KEGG   ORTHOLOGY: K18384
Entry
K18384                      KO                                     
Symbol
L3HYPDH
Name
trans-L-3-hydroxyproline dehydratase [EC:4.2.1.77]
Pathway
map00330  Arginine and proline metabolism
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00330 Arginine and proline metabolism
    K18384  L3HYPDH; trans-L-3-hydroxyproline dehydratase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.77  trans-L-3-hydroxyproline dehydratase
     K18384  L3HYPDH; trans-L-3-hydroxyproline dehydratase
Other DBs
RN: R04374
GO: 0050346
Genes
HSA: 112849(L3HYPDH)
PTR: 112204140(L3HYPDH)
PPS: 100973980(L3HYPDH)
GGO: 101151045(L3HYPDH)
PON: 100172276(L3HYPDH)
NLE: 100585615(L3HYPDH)
MCC: 702076(L3HYPDH)
MCF: 102115940(L3HYPDH)
CSAB: 103229098(L3HYPDH)
CATY: 105586695(L3HYPDH)
PANU: 101020713(L3HYPDH)
TGE: 112628556(L3HYPDH)
RRO: 104662157(L3HYPDH)
RBB: 108524789(L3HYPDH)
TFN: 117069548(L3HYPDH)
PTEH: 111555465(L3HYPDH)
CJC: 100402030(L3HYPDH)
SBQ: 101037339(L3HYPDH)
CSYR: 103270543(L3HYPDH)
MMUR: 105882923(L3HYPDH)
LCAT: 123648487(L3HYPDH)
OGA: 100963751(L3HYPDH)
MMU: 67217(L3hypdh)
MCAL: 110306956(L3hypdh)
MPAH: 110324746(L3hypdh)
RNO: 314214(L3hypdh)
MCOC: 116080342(L3hypdh)
MUN: 110553551(L3hypdh)
CGE: 100764709(L3hypdh)
MAUA: 101836204(L3hypdh)
PLEU: 114683942(L3hypdh)
MORG: 121452501(L3hypdh)
AAMP: 119819615(L3hypdh)
NGI: 103739192(L3hypdh)
HGL: 101725460(L3hypdh)
CPOC: 100717752(L3hypdh)
CCAN: 109696080(L3hypdh)
DORD: 105986776(L3hypdh)
DSP: 122110094(L3hypdh)
NCAR: 124976845
OCU: 100354746(L3HYPDH)
OPI: 101531052(L3HYPDH)
TUP: 102490555(L3HYPDH)
CFA: 490715(L3HYPDH)
VVP: 112921377(L3HYPDH)
VLG: 121493177(L3HYPDH)
AML: 100471249(L3HYPDH)
UMR: 103672703(L3HYPDH)
UAH: 113242387(L3HYPDH)
UAR: 123800580(L3HYPDH)
LLV: 125103979
MPUF: 101686493(L3HYPDH)
ORO: 101365481(L3HYPDH)
EJU: 114216648(L3HYPDH)
ZCA: 113909791(L3HYPDH)
MLX: 118002357(L3HYPDH)
FCA: 101098960(L3HYPDH)
PYU: 121031841(L3HYPDH)
PBG: 122469162(L3HYPDH)
PTG: 102955955(L3HYPDH)
PPAD: 109268398(L3HYPDH)
AJU: 106974568(L3HYPDH)
HHV: 120237472(L3HYPDH)
BTA: 510525(L3HYPDH)
BOM: 102267712(L3HYPDH)
BIU: 109565207(L3HYPDH)
BBUB: 102410346(L3HYPDH)
CHX: 102170980(L3HYPDH)
OAS: 101102239(L3HYPDH)
ODA: 120852876(L3HYPDH)
CCAD: 122443710(L3HYPDH)
SSC: 110262303(L3HYPDH)
CFR: 102510698(L3HYPDH)
CBAI: 105074630(L3HYPDH)
CDK: 105086230(L3HYPDH)
VPC: 102545772(L3HYPDH)
BACU: 103001798(L3HYPDH)
LVE: 103089729(L3HYPDH)
OOR: 101288505(L3HYPDH)
DLE: 111173103(L3HYPDH)
PCAD: 102982447(L3HYPDH)
PSIU: 116749971(L3HYPDH)
ECB: 100059502(L3HYPDH)
EPZ: 103560585(L3HYPDH)
EAI: 106846079(L3HYPDH)
MYB: 102251331(L3HYPDH)
MYD: 102751344(L3HYPDH)
MMYO: 118656113(L3HYPDH)
MLF: 102417956(L3HYPDH)
MNA: 107525912(L3HYPDH)
PKL: 118717232(L3HYPDH)
HAI: 109383857(L3HYPDH)
DRO: 112311822(L3HYPDH)
SHON: 118992457(L3HYPDH)
AJM: 119045233(L3HYPDH)
PDIC: 114492810(L3HYPDH)
PHAS: 123808412(L3HYPDH)
MMF: 118615926(L3HYPDH)
