KEGG   ORTHOLOGY: K18445
Entry
K18445                      KO                                     
Symbol
ndx1
Name
diadenosine hexaphosphate hydrolase (ATP-forming) [EC:3.6.1.61]
Pathway
map00230  Purine metabolism
map01100  Metabolic pathways
Reaction
R00184  P1,P4-bis(5'-adenosyl)-tetraphosphate adenylohydrolase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K18445  ndx1; diadenosine hexaphosphate hydrolase (ATP-forming)
Enzymes [BR:ko01000]
 3. Hydrolases
  3.6  Acting on acid anhydrides
   3.6.1  In phosphorus-containing anhydrides
    3.6.1.61  diadenosine hexaphosphate hydrolase (ATP-forming)
     K18445  ndx1; diadenosine hexaphosphate hydrolase (ATP-forming)
Genes
DECH: GBK02_15975
PTUN: V6W81_20630
PTAC: ACJYJG_22565
AHK: NCTC10172_00318
DGE: Dgeo_1007
DMR: Deima_2556
DPD: Deipe_3189
DPU: SU48_08635
DPH: EHF33_03030
DRB: N0D28_09580
DAH: DAETH_13030
DMB: E5F05_12680
DSC: ABOD76_15495
TRA: Trad_2852
TTH: TT_C1519
TTJ: TTHA1880(TTHA1880)
TTS: Ththe16_1884
TTL: TtJL18_1964
TSC: TSC_c24030
THC: TCCBUS3UF1_21630
TOS: Theos_0154
TAQ: TO73_2290
TBC: A0O31_00827
TANT: KNN15_03610
MRB: Mrub_1608
MRE: K649_14515
MTAI: Mtai_v1c13500
MSV: Mesil_0927
OPR: Ocepr_0595
MHD: Marky_0630
 » show all
Reference
PMID:15024014
  Authors
Iwai T, Kuramitsu S, Masui R
  Title
The Nudix hydrolase Ndx1 from Thermus thermophilus HB8 is a diadenosine hexaphosphate hydrolase with a novel activity.
  Journal
J Biol Chem 279:21732-9 (2004)
DOI:10.1074/jbc.M312018200
  Sequence
[ttj:TTHA1880]
LinkDB

KEGG   ENZYME: 3.6.1.61
Entry
EC 3.6.1.61                 Enzyme                                 
Name
diadenosine hexaphosphate hydrolase (ATP-forming);
Ndx1
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
Sysname
P1,P6-bis(5'-adenosyl)hexaphosphate nucleotidohydrolase (ATP-forming)
Reaction(IUBMB)
(1) P1,P6-bis(5'-adenosyl)hexaphosphate + H2O = 2 ATP [RN:R09879];
(2) P1,P5-bis(5'-adenosyl)pentaphosphate + H2O = ATP + ADP [RN:R09880];
(3) P1,P4-bis(5'-adenosyl)tetraphosphate + H2O = ATP + AMP [RN:R00184]
Reaction(KEGG)
R00184 R09879 R09880
Substrate
P1,P6-bis(5'-adenosyl)hexaphosphate [CPD:C20190];
H2O [CPD:C00001];
P1,P5-bis(5'-adenosyl)pentaphosphate [CPD:C04058];
P1,P4-bis(5'-adenosyl)tetraphosphate [CPD:C01260]
Product
ATP [CPD:C00002];
ADP [CPD:C00008];
AMP [CPD:C00020]
Comment
The enzyme requires the presence of the divalent cations (Mn2+, Mg2+, Zn2+, and Co2+). It hydrolyses P1,P4-bis(5'-guanosyl) tetraphosphate very slowly [cf. EC 3.6.1.17, bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)].
History
EC 3.6.1.61 created 2012
Pathway
ec00230  Purine metabolism
ec01100  Metabolic pathways
Orthology
K18445  diadenosine hexaphosphate hydrolase (ATP-forming)
Genes
DECH: GBK02_15975
PTUN: V6W81_20630
PTAC: ACJYJG_22565
AHK: NCTC10172_00318
DGE: Dgeo_1007
DMR: Deima_2556
DPD: Deipe_3189
DPU: SU48_08635
DPH: EHF33_03030
DRB: N0D28_09580
DAH: DAETH_13030
DMB: E5F05_12680
DSC: ABOD76_15495
TRA: Trad_2852
TTH: TT_C1519
TTJ: TTHA1880(TTHA1880)
TTS: Ththe16_1884
TTL: TtJL18_1964
TSC: TSC_c24030
THC: TCCBUS3UF1_21630
TOS: Theos_0154
TAQ: TO73_2290
TBC: A0O31_00827
TANT: KNN15_03610
MRB: Mrub_1608
MRE: K649_14515
MTAI: Mtai_v1c13500
MSV: Mesil_0927
OPR: Ocepr_0595
MHD: Marky_0630
 » show all
Reference
1  [PMID:15024014]
  Authors
Iwai T, Kuramitsu S, Masui R
  Title
The Nudix hydrolase Ndx1 from Thermus thermophilus HB8 is a diadenosine hexaphosphate hydrolase with a novel activity.
  Journal
J Biol Chem 279:21732-9 (2004)
DOI:10.1074/jbc.M312018200
  Sequence
[ttj:TTHA1880]
Other DBs
ExplorEnz - The Enzyme Database: 3.6.1.61
IUBMB Enzyme Nomenclature: 3.6.1.61
ExPASy - ENZYME nomenclature database: 3.6.1.61
BRENDA, the Enzyme Database: 3.6.1.61
LinkDB

KEGG   REACTION: R00184
Entry
R00184                      Reaction                               
Name
P1,P4-bis(5'-adenosyl)-tetraphosphate adenylohydrolase
Definition
P1,P4-Bis(5'-adenosyl)tetraphosphate + H2O <=> ATP + AMP
Equation
C01260 + C00001 <=> C00002 + C00020
Reaction class
RC00002  C00002_C01260  C00020_C01260
Enzyme
3.6.1.17        3.6.1.61
Pathway
rn00230  Purine metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 3. Hydrolase reactions
  3.6  Acting on acid anhydrides
   3.6.1  In phosphorus-containing anhydrides
    3.6.1.17
     R00184  P1,P4-Bis(5'-adenosyl)tetraphosphate + H2O <=> ATP + AMP
    3.6.1.61
     R00184  P1,P4-Bis(5'-adenosyl)tetraphosphate + H2O <=> ATP + AMP
Orthology
K01518  bis(5'-nucleosidyl)-tetraphosphatase [EC:3.6.1.17]
K18445  diadenosine hexaphosphate hydrolase (ATP-forming) [EC:3.6.1.61]
K26955  bis(5'-nucleosidyl)-tetraphosphatase [EC:3.6.1.17]
Other DBs
RHEA: 32042
LinkDB

DBGET integrated database retrieval system