KEGG   ORTHOLOGY: K18310
Entry
K18310                      KO                                     
Symbol
RIMKLB, NAAGS-I
Name
beta-citrylglutamate/N-acetylaspartylglutamate synthase [EC:6.3.1.17 6.3.2.41]
Pathway
map00250  Alanine, aspartate and glutamate metabolism
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00250 Alanine, aspartate and glutamate metabolism
    K18310  RIMKLB, NAAGS-I; beta-citrylglutamate/N-acetylaspartylglutamate synthase
Enzymes [BR:ko01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.1  Acid-D-ammonia (or amine) ligases (amide synthases)
    6.3.1.17  beta-citrylglutamate synthase
     K18310  RIMKLB, NAAGS-I; beta-citrylglutamate/N-acetylaspartylglutamate synthase
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.41  N-acetylaspartylglutamate synthase
     K18310  RIMKLB, NAAGS-I; beta-citrylglutamate/N-acetylaspartylglutamate synthase
Other DBs
RN: R10677 R10678
Genes
HSA: 57494(RIMKLB)
PTR: 735860(RIMKLB)
PPS: 100974820(RIMKLB)
GGO: 101136567(RIMKLB)
PON: 100441104(RIMKLB)
NLE: 100593570(RIMKLB)
MCC: 722261(RIMKLB)
MCF: 102124154(RIMKLB) 102128847 123572791
CSAB: 103218536(RIMKLB)
CATY: 105587959(RIMKLB)
PANU: 101024010(RIMKLB)
TGE: 112635206(RIMKLB)
RRO: 104672842(RIMKLB)
RBB: 108543684(RIMKLB)
TFN: 117090541(RIMKLB)
PTEH: 111526616(RIMKLB)
CJC: 100406491(RIMKLB)
SBQ: 101033047(RIMKLB)
CSYR: 103251714(RIMKLB)
MMUR: 105878274(RIMKLB)
OGA: 100941690(RIMKLB)
MMU: 108653(Rimklb)
MCAL: 110296264(Rimklb)
MPAH: 110316335(Rimklb)
RNO: 362428(Rimklb)
MCOC: 116099539(Rimklb)
MUN: 110556298(Rimklb)
CGE: 100760031(Rimklb)
PLEU: 114683483(Rimklb)
NGI: 103727467(Rimklb)
HGL: 101706744(Rimklb)
CPOC: 100732576(Rimklb)
CCAN: 109697724(Rimklb)
DORD: 105991108(Rimklb)
DSP: 122127019(Rimklb)
NCAR: 124983424
OCU: 100346793(RIMKLB)
OPI: 101523234(RIMKLB)
TUP: 102472940(RIMKLB)
CFA: 486698(RIMKLB)
VVP: 112917302(RIMKLB)
VLG: 121479857(RIMKLB)
AML: 100473320(RIMKLB)
UMR: 103669163(RIMKLB)
UAH: 113257923(RIMKLB)
UAR: 123781552(RIMKLB)
ELK: 111142053
LLV: 125106794
MPUF: 101680352(RIMKLB)
ORO: 101374535(RIMKLB)
EJU: 114221687(RIMKLB)
ZCA: 113921819(RIMKLB)
MLX: 118025692(RIMKLB)
FCA: 101097740(RIMKLB)
PYU: 121022064(RIMKLB)
PBG: 122473789(RIMKLB)
PTG: 102963865(RIMKLB)
PPAD: 109276058(RIMKLB)
AJU: 106965320(RIMKLB)
HHV: 120222721(RIMKLB)
BTA: 538579(RIMKLB)
BOM: 102269649(RIMKLB)
BIU: 109559695(RIMKLB)
BBUB: 102397788(RIMKLB)
CHX: 102176861(RIMKLB)
OAS: 101102554(RIMKLB)
ODA: 120858791(RIMKLB)
CCAD: 122423372(RIMKLB) 122439954
SSC: 100152915(RIMKLB)
CFR: 102503881(RIMKLB)
CBAI: 105062179(RIMKLB)
CDK: 105098170(RIMKLB)
VPC: 102526778(RIMKLB)
BACU: 103019013(RIMKLB)
LVE: 103069710(RIMKLB)
OOR: 101273054(RIMKLB)
DLE: 111176728(RIMKLB)
PCAD: 102981532(RIMKLB)
PSIU: 116746837 116760947(RIMKLB)
