNB15_08990 FNB15_08995
AALU: ABWI00_09340 ABWI00_09345
TMO: TMO_a0553 TMO_a0554(bphA)
NFR: ERS450000_00310(andAd)
RHOJ: JVH1_39340
RHZP: HYG77_33165
AGRA: AGRA3207_001975
ACTI: UA75_12800
ACAD: UA74_12720
AHG: AHOG_11995(nagG)
LEPV: J4558_27375
VAB: WPS_05620 WPS_05630
 » show all
Reference
1  [PMID:9573207]
  Authors
Fuenmayor SL, Wild M, Boyes AL, Williams PA
  Title
A gene cluster encoding steps in conversion of naphthalene to gentisate in Pseudomonas sp. strain U2.
  Journal
J Bacteriol 180:2522-30 (1998)
DOI:10.1128/JB.180.9.2522-2530.1998
  Sequence
[ag:AAD12607 AAD12608]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.172
IUBMB Enzyme Nomenclature: 1.14.13.172
ExPASy - ENZYME nomenclature database: 1.14.13.172
BRENDA, the Enzyme Database: 1.14.13.172
LinkDB

KEGG   REACTION: R07709
Entry
R07709                      Reaction                               
Name
salicylate,NADH:oxygen oxidoreductase (5-hydroxylating)
Definition
Salicylate + NADH + Oxygen + H+ <=> 2,5-Dihydroxybenzoate + NAD+ + H2O
Equation
C00805 + C00004 + C00007 + C00080 <=> C00628 + C00003 + C00001
Comment
NADPH (see R07710)
Reaction class
RC00001  C00003_C00004
RC00490  C00628_C00805
Enzyme
1.14.13.172
Pathway
rn00626  Naphthalene degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Module
M00638  Salicylate degradation, salicylate => gentisate
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.172
     R07709  Salicylate + NADH + Oxygen + H+ <=> 2,5-Dihydroxybenzoate + NAD+ + H2O
Orthology
K14578  naphthalene 1,2-dioxygenase ferredoxin component
K14581  naphthalene 1,2-dioxygenase ferredoxin reductase component [EC:1.18.1.7]
K18242  salicylate 5-hydroxylase large subunit [EC:1.14.13.172]
K18243  salicylate 5-hydroxylase small subunit [EC:1.14.13.172]
Other DBs
RHEA: 35310
LinkDB

KEGG   REACTION: R07710
Entry
R07710                      Reaction                               
Name
salicylate,NADPH:oxygen oxidoreductase (5-hydroxylating)
Definition
Salicylate + NADPH + Oxygen + H+ <=> 2,5-Dihydroxybenzoate + NADP+ + H2O
Equation
C00805 + C00005 + C00007 + C00080 <=> C00628 + C00006 + C00001
Comment
NADH (see R07709)
Reaction class
RC00001  C00005_C00006
RC00490  C00628_C00805
Enzyme
1.14.13.172
Pathway
rn00626  Naphthalene degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Module
M00638  Salicylate degradation, salicylate => gentisate
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.172
     R07710  Salicylate + NADPH + Oxygen + H+ <=> 2,5-Dihydroxybenzoate + NADP+ + H2O
Orthology
K14578  naphthalene 1,2-dioxygenase ferredoxin component
K14581  naphthalene 1,2-dioxygenase ferredoxin reductase component [EC:1.18.1.7]
K18242  salicylate 5-hydroxylase large subunit [EC:1.14.13.172]
K18243  salicylate 5-hydroxylase small subunit [EC:1.14.13.172]
LinkDB

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