KEGG   ORTHOLOGY: K18311
Entry
K18311                      KO                                     
Symbol
RIMKLA, NAAGS-II
Name
N-acetylaspartylglutamate/N-acetylaspartylglutamylglutamate synthase [EC:6.3.2.41 6.3.2.42]
Pathway
map00250  Alanine, aspartate and glutamate metabolism
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00250 Alanine, aspartate and glutamate metabolism
    K18311  RIMKLA, NAAGS-II; N-acetylaspartylglutamate/N-acetylaspartylglutamylglutamate synthase
Enzymes [BR:ko01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.41  N-acetylaspartylglutamate synthase
     K18311  RIMKLA, NAAGS-II; N-acetylaspartylglutamate/N-acetylaspartylglutamylglutamate synthase
    6.3.2.42  N-acetylaspartylglutamylglutamate synthase
     K18311  RIMKLA, NAAGS-II; N-acetylaspartylglutamate/N-acetylaspartylglutamylglutamate synthase
Other DBs
RN: R10678 R10679 R10693
Genes
HSA: 284716(RIMKLA)
PTR: 748944(RIMKLA)
PPS: 100970527(RIMKLA)
GGO: 101137769(RIMKLA)
PON: 100457877(RIMKLA)
NLE: 100589997(RIMKLA)
MCC: 699767(RIMKLA)
MCF: 102128755(RIMKLA)
CSAB: 103225007(RIMKLA)
CATY: 105594671(RIMKLA)
PANU: 101017885(RIMKLA)
TGE: 112631615(RIMKLA)
RRO: 104668996(RIMKLA)
RBB: 108530380(RIMKLA)
TFN: 117092770(RIMKLA)
PTEH: 111548818(RIMKLA)
CJC: 100400904(RIMKLA)
SBQ: 101028223(RIMKLA)
CSYR: 103269612(RIMKLA)
MMUR: 105862291(RIMKLA)
OGA: 100962508(RIMKLA)
MMU: 194237(Rimkla)
MCAL: 110293598(Rimkla)
MPAH: 110323614(Rimkla)
MCOC: 116096541(Rimkla)
MUN: 110547458(Rimkla)
CGE: 100759423(Rimkla)
PLEU: 114704934(Rimkla)
NGI: 103735994(Rimkla)
HGL: 101721728(Rimkla)
CPOC: 100713055(Rimkla)
CCAN: 109702396(Rimkla)
DORD: 105986036(Rimkla)
DSP: 122111270(Rimkla)
NCAR: 124969199
OCU: 100356205(RIMKLA)
OPI: 101536112(RIMKLA)
TUP: 102474653(RIMKLA)
CFA: 482445(RIMKLA)
VVP: 112908198(RIMKLA)
VLG: 121481599(RIMKLA)
AML: 100472546(RIMKLA)
UMR: 103670923(RIMKLA)
UAH: 113254814(RIMKLA)
UAR: 123793822(RIMKLA)
ELK: 111143454
LLV: 125098454
MPUF: 101690597(RIMKLA)
ORO: 101368732(RIMKLA)
EJU: 114224206(RIMKLA)
ZCA: 113919895(RIMKLA)
MLX: 118019547(RIMKLA)
FCA: 101099388(RIMKLA)
PYU: 121026952(RIMKLA)
PBG: 122480352(RIMKLA)
PTG: 102959348(RIMKLA)
PPAD: 109254893(RIMKLA)
AJU: 106970196(RIMKLA)
HHV: 120236090(RIMKLA)
BTA: 507323(RIMKLA)
BOM: 102285876(RIMKLA)
BIU: 109556903(RIMKLA)
BBUB: 102407086(RIMKLA)
CHX: 102179728(RIMKLA)
OAS: 101104941(RIMKLA)
ODA: 120856323(RIMKLA)
CCAD: 122437135(RIMKLA)
SSC: 100522878(RIMKLA)
CFR: 102522941(RIMKLA)
CBAI: 105072857(RIMKLA)
CDK: 105105491(RIMKLA)
VPC: 102545512(RIMKLA)
BACU: 103018606(RIMKLA)
LVE: 103083571(RIMKLA)
OOR: 101275823(RIMKLA)
DLE: 111175673(RIMKLA)
PCAD: 102982103(RIMKLA)
PSIU: 116762902(RIMKLA)
ECB: 100067475(RIMKLA)
EPZ: 103557317(RIMKLA)
EAI: 106847814(RIMKLA)
MYB: 102249129(RIMKLA)
MYD: 102754710(RIMKLA)
MMYO: 118677485(RIMKLA)
MLF: 102430712(RIMKLA)
MNA: 107531164(RIMKLA)
PKL: 118723941(RIMKLA)
HAI: 109383339(RIMKLA)
