KEGG ORTHOLOGY: K18365

ORTHOLOGY: K18365

Entry

K18365                      KO

Symbol

bphI, xylK, nahM, tesG

Name

4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase [EC:4.1.3.39 4.1.3.43]

Pathway

map00362

Benzoate degradation

map00621

Dioxin degradation

map00622

Xylene degradation

map00984

Steroid degradation

map01100

Metabolic pathways

map01120

Microbial metabolism in diverse environments

map01220

Degradation of aromatic compounds

Module

M00569

Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA

Reaction

R00750

4-hydroxy-2-oxopentanoate pyruvate-lyase (acetaldehyde-forming)

R05298

4-hydroxy-2-oxohexanoate pyruvate-lyase (propanal-forming)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K18365  bphI, xylK, nahM, tesG; 4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase
   00622 Xylene degradation
    K18365  bphI, xylK, nahM, tesG; 4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase
   00621 Dioxin degradation
    K18365  bphI, xylK, nahM, tesG; 4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase
   00984 Steroid degradation
    K18365  bphI, xylK, nahM, tesG; 4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase
Enzymes [BR:ko01000]
4. Lyases
  4.1  Carbon-carbon lyases
   4.1.3  Oxo-acid-lyases
    4.1.3.39  4-hydroxy-2-oxovalerate aldolase
     K18365  bphI, xylK, nahM, tesG; 4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase
    4.1.3.43  4-hydroxy-2-oxohexanoate aldolase
     K18365  bphI, xylK, nahM, tesG; 4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase
Dioxygenases [br01602.html]
Dioxygenases in aromatic ring cleavage
  K18365

Other DBs

COG:

COG0119

GO:

0008701

Genes

PSD:

DSC_09375

LSY:	H8L67_00480(dmpG)

RGL:	CS053_01770(dmpG)

RTH:	LRK53_10290(dmpG)

RBD:	ALSL_0877 ALSL_1082

VAF:	D1115_22440(dmpG)

PATE:

NNL38_21645(dmpG)

PRE:	PCA10_13840

PFUW:

KF707C_12190 KF707C_16050(salH) KF707C_16230(bphX3)

PLAL:

FXN65_06430(dmpG)

PPI:	ND084(nahM)

PPUT:

L483_14055

PPUN:

PP4_27280(mhpE)

PVR:	PverR02_11585 PverR02_14710

PPUU:

PputUW4_01662(mhpE)

PKC:	PKB_4237(nahM)

PFZ:	AV641_10525

PALK:

PSAKL28_05980

PPSY:

AOC04_07825

PFK:	PFAS1_28765

PSET:

THL1_1435

PSIL:

PMA3_11725

PKE:	DLD99_14740(dmpG)

PUM:	HGP31_20770(dmpG)

PPSH:

G5J76_13480(dmpG)

PAZE:

KSS91_19285(dmpG)

PTAE:

NCTC10697_02055(bphI)

PCAV:

D3880_17515(dmpG)

PPHN:

HU825_04960(dmpG) HU825_14765(dmpG)

PIZ:	LAB08_R40950(dmpG)

PKM:	PZ739_11535(dmpG)

PSHS:

JJN09_05435(dmpG)

PLAU:

I0D68_06170(dmpG)

PFOU:

OZ911_14070(dmpG)

PSKP:

KU43P_19460(mhpE_1)

PDEU:

QEP73_19150(dmpG)

PBUB:

V6B39_16915(dmpG)

PSML:

V6P94_13780(dmpG)

PSMZ:

V6L79_14200(dmpG)

PSWO:

SD196_12925(dmpG)

PMOR:

PMm318_A52870(dmpG)

PSAO:

SK095_02800(dmpG) SK095_03830(dmpG) SK095_14850(dmpG)

PALL:

UYA_06970 UYA_07050

PSC:	A458_06510

PSTU:

UIB01_22750

PBM:	CL52_14720

SDEG:

GOM96_01770(dmpG)

AVN:	Avin_30570(lapG)

AVL:	AvCA_30570(lapG)

AVD:	AvCA6_30570(lapG)

HARR:

HV822_17985(dmpG)

PPHA:

BVH74_17970

HASM:

QAO71_12440(dmpG)

MARJ:

MARI_05460(bphI)

MSHE:

MAALD49_03450(mhpE)

KAK:	Kalk_07865(dmpG)

ALC:	OTEC02_08820

AEI:	AOY20_01975

ASJ:	AsACE_CH00352(nahM)

ADV:	DJ533_16960(dmpG)

ARJ:	DOM24_01575(dmpG)

AWU:	BEN71_02690(dmpG)

