KEGG   ORTHOLOGY: K18365
Entry
K18365                      KO                                     
Symbol
bphI, xylK, nahM, tesG
Name
4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase [EC:4.1.3.39 4.1.3.43]
Pathway
map00362  Benzoate degradation
map00621  Dioxin degradation
map00622  Xylene degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00569  Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA
Reaction
R00750  4-hydroxy-2-oxopentanoate pyruvate-lyase (acetaldehyde-forming)
R05298  4-hydroxy-2-oxohexanoate pyruvate-lyase (propanal-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K18365  bphI, xylK, nahM, tesG; 4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase
   00622 Xylene degradation
    K18365  bphI, xylK, nahM, tesG; 4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase
   00621 Dioxin degradation
    K18365  bphI, xylK, nahM, tesG; 4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.3  Oxo-acid-lyases
    4.1.3.39  4-hydroxy-2-oxovalerate aldolase
     K18365  bphI, xylK, nahM, tesG; 4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase
    4.1.3.43  4-hydroxy-2-oxohexanoate aldolase
     K18365  bphI, xylK, nahM, tesG; 4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase
Dioxygenases [br01602.html]
 Dioxygenases in aromatic ring cleavage
  K18365
Other DBs
COG: COG0119
GO: 0008701
Genes
PSD: DSC_09375
LSY: H8L67_00480(dmpG)
RGL: CS053_01770(dmpG)
RTH: LRK53_10290(dmpG)
RBD: ALSL_0877 ALSL_1082
VAF: D1115_22440(dmpG)
PRE: PCA10_13840
PFUW: KF707C_12190 KF707C_16050(salH) KF707C_16230(bphX3)
PPI: ND084(nahM)
PPUT: L483_14055
PPUN: PP4_27280(mhpE)
PVR: PverR02_11585 PverR02_14710
PPUU: PputUW4_01662(mhpE)
PKC: PKB_4237(nahM)
PFZ: AV641_10525
PALK: PSAKL28_05980
PPSY: AOC04_07825
PFK: PFAS1_28765
PSET: THL1_1435
PSIL: PMA3_11725
PKE: DLD99_14740(dmpG)
PALL: UYA_06970 UYA_07050
PUM: HGP31_20770(dmpG)
PPSH: G5J76_13480(dmpG)
PLAL: FXN65_06430(dmpG)
PAZE: KSS91_19285(dmpG)
PTAE: NCTC10697_02055(bphI)
PCAV: D3880_17515(dmpG)
PPHN: HU825_04960(dmpG) HU825_14765(dmpG)
PIZ: LAB08_R40950(dmpG)
PKM: PZ739_11535(dmpG)
PSHS: JJN09_05435(dmpG)
PLAU: I0D68_06170(dmpG)
PFOU: OZ911_14070(dmpG)
PSKP: KU43P_19460(mhpE_1)
PSC: A458_06510
PSTU: UIB01_22750
PBM: CL52_14720
SDEG: GOM96_01770(dmpG)
AVN: Avin_30570(lapG)
AVL: AvCA_30570(lapG)
AVD: AvCA6_30570(lapG)
HARR: HV822_17985(dmpG)
PPHA: BVH74_17970