DRO: 112299564(RIMKLA)
SHON: 118977580(RIMKLA)
AJM: 119052488(RIMKLA)
PDIC: 114497212(RIMKLA)
PHAS: 123831998(RIMKLA)
MMF: 118627179(RIMKLA)
RFQ: 117027770(RIMKLA)
PALE: 102882758(RIMKLA)
PGIG: 120607199(RIMKLA)
PVP: 105304029(RIMKLA)
RAY: 107508299(RIMKLA)
MJV: 108399391(RIMKLA) 108403838
TOD: 119236219(RIMKLA)
SARA: 101544446(RIMKLA)
LAV: 100664484(RIMKLA)
TMU: 101348075
DNM: 101421529(RIMKLA)
MDO: 100026482(RIMKLA)
GAS: 123243217(RIMKLA)
SHR: 100913508(RIMKLA)
PCW: 110206227(RIMKLA)
OAA: 100073839(RIMKLA)
XLA: 108696583
XTR: 100145548(rimkla)
NPR: 108783941(RIMKLA)
RTEM: 120915609(RIMKLA)
BBUF: 120998179(RIMKLA)
BGAR: 122926877(RIMKLA)
 » show all
Reference
  Authors
Lodder-Gadaczek J, Becker I, Gieselmann V, Wang-Eckhardt L, Eckhardt M
  Title
N-acetylaspartylglutamate synthetase II synthesizes N-acetylaspartylglutamylglutamate.
  Journal
J Biol Chem 286:16693-706 (2011)
DOI:10.1074/jbc.M111.230136
  Sequence
[mmu:194237] [hsa:284716]
LinkDB

KEGG   ENZYME: 6.3.2.42
Entry
EC 6.3.2.42                 Enzyme                                 
Name
N-acetylaspartylglutamylglutamate synthase;
N-acetylaspartylglutamylglutamate synthetase;
NAAG(2) synthase;
NAAG synthetase II;
NAAGS-II;
RIMKLA (gene name) (ambiguous)
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
Sysname
N-acetyl-L-aspartate:L-glutamate ligase (ADP, N-acetyl-L-aspartyl-L-glutamyl-L-glutamate-forming)
Reaction(IUBMB)
2 ATP + N-acetyl-L-aspartate + 2 L-glutamate = 2 ADP + 2 phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate [RN:R10679]
Reaction(KEGG)
R10679;
(other) R10678 R10693
Substrate
ATP [CPD:C00002];
N-acetyl-L-aspartate [CPD:C01042];
L-glutamate [CPD:C00025]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
N-acetyl-L-aspartyl-L-glutamyl-L-glutamate [CPD:C20776]
Comment
The enzyme, found in mammals, also has the activity of EC 6.3.2.41, N-acetylaspartylglutamate synthase.
History
EC 6.3.2.42 created 2014
Pathway
ec00250  Alanine, aspartate and glutamate metabolism
ec01100  Metabolic pathways
Orthology
K18311  N-acetylaspartylglutamate/N-acetylaspartylglutamylglutamate synthase
Genes
HSA284716(RIMKLA)
PTR748944(RIMKLA)
PPS100970527(RIMKLA)
GGO101137769(RIMKLA)
PON100457877(RIMKLA)
NLE100589997(RIMKLA)
MCC699767(RIMKLA)
MCF102128755(RIMKLA)
CSAB103225007(RIMKLA)
CATY105594671(RIMKLA)
PANU101017885(RIMKLA)
TGE112631615(RIMKLA)
RRO104668996(RIMKLA)
RBB108530380(RIMKLA)
TFN117092770(RIMKLA)
PTEH111548818(RIMKLA)
CJC100400904(RIMKLA)
SBQ101028223(RIMKLA)
CSYR103269612(RIMKLA)
MMUR105862291(RIMKLA)
OGA100962508(RIMKLA)
MMU194237(Rimkla)
MCAL110293598(Rimkla)
MPAH110323614(Rimkla)
MCOC116096541(Rimkla)
MUN110547458(Rimkla)
CGE100759423(Rimkla)
PLEU114704934(Rimkla)
NGI103735994(Rimkla)
HGL101721728(Rimkla)
CPOC100713055(Rimkla)
CCAN109702396(Rimkla)
DORD105986036(Rimkla)
DSP122111270(Rimkla)
NCAR124969199
OCU100356205(RIMKLA)
OPI101536112(RIMKLA)