ACUM:

C9E88_006015(dmpG)

ALW:	FOB21_11710(dmpG)

ATN:	FM020_13980(dmpG)

ACHI:

CDG60_02965(dmpG)

ALJ:	G8D99_13400(dmpG)

AWG:	GFH30_01715(dmpG)

ASHA:

G8E00_02255(dmpG)

ATG:	J4G44_04390(dmpG)

AVB:	RYU24_27150(mhpE)

ABOU:

ACBO_27740(mhpE_2)

ACIU:

A3K93_01265

APOT:

MZO21_10840(dmpG)

ATZ:	M5E07_14190(dmpG)

ACIE:

KIP84_08190(dmpG)

ACIG:

BS636_03595(dmpG)

ATV:	ABEF79_01860(dmpG)

APIS:

ACDW34_15755(dmpG)

ACAZ:

ABJ384_12945(dmpG)

SPL:

Spea_2116

SHL:

Shal_2088

SWD:

Swoo_1390

SHEM:

HWQ47_08245(dmpG)

COLW:

A3Q33_18585

CBER:

B5D82_11260(dmpG)

THT:	E2K93_11210(dmpG)

PHA:	PSHAa2143(mhpE)

PTN:	PTRA_a2596(bphI)

PNG:	PNIG_a2790(bphI)

LAL:	AT746_01290

SALH:

HMF8227_02732(bphI)

HARO:

R50071_12480(dmpG_2) R50071_15480(dmpG_3)

TTU:	TERTU_1283(dmpG)

SPOI:

IMCC21906_00395 IMCC21906_02714

SNAN:

I6N98_10790(dmpG)

STAW:

NCG89_14280(dmpG)

ZAL:	AZF00_03870 AZF00_11420 AZF00_17810

HJA:	BST95_09515

HALC:

EY643_13285(dmpG)

AFUS:

EYZ66_02685(dmpG) EYZ66_12975(dmpG)

PAQM:

E0F26_07465(dmpG)

CYQ:	Q91_0510 Q91_1491(lapG)

CZA:	CYCME_0969(lapG) CYCME_2101(dmpG)

CYY:	CPC19_05395(dmpG) CPC19_10505(dmpG)

BLEP:

AL038_01290(dmpG)

THIS:

HZT40_10615(dmpG)

AEH:

Mlg_2462

TBN:

TBH_C0930

MMW:	Mmwyl1_3801

MPRI:

MP3633_3149(mhpE)

MGEO:

CFI10_00435(dmpG) CFI10_04970(dmpG) CFI10_06050(dmpG)

MSEC:

LN244_04515(dmpG) LN244_04765(dmpG) LN244_11320(dmpG)

MRZ:	KDW95_00755(dmpG)

NCU:	F0U83_03055(dmpG)

NJP:	NEJAP_0673(mhpE)

NIK:	F5I99_02020(dmpG) F5I99_10095(dmpG) F5I99_10510(dmpG)

AJP:	AMJAP_2526 AMJAP_2997

ENW:	MJO57_21390(dmpG)

EMP:	EZMO1_1319(tesG)

ASIM:

FE240_03470(dmpG)

ZDF:	AN401_14615

ZOB:	ACEVBK_04810(dmpG) ACEVBK_04895(dmpG)

SOK:	D0B54_06190(dmpG)

SINI:

GT972_14660(dmpG)

FCE:	JN531_005840(dmpG)

GBI:	PG2T_09675

GPB:	HDN1F_27070(tesG)

NZO:	SAMEA4504057_0444(bphI)

NCI:	NCTC10296_00917(bphI)

NWD:	H3L96_04775(dmpG)

NDU:	LVJ88_00580(dmpG)

VFF:	VITFI_CDS1376

PTES:

JQU52_04850(dmpG)

USU:	LVJ78_03650(dmpG)

AQL:	BXU06_16260 BXU06_16885 BXU06_17065

RPI:

Rpic_4617

RPF:	Rpic12D_3541

RIN:	ACS15_4356

REH:	H16_B0595(bpHI)

CNC:	CNE_2c05400(bpHI)

CUH:	BJN34_24650

RME:	Rmet_1319(bphI)

CTI:	RALTA_B0399(mhpE)

CBW:	RR42_s2315

COX:	E0W60_08015(dmpG)

CCAX:

KZ686_10005(dmpG)

CUK:	KB879_20415(dmpG)

CUPP:

CTP10_R38450(dmpG)

BVI:	Bcep1808_7605

BUR:	Bcep18194_B1457 Bcep18194_B2959

BCJ:	BCAM1615(bphI)

BCEN:

DM39_3381(dmpG) DM39_4832(dmpG)