ECB: 100061350(RIMKLB)
EPZ: 103564581(RIMKLB)
EAI: 106837431(RIMKLB)
MYB: 102245342(RIMKLB)
MYD: 102752373(RIMKLB)
MMYO: 118650363(RIMKLB)
MLF: 102441683(RIMKLB)
MNA: 107544073(RIMKLB)
PKL: 118728963(RIMKLB)
HAI: 109372752(RIMKLB)
DRO: 112322046(RIMKLB)
SHON: 119002540(RIMKLB)
AJM: 119065675(RIMKLB)
PDIC: 114514072(RIMKLB)
PHAS: 123819342(RIMKLB)
MMF: 118624708(RIMKLB)
RFQ: 117028564(RIMKLB)
PALE: 102880426(RIMKLB)
PGIG: 120611695(RIMKLB)
PVP: 105295916(RIMKLB)
RAY: 107501656(RIMKLB)
MJV: 108396116(RIMKLB)
TOD: 119247737(RIMKLB)
SARA: 101554225(RIMKLB)
LAV: 100657534(RIMKLB)
TMU: 101361972
DNM: 101416522(RIMKLB)
MDO: 100013787(RIMKLB)
GAS: 123250757(RIMKLB)
SHR: 100930894(RIMKLB)
PCW: 110213807(RIMKLB)
OAA: 100090307(RIMKLB)
GGA: 418255(RIMKLB)
PCOC: 116240958(RIMKLB)
MGP: 104916636
CJO: 107318392(RIMKLB)
NMEL: 110397764(RIMKLB)
APLA: 101792875(RIMKLB)
ACYG: 106048091(RIMKLB)
AFUL: 116490791(RIMKLB)
TGU: 100220208(RIMKLB)
LSR: 110472321(RIMKLB)
SCAN: 103827201(RIMKLB)
PMOA: 120497743(RIMKLB)
OTC: 121341027(RIMKLB)
PRUF: 121349851(RIMKLB)
GFR: 102035986(RIMKLB)
FAB: 101814507(RIMKLB)
PHI: 102111957(RIMKLB)
PMAJ: 107210434(RIMKLB)
CCAE: 111925810(RIMKLB)
CCW: 104690266(RIMKLB)
ETL: 114069342(RIMKLB)
ZAB: 102064947(RIMKLB)
FPG: 101913481(RIMKLB)
FCH: 102056126(RIMKLB)
CLV: 102098362(RIMKLB)
EGZ: 104122771(RIMKLB)
NNI: 104014577(RIMKLB)
ACUN: 113491069(RIMKLB)
TALA: 104365181(RIMKLB)
PADL: 103915115(RIMKLB)
ACHC: 115352600(RIMKLB)
AAM: 106495722(RIMKLB)
AROW: 112973974(RIMKLB)
NPD: 112952039(RIMKLB)
DNE: 112992432(RIMKLB)
ASN: 102373845(RIMKLB)
AMJ: 102576775(RIMKLB)
CPOO: 109316234(RIMKLB)
GGN: 109296594(RIMKLB)
PSS: 102451018(RIMKLB)
CMY: 102933090(RIMKLB)
CPIC: 101943668(RIMKLB)
TST: 117884982(RIMKLB)
CABI: 116823843(RIMKLB)
MRV: 120404562(RIMKLB)
ACS: 100563778(rimklb)
PVT: 110069781(RIMKLB)
SUND: 121921715(RIMKLB)
PBI: 103055545(RIMKLB)
PMUR: 107288539(RIMKLB)
TSR: 106544566(RIMKLB)
PGUT: 117661914(RIMKLB)
VKO: 123017759(RIMKLB)
PMUA: 114588043(RIMKLB)
ZVI: 118097943(RIMKLB)
GJA: 107117747(RIMKLB)
XTR: 100486701(rimklb)
NPR: 108799485(RIMKLB)
RTEM: 120946910(RIMKLB)
BBUF: 121005412(RIMKLB)
BGAR: 122941782(RIMKLB)
DRE: 447815(rimkla)
SANH: 107669631
IPU: 108265850(rimkla)
PHYP: 113529230
SMEO: 124399561(rimkla)
TFD: 113655760(rimkla)
AMEX: 103035057
EEE: 113572086
TRU: 101062827
LCO: 104920219
NCC: 104955181(rimkla)
CGOB: 115011073
ELY: 117258509(rimkla)
PLEP: 121947276(rimkla)
SLUC: 116040663(rimkla)
ECRA: 117948232(rimkla)
PFLV: 114558866
GAT: 120828693(rimkla)
MSAM: 119905637(rimkla)
CUD: 121518035(rimkla)
MZE: 101477475
ONL: 100698845
OAU: 116309725(rimkla)
OLA: 101169452(rimklb)
OML: 112159079(rimkla)
XMA: 102218635
XCO: 114141086
XHE: 116725681
PRET: 103467997(rimkla)
PFOR: 103138952(rimkla)