RFQ: 117023350(L3HYPDH)
PALE: 102892379(L3HYPDH)
PGIG: 120603566(L3HYPDH)
PVP: 105308841(L3HYPDH)
RAY: 107519593(L3HYPDH)
MJV: 108399464(L3HYPDH)
SARA: 101548981(L3HYPDH)
LAV: 100671364(L3HYPDH)
TMU: 101343227
DNM: 101430455(L3HYPDH)
MDO: 100026616(L3HYPDH)
GAS: 123237762(L3HYPDH)
SHR: 100916958(L3HYPDH)
PCW: 110208425(L3HYPDH)
OAA: 100086994(L3HYPDH)
GGA: 423531(L3HYPDH)
PCOC: 116236621(L3HYPDH)
MGP: 104911286(L3HYPDH)
CJO: 107315418(L3HYPDH)
NMEL: 110401546(L3HYPDH)
ACYG: 106037183(L3HYPDH)
AFUL: 116489961(L3HYPDH)
TGU: 100232596(L3HYPDH)
LSR: 110484108(L3HYPDH)
SCAN: 103826352(L3HYPDH)
PMOA: 120513519(L3HYPDH)
OTC: 121332936(L3HYPDH)
PRUF: 121349189(L3HYPDH)
GFR: 102042007(L3HYPDH)
FAB: 101810740(L3HYPDH)
PHI: 102107944(L3HYPDH)
PMAJ: 107206387(L3HYPDH)
CCAE: 111929702(L3HYPDH)
CCW: 104684550(L3HYPDH)
ETL: 114069015(L3HYPDH)
ZAB: 102060997(L3HYPDH)
FPG: 101918943(L3HYPDH)
FCH: 102059456(L3HYPDH)
CLV: 102096316(L3HYPDH)
EGZ: 104135281(L3HYPDH)
NNI: 104009686(L3HYPDH)
PLET: 104613909(L3HYPDH)
ACUN: 113480427(L3HYPDH)
TALA: 104365648(L3HYPDH)
PADL: 103924269(L3HYPDH)
ACHC: 115338590(L3HYPDH)
AAM: 106495231(L3HYPDH)
AROW: 112976272(L3HYPDH)
NPD: 112959680(L3HYPDH)
DNE: 112992064(L3HYPDH)
ASN: 102369998(L3HYPDH)
AMJ: 102565530(L3HYPDH)
CPOO: 109320683(L3HYPDH)
GGN: 109299284(L3HYPDH)
PSS: 102462476(L3HYPDH)
CMY: 102947990(L3HYPDH)
CPIC: 101931630(L3HYPDH)
TST: 117876845(L3HYPDH)
CABI: 116825945(L3HYPDH)
MRV: 120404156(L3HYPDH)
ACS: 100559609(l3hypdh)
PVT: 110083781(L3HYPDH)
SUND: 121931884(L3HYPDH)
PBI: 103049310(L3HYPDH)
PMUR: 107294579(L3HYPDH)
TSR: 106554612(L3HYPDH)
PGUT: 117675140(L3HYPDH)
VKO: 123026717(L3HYPDH)
PMUA: 114600110(L3HYPDH)
ZVI: 118079650(L3HYPDH)
GJA: 107120397(L3HYPDH)
STOW: 125427362(L3HYPDH)
XLA: 108698829(l3hypdh.L)
XTR: 493490(l3hypdh)
NPR: 108791712(L3HYPDH)
RTEM: 120920367(L3HYPDH)
BBUF: 120981724(L3HYPDH)
BGAR: 122921506(L3HYPDH)
DRE: 565785(l3hypdh)
SRX: 107755210
SANH: 107684001
SGH: 107601901(l3hypdh)
CCAR: 109058095(l3hypdh)
CAUA: 113120994(l3hypdh)
PPRM: 120493622
MAMB: 125277989
IPU: 108257951
PHYP: 113545195(l3hypdh)
SMEO: 124376736
TFD: 113644260
AMEX: 103042342(l3hypdh)
EEE: 113568740(l3hypdh)
TRU: 101066682(l3hypdh)
LCO: 104930547(l3hypdh)
NCC: 104951072(l3hypdh)
CGOB: 115028812(l3hypdh)
ELY: 117270369
PLEP: 121955395
SLUC: 116066328
ECRA: 117961233
PFLV: 114573751(l3hypdh)
GAT: 120808554
PPUG: 119195400
CUD: 121521402
ALAT: 119012688
MZE: 101483912(l3hypdh)
ONL: 100711126(l3hypdh)
OAU: 116310790
OLA: 101166521(l3hypdh)
XMA: 102217165(l3hypdh)
XCO: 114158489(l3hypdh)
XHE: 116734076(l3hypdh)
PRET: 103457582(l3hypdh)
PFOR: 103138615(l3hypdh)
PLAI: 106949069(l3hypdh)
PMEI: 106919669(l3hypdh)
GAF: 122825837
CVG: 107083634(l3hypdh)
CTUL: 119785061
GMU: 124881893
NFU: 107377581(l3hypdh)
KMR: 108240087
ALIM: 106516924(l3hypdh)
NWH: 119418192
AOCE: 111566664(l3hypdh)
LCF: 108895649(l3hypdh)
SDU: 111216353(l3hypdh)
SLAL: 111652661(l3hypdh)