HASM: QAO71_12440(dmpG)
MARJ: MARI_05460(bphI)
MSHE: MAALD49_03450(mhpE)
KAK: Kalk_07865(dmpG)
ALC: OTEC02_08820
AEI: AOY20_01975
ASJ: AsACE_CH00352(nahM)
ADV: DJ533_16960(dmpG)
ARJ: DOM24_01575(dmpG)
AWU: BEN71_02690(dmpG)
ACUM: C9E88_006015(dmpG)
ALW: FOB21_11710(dmpG)
ATN: FM020_13980(dmpG)
ACHI: CDG60_02965(dmpG)
ALJ: G8D99_13400(dmpG)
AWG: GFH30_01715(dmpG)
ASHA: G8E00_02255(dmpG)
ATG: J4G44_04390(dmpG)
AVB: RYU24_27150(mhpE)
ABOU: ACBO_27740(mhpE_2)
ACIU: A3K93_01265
APOT: MZO21_10840(dmpG)
ATZ: M5E07_14190(dmpG)
ACIE: KIP84_08190(dmpG)
ACIG: BS636_03595(dmpG)
SPL: Spea_2116
SHL: Shal_2088
SWD: Swoo_1390
COLW: A3Q33_18585
CBER: B5D82_11260(dmpG)
THT: E2K93_11210(dmpG)
PHA: PSHAa2143(mhpE)
PTN: PTRA_a2596(bphI)
PNG: PNIG_a2790(bphI)
LAL: AT746_01290
SALH: HMF8227_02732(bphI)
TTU: TERTU_1283(dmpG)
SPOI: IMCC21906_00395 IMCC21906_02714
SNAN: I6N98_10790(dmpG)
STAW: NCG89_14280(dmpG)
ZAL: AZF00_03870 AZF00_11420 AZF00_17810
HJA: BST95_09515
HALC: EY643_13285(dmpG)
AFUS: EYZ66_02685(dmpG) EYZ66_12975(dmpG)
PAQM: E0F26_07465(dmpG)
CYQ: Q91_0510 Q91_1491(lapG)
CZA: CYCME_0969(lapG) CYCME_2101(dmpG)
CYY: CPC19_05395(dmpG) CPC19_10505(dmpG)
BLEP: AL038_01290(dmpG)
THIS: HZT40_10615(dmpG)
AEH: Mlg_2462
TBN: TBH_C0930
MMW: Mmwyl1_3801
MPRI: MP3633_3149(mhpE)
MGEO: CFI10_00435(dmpG) CFI10_04970(dmpG) CFI10_06050(dmpG)
MSEC: LN244_04515(dmpG) LN244_04765(dmpG) LN244_11320(dmpG)
MRZ: KDW95_00755(dmpG)
NCU: F0U83_03055(dmpG)
NJP: NEJAP_0673(mhpE)
NIK: F5I99_02020(dmpG) F5I99_10095(dmpG) F5I99_10510(dmpG)
AJP: AMJAP_2526 AMJAP_2997
ENW: MJO57_21390(dmpG)
EMP: EZMO1_1319(tesG)
ASIM: FE240_03470(dmpG)
ZDF: AN401_14615
SOK: D0B54_06190(dmpG)
SINI: GT972_14660(dmpG)
FCE: JN531_005840(dmpG)
GBI: PG2T_09675
GPB: HDN1F_27070(tesG)
NZO: SAMEA4504057_0444(bphI)
NCI: NCTC10296_00917(bphI)
NWD: H3L96_04775(dmpG)
NDU: LVJ88_00580(dmpG)
VFF: VITFI_CDS1376
PTES: JQU52_04850(dmpG)
USU: LVJ78_03650(dmpG)
AQL: BXU06_16260 BXU06_16885 BXU06_17065
RPI: Rpic_4617
RPF: Rpic12D_3541
RIN: ACS15_4356
REH: H16_B0595(bpHI)
CNC: CNE_2c05400(bpHI)
CUH: BJN34_24650
RME: Rmet_1319(bphI)
CTI: RALTA_B0399(mhpE)
CBW: RR42_s2315
COX: E0W60_08015(dmpG)
CCAX: KZ686_10005(dmpG)
CUK: KB879_20415(dmpG)
BVI: Bcep1808_7605
BUR: Bcep18194_B1457 Bcep18194_B2959
BCJ: BCAM1615(bphI)
BCEN: DM39_3381(dmpG) DM39_4832(dmpG)
BCEO: I35_5475(bphI)
BCT: GEM_4109 GEM_5401
BCED: DM42_4991(dmpG) DM42_6343(dmpG)