PLAI: 106957454(rimkla)
PMEI: 106907435(rimkla)
GAF: 122836233(rimkla)
CVG: 107088869(rimkla)
CTUL: 119797064(rimkla)
GMU: 124867677(rimkla)
NFU: 107390714
KMR: 108236831(rimkla)
ALIM: 106524174
NWH: 119417065(rimkla)
AOCE: 111585273
CSEM: 103384935
POV: 109630621(rimkla)
SSEN: 122776960(rimkla)
HHIP: 117764653(rimkla)
LCF: 108891717(rimkla)
SDU: 111219047
SLAL: 111670604
XGL: 120804092(rimkla)
HCQ: 109526583
BPEC: 110161111
MALB: 109970719
ELS: 105013808
PKI: 111856970 111859075(rimkla)
AANG: 118208179(rimkla)
LOC: 102687393(rimkla)
LCM: 102351441(RIMKLB) 102354509(RIMKLA)
CMK: 103190080(rimkla)
RTP: 109924989
 » show all
Reference
  Authors
Collard F, Stroobant V, Lamosa P, Kapanda CN, Lambert DM, Muccioli GG, Poupaert JH, Opperdoes F, Van Schaftingen E
  Title
Molecular identification of N-acetylaspartylglutamate synthase and beta-citrylglutamate synthase.
  Journal
J Biol Chem 285:29826-33 (2010)
DOI:10.1074/jbc.M110.152629
  Sequence
[mmu:108653]
LinkDB

KEGG   ENZYME: 6.3.1.17
Entry
EC 6.3.1.17                 Enzyme                                 
Name
beta-citrylglutamate synthase;
NAAG synthetase I;
NAAGS-I;
RIMKLB (gene name) (ambiguous)
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-ammonia (or amine) ligases (amide synthases)
Sysname
citrate:L-glutamate ligase (ADP-forming)
Reaction(IUBMB)
ATP + citrate + L-glutamate = ADP + phosphate + beta-citryl-L-glutamate [RN:R10677]
Reaction(KEGG)
R10677
Substrate
ATP [CPD:C00002];
citrate [CPD:C00158];
L-glutamate [CPD:C00025]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
beta-citryl-L-glutamate [CPD:C20775]
Comment
The enzyme, found in animals, also has the activity of EC 6.3.2.41, N-acetylaspartylglutamate synthase.
History
EC 6.3.1.17 created 2014
Pathway
ec00250  Alanine, aspartate and glutamate metabolism
ec01100  Metabolic pathways
Orthology
K18310  beta-citrylglutamate/N-acetylaspartylglutamate synthase
Genes
HSA57494(RIMKLB)
PTR735860(RIMKLB)
PPS100974820(RIMKLB)
GGO101136567(RIMKLB)
PON100441104(RIMKLB)
NLE100593570(RIMKLB)
MCC722261(RIMKLB)
MCF102124154(RIMKLB) 102128847 123572791
CSAB103218536(RIMKLB)
CATY105587959(RIMKLB)
PANU101024010(RIMKLB)
TGE112635206(RIMKLB)
RRO104672842(RIMKLB)
RBB108543684(RIMKLB)
TFN117090541(RIMKLB)
PTEH111526616(RIMKLB)
CJC100406491(RIMKLB)
SBQ101033047(RIMKLB)
CSYR103251714(RIMKLB)
MMUR105878274(RIMKLB)
OGA100941690(RIMKLB)
MMU108653(Rimklb)
MCAL110296264(Rimklb)
MPAH110316335(Rimklb)
RNO362428(Rimklb)
MCOC116099539(Rimklb)
MUN110556298(Rimklb)
CGE100760031(Rimklb)
PLEU114683483(Rimklb)
NGI103727467(Rimklb)
HGL101706744(Rimklb)
CPOC100732576(Rimklb)
CCAN109697724(Rimklb)
DORD105991108(Rimklb)
DSP122127019(Rimklb)
NCAR124983424
OCU100346793(RIMKLB)
OPI101523234(RIMKLB)
TUP102472940(RIMKLB)