XGL: 120788715
HCQ: 109524865(l3hypdh)
BPEC: 110155871(l3hypdh)
MALB: 109953913(l3hypdh)
BSPL: 114850092
SASA: 106571502(l3hypdh)
OTW: 112250415
OMY: 110529713
OGO: 123990851
ONE: 115107855(l3hypdh)
SALP: 111954005(l3hypdh)
SNH: 120024397
ELS: 105017645(l3hypdh)
SFM: 108930829(l3hypdh)
PKI: 111844408(l3hypdh)
AANG: 118229933
LOC: 102698417(l3hypdh)
PSPA: 121324778
LCM: 102352794(L3HYPDH)
CMK: 103178517
APLC: 110978363
PPOI: 119092077
CSCU: 111618061
PTEP: 107454194
SDM: 118183059
PCAN: 112570601
BGT: 106069189
HRJ: 124260739
OBI: 106881453
OSN: 115213294
EPA: 110254897
ATEN: 116300698
PDAM: 113665581
SPIS: 111328850
XEN: 124438102
HMG: 100198440
AQU: 100638966
MAW: MAC_07874
MAJ: MAA_06218
ANI: AN2121.2
ANG: ANI_1_1948074(An08g04750) ANI_1_574044(An05g02210)
 » show all
Reference
  Authors
Visser WF, Verhoeven-Duif NM, de Koning TJ
  Title
Identification of a human trans-3-hydroxy-L-proline dehydratase, the first characterized member of a novel family of proline racemase-like enzymes.
  Journal
J Biol Chem 287:21654-62 (2012)
DOI:10.1074/jbc.M112.363218
  Sequence
[hsa:112849]
LinkDB

KEGG   ORTHOLOGY: K22548
Entry
K22548                      KO                                     
Symbol
lhpL
Name
trans-L-3-hydroxyproline dehydratase [EC:4.2.1.77]
Pathway
map00330  Arginine and proline metabolism
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00330 Arginine and proline metabolism
    K22548  lhpL; trans-L-3-hydroxyproline dehydratase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.77  trans-L-3-hydroxyproline dehydratase
     K22548  lhpL; trans-L-3-hydroxyproline dehydratase
Other DBs
RN: R04374
COG: COG3938
GO: 0050346
Genes
SLIG: GTU79_12555
TCI: A7K98_03625
PAE: PA1255
PAEV: N297_1294
PAEI: N296_1294
PAU: PA14_47970
PAP: PSPA7_4137
PAG: PLES_40571
PAF: PAM18_3776
PNC: NCGM2_2137
PAEP: PA1S_19640
PAEM: U769_19480
PAEL: T223_20730
PAEG: AI22_14325
PAEC: M802_1291
PAEO: M801_1294
PDW: BV82_1489
PSTT: CH92_01025
MAQ: Maqu_2141
MHC: MARHY1085
MAD: HP15_922(pa45-A)
PIN: Ping_2117
CSA: Csal_2339
HEL: HELO_2887
HAM: HALO1503
HBE: BEI_1471
MLO: mlr6810
MHUA: MCHK_0429
SME: SM_b20270
SMER: DU99_32020
SMD: Smed_3861
ATU: Atu4684
AVI: Avi_7022
RHT: NT26_3279
SHZ: shn_21240
BME: BMEI1586
BMEL: DK63_1903
BMEE: DK62_1049
BMF: BAB1_0366
BABO: DK55_382
BABR: DO74_1505
BABT: DK49_145
BABB: DK48_1745
BABU: DK53_372
BABS: DK51_1092
BABC: DO78_289
BMS: BR0337
BSZ: DK67_1276
BOV: BOV_0353
BCAR: DK60_429
BCAS: DA85_01640
BMR: BMI_I342
BPP: BPI_I371
BPV: DK65_1009
OAN: Oant_0439
OAH: DR92_2500
SNO: Snov_0155
PHL: KKY_1201
SIL: SPO0607
JAN: Jann_1529
PGD: Gal_03751
OTM: OSB_16560
MALG: MALG_04515
MALU: KU6B_09310
PDE: Pden_1184
SECH: B18_18010
 » show all
Reference
  Authors
Watanabe S, Tajima K, Fujii S, Fukumori F, Hara R, Fukuda R, Miyazaki M, Kino K, Watanabe Y
  Title
Functional characterization of aconitase X as a cis-3-hydroxy-L-proline dehydratase.