BCEP: APZ15_31145
BPYR: ABD05_27810
BCON: NL30_04130 NL30_24590
BDF: WI26_15995 WI26_21155
BTEI: WS51_00570 WS51_05705
BPSL: WS57_06035 WS57_12155
BMEC: WJ16_26800
BSTL: BBJ41_10520 BBJ41_21350
BANN: JFN94_19135(dmpG) JFN94_25660(dmpG)
BARI: NLX30_30175(dmpG)
BAEN: L3V59_21750(dmpG) L3V59_30405(dmpG)
BUQ: AC233_11185
BURK: DM992_32615(dmpG)
BXE: Bxe_C1187(bphI)
BXB: DR64_8618(dmpG)
BFN: OI25_4591(dmpG)
PARB: CJU94_37880(dmpG) CJU94_38125(dmpG)
PCAF: DSC91_003289
PMEG: FNZ07_21155(dmpG)
PBRY: NDK50_32885(dmpG)
PPAI: E1956_37230(dmpG)
PHUN: U0042_26780(dmpG)
PPK: U875_01890
PRB: X636_07580
CABA: SBC2_49000(bphI)
LIMN: HKT17_03830(dmpG)
AXY: AXYL_04307(dmpG)
APES: FOC84_00305(dmpG)
AALN: Q3V95_01645(dmpG)
CDN: BN940_14431
RFR: Rfer_0454
RLH: MIZ03_0650 MIZ03_1026
PNA: Pnap_4142
AJS: Ajs_0224
ACID: CBP33_01115
ACIP: CBP36_01210
ACIN: CBP34_01120
ACIS: CBP35_17740
AMON: H9L24_14175(dmpG)
VEI: Veis_2781
VBO: CKY39_28495(dmpG)
VAV: IG196_08140(dmpG)
CTT: CtCNB1_1351 CtCNB1_3147
CTES: O987_07730
COF: FOZ74_08315(dmpG)
CRJ: QMY55_07010(dmpG)
ADN: Alide_0339
ADK: Alide2_0284
OTD: J1M35_00045(dmpG)
HYL: LPB072_18200
HPSE: HPF_01850(bphI)
HYN: F9K07_02775(dmpG) F9K07_11450(dmpG) F9K07_31030(dmpG)
HTN: KI616_01945(dmpG)
DIH: G7047_09695(dmpG)
SIMP: C6571_13625(dmpG)
MELA: C6568_07850(dmpG)
MJE: LVC68_01015(dmpG)
STHM: IS481_10550(dmpG)
SAQA: OMP39_09130(dmpG)
MPT: Mpe_A2266 Mpe_A3321
METP: C1M51_06440(dmpG) C1M51_16320(dmpG)
SNN: EWH46_19310(dmpG)
SMIO: CATMQ487_04050(mhpE_1) CATMQ487_17590(mhpE_2) CATMQ487_31630(mhpE_3)
IDC: LRM40_19585(dmpG)
LCH: Lcho_3340
JAJ: EKL02_01800(dmpG) EKL02_13150(dmpG)
MASW: AM586_18660
TMJ: P0M04_30655(dmpG)
RBU: PG1C_14090
ABRE: pbN1_20580(mhpE)
DAR: Daro_0907 Daro_1356 Daro_3782 Daro_3808
DEY: HYN24_14110(dmpG) HYN24_14200(dmpG)
DDEN: KI615_16870(dmpG)
QAU: KI612_15145(dmpG)
FLE: KI610_08595(dmpG) KI610_13435(dmpG) KI610_15450(dmpG)
AZO: azo1857(lapG) azo1972(mhpE) azo2431(nahM)
AOA: dqs_2010 dqs_2127 dqs_2575
AZI: AzCIB_1509 AzCIB_4409
AZD: CDA09_09965(dmpG) CDA09_10335(dmpG) CDA09_10460(dmpG) CDA09_21430(dmpG)
AZR: CJ010_12270(dmpG) CJ010_12835(dmpG) CJ010_15205(dmpG)
TMZ: Tmz1t_2079 Tmz1t_3105
THU: AC731_001820 AC731_008905
THAU: C4PIVTH_2809(mhpE) C4PIVTH_4319(mhpE) C4PIVTH_4382(mhpE)
THK: CCZ27_04605(dmpG) CCZ27_10750(dmpG)
THAG: CKCBHOJB_01548(bphI_1) CKCBHOJB_02381(bphI_2)
