KEGG   ORTHOLOGY: K18388
Entry
K18388                      KO                                     
Symbol
PAXP, ATMP, CYP653C
Name
cytochrome P450 monooxygenase [EC:1.14.13.-]
Pathway
map00403  Indole diterpene alkaloid biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R10356  paspaline-B,NADPH:oxygen oxidoreductase
R10357  
R10358  
R10371  paspaline,NADPH:oxygen oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00403 Indole diterpene alkaloid biosynthesis
    K18388  PAXP, ATMP, CYP653C; cytochrome P450 monooxygenase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K18388  PAXP, ATMP, CYP653C; cytochrome P450 monooxygenase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, fungi type
  CYP653 family
   K18388  PAXP, ATMP, CYP653C; cytochrome P450 monooxygenase
Other DBs
COG: COG2124
Genes
AOR: AO090011000743
AFV: AFLA_008141
AG: AAK11528(PAXP)
Reference
  Authors
Nicholson MJ, Koulman A, Monahan BJ, Pritchard BL, Payne GA, Scott B
  Title
Identification of two aflatrem biosynthesis gene loci in Aspergillus flavus and metabolic engineering of Penicillium paxilli to elucidate their function.
  Journal
Appl Environ Microbiol 75:7469-81 (2009)
DOI:10.1128/AEM.02146-08
  Sequence
Reference
  Authors
Young C, McMillan L, Telfer E, Scott B
  Title
Molecular cloning and genetic analysis of an indole-diterpene gene cluster from Penicillium paxilli.
  Journal
Mol Microbiol 39:754-64 (2001)
DOI:10.1046/j.1365-2958.2001.02265.x
  Sequence
LinkDB

KEGG   REACTION: R10371
Entry
R10371                      Reaction                               
Name
paspaline,NADPH:oxygen oxidoreductase
Definition
Paspaline + 2 NADPH + 2 H+ + 2 Oxygen <=> Paspaline B + 2 NADP+ + 3 H2O
Equation
C20530 + 2 C00005 + 2 C00080 + 2 C00007 <=> C20587 + 2 C00006 + 3 C00001
Comment
two-step reaction
Reaction class
RC00001  C00005_C00006
RC03242  C20530_C20587
Enzyme
1.14.13.-
Pathway
rn00403  Indole diterpene alkaloid biosynthesis
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.-
     R10371  Paspaline + 2 NADPH + 2 H+ + 2 Oxygen <=> Paspaline B + 2 NADP+ + 3 H2O
Orthology
K18388  cytochrome P450 monooxygenase [EC:1.14.13.-]
K18392  cytochrome P450 monooxygenase [EC:1.14.13.-]
LinkDB

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