  Journal
Sci Rep 6:38720 (2016)
DOI:10.1038/srep38720
  Sequence
[pae:PA1255]
LinkDB

KEGG   ENZYME: 4.2.1.77
Entry
EC 4.2.1.77                 Enzyme                                 
Name
trans-L-3-hydroxyproline dehydratase;
trans-L-3-hydroxyproline hydro-lyase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
trans-3-hydroxy-L-proline hydro-lyase (1-pyrroline-2-carboxylate-forming)
Reaction(IUBMB)
trans-3-hydroxy-L-proline = 1-pyrroline 2-carboxylate + H2O [RN:R04374]
Reaction(KEGG)
R04374
Substrate
trans-3-hydroxy-L-proline [CPD:C05147]
Product
1-pyrroline 2-carboxylate [CPD:C03564];
H2O [CPD:C00001]
Comment
Highly specific.
History
EC 4.2.1.77 created 1984
Pathway
ec00330  Arginine and proline metabolism
ec01100  Metabolic pathways
Orthology
K18384  trans-L-3-hydroxyproline dehydratase
K22548  trans-L-3-hydroxyproline dehydratase
Genes
HSA112849(L3HYPDH)
PTR112204140(L3HYPDH)
PPS100973980(L3HYPDH)
GGO101151045(L3HYPDH)
PON100172276(L3HYPDH)
NLE100585615(L3HYPDH)
MCC702076(L3HYPDH)
MCF102115940(L3HYPDH)
CSAB103229098(L3HYPDH)
CATY105586695(L3HYPDH)
PANU101020713(L3HYPDH)
TGE112628556(L3HYPDH)
RRO104662157(L3HYPDH)
RBB108524789(L3HYPDH)
TFN117069548(L3HYPDH)
PTEH111555465(L3HYPDH)
CJC100402030(L3HYPDH)
SBQ101037339(L3HYPDH)
CSYR103270543(L3HYPDH)
MMUR105882923(L3HYPDH)
LCAT123648487(L3HYPDH)
OGA100963751(L3HYPDH)
MMU67217(L3hypdh)
MCAL110306956(L3hypdh)
MPAH110324746(L3hypdh)
RNO314214(L3hypdh)
MCOC116080342(L3hypdh)
MUN110553551(L3hypdh)
CGE100764709(L3hypdh)
MAUA101836204(L3hypdh)
PLEU114683942(L3hypdh)
MORG121452501(L3hypdh)
AAMP119819615(L3hypdh)
NGI103739192(L3hypdh)
HGL101725460(L3hypdh)
CPOC100717752(L3hypdh)
CCAN109696080(L3hypdh)
DORD105986776(L3hypdh)
DSP122110094(L3hypdh)
NCAR124976845
OCU100354746(L3HYPDH)
OPI101531052(L3HYPDH)
TUP102490555(L3HYPDH)
CFA490715(L3HYPDH)
VVP112921377(L3HYPDH)
VLG121493177(L3HYPDH)
AML100471249(L3HYPDH)
UMR103672703(L3HYPDH)
UAH113242387(L3HYPDH)
UAR123800580(L3HYPDH)
ELK111139883 111158350
LLV125103979
MPUF101686493(L3HYPDH)
ORO101365481(L3HYPDH)
EJU114216648(L3HYPDH)
ZCA113909791(L3HYPDH)
MLX118002357(L3HYPDH)
FCA101098960(L3HYPDH)
PYU121031841(L3HYPDH)
PBG122469162(L3HYPDH)
PTG102955955(L3HYPDH)
PPAD109268398(L3HYPDH)
AJU106974568(L3HYPDH)
HHV120237472(L3HYPDH)
BTA510525(L3HYPDH)
BOM102267712(L3HYPDH)
BIU109565207(L3HYPDH)
BBUB102410346(L3HYPDH)
CHX102170980(L3HYPDH)
OAS101102239(L3HYPDH)
ODA120852876(L3HYPDH)
CCAD122443710(L3HYPDH)
SSC110262303(L3HYPDH)
CFR102510698(L3HYPDH)
CBAI105074630(L3HYPDH)
CDK105086230(L3HYPDH)
VPC102545772(L3HYPDH)
BACU103001798(L3HYPDH)
LVE103089729(L3HYPDH)
OOR101288505(L3HYPDH)
DLE111173103(L3HYPDH)
PCAD102982447(L3HYPDH)
PSIU116749971(L3HYPDH)