AZQ: G3580_00550(dmpG) G3580_08280(dmpG)
ACOM: CEW83_03610(dmpG)
NPM: QEO92_31660(dmpG)
SHZ: shn_33310
CID: P73_1382
DAA: AKL17_3p0139
TEC: AKL02_008270(dmpG)
PGV: SL003B_p0059
NPP: PP1Y_AT32722
SGI: SGRAN_1579(mhpE)
SJP: SJA_C1-11910(mhpE_xylK)
SINB: SIDU_08310
SYB: TZ53_09030 TZ53_23475
SHYD: CJD35_06515(dmpG)
SBAR: H5V43_20635(dmpG)
SFLA: SPHFLASMR4Y_02366(bphI)
SPHJ: BSL82_10435
ALTN: LBX01_06750(dmpG)
PMAS: NCF86_10605(dmpG)
TFV: IDJ81_04960(dmpG)
TXI: TH3_21418
HTL: HPTL_0047
ACIB: ACBT_0259(dmpG)
AFC: AFAEC_1844(dmpG)
AAQI: AAQM_0982(dmpG)
ACLO: ACLO_a0139(dmpG)
ADZ: ADFLV_2551(dmpG)
ARC: ABLL_2442
AROS: NJU99_01650(dmpG)
ALK: ALEK_0383(dmpG)
AANA: AANAER_1260(dmpG)
GYC: GYMC61_2298
GYA: GYMC52_1426
GCT: GC56T3_2055
GGH: GHH_c14840(pheE)
GJF: M493_17920
AAD: TC41_0802(mhpE)
AACO: K1I37_06160(dmpG)
ADAU: NZD86_00705(dmpG) NZD86_06135(dmpG)
AFAS: NZD89_10110(dmpG)
ALIC: GI364_17540(dmpG)
BTS: Btus_0969
KYR: CVV65_10345(dmpG) CVV65_11290(dmpG)
DHD: Dhaf_1245
DCA: Desca_1927
LACY: A4V08_07730
MTHO: MOTHE_c17890
MTHZ: MOTHA_c18720
TOC: Toce_0378
STED: SPTER_03000 SPTER_36960(bphI)
SSPH: SPSPH_044540(mhpE)
SSM: Spirs_4175
 » show all
Reference
PMID:16151114
  Authors
Horinouchi M, Hayashi T, Koshino H, Kurita T, Kudo T
  Title
Identification of 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid, 4-hydroxy-2-oxohexanoic acid, and 2-hydroxyhexa-2,4-dienoic acid and related enzymes involved in testosterone degradation in Comamonas testosteroni TA441.
  Journal
Appl Environ Microbiol 71:5275-81 (2005)
DOI:10.1128/AEM.71.9.5275-5281.2005
  Sequence
[ctt:CtCNB1_1351]
LinkDB

KEGG   ENZYME: 4.1.3.43
Entry
EC 4.1.3.43                 Enzyme                                 
Name
4-hydroxy-2-oxohexanoate aldolase;
BphI
Class
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
Sysname
(S)-4-hydroxy-2-oxohexanoate pyruvate-lyase (propanal-forming)
Reaction(IUBMB)
(S)-4-hydroxy-2-oxohexanoate = propanal + pyruvate
Reaction(KEGG)
(other) R05298
Substrate
(S)-4-hydroxy-2-oxohexanoate
Product
propanal [CPD:C00479];
pyruvate [CPD:C00022]
Comment
Requires Mn2+ for maximal activity [1,2]. The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of EC 4.1.3.39, 4-hydroxy-2-oxovalerate aldolase [1,2,6]. The enzyme forms a bifunctional complex with EC 1.2.1.87, propanal dehydrogenase (CoA-propanoylating), with a tight channel connecting the two subunits [3,4,6].