CFA486698(RIMKLB)
VVP112917302(RIMKLB)
VLG121479857(RIMKLB)
AML100473320(RIMKLB)
UMR103669163(RIMKLB)
UAH113257923(RIMKLB)
UAR123781552(RIMKLB)
ELK111142053
LLV125106794
MPUF101680352(RIMKLB)
ORO101374535(RIMKLB)
EJU114221687(RIMKLB)
ZCA113921819(RIMKLB)
MLX118025692(RIMKLB)
FCA101097740(RIMKLB)
PYU121022064(RIMKLB)
PBG122473789(RIMKLB)
PTG102963865(RIMKLB)
PPAD109276058(RIMKLB)
AJU106965320(RIMKLB)
HHV120222721(RIMKLB)
BTA538579(RIMKLB)
BOM102269649(RIMKLB)
BIU109559695(RIMKLB)
BBUB102397788(RIMKLB)
CHX102176861(RIMKLB)
OAS101102554(RIMKLB)
ODA120858791(RIMKLB)
CCAD122423372(RIMKLB) 122439954
SSC100152915(RIMKLB)
CFR102503881(RIMKLB)
CBAI105062179(RIMKLB)
CDK105098170(RIMKLB)
VPC102526778(RIMKLB)
BACU103019013(RIMKLB)
LVE103069710(RIMKLB)
OOR101273054(RIMKLB)
DLE111176728(RIMKLB)
PCAD102981532(RIMKLB)
PSIU116746837 116760947(RIMKLB)
ECB100061350(RIMKLB)
EPZ103564581(RIMKLB)
EAI106837431(RIMKLB)
MYB102245342(RIMKLB)
MYD102752373(RIMKLB)
MMYO118650363(RIMKLB)
MLF102441683(RIMKLB)
MNA107544073(RIMKLB)
PKL118728963(RIMKLB)
HAI109372752(RIMKLB)
DRO112322046(RIMKLB)
SHON119002540(RIMKLB)
AJM119065675(RIMKLB)
PDIC114514072(RIMKLB)
PHAS123819342(RIMKLB)
MMF118624708(RIMKLB)
RFQ117028564(RIMKLB)
PALE102880426(RIMKLB)
PGIG120611695(RIMKLB)
PVP105295916(RIMKLB)
RAY107501656(RIMKLB)
MJV108396116(RIMKLB)
TOD119247737(RIMKLB)
SARA101554225(RIMKLB)
LAV100657534(RIMKLB)
TMU101361972
DNM101416522(RIMKLB)
MDO100013787(RIMKLB)
GAS123250757(RIMKLB)
SHR100930894(RIMKLB)
PCW110213807(RIMKLB)
OAA100090307(RIMKLB)
GGA418255(RIMKLB)
PCOC116240958(RIMKLB)
MGP104916636
CJO107318392(RIMKLB)
NMEL110397764(RIMKLB)
APLA101792875(RIMKLB)
ACYG106048091(RIMKLB)
AFUL116490791(RIMKLB)
TGU100220208(RIMKLB)
LSR110472321(RIMKLB)
SCAN103827201(RIMKLB)
PMOA120497743(RIMKLB)
OTC121341027(RIMKLB)
PRUF121349851(RIMKLB)
GFR102035986(RIMKLB)
FAB101814507(RIMKLB)
PHI102111957(RIMKLB)
PMAJ107210434(RIMKLB)
CCAE111925810(RIMKLB)
CCW104690266(RIMKLB)
ETL114069342(RIMKLB)
ZAB102064947(RIMKLB)
FPG101913481(RIMKLB)
FCH102056126(RIMKLB)
CLV102098362(RIMKLB)
EGZ104122771(RIMKLB)
NNI104014577(RIMKLB)
ACUN113491069(RIMKLB)
TALA104365181(RIMKLB)
PADL103915115(RIMKLB)
ACHC115352600(RIMKLB)
AAM106495722(RIMKLB)
AROW112973974(RIMKLB)
NPD112952039(RIMKLB)
DNE112992432(RIMKLB)
ASN102373845(RIMKLB)
AMJ102576775(RIMKLB)
CPOO109316234(RIMKLB)
GGN109296594(RIMKLB)
PSS102451018(RIMKLB)
CMY102933090(RIMKLB)
CPIC101943668(RIMKLB)
TST117884982(RIMKLB)
CABI116823843(RIMKLB)
MRV120404562(RIMKLB)
ACS100563778(rimklb)
PVT110069781(RIMKLB)
SUND121921715(RIMKLB)
PBI103055545(RIMKLB)
PMUR107288539(RIMKLB)
TSR106544566(RIMKLB)
PGUT117661914(RIMKLB)
VKO123017759(RIMKLB)
PMUA114588043(RIMKLB)
ZVI118097943(RIMKLB)
GJA107117747(RIMKLB)
XLA108696039 108697330
XTR100486701(rimklb)