ECB100059502(L3HYPDH)
EPZ103560585(L3HYPDH)
EAI106846079(L3HYPDH)
MYB102251331(L3HYPDH)
MYD102751344(L3HYPDH)
MMYO118656113(L3HYPDH)
MLF102417956(L3HYPDH)
MNA107525912(L3HYPDH)
PKL118717232(L3HYPDH)
HAI109383857(L3HYPDH)
DRO112311822(L3HYPDH)
SHON118992457(L3HYPDH)
AJM119045233(L3HYPDH)
PDIC114492810(L3HYPDH)
PHAS123808412(L3HYPDH)
MMF118615926(L3HYPDH)
RFQ117023350(L3HYPDH)
PALE102892379(L3HYPDH)
PGIG120603566(L3HYPDH)
PVP105308841(L3HYPDH)
RAY107519593(L3HYPDH)
MJV108399464(L3HYPDH)
TOD119239143(L3HYPDH) 119242889 119242891
SARA101548981(L3HYPDH)
LAV100671364(L3HYPDH)
TMU101343227
DNM101430455(L3HYPDH)
MDO100026616(L3HYPDH)
GAS123237762(L3HYPDH)
SHR100916958(L3HYPDH)
PCW110208425(L3HYPDH)
OAA100086994(L3HYPDH)
GGA423531(L3HYPDH)
PCOC116236621(L3HYPDH)
MGP104911286(L3HYPDH)
CJO107315418(L3HYPDH)
NMEL110401546(L3HYPDH)
ACYG106037183(L3HYPDH)
AFUL116489961(L3HYPDH)
TGU100232596(L3HYPDH)
LSR110484108(L3HYPDH)
SCAN103826352(L3HYPDH)
PMOA120513519(L3HYPDH)
OTC121332936(L3HYPDH)
PRUF121349189(L3HYPDH)
GFR102042007(L3HYPDH)
FAB101810740(L3HYPDH)
PHI102107944(L3HYPDH)
PMAJ107206387(L3HYPDH)
CCAE111929702(L3HYPDH)
CCW104684550(L3HYPDH)
ETL114069015(L3HYPDH)
ZAB102060997(L3HYPDH)
FPG101918943(L3HYPDH)
FCH102059456(L3HYPDH)
CLV102096316(L3HYPDH)
EGZ104135281(L3HYPDH)
NNI104009686(L3HYPDH)
PLET104613909(L3HYPDH)
ACUN113480427(L3HYPDH)
TALA104365648(L3HYPDH)
PADL103924269(L3HYPDH)
ACHC115338590(L3HYPDH)
AAM106495231(L3HYPDH)
AROW112976272(L3HYPDH)
NPD112959680(L3HYPDH)
DNE112992064(L3HYPDH)
ASN102369998(L3HYPDH)
AMJ102565530(L3HYPDH)
CPOO109320683(L3HYPDH)
GGN109299284(L3HYPDH)
PSS102462476(L3HYPDH)
CMY102947990(L3HYPDH)
CPIC101931630(L3HYPDH)
TST117876845(L3HYPDH)
CABI116825945(L3HYPDH)
MRV120404156(L3HYPDH)
ACS100559609(l3hypdh)
PVT110083781(L3HYPDH)
SUND121931884(L3HYPDH)
PBI103049310(L3HYPDH)
PMUR107294579(L3HYPDH)
TSR106554612(L3HYPDH)
PGUT117675140(L3HYPDH)
VKO123026717(L3HYPDH)
PMUA114600110(L3HYPDH)
ZVI118079650(L3HYPDH)
GJA107120397(L3HYPDH)
STOW125427362(L3HYPDH)
XLA108698829(l3hypdh.L)
XTR493490(l3hypdh)
NPR108791712(L3HYPDH)
RTEM120920367(L3HYPDH)
BBUF120981724(L3HYPDH)
BGAR122921506(L3HYPDH)
DRE565785(l3hypdh)
SRX107755210
SANH107684001
SGH107601901(l3hypdh)
CCAR109058095(l3hypdh)
CAUA113120994(l3hypdh)
PPRM120493622
MAMB125277989
IPU108257951
PHYP113545195(l3hypdh)
SMEO124376736
TFD113644260
AMEX103042342(l3hypdh)
EEE113568740(l3hypdh)
TRU101066682(l3hypdh)
TNGGSTEN00023082G001
LCO104930547(l3hypdh)
NCC104951072(l3hypdh)
CGOB115028812(l3hypdh)
ELY117270369
PLEP121955395
SLUC116066328
ECRA117961233
PFLV114573751(l3hypdh)
GAT120808554
PPUG119195400
MSAM119908610 119919384
CUD121521402
ALAT119012688
MZE101483912(l3hypdh)