History
EC 4.1.3.43 created 2013
Pathway
ec00622  Xylene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K18365  4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase
Genes
PSD: DSC_09375
LSY: H8L67_00480(dmpG)
RGL: CS053_01770(dmpG)
RTH: LRK53_10290(dmpG)
RBD: ALSL_0877 ALSL_1082
VAF: D1115_22440(dmpG)
PRE: PCA10_13840
PFUW: KF707C_12190 KF707C_16050(salH) KF707C_16230(bphX3)
PPI: ND084(nahM)
PPUT: L483_14055
PPUN: PP4_27280(mhpE)
PVR: PverR02_11585 PverR02_14710
PPUU: PputUW4_01662(mhpE)
PKC: PKB_4237(nahM)
PFZ: AV641_10525
PALK: PSAKL28_05980
PPSY: AOC04_07825
PFK: PFAS1_28765
PSET: THL1_1435
PSIL: PMA3_11725
PKE: DLD99_14740(dmpG)
PALL: UYA_06970 UYA_07050
PUM: HGP31_20770(dmpG)
PPSH: G5J76_13480(dmpG)
PLAL: FXN65_06430(dmpG)
PAZE: KSS91_19285(dmpG)
PTAE: NCTC10697_02055(bphI)
PCAV: D3880_17515(dmpG)
PPHN: HU825_04960(dmpG) HU825_14765(dmpG)
PIZ: LAB08_R40950(dmpG)
PKM: PZ739_11535(dmpG)
PSHS: JJN09_05435(dmpG)
PLAU: I0D68_06170(dmpG)
PFOU: OZ911_14070(dmpG)
PSKP: KU43P_19460(mhpE_1)
PSC: A458_06510
PSTU: UIB01_22750
PBM: CL52_14720
SDEG: GOM96_01770(dmpG)
AVN: Avin_30570(lapG)
AVL: AvCA_30570(lapG)
AVD: AvCA6_30570(lapG)
HARR: HV822_17985(dmpG)
PPHA: BVH74_17970
HASM: QAO71_12440(dmpG)
MARJ: MARI_05460(bphI)
MSHE: MAALD49_03450(mhpE)
KAK: Kalk_07865(dmpG)
ALC: OTEC02_08820
AEI: AOY20_01975
ASJ: AsACE_CH00352(nahM)
ADV: DJ533_16960(dmpG)
ARJ: DOM24_01575(dmpG)
AWU: BEN71_02690(dmpG)
ACUM: C9E88_006015(dmpG)
ALW: FOB21_11710(dmpG)
ATN: FM020_13980(dmpG)
ACHI: CDG60_02965(dmpG)
ALJ: G8D99_13400(dmpG)
AWG: GFH30_01715(dmpG)
ASHA: G8E00_02255(dmpG)
ATG: J4G44_04390(dmpG)
AVB: RYU24_27150(mhpE)
ABOU: ACBO_27740(mhpE_2)
ACIU: A3K93_01265
APOT: MZO21_10840(dmpG)
ATZ: M5E07_14190(dmpG)
ACIE: KIP84_08190(dmpG)
ACIG: BS636_03595(dmpG)
SPL: Spea_2116
SHL: Shal_2088
SWD: Swoo_1390
COLW: A3Q33_18585
CBER: B5D82_11260(dmpG)
THT: E2K93_11210(dmpG)
PHA: PSHAa2143(mhpE)
PTN: PTRA_a2596(bphI)
PNG: PNIG_a2790(bphI)
LAL: AT746_01290
SALH: HMF8227_02732(bphI)
TTU: TERTU_1283(dmpG)
SPOI: IMCC21906_00395 IMCC21906_02714
SNAN: I6N98_10790(dmpG)
STAW: NCG89_14280(dmpG)
ZAL: AZF00_03870 AZF00_11420 AZF00_17810
HJA: BST95_09515
HALC: EY643_13285(dmpG)
AFUS: EYZ66_02685(dmpG) EYZ66_12975(dmpG)
PAQM: E0F26_07465(dmpG)
CYQ: Q91_0510 Q91_1491(lapG)
CZA: CYCME_0969(lapG) CYCME_2101(dmpG)
CYY: CPC19_05395(dmpG) CPC19_10505(dmpG)
BLEP: AL038_01290(dmpG)
THIS: HZT40_10615(dmpG)
AEH: Mlg_2462
TBN: TBH_C0930
MMW: Mmwyl1_3801
