KEGG   ORTHOLOGY: K18387
Entry
K18387                      KO                                     
Symbol
PAXB, ATMB, LTMB
Name
paspaline synthase
Pathway
map00403  Indole diterpene alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00661  Paspaline biosynthesis, geranylgeranyl-PP + indoleglycerol phosphate => paspaline
Reaction
R10352  
R10353  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00403 Indole diterpene alkaloid biosynthesis
    K18387  PAXB, ATMB, LTMB; paspaline synthase
Genes
PPEI: PpBr36_10629
FGR: FGSG_12222
FPU: FPSE_10837
MAW: 19251251(J3458_002675)
MAJ: MAA_00081
MBRN: 26245743(ltmB) 90968212(atmB)
CHIG: CH63R_05476
CDET: 87948445(CDEST_11945) 87949560(CDEST_13060)
BFU: BCIN_05g05660
AFM: AFUA_6G13950
 » show all
Reference
  Authors
Nicholson MJ, Koulman A, Monahan BJ, Pritchard BL, Payne GA, Scott B
  Title
Identification of two aflatrem biosynthesis gene loci in Aspergillus flavus and metabolic engineering of Penicillium paxilli to elucidate their function.
  Journal
Appl Environ Microbiol 75:7469-81 (2009)
DOI:10.1128/AEM.02146-08
  Sequence
Reference
  Authors
Saikia S, Parker EJ, Koulman A, Scott B
  Title
Four gene products are required for the fungal synthesis of the indole-diterpene, paspaline.
  Journal
FEBS Lett 580:1625-30 (2006)
DOI:10.1016/j.febslet.2006.02.008
Reference
  Authors
Tagami K, Liu C, Minami A, Noike M, Isaka T, Fueki S, Shichijo Y, Toshima H, Gomi K, Dairi T, Oikawa H
  Title
Reconstitution of biosynthetic machinery for indole-diterpene paxilline in Aspergillus oryzae.
  Journal
J Am Chem Soc 135:1260-3 (2013)
DOI:10.1021/ja3116636
LinkDB

KEGG   REACTION: R10353
Entry
R10353                      Reaction                               
Definition
14,15-Epoxyemindole SB <=> Paspaline
Equation
Comment
cyclase
Reaction class
RC03136  C20529_C20530
Pathway
rn00403  Indole diterpene alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00661  Paspaline biosynthesis, geranylgeranyl-PP + indoleglycerol phosphate => paspaline
Orthology
K18387  paspaline synthase
LinkDB

DBGET integrated database retrieval system