KEGG   ORTHOLOGY: K18386
Entry
K18386                      KO                                     
Symbol
PAXM, ATMM, LTMM
Name
FAD dependent monooxygenase [EC:1.14.13.-]
Pathway
map00403  Indole diterpene alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00661  Paspaline biosynthesis, geranylgeranyl-PP + indoleglycerol phosphate => paspaline
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00403 Indole diterpene alkaloid biosynthesis
    K18386  PAXM, ATMM, LTMM; FAD dependent monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.-
     K18386  PAXM, ATMM, LTMM; FAD dependent monooxygenase
Other DBs
RN: R10350 R10351
Genes
PPEI: PpBr36_10630
FGR: FGSG_04595
FPU: FPSE_10836
MAW: MAC_08211
MAJ: MAA_00078 MAA_07499
CHIG: CH63R_05475
ANI: AN8140.2
AFM: AFUA_6G13970 AFUA_8G02380
ACT: ACLA_008510
NFI: NFIA_096050 NFIA_100480
ANG: ANI_1_1734094(An11g02480)
 » show all
Reference
  Authors
Nicholson MJ, Koulman A, Monahan BJ, Pritchard BL, Payne GA, Scott B
  Title
Identification of two aflatrem biosynthesis gene loci in Aspergillus flavus and metabolic engineering of Penicillium paxilli to elucidate their function.
  Journal
Appl Environ Microbiol 75:7469-81 (2009)
DOI:10.1128/AEM.02146-08
  Sequence
Reference
  Authors
Young C, McMillan L, Telfer E, Scott B
  Title
Molecular cloning and genetic analysis of an indole-diterpene gene cluster from Penicillium paxilli.
  Journal
Mol Microbiol 39:754-64 (2001)
DOI:10.1046/j.1365-2958.2001.02265.x
Reference
  Authors
Tagami K, Liu C, Minami A, Noike M, Isaka T, Fueki S, Shichijo Y, Toshima H, Gomi K, Dairi T, Oikawa H
  Title
Reconstitution of biosynthetic machinery for indole-diterpene paxilline in Aspergillus oryzae.
  Journal
J Am Chem Soc 135:1260-3 (2013)
DOI:10.1021/ja3116636
LinkDB

KEGG   REACTION: R10351
Entry
R10351                      Reaction                               
Name
emindole-SB,NADPH:oxygen oxidoreductase (14,15-epoxidizing)
Definition
Emindole SB + Oxygen + NADPH + H+ <=> 14,15-Epoxyemindole SB + NADP+ + H2O
Equation
Reaction class
RC00001  C00005_C00006
RC00201  C20527_C20529
Enzyme
1.14.13.-
Pathway
rn00403  Indole diterpene alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00661  Paspaline biosynthesis, geranylgeranyl-PP + indoleglycerol phosphate => paspaline
Orthology
K18386  FAD dependent monooxygenase [EC:1.14.13.-]
LinkDB

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