MPRI: MP3633_3149(mhpE)
MGEO: CFI10_00435(dmpG) CFI10_04970(dmpG) CFI10_06050(dmpG)
MSEC: LN244_04515(dmpG) LN244_04765(dmpG) LN244_11320(dmpG)
MRZ: KDW95_00755(dmpG)
NCU: F0U83_03055(dmpG)
NJP: NEJAP_0673(mhpE)
NIK: F5I99_02020(dmpG) F5I99_10095(dmpG) F5I99_10510(dmpG)
AJP: AMJAP_2526 AMJAP_2997
ENW: MJO57_21390(dmpG)
EMP: EZMO1_1319(tesG)
ASIM: FE240_03470(dmpG)
ZDF: AN401_14615
SOK: D0B54_06190(dmpG)
SINI: GT972_14660(dmpG)
FCE: JN531_005840(dmpG)
GBI: PG2T_09675
GPB: HDN1F_27070(tesG)
NZO: SAMEA4504057_0444(bphI)
NCI: NCTC10296_00917(bphI)
NWD: H3L96_04775(dmpG)
NDU: LVJ88_00580(dmpG)
VFF: VITFI_CDS1376
PTES: JQU52_04850(dmpG)
USU: LVJ78_03650(dmpG)
AQL: BXU06_16260 BXU06_16885 BXU06_17065
RPI: Rpic_4617
RPF: Rpic12D_3541
RIN: ACS15_4356
REH: H16_B0595(bpHI)
CNC: CNE_2c05400(bpHI)
CUH: BJN34_24650
RME: Rmet_1319(bphI)
CTI: RALTA_B0399(mhpE)
CBW: RR42_s2315
COX: E0W60_08015(dmpG)
CCAX: KZ686_10005(dmpG)
CUK: KB879_20415(dmpG)
BVI: Bcep1808_7605
BUR: Bcep18194_B1457 Bcep18194_B2959
BCJ: BCAM1615(bphI)
BCEN: DM39_3381(dmpG) DM39_4832(dmpG)
BCEO: I35_5475(bphI)
BCT: GEM_4109 GEM_5401
BCED: DM42_4991(dmpG) DM42_6343(dmpG)
BCEP: APZ15_31145
BPYR: ABD05_27810
BCON: NL30_04130 NL30_24590
BDF: WI26_15995 WI26_21155
BTEI: WS51_00570 WS51_05705
BPSL: WS57_06035 WS57_12155
BMEC: WJ16_26800
BSTL: BBJ41_10520 BBJ41_21350
BANN: JFN94_19135(dmpG) JFN94_25660(dmpG)
BARI: NLX30_30175(dmpG)
BAEN: L3V59_21750(dmpG) L3V59_30405(dmpG)
BUQ: AC233_11185
BURK: DM992_32615(dmpG)
BXE: Bxe_C1187(bphI)
BXB: DR64_8618(dmpG)
BFN: OI25_4591(dmpG)
PARB: CJU94_37880(dmpG) CJU94_38125(dmpG)
PCAF: DSC91_003289
PMEG: FNZ07_21155(dmpG)
PBRY: NDK50_32885(dmpG)
PPAI: E1956_37230(dmpG)
PHUN: U0042_26780(dmpG)
PPK: U875_01890
PRB: X636_07580
CABA: SBC2_49000(bphI)
LIMN: HKT17_03830(dmpG)
AXY: AXYL_04307(dmpG)
APES: FOC84_00305(dmpG)
AALN: Q3V95_01645(dmpG)
CDN: BN940_14431
RFR: Rfer_0454
RLH: MIZ03_0650 MIZ03_1026
PNA: Pnap_4142
AJS: Ajs_0224
ACID: CBP33_01115
ACIP: CBP36_01210
ACIN: CBP34_01120
ACIS: CBP35_17740
AMON: H9L24_14175(dmpG)
VEI: Veis_2781
VBO: CKY39_28495(dmpG)
VAV: IG196_08140(dmpG)
CTT: CtCNB1_1351 CtCNB1_3147
CTES: O987_07730
COF: FOZ74_08315(dmpG)
CRJ: QMY55_07010(dmpG)
ADN: Alide_0339
ADK: Alide2_0284
OTD: J1M35_00045(dmpG)
HYL: LPB072_18200
HPSE: HPF_01850(bphI)
HYN: F9K07_02775(dmpG) F9K07_11450(dmpG) F9K07_31030(dmpG)
HTN: KI616_01945(dmpG)
DIH: G7047_09695(dmpG)
SIMP: C6571_13625(dmpG)
MELA: C6568_07850(dmpG)