ONL100711126(l3hypdh)
OAU116310790
OLA101166521(l3hypdh)
OML112140416 112157886
XMA102217165(l3hypdh)
XCO114158489(l3hypdh)
XHE116734076(l3hypdh)
PRET103457582(l3hypdh)
PFOR103138615(l3hypdh)
PLAI106949069(l3hypdh)
PMEI106919669(l3hypdh)
GAF122825837
CVG107083634(l3hypdh)
CTUL119785061
GMU124881893
NFU107377581(l3hypdh)
KMR108240087
ALIM106516924(l3hypdh)
NWH119418192
AOCE111566664(l3hypdh)
LCF108895649(l3hypdh)
SDU111216353(l3hypdh)
SLAL111652661(l3hypdh)
XGL120788715
HCQ109524865(l3hypdh)
BPEC110155871(l3hypdh)
MALB109953913(l3hypdh)
BSPL114850092
SASA106571502(l3hypdh)
OTW112250415
OMY110529713
OGO123990851
ONE115107855(l3hypdh)
SALP111954005(l3hypdh)
SNH120024397
ELS105017645(l3hypdh)
SFM108930829(l3hypdh)
PKI111844408(l3hypdh)
AANG118229933
LOC102698417(l3hypdh)
PSPA121324778
ARUT117405268 117421952
LCM102352794(L3HYPDH)
CMK103178517
RTP109931773 109934736
BFO118406711 118406712 118406713 118407066 118407067 118419782
BBEL109467419 109467423
CIN100178125 100178684 113474013
SCLV120327094 120327095 120327099 120327100 120331895
SPU582891 585737
APLC110978363
SKO100374014(l3hypdh) 100375070 100375215 100376940
PPOI119092077
CSCU111618061
PTEP107454194
SDM118183059
HROHELRODRAFT_110204
LGILOTGIDRAFT_118524 LOTGIDRAFT_118892
PCAN112570601
BGT106069189
GAE121366440 121371867 121390587
HRF124151491 124151526
HRJ124260739
CRG105344406 105346271 105346272
MYI110457033 110457034 110457035 110457044
PMAX117322638 117323495 117323496 117323497
MMER123536541 123536542 123545553
OBI106881453
OSN115213294
LAK106170700 106170725
NVE5495736 5501579 5507229
EPA110254897
ATEN116300698
ADF107329603 107343685 107343686
AMIL114976260 114976269
PDAM113665581
SPIS111328850
DGT114533622 114533660 114533661
XEN124438102
HMG100198440
AQU100638966
MTMMYCTH_2307630
FGRFGSG_07885
FPUFPSE_11038
FVRFVEG_12059
FOXFOXG_03798
NHENECHADRAFT_29955 NECHADRAFT_48195 NECHADRAFT_83096 NECHADRAFT_85483 NECHADRAFT_86269 NECHADRAFT_97182
MAWMAC_07874
MAJMAA_06218
PLJVFPFJ_01628
CFJCFIO01_04717 CFIO01_08980
CHIGCH63R_12526
SAPOSAPIO_CDS4802
PFYPFICI_09227 PFICI_13991
PSCOLY89DRAFT_595446 LY89DRAFT_688136
ANIAN2121.2
AFMAFUA_5G02000
NFINFIA_040120
ANGANI_1_1948074(An08g04750) ANI_1_574044(An05g02210)
AFVAFLA_000360
ALUCAKAW2_30571A AKAW2_81362A
ACHEACHE_51054S
APUUAPUU_20930S
PCSPc12g00270
PDPPDIP_88540
TMFPMAA_092710
PNOSNOG_02266
PFJMYCFIDRAFT_214964
FFUCLAFUR5_06126
NPAUCRNP2_5499
TVSTRAVEDRAFT_84985
DSQDICSQDRAFT_166099
PSQPUNSTDRAFT_62142
MRRMoror_4294 Moror_5541
MOREE1B28_000033
SLIGGTU79_12555
TCIA7K98_03625
PAEPA1255
PAEVN297_1294
PAEIN296_1294
PAUPA14_47970
PAPPSPA7_4137
PAGPLES_40571
PAFPAM18_3776
PNCNCGM2_2137
PAEBNCGM1900_1321
PDKPADK2_19375
