KEGG   ORTHOLOGY: K18550
Entry
K18550                      KO                                     
Symbol
ISN1
Name
IMP and pyridine-specific 5'-nucleotidase [EC:3.1.3.99 3.1.3.-]
Pathway
map00230  Purine metabolism
map00760  Nicotinate and nicotinamide metabolism
map01100  Metabolic pathways
map01232  Nucleotide metabolism
Module
M00958  Adenine ribonucleotide degradation, AMP => Urate
Reaction
R01126  inosine 5'-monophosphate phosphohydrolase
R02323  nicotinamide ribonucleotide phosphohydrolase
R03346  nicotinate D-ribonucleotide phosphohydrolase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K18550  ISN1; IMP and pyridine-specific 5'-nucleotidase
  09108 Metabolism of cofactors and vitamins
   00760 Nicotinate and nicotinamide metabolism
    K18550  ISN1; IMP and pyridine-specific 5'-nucleotidase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.99  IMP-specific 5'-nucleotidase
     K18550  ISN1; IMP and pyridine-specific 5'-nucleotidase
Other DBs
GO: 0050483
Genes
CJF: 131041906
SMO: SELMODRAFT_103387 SELMODRAFT_413967 SELMODRAFT_415743 SELMODRAFT_99737
PPP: 112282666 112283810 112286598 112287728 112291556 112292774
CRE: CHLRE_04g225750v5
VCN: VOLCADRAFT_105288