MJE: LVC68_01015(dmpG)
STHM: IS481_10550(dmpG)
SAQA: OMP39_09130(dmpG)
MPT: Mpe_A2266 Mpe_A3321
METP: C1M51_06440(dmpG) C1M51_16320(dmpG)
SNN: EWH46_19310(dmpG)
SMIO: CATMQ487_04050(mhpE_1) CATMQ487_17590(mhpE_2) CATMQ487_31630(mhpE_3)
IDC: LRM40_19585(dmpG)
LCH: Lcho_3340
JAJ: EKL02_01800(dmpG) EKL02_13150(dmpG)
MASW: AM586_18660
TMJ: P0M04_30655(dmpG)
RBU: PG1C_14090
ABRE: pbN1_20580(mhpE)
DAR: Daro_0907 Daro_1356 Daro_3782 Daro_3808
DEY: HYN24_14110(dmpG) HYN24_14200(dmpG)
DDEN: KI615_16870(dmpG)
QAU: KI612_15145(dmpG)
FLE: KI610_08595(dmpG) KI610_13435(dmpG) KI610_15450(dmpG)
AZO: azo1857(lapG) azo1972(mhpE) azo2431(nahM)
AOA: dqs_2010 dqs_2127 dqs_2575
AZI: AzCIB_1509 AzCIB_4409
AZD: CDA09_09965(dmpG) CDA09_10335(dmpG) CDA09_10460(dmpG) CDA09_21430(dmpG)
AZR: CJ010_12270(dmpG) CJ010_12835(dmpG) CJ010_15205(dmpG)
TMZ: Tmz1t_2079 Tmz1t_3105
THU: AC731_001820 AC731_008905
THAU: C4PIVTH_2809(mhpE) C4PIVTH_4319(mhpE) C4PIVTH_4382(mhpE)
THK: CCZ27_04605(dmpG) CCZ27_10750(dmpG)
THAG: CKCBHOJB_01548(bphI_1) CKCBHOJB_02381(bphI_2)
AZQ: G3580_00550(dmpG) G3580_08280(dmpG)
ACOM: CEW83_03610(dmpG)
NPM: QEO92_31660(dmpG)
SHZ: shn_33310
CID: P73_1382
DAA: AKL17_3p0139
TEC: AKL02_008270(dmpG)
PGV: SL003B_p0059
NPP: PP1Y_AT32722
SGI: SGRAN_1579(mhpE)
SJP: SJA_C1-11910(mhpE_xylK)
SINB: SIDU_08310
SYB: TZ53_09030 TZ53_23475
SHYD: CJD35_06515(dmpG)
SBAR: H5V43_20635(dmpG)
SFLA: SPHFLASMR4Y_02366(bphI)
SPHJ: BSL82_10435
ALTN: LBX01_06750(dmpG)
PMAS: NCF86_10605(dmpG)
TFV: IDJ81_04960(dmpG)
TXI: TH3_21418
HTL: HPTL_0047
ACIB: ACBT_0259(dmpG)
AFC: AFAEC_1844(dmpG)
AAQI: AAQM_0982(dmpG)
ACLO: ACLO_a0139(dmpG)
ADZ: ADFLV_2551(dmpG)
ARC: ABLL_2442
AROS: NJU99_01650(dmpG)
ALK: ALEK_0383(dmpG)
AANA: AANAER_1260(dmpG)
GYC: GYMC61_2298
GYA: GYMC52_1426
GCT: GC56T3_2055
GGH: GHH_c14840(pheE)
GJF: M493_17920
AAD: TC41_0802(mhpE)
AACO: K1I37_06160(dmpG)
ADAU: NZD86_00705(dmpG) NZD86_06135(dmpG)
AFAS: NZD89_10110(dmpG)
ALIC: GI364_17540(dmpG)
BTS: Btus_0969
KYR: CVV65_10345(dmpG) CVV65_11290(dmpG)
DHD: Dhaf_1245
DCA: Desca_1927
LACY: A4V08_07730
MTHO: MOTHE_c17890
MTHZ: MOTHA_c18720
TOC: Toce_0378
STED: SPTER_03000 SPTER_36960(bphI)
SSPH: SPSPH_044540(mhpE)
SSM: Spirs_4175
 » show all
Reference
1  [PMID:19476337]
  Authors
Baker P, Pan D, Carere J, Rossi A, Wang W, Seah SY
  Title
Characterization of an aldolase-dehydrogenase complex that exhibits substrate channeling in the polychlorinated biphenyls degradation pathway.