BCEO:

I35_5475(bphI)

BCT:	GEM_4109 GEM_5401

BCED:

DM42_4991(dmpG) DM42_6343(dmpG)

BCEP:

APZ15_31145

BPYR:

ABD05_27810

BCON:

NL30_04130 NL30_24590

BDF:	WI26_15995 WI26_21155

BTEI:

WS51_00570 WS51_05705

BPSL:

WS57_06035 WS57_12155

BMEC:

WJ16_26800

BSTL:

BBJ41_10520 BBJ41_21350

BANN:

JFN94_19135(dmpG) JFN94_25660(dmpG)

BARI:

NLX30_30175(dmpG)

BAEN:

L3V59_21750(dmpG) L3V59_30405(dmpG)

BUQ:	AC233_11185

BURK:

DM992_32615(dmpG)

BURF:

Bsp3421_002158(dmpG)

BXE:	Bxe_C1187(bphI)

BXB:	DR64_8618(dmpG)

BFN:	OI25_4591(dmpG)

PARB:

CJU94_37880(dmpG) CJU94_38125(dmpG)

PCAF:

DSC91_003289

PMEG:

FNZ07_21155(dmpG)

PBRY:

NDK50_32885(dmpG)

PPAI:

E1956_37230(dmpG)

PHUN:

U0042_26780(dmpG)

PPK:	U875_01890

PRB:	X636_07580

CABA:

SBC2_49000(bphI)

LIMN:

HKT17_03830(dmpG)

AXY:	AXYL_04307(dmpG)

APES:

FOC84_00305(dmpG)

AALN:

Q3V95_01645(dmpG)

CDN:	BN940_14431

AAQA:

ACMYR3_10250(dmpG) ACMYR3_10405(dmpG) ACMYR3_13290(dmpG)

RFR:

Rfer_0454

RLH:	MIZ03_0650 MIZ03_1026

PNA:

AJS:

ACID:

ACIP:

ACIN:

ACIS:

AMON:

H9L24_14175(dmpG)

VEI:

Veis_2781

VBO:	CKY39_28495(dmpG)

VAV:	IG196_08140(dmpG)

VAE:	RZE79_18240(dmpG)

CTT:	CtCNB1_1351 CtCNB1_3147

CTES:

O987_07730

COF:	FOZ74_08315(dmpG)

CRJ:	QMY55_07010(dmpG)

ADN:	Alide_0339

ADK:	Alide2_0284

OTD:	J1M35_00045(dmpG)

HYL:	LPB072_18200

HPSE:

HPF_01850(bphI)

HYN:	F9K07_02775(dmpG) F9K07_11450(dmpG) F9K07_31030(dmpG)

HTN:	KI616_01945(dmpG)

DIH:	G7047_09695(dmpG)

DIM:	K2L43_01285(dmpG)

DIS:	I3K84_11915(dmpG)

SIMP:

C6571_13625(dmpG)

MELA:

C6568_07850(dmpG)

MJE:	LVC68_01015(dmpG)

STHM:

IS481_10550(dmpG)

SAQA:

OMP39_09130(dmpG)

MPT:	Mpe_A2266 Mpe_A3321

METP:

C1M51_06440(dmpG) C1M51_16320(dmpG)

SNN:	EWH46_19310(dmpG)

SMIO:

CATMQ487_04050(mhpE_1) CATMQ487_17590(mhpE_2) CATMQ487_31630(mhpE_3)

LCH:

Lcho_3340

IDC:	LRM40_19585(dmpG)

JAJ:	EKL02_01800(dmpG) EKL02_13150(dmpG)

MASW:

AM586_18660

TMJ:	P0M04_30655(dmpG)

RBU:	PG1C_14090

ABRE:

pbN1_20580(mhpE)

DAR:	Daro_0907 Daro_1356 Daro_3782 Daro_3808

DEY:	HYN24_14110(dmpG) HYN24_14200(dmpG)

DDEN:

KI615_16870(dmpG)

QAU:	KI612_15145(dmpG)

FLE:	KI610_08595(dmpG) KI610_13435(dmpG) KI610_15450(dmpG)

AZO:	azo1857(lapG) azo1972(mhpE) azo2431(nahM)

AOA:	dqs_2010 dqs_2127 dqs_2575

AZI:	AzCIB_1509 AzCIB_4409

AZD:	CDA09_09965(dmpG) CDA09_10335(dmpG) CDA09_10460(dmpG) CDA09_21430(dmpG)

AZR:	CJ010_12270(dmpG) CJ010_12835(dmpG) CJ010_15205(dmpG)