PSGG655_18895
PRPM062_06830
PAEPPA1S_19640
PAERPA1R_gp4861
PAEMU769_19480
PAELT223_20730
PAESSCV20265_4159
PAEUBN889_01334
PAEGAI22_14325
PAECM802_1291
PAEOM801_1294
PALCA0T30_01515
PMUIG4G71_28410
PFEPSF113_3720
PCGAXG94_01215
PMEDE3Z27_15380
PBAPSEBR_a3206
PBCCD58_14015
PDRH681_03710
PFZAV641_10900
PALKPSAKL28_28710
PFKPFAS1_24865
PUMHGP31_13890
PGGFX982_00235
PPSHG5J76_14155
PLALFXN65_03335
PVKEPZ47_13960
PBZGN234_05125
PKHJLK41_24670
PDWBV82_1489
PVWHU752_014585
PQIKH389_15885
PAZEKSS91_13920
PALVKSS97_15490
PTKEXN22_15870
PZAHU749_017255
PSTTCH92_01025
HPEGEAO82_15620
MAQMaqu_2141
MHCMARHY1085
MADHP15_922(pa45-A)
MBSMRBBS_3066
MSXAU14_10275
MPQABA45_14450
MARIACP86_15690
MLQASQ50_17215
MSQBKP64_09560
MARAD0851_18225
PINPing_2117
SSALSPISAL_05430
SPIUSPICUR_06135
SROSBBH56_05340
GAIIMCC3135_13045
CSACsal_2339
HELHELO_2887
HCSFF32_00800
HAKKO116_01421
HAMHALO1503
HHUAR456_08180
HCOLOKO_00314
HSIBOX17_00455
HALOBWR19_15585
HHHCLM76_00690
HBEBEI_1471
HAGBB497_15940
HALKCUU95_11380
HVNEI420_14755
HOLHORIV_48420 HORIV_50770
HSRHSBAA_46260
HMDCTT34_13280
HAXIHAALTHF_25520n
HTTHZS52_12135
HCAMI4484_17365
HPIZGYM47_12560
HSXHNO51_17220
HSVHNO53_17600
HTXEKK97_19430
HAAA5892_04205
PAURFGL86_06155
MPRIMP3633_0051
NIKF5I99_08175
TSNW908_03180
THINCRN91_06540
PLGNCTC10937_03094
MLOmlr6810
MLNA9174_14110
MOPMesop_2071
MAMOA6B35_24580
MESPC1M53_22695
MHUAMCHK_0429
MJREB229_14225
MERDEB233_28095
MESRFGU64_08340
AAKAA2016_5690
NKIKW403_09935
SMESM_b20270
SMKSinme_3903
SMQSinmeB_4400
SMXSM11_pD1341
SMIBN406_06396
SMEGC770_GR4pD1327
SMELSM2011_b20270
SMERDU99_32020
SMDSmed_3861
RHINGR_c20530
SIXBSY16_2971
SAMESAMCFNEI73_Ch0738
EADOV14_a0432
EAHFA04_22255
ESJSJ05684_b60000
EAKEKH55_4113
EMXFKV68_18760
ATUAtu4684
ATAAWN88_02295
AGRAGROH133_09590
ATFAch5_44060
AVIAvi_7022
AROB0909_14105
AGTEYD00_22640
RLTRleg2_2641
RIRBN877_II1778
RPUSCFBP5875_22535
RHLLPU83_0080
RHVBA939_17430
RJGCCGE525_00885
RGRFZ934_22350
RADCO657_13405
ROYG3A56_25255
RHIDFFM81_006675
NENNCHU2750_24020
RHTNT26_3279
SHZshn_21240
SZOK8M09_18860
PDESFE840_019540
BMEBMEI1586
BMELDK63_1903
BMIBMEA_A0374
BMZBM28_A0368
BMGBM590_A0364
BMWBMNI_I0361
BMEEDK62_1049
BMFBAB1_0366
BMBBruAb1_0363
BMCBAbS19_I03350
BAABAA13334_I03384
BABODK55_382
BABRDO74_1505
BABTDK49_145
BABBDK48_1745
BABUDK53_372
BABSDK51_1092
BABCDO78_289
BMSBR0337
BSIBS1330_I0338
BSFBSS2_I0333
BSUIBSSP1_I0356
BSUPBSPT1_I0361
BSUVBSPT2_I0357
BSUCBSSP2_I0357
BMTBSUIS_A0368
BSZDK67_1276
BSVBSVBI22_A0338
BSWIY71_01780
BSGIY72_01505
BOVBOV_0353
BCSBCAN_A0346
BSKBCA52141_I1147
BOLBCOUA_I0337
BCARDK60_429
BCASDA85_01640
BMRBMI_I342
BPPBPI_I371
BPVDK65_1009
BCETV910_101609
BCEEV568_101803
BVLBF3285c1_0342
BRUBFS01_01740