TUP102474653(RIMKLA)
CFA482445(RIMKLA)
VVP112908198(RIMKLA)
VLG121481599(RIMKLA)
AML100472546(RIMKLA)
UMR103670923(RIMKLA)
UAH113254814(RIMKLA)
UAR123793822(RIMKLA)
ELK111143454
LLV125098454
MPUF101690597(RIMKLA)
ORO101368732(RIMKLA)
EJU114224206(RIMKLA)
ZCA113919895(RIMKLA)
MLX118019547(RIMKLA)
FCA101099388(RIMKLA)
PYU121026952(RIMKLA)
PBG122480352(RIMKLA)
PTG102959348(RIMKLA)
PPAD109254893(RIMKLA)
AJU106970196(RIMKLA)
HHV120236090(RIMKLA)
BTA507323(RIMKLA)
BOM102285876(RIMKLA)
BIU109556903(RIMKLA)
BBUB102407086(RIMKLA)
CHX102179728(RIMKLA)
OAS101104941(RIMKLA)
ODA120856323(RIMKLA)
CCAD122437135(RIMKLA)
SSC100522878(RIMKLA)
CFR102522941(RIMKLA)
CBAI105072857(RIMKLA)
CDK105105491(RIMKLA)
VPC102545512(RIMKLA)
BACU103018606(RIMKLA)
LVE103083571(RIMKLA)
OOR101275823(RIMKLA)
DLE111175673(RIMKLA)
PCAD102982103(RIMKLA)
PSIU116762902(RIMKLA)
ECB100067475(RIMKLA)
EPZ103557317(RIMKLA)
EAI106847814(RIMKLA)
MYB102249129(RIMKLA)
MYD102754710(RIMKLA)
MMYO118677485(RIMKLA)
MLF102430712(RIMKLA)
MNA107531164(RIMKLA)
PKL118723941(RIMKLA)
HAI109383339(RIMKLA)
DRO112299564(RIMKLA)
SHON118977580(RIMKLA)
AJM119052488(RIMKLA)
PDIC114497212(RIMKLA)
PHAS123831998(RIMKLA)
MMF118627179(RIMKLA)
RFQ117027770(RIMKLA)
PALE102882758(RIMKLA)
PGIG120607199(RIMKLA)
PVP105304029(RIMKLA)
RAY107508299(RIMKLA)
MJV108399391(RIMKLA) 108403838
TOD119236219(RIMKLA)
SARA101544446(RIMKLA)
LAV100664484(RIMKLA)
TMU101348075
DNM101421529(RIMKLA)
MDO100026482(RIMKLA)
GAS123243217(RIMKLA)
SHR100913508(RIMKLA)
PCW110206227(RIMKLA)
OAA100073839(RIMKLA)
XLA108696583
XTR100145548(rimkla)
NPR108783941(RIMKLA)
RTEM120915609(RIMKLA)
BBUF120998179(RIMKLA)
BGAR122926877(RIMKLA)
 » show all
Reference
1  [PMID:21454531]
  Authors
Lodder-Gadaczek J, Becker I, Gieselmann V, Wang-Eckhardt L, Eckhardt M
  Title
N-acetylaspartylglutamate synthetase II synthesizes N-acetylaspartylglutamylglutamate.
  Journal
J Biol Chem 286:16693-706 (2011)
DOI:10.1074/jbc.M111.230136
  Sequence
[mmu:194237] [hsa:284716]
Other DBs
ExplorEnz - The Enzyme Database: 6.3.2.42
IUBMB Enzyme Nomenclature: 6.3.2.42
ExPASy - ENZYME nomenclature database: 6.3.2.42
BRENDA, the Enzyme Database: 6.3.2.42
LinkDB

KEGG   REACTION: R10693
Entry
R10693                      Reaction                               
Name
N-acetyl-L-aspartyl-L-glutamate:L-glutamate ligase (ADP, N-acetyl-L-aspartyl-L-glutamyl-L-glutamate-forming)
Definition
ATP + N-Acetylaspartylglutamate + L-Glutamate <=> ADP + Orthophosphate + N-Acetylaspartylglutamylglutamate
Equation
Comment
two-step reaction (see R10679, R10678+R10693)
Reaction class
RC00002  C00002_C00008
RC00064  C00025_C20776
RC00141  C12270_C20776
Enzyme
Pathway
rn00250  Alanine, aspartate and glutamate metabolism
rn01100  Metabolic pathways
Orthology
K18311  N-acetylaspartylglutamate/N-acetylaspartylglutamylglutamate synthase [EC:6.3.2.41 6.3.2.42]
LinkDB

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