KEGG   ORTHOLOGY: K18392
Entry
K18392            Tight     KO                                     
Symbol
LTMP, TERP
Name
cytochrome P450 monooxygenase [EC:1.14.13.-]
Pathway
map00403  Indole diterpene alkaloid biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R10356  paspaline-B,NADPH:oxygen oxidoreductase
R10371  paspaline,NADPH:oxygen oxidoreductase
R10376  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00403 Indole diterpene alkaloid biosynthesis
    K18392  LTMP, TERP; cytochrome P450 monooxygenase
Genes
AG: AFO85406(LTMP) BAM84050(TERP)
Reference
  Authors
Saikia S, Takemoto D, Tapper BA, Lane GA, Fraser K, Scott B
  Title
Functional analysis of an indole-diterpene gene cluster for lolitrem B biosynthesis in the grass endosymbiont Epichloe festucae.
  Journal
FEBS Lett 586:2563-9 (2012)
DOI:10.1016/j.febslet.2012.06.035
Reference
  Authors
Motoyama T, Hayashi T, Hirota H, Ueki M, Osada H
  Title
Terpendole E, a kinesin Eg5 inhibitor, is a key biosynthetic intermediate of indole-diterpenes in the producing fungus Chaunopycnis alba.
  Journal
Chem Biol 19:1611-9 (2012)
DOI:10.1016/j.chembiol.2012.10.010
  Sequence
LinkDB

KEGG   REACTION: R10371
Entry
R10371                      Reaction                               
Name
paspaline,NADPH:oxygen oxidoreductase
Definition
Paspaline + 2 NADPH + 2 H+ + 2 Oxygen <=> Paspaline B + 2 NADP+ + 3 H2O
Equation
C20530 + 2 C00005 + 2 C00080 + 2 C00007 <=> C20587 + 2 C00006 + 3 C00001
Comment
two-step reaction
Reaction class
RC00001  C00005_C00006
RC03242  C20530_C20587
Enzyme
1.14.13.-
Pathway
rn00403  Indole diterpene alkaloid biosynthesis
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.-
     R10371  Paspaline + 2 NADPH + 2 H+ + 2 Oxygen <=> Paspaline B + 2 NADP+ + 3 H2O
Orthology
K18388  cytochrome P450 monooxygenase [EC:1.14.13.-]
K18392  cytochrome P450 monooxygenase [EC:1.14.13.-]
LinkDB

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