BRJBKD03_09100
OINIAR37_04890
BIOBR141012304_10213
OANOant_0439
OAHDR92_2500
OPSA8A54_01435
OCHCES85_0376
OCRHGK82_01475
OCLGTN27_01950
BOFFQV39_00960
SNOSnov_0155
STARG3545_19655
LNEFZC33_04690
ANCGBB76_15700
APRAG3A50_11690
APOLK9D25_02015
PHLKKY_1201
DEQXM25_15050
MMYRMXMO3_02557
YTIFNA67_18755
AUAM673_01840
NOHG5V57_04300
LAPACP90_03850
LABRCHH27_16895
LABPFJ695_09460
LABTFIU93_09485
LAGGB0E33_15410
LIZLGH83_15015
ACUTMRB58_03895
SILSPO0607
SITTM1040_3201
RUAD1823_21565
RUTFIU92_20920
JANJann_1529
PGAPGA1_262p00280
PGLPGA2_239p0280
PGDGal_03751
PPICPhaeoP14_03489
PHQD1820_17355
OAROA238_c13640
OTMOSB_16560
LMDMETH_17515
REDroselon_01466
MALGMALG_04515
YPACCEW88_21675
SULDB5M07_16975
SINLDSM14862_03939
SPSESULPSESMR1_03590 SULPSESMR1_03888 SULPSESMR1_04291
RMMROSMUCSMR3_03763
ROKRAK1035_2603
SAGUCDO87_12160
MALUKU6B_09310
HATRC74_17910
LSALKBK07_17625
RBLB6K69_11130
PDEPden_1184
PAMIJCM7686_pAMI5p195
PCONB0A89_11860
PZHCX676_19060
PARUCYR75_12380
PARSDRW48_02025
PKDF8A10_10080
PPANESD82_09105 ESD82_09165
PSANHGN31_03525
RMBK529_019735
GEHHYN69_18935
GFUKM031_16590
TAWEI545_09005
PSEBEOK75_17435
LITFPZ52_12355
PAEDG5B38_02510
PALWPSAL_037640
THASC6Y53_15235
FAPGR316_11100
SECHB18_18010
KSCCD178_00243
HTQFRZ44_49700
HADHFRZ61_48240
APBSAR116_0313
PFLAPflav_031310
ABAMB1s21122_02160
GOGC1280_19355
 » show all
Reference
1
  Authors
Ramaswamy, S.G.
  Title
Conversion of 3-hydroxyproline to proline in the rat requires reduced pyridine-nucleotides.
  Journal
Fed Proc 42:2232 (1983)
Reference
2  [PMID:22528483]
  Authors
Visser WF, Verhoeven-Duif NM, de Koning TJ
  Title
Identification of a human trans-3-hydroxy-L-proline dehydratase, the first characterized member of a novel family of proline racemase-like enzymes.
  Journal
J Biol Chem 287:21654-62 (2012)
DOI:10.1074/jbc.M112.363218
  Sequence
[hsa:112849]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.77
IUBMB Enzyme Nomenclature: 4.2.1.77
ExPASy - ENZYME nomenclature database: 4.2.1.77
BRENDA, the Enzyme Database: 4.2.1.77
LinkDB

KEGG   REACTION: R04374
Entry
R04374                      Reaction                               
Name
trans-3-hydroxy-L-proline hydro-lyase (1-pyrroline-2-carboxylate-forming)
Definition
trans-3-Hydroxy-L-proline <=> 1-Pyrroline-2-carboxylate + H2O
Equation
Comment
two-step reaction
2,3-Dehydroproline is an intermediate
Reaction class
RC01139  C03564_C05147
Enzyme
Pathway
rn00330  Arginine and proline metabolism
rn01100  Metabolic pathways
Orthology
K18384  trans-L-3-hydroxyproline dehydratase [EC:4.2.1.77]
K22548  trans-L-3-hydroxyproline dehydratase [EC:4.2.1.77]
Other DBs
RHEA: 10323
LinkDB

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