  Journal
Biochemistry 48:6551-8 (2009)
DOI:10.1021/bi9006644
  Sequence
[bxe:Bxe_C1187]
Reference
2  [PMID:20364820]
  Authors
Wang W, Baker P, Seah SY
  Title
Comparison of two metal-dependent pyruvate aldolases related by convergent evolution: substrate specificity, kinetic mechanism, and substrate channeling.
  Journal
Biochemistry 49:3774-82 (2010)
DOI:10.1021/bi100251u
  Sequence
[bxe:Bxe_C1187]
Reference
3  [PMID:21425833]
  Authors
Baker P, Carere J, Seah SY
  Title
Probing the molecular basis of substrate specificity, stereospecificity, and catalysis in the class II pyruvate aldolase, BphI.
  Journal
Biochemistry 50:3559-69 (2011)
DOI:10.1021/bi101947g
  Sequence
[bxe:Bxe_C1187]
Reference
4  [PMID:21838275]
  Authors
Carere J, Baker P, Seah SY
  Title
Investigating the molecular determinants for substrate channeling in BphI-BphJ, an aldolase-dehydrogenase complex from the polychlorinated biphenyls degradation  pathway.
  Journal
Biochemistry 50:8407-16 (2011)
DOI:10.1021/bi200960j
  Sequence
[bxe:Bxe_C1187]
Reference
5  [PMID:22081904]
  Authors
Baker P, Seah SY
  Title
Rational design of stereoselectivity in the class II pyruvate aldolase BphI.
  Journal
J Am Chem Soc 134:507-13 (2012)
DOI:10.1021/ja208754r
  Sequence
[bxe:Bxe_C1187]
Reference
6  [PMID:22316175]
  Authors
Baker P, Hillis C, Carere J, Seah SY
  Title
Protein-protein interactions and substrate channeling in orthologous and chimeric aldolase-dehydrogenase complexes.
  Journal
Biochemistry 51:1942-52 (2012)
DOI:10.1021/bi201832a
  Sequence
[ttj:TTHB246]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.3.43
IUBMB Enzyme Nomenclature: 4.1.3.43
ExPASy - ENZYME nomenclature database: 4.1.3.43
BRENDA, the Enzyme Database: 4.1.3.43
LinkDB

KEGG   REACTION: R05298
Entry
R05298                      Reaction                               
Name
4-hydroxy-2-oxohexanoate pyruvate-lyase (propanal-forming)
Definition
Propanal + Pyruvate <=> 4-Hydroxy-2-oxohexanoic acid
Equation
C00479 + C00022 <=> C06762
Reaction class
RC00307  C00022_C06762
RC00572  C00479_C06762
Enzyme
4.1.3.43
Pathway
rn00622  Xylene degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Module
M00569  Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.1  Carbon-carbon lyases
   4.1.3  Oxo-acid-lyases
    4.1.3.43
     R05298  Propanal + Pyruvate <=> 4-Hydroxy-2-oxohexanoic acid
Orthology
K18365  4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase [EC:4.1.3.39 4.1.3.43]
Other DBs
RHEA: 36006
LinkDB

DBGET integrated database retrieval system