TMZ:	Tmz1t_2079 Tmz1t_3105

THU:	AC731_001820 AC731_008905

THAU:

C4PIVTH_2809(mhpE) C4PIVTH_4319(mhpE) C4PIVTH_4382(mhpE)

THK:	CCZ27_04605(dmpG) CCZ27_10750(dmpG)

THAG:

CKCBHOJB_01548(bphI_1) CKCBHOJB_02381(bphI_2)

AZQ:	G3580_00550(dmpG) G3580_08280(dmpG)

ACOM:

CEW83_03610(dmpG)

NPM:	QEO92_31660(dmpG)

SHZ:

shn_33310

CID:

P73_1382

DAA:	AKL17_3p0139

TEC:	AKL02_008270(dmpG)

PGV:	SL003B_p0059

NPP:	PP1Y_AT32722

SPHJ:

BSL82_10435

SGI:	SGRAN_1579(mhpE)

SJP:	SJA_C1-11910(mhpE_xylK)

SINB:

SIDU_08310

SYB:	TZ53_09030 TZ53_23475

SHYD:

CJD35_06515(dmpG)

SBAR:

H5V43_20635(dmpG)

SPTA:

Sj15T_03550(mhpE)

SFLA:

SPHFLASMR4Y_02366(bphI)

ALTN:

LBX01_06750(dmpG)

PMAS:

NCF86_10605(dmpG)

TFV:	IDJ81_04960(dmpG)

TXI:

TH3_21418

HTL:

HPTL_0047

ACIB:

ACBT_0259(dmpG)

AFC:	AFAEC_1844(dmpG)

AAQI:

AAQM_0982(dmpG)

ACLO:

ACLO_a0139(dmpG)

ADZ:	ADFLV_2551(dmpG)

ARC:

ABLL_2442

AROS:

NJU99_01650(dmpG)

ALK:	ALEK_0383(dmpG)

AANA:

AANAER_1260(dmpG)

SSM:	Spirs_4175

GYC:	GYMC61_2298

GYA:	GYMC52_1426

GCT:	GC56T3_2055

GGH:	GHH_c14840(pheE)

GJF:	M493_17920

AAD:	TC41_0802(mhpE)

AACO:

K1I37_06160(dmpG)

ADAU:

NZD86_00705(dmpG) NZD86_06135(dmpG)

AFAS:

NZD89_10110(dmpG)

ALIC:

GI364_17540(dmpG)

BTS:

Btus_0969

KYR:	CVV65_10345(dmpG) CVV65_11290(dmpG)

DHD:

Dhaf_1245

DCA:	Desca_1927

LACY:

MTHO:

MTHZ:

TOC:

STED:

SPTER_03000 SPTER_36960(bphI)

SSPH:

SPSPH_044540(mhpE)

» show all

Reference

PMID:16151114

Authors

Horinouchi M, Hayashi T, Koshino H, Kurita T, Kudo T

Title

Identification of 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid, 4-hydroxy-2-oxohexanoic acid, and 2-hydroxyhexa-2,4-dienoic acid and related enzymes involved in testosterone degradation in Comamonas testosteroni TA441.

Journal

Appl Environ Microbiol 71:5275-81 (2005)
DOI:10.1128/AEM.71.9.5275-5281.2005

Sequence

[ctt:CtCNB1_1351]

LinkDB

ENZYME: 4.1.3.43

Entry

EC 4.1.3.43                 Enzyme

Name

4-hydroxy-2-oxohexanoate aldolase;
BphI

Class

Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases

Sysname

(S)-4-hydroxy-2-oxohexanoate pyruvate-lyase (propanal-forming)

Reaction(IUBMB)

(S)-4-hydroxy-2-oxohexanoate = propanal + pyruvate

Reaction(KEGG)

(other) R05298

Substrate

(S)-4-hydroxy-2-oxohexanoate

Product

propanal [CPD:C00479];
pyruvate [CPD:C00022]

Comment

Requires Mn2+ for maximal activity [1,2]. The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of EC 4.1.3.39, 4-hydroxy-2-oxovalerate aldolase [1,2,6]. The enzyme forms a bifunctional complex with EC 1.2.1.87, propanal dehydrogenase (CoA-propanoylating), with a tight channel connecting the two subunits [3,4,6].