NPR108799485(RIMKLB)
RTEM120946910(RIMKLB)
BBUF121005412(RIMKLB)
BGAR122941782(RIMKLB)
DRE447815(rimkla)
SRX107711947 107717536
SANH107669631
SGH107556480 107591767
CCAR109084979 109084984
CAUA113078389 113093917 113107768
IPU108265850(rimkla)
PHYP113529230
SMEO124399561(rimkla)
TFD113655760(rimkla)
AMEX103035057
EEE113572086
TRU101062827
TNGGSTEN00013753G001
LCO104920219
NCC104955181(rimkla)
CGOB115011073
ELY117258509(rimkla)
PLEP121947276(rimkla)
SLUC116040663(rimkla)
ECRA117948232(rimkla)
PFLV114558866
GAT120828693(rimkla)
PPUG119205701 119222662
MSAM119905637(rimkla)
CUD121518035(rimkla)
MZE101477475
ONL100698845
OAU116309725(rimkla)
OLA101169452(rimklb)
OML112159079(rimkla)
XMA102218635
XCO114141086
XHE116725681
PRET103467997(rimkla)
PFOR103138952(rimkla)
PLAI106957454(rimkla)
PMEI106907435(rimkla)
GAF122836233(rimkla)
CVG107088869(rimkla)
CTUL119797064(rimkla)
GMU124867677(rimkla)
NFU107390714
KMR108236831(rimkla)
ALIM106524174
NWH119417065(rimkla)
AOCE111585273
CSEM103384935
POV109630621(rimkla)
SSEN122776960(rimkla)
HHIP117764653(rimkla)
LCF108891717(rimkla)
SDU111219047
SLAL111670604
XGL120804092(rimkla)
HCQ109526583
BPEC110161111
MALB109970719
SASA106567384 106572158
OTW112215953 112221609
OMY110491822 110532211
OGO124017459 124031877
ONE115102623 115132092
SALP111966388 111976646
SNH120059373 120060966
ELS105013808
SFM108918203 108924922
PKI111856970 111859075(rimkla)
AANG118208179(rimkla)
LOC102687393(rimkla)
PSPA121296514 121325367 121328885 121329280
ARUT117424072 117425213 117425745 117432003
LCM102351441(RIMKLB) 102354509(RIMKLA)
CMK103190080(rimkla)
RTP109924989
 » show all
Reference
1  [PMID:20657015]
  Authors
Collard F, Stroobant V, Lamosa P, Kapanda CN, Lambert DM, Muccioli GG, Poupaert JH, Opperdoes F, Van Schaftingen E
  Title
Molecular identification of N-acetylaspartylglutamate synthase and beta-citrylglutamate synthase.
  Journal
J Biol Chem 285:29826-33 (2010)
DOI:10.1074/jbc.M110.152629
  Sequence
[mmu:108653]
Other DBs
ExplorEnz - The Enzyme Database: 6.3.1.17
IUBMB Enzyme Nomenclature: 6.3.1.17
ExPASy - ENZYME nomenclature database: 6.3.1.17
BRENDA, the Enzyme Database: 6.3.1.17
LinkDB

KEGG   REACTION: R10677
Entry
R10677                      Reaction                               
Name
citrate:L-glutamate ligase (ADP-forming)
Definition
ATP + Citrate + L-Glutamate <=> ADP + Orthophosphate + beta-Citryl-L-glutamate
Equation
Reaction class
RC00002  C00002_C00008
RC00064  C00025_C20775
RC03233  C00158_C20775
Enzyme
Pathway
rn00250  Alanine, aspartate and glutamate metabolism
rn01100  Metabolic pathways
Orthology
K18310  beta-citrylglutamate/N-acetylaspartylglutamate synthase [EC:6.3.1.17 6.3.2.41]
Other DBs
RHEA: 40046
LinkDB

DBGET integrated database retrieval system