History

EC 4.1.3.43 created 2013

Pathway

ec00622

Xylene degradation

ec00984

Steroid degradation

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K18365

4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase

Genes

PSD:

DSC_09375

LSY:	H8L67_00480(dmpG)

RGL:	CS053_01770(dmpG)

RTH:	LRK53_10290(dmpG)

RBD:	ALSL_0877 ALSL_1082

VAF:	D1115_22440(dmpG)

PATE:

NNL38_21645(dmpG)

PRE:	PCA10_13840

PFUW:

KF707C_12190 KF707C_16050(salH) KF707C_16230(bphX3)

PLAL:

FXN65_06430(dmpG)

PPI:	ND084(nahM)

PPUT:

L483_14055

PPUN:

PP4_27280(mhpE)

PVR:	PverR02_11585 PverR02_14710

PPUU:

PputUW4_01662(mhpE)

PKC:	PKB_4237(nahM)

PFZ:	AV641_10525

PALK:

PSAKL28_05980

PPSY:

AOC04_07825

PFK:	PFAS1_28765

PSET:

THL1_1435

PSIL:

PMA3_11725

PKE:	DLD99_14740(dmpG)

PUM:	HGP31_20770(dmpG)

PPSH:

G5J76_13480(dmpG)

PAZE:

KSS91_19285(dmpG)

PTAE:

NCTC10697_02055(bphI)

PCAV:

D3880_17515(dmpG)

PPHN:

HU825_04960(dmpG) HU825_14765(dmpG)

PIZ:	LAB08_R40950(dmpG)

PKM:	PZ739_11535(dmpG)

PSHS:

JJN09_05435(dmpG)

PLAU:

I0D68_06170(dmpG)

PFOU:

OZ911_14070(dmpG)

PSKP:

KU43P_19460(mhpE_1)

PDEU:

QEP73_19150(dmpG)

PBUB:

V6B39_16915(dmpG)

PSML:

V6P94_13780(dmpG)

PSMZ:

V6L79_14200(dmpG)

PSWO:

SD196_12925(dmpG)

PMOR:

PMm318_A52870(dmpG)

PSAO:

SK095_02800(dmpG) SK095_03830(dmpG) SK095_14850(dmpG)

PALL:

UYA_06970 UYA_07050

PSC:	A458_06510

PSTU:

UIB01_22750

PBM:	CL52_14720

SDEG:

GOM96_01770(dmpG)

AVN:	Avin_30570(lapG)

AVL:	AvCA_30570(lapG)

AVD:	AvCA6_30570(lapG)

HARR:

HV822_17985(dmpG)

PPHA:

BVH74_17970

HASM:

QAO71_12440(dmpG)

MARJ:

MARI_05460(bphI)

MSHE:

MAALD49_03450(mhpE)

KAK:	Kalk_07865(dmpG)

ALC:	OTEC02_08820

AEI:	AOY20_01975

ASJ:	AsACE_CH00352(nahM)

ADV:	DJ533_16960(dmpG)

ARJ:	DOM24_01575(dmpG)

AWU:	BEN71_02690(dmpG)

ACUM:

C9E88_006015(dmpG)

ALW:	FOB21_11710(dmpG)

ATN:	FM020_13980(dmpG)

ACHI:

CDG60_02965(dmpG)

ALJ:	G8D99_13400(dmpG)

AWG:	GFH30_01715(dmpG)

ASHA:

G8E00_02255(dmpG)

ATG:	J4G44_04390(dmpG)

AVB:	RYU24_27150(mhpE)

ABOU:

ACBO_27740(mhpE_2)

ACIU:

A3K93_01265

APOT:

MZO21_10840(dmpG)

ATZ:	M5E07_14190(dmpG)

ACIE:

KIP84_08190(dmpG)

ACIG:

BS636_03595(dmpG)

ATV:	ABEF79_01860(dmpG)

APIS:

ACDW34_15755(dmpG)

ACAZ:

ABJ384_12945(dmpG)

SPL:

Spea_2116

SHL:

Shal_2088

SWD:

Swoo_1390

SHEM:

HWQ47_08245(dmpG)

COLW:

A3Q33_18585

CBER:

B5D82_11260(dmpG)

THT:	E2K93_11210(dmpG)

PHA:	PSHAa2143(mhpE)

PTN:	PTRA_a2596(bphI)

PNG:	PNIG_a2790(bphI)

LAL:	AT746_01290

SALH:

HMF8227_02732(bphI)

HARO:

R50071_12480(dmpG_2) R50071_15480(dmpG_3)

TTU:	TERTU_1283(dmpG)

SPOI:

IMCC21906_00395 IMCC21906_02714

SNAN:

I6N98_10790(dmpG)

STAW:

NCG89_14280(dmpG)

ZAL:	AZF00_03870 AZF00_11420 AZF00_17810

HJA:	BST95_09515

HALC:

EY643_13285(dmpG)

AFUS:

EYZ66_02685(dmpG) EYZ66_12975(dmpG)

PAQM:

E0F26_07465(dmpG)

CYQ:	Q91_0510 Q91_1491(lapG)

CZA:	CYCME_0969(lapG) CYCME_2101(dmpG)

CYY:	CPC19_05395(dmpG) CPC19_10505(dmpG)

BLEP:

AL038_01290(dmpG)

THIS:

HZT40_10615(dmpG)

AEH:

Mlg_2462

TBN:

TBH_C0930

MMW:	Mmwyl1_3801

MPRI:

MP3633_3149(mhpE)

MGEO:

CFI10_00435(dmpG) CFI10_04970(dmpG) CFI10_06050(dmpG)

MSEC:

LN244_04515(dmpG) LN244_04765(dmpG) LN244_11320(dmpG)

MRZ:	KDW95_00755(dmpG)

NCU:	F0U83_03055(dmpG)

NJP:	NEJAP_0673(mhpE)

NIK:	F5I99_02020(dmpG) F5I99_10095(dmpG) F5I99_10510(dmpG)

AJP:	AMJAP_2526 AMJAP_2997

ENW:	MJO57_21390(dmpG)

EMP:	EZMO1_1319(tesG)

ASIM:

FE240_03470(dmpG)

ZDF:	AN401_14615

ZOB:	ACEVBK_04810(dmpG) ACEVBK_04895(dmpG)

SOK:	D0B54_06190(dmpG)

SINI:

GT972_14660(dmpG)

FCE:	JN531_005840(dmpG)

GBI:	PG2T_09675

GPB:	HDN1F_27070(tesG)

NZO:	SAMEA4504057_0444(bphI)

NCI:	NCTC10296_00917(bphI)

NWD:	H3L96_04775(dmpG)

NDU:	LVJ88_00580(dmpG)

VFF:	VITFI_CDS1376

PTES:

JQU52_04850(dmpG)

USU:	LVJ78_03650(dmpG)

AQL:	BXU06_16260 BXU06_16885 BXU06_17065

RPI:

Rpic_4617

RPF:	Rpic12D_3541

RIN:	ACS15_4356

REH:	H16_B0595(bpHI)

CNC:	CNE_2c05400(bpHI)

CUH:	BJN34_24650

RME:	Rmet_1319(bphI)

CTI:	RALTA_B0399(mhpE)

CBW:	RR42_s2315

COX:	E0W60_08015(dmpG)

CCAX:

KZ686_10005(dmpG)

CUK:	KB879_20415(dmpG)

CUPP:

CTP10_R38450(dmpG)

BVI:	Bcep1808_7605

BUR:	Bcep18194_B1457 Bcep18194_B2959

BCJ:	BCAM1615(bphI)

BCEN:

DM39_3381(dmpG) DM39_4832(dmpG)

BCEO:

I35_5475(bphI)

BCT:	GEM_4109 GEM_5401

BCED:

DM42_4991(dmpG) DM42_6343(dmpG)

BCEP:

APZ15_31145

BPYR:

ABD05_27810

BCON:

NL30_04130 NL30_24590

BDF:	WI26_15995 WI26_21155

BTEI:

WS51_00570 WS51_05705

BPSL:

WS57_06035 WS57_12155

BMEC:

WJ16_26800

BSTL:

BBJ41_10520 BBJ41_21350

BANN:

JFN94_19135(dmpG) JFN94_25660(dmpG)

BARI:

NLX30_30175(dmpG)

BAEN:

L3V59_21750(dmpG) L3V59_30405(dmpG)

BUQ:	AC233_11185

BURK:

DM992_32615(dmpG)

BURF:

Bsp3421_002158(dmpG)

BXE:	Bxe_C1187(bphI)

BXB:	DR64_8618(dmpG)

BFN:	OI25_4591(dmpG)

PARB:

CJU94_37880(dmpG) CJU94_38125(dmpG)

PCAF:

DSC91_003289

PMEG:

FNZ07_21155(dmpG)

PBRY:

NDK50_32885(dmpG)

PPAI:

E1956_37230(dmpG)

PHUN:

U0042_26780(dmpG)

PPK:	U875_01890

PRB:	X636_07580

CABA:

SBC2_49000(bphI)

LIMN:

HKT17_03830(dmpG)

AXY:	AXYL_04307(dmpG)

APES:

FOC84_00305(dmpG)

AALN:

Q3V95_01645(dmpG)

CDN:	BN940_14431

AAQA:

ACMYR3_10250(dmpG) ACMYR3_10405(dmpG) ACMYR3_13290(dmpG)

RFR:

Rfer_0454

RLH:	MIZ03_0650 MIZ03_1026

PNA:

Pnap_4142

AJS:

Ajs_0224

ACID:

CBP33_01115

ACIP:

CBP36_01210

ACIN:

CBP34_01120

ACIS:

CBP35_17740

AMON:

H9L24_14175(dmpG)

VEI:

Veis_2781

VBO:	CKY39_28495(dmpG)

VAV:	IG196_08140(dmpG)

VAE:	RZE79_18240(dmpG)

CTT:	CtCNB1_1351 CtCNB1_3147

CTES:

O987_07730

COF:	FOZ74_08315(dmpG)

CRJ:	QMY55_07010(dmpG)

ADN:	Alide_0339

ADK:	Alide2_0284

OTD:	J1M35_00045(dmpG)

HYL:	LPB072_18200

HPSE:

HPF_01850(bphI)

HYN:	F9K07_02775(dmpG) F9K07_11450(dmpG) F9K07_31030(dmpG)

HTN:	KI616_01945(dmpG)

DIH:	G7047_09695(dmpG)

DIM:	K2L43_01285(dmpG)

DIS:	I3K84_11915(dmpG)

SIMP:

C6571_13625(dmpG)

MELA:

C6568_07850(dmpG)

MJE:	LVC68_01015(dmpG)

STHM:

IS481_10550(dmpG)

SAQA:

OMP39_09130(dmpG)

MPT:	Mpe_A2266 Mpe_A3321

METP:

C1M51_06440(dmpG) C1M51_16320(dmpG)

SNN:	EWH46_19310(dmpG)

SMIO:

CATMQ487_04050(mhpE_1) CATMQ487_17590(mhpE_2) CATMQ487_31630(mhpE_3)

LCH:

Lcho_3340

IDC:	LRM40_19585(dmpG)

JAJ:	EKL02_01800(dmpG) EKL02_13150(dmpG)

MASW:

AM586_18660

TMJ:	P0M04_30655(dmpG)

RBU:	PG1C_14090

ABRE:

pbN1_20580(mhpE)

DAR:	Daro_0907 Daro_1356 Daro_3782 Daro_3808

DEY:	HYN24_14110(dmpG) HYN24_14200(dmpG)

DDEN:

KI615_16870(dmpG)

QAU:	KI612_15145(dmpG)

FLE:	KI610_08595(dmpG) KI610_13435(dmpG) KI610_15450(dmpG)

AZO:	azo1857(lapG) azo1972(mhpE) azo2431(nahM)

AOA:	dqs_2010 dqs_2127 dqs_2575

AZI:	AzCIB_1509 AzCIB_4409

AZD:	CDA09_09965(dmpG) CDA09_10335(dmpG) CDA09_10460(dmpG) CDA09_21430(dmpG)

AZR:	CJ010_12270(dmpG) CJ010_12835(dmpG) CJ010_15205(dmpG)

TMZ:	Tmz1t_2079 Tmz1t_3105

THU:	AC731_001820 AC731_008905

THAU:

C4PIVTH_2809(mhpE) C4PIVTH_4319(mhpE) C4PIVTH_4382(mhpE)

THK:	CCZ27_04605(dmpG) CCZ27_10750(dmpG)

THAG:

CKCBHOJB_01548(bphI_1) CKCBHOJB_02381(bphI_2)

AZQ:	G3580_00550(dmpG) G3580_08280(dmpG)

ACOM:

CEW83_03610(dmpG)

NPM:	QEO92_31660(dmpG)

SHZ:

shn_33310

CID:

P73_1382

DAA:	AKL17_3p0139

TEC:	AKL02_008270(dmpG)

PGV:	SL003B_p0059

NPP:	PP1Y_AT32722

SPHJ:

BSL82_10435

SGI:	SGRAN_1579(mhpE)

SJP:	SJA_C1-11910(mhpE_xylK)

SINB:

SIDU_08310

SYB:	TZ53_09030 TZ53_23475

SHYD:

CJD35_06515(dmpG)

SBAR:

H5V43_20635(dmpG)

SPTA:

Sj15T_03550(mhpE)

SFLA:

SPHFLASMR4Y_02366(bphI)

ALTN:

LBX01_06750(dmpG)

PMAS:

NCF86_10605(dmpG)

TFV:	IDJ81_04960(dmpG)

TXI:

TH3_21418

HTL:

HPTL_0047

ACIB:

ACBT_0259(dmpG)

AFC:	AFAEC_1844(dmpG)

AAQI:

AAQM_0982(dmpG)

ACLO:

ACLO_a0139(dmpG)

ADZ:	ADFLV_2551(dmpG)

ARC:

ABLL_2442

AROS:

NJU99_01650(dmpG)

ALK:	ALEK_0383(dmpG)

AANA:

AANAER_1260(dmpG)

SSM:	Spirs_4175

GYC:	GYMC61_2298

GYA:	GYMC52_1426

GCT:	GC56T3_2055

GGH:	GHH_c14840(pheE)

GJF:	M493_17920

AAD:	TC41_0802(mhpE)

AACO:

K1I37_06160(dmpG)

ADAU:

NZD86_00705(dmpG) NZD86_06135(dmpG)

AFAS:

NZD89_10110(dmpG)

ALIC:

GI364_17540(dmpG)

BTS:

Btus_0969

KYR:	CVV65_10345(dmpG) CVV65_11290(dmpG)

DHD:

Dhaf_1245

DCA:	Desca_1927

LACY:

A4V08_07730

MTHO:

MOTHE_c17890

MTHZ:

MOTHA_c18720

TOC:

Toce_0378

STED:

SPTER_03000 SPTER_36960(bphI)

SSPH:

SPSPH_044540(mhpE)

» show all

Reference

1 [PMID:19476337]

Authors

Baker P, Pan D, Carere J, Rossi A, Wang W, Seah SY

Title

Characterization of an aldolase-dehydrogenase complex that exhibits substrate channeling in the polychlorinated biphenyls degradation pathway.

Journal

Biochemistry 48:6551-8 (2009)
DOI:10.1021/bi9006644

Sequence

[bxe:Bxe_C1187]

Reference

2 [PMID:20364820]

Authors

Wang W, Baker P, Seah SY

Title

Comparison of two metal-dependent pyruvate aldolases related by convergent evolution: substrate specificity, kinetic mechanism, and substrate channeling.

Journal

Biochemistry 49:3774-82 (2010)
DOI:10.1021/bi100251u

Sequence

[bxe:Bxe_C1187]

Reference

3 [PMID:21425833]

Authors

Baker P, Carere J, Seah SY

Title

Probing the molecular basis of substrate specificity, stereospecificity, and catalysis in the class II pyruvate aldolase, BphI.

Journal

Biochemistry 50:3559-69 (2011)
DOI:10.1021/bi101947g

Sequence

[bxe:Bxe_C1187]

Reference

4 [PMID:21838275]

Authors

Carere J, Baker P, Seah SY

Title

Investigating the molecular determinants for substrate channeling in BphI-BphJ, an aldolase-dehydrogenase complex from the polychlorinated biphenyls degradation pathway.

Journal

Biochemistry 50:8407-16 (2011)
DOI:10.1021/bi200960j

Sequence

[bxe:Bxe_C1187]

Reference

5 [PMID:22081904]

Authors

Baker P, Seah SY

Title

Rational design of stereoselectivity in the class II pyruvate aldolase BphI.

Journal

J Am Chem Soc 134:507-13 (2012)
DOI:10.1021/ja208754r

Sequence

[bxe:Bxe_C1187]

Reference

6 [PMID:22316175]

Authors

Baker P, Hillis C, Carere J, Seah SY

Title

Protein-protein interactions and substrate channeling in orthologous and chimeric aldolase-dehydrogenase complexes.

Journal

Biochemistry 51:1942-52 (2012)
DOI:10.1021/bi201832a

Sequence

[ttj:TTHB246]

Other DBs

ExplorEnz - The Enzyme Database:

4.1.3.43

IUBMB Enzyme Nomenclature:

4.1.3.43

ExPASy - ENZYME nomenclature database:

4.1.3.43

BRENDA, the Enzyme Database:

4.1.3.43

LinkDB

REACTION: R05298

Entry

R05298                      Reaction

Name

4-hydroxy-2-oxohexanoate pyruvate-lyase (propanal-forming)

Definition

Propanal + Pyruvate <=> 4-Hydroxy-2-oxohexanoic acid

Equation

C00479 + C00022 <=> C06762

Reaction class

RC00307

C00022_C06762

RC00572

C00479_C06762

Enzyme

4.1.3.43

Pathway

rn00622

Xylene degradation

rn00984

Steroid degradation

rn01100

Metabolic pathways

rn01120

Microbial metabolism in diverse environments

rn01220

Degradation of aromatic compounds

Module

M00569

Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA

Brite

Enzymatic reactions [BR:br08201]
4. Lyase reactions
  4.1  Carbon-carbon lyases
   4.1.3  Oxo-acid-lyases
    4.1.3.43
     R05298  Propanal + Pyruvate <=> 4-Hydroxy-2-oxohexanoic acid

Orthology

K18365

4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase [EC:4.1.3.39 4.1.3.43]

Other DBs

RHEA:

36006

LinkDB

DBGET integrated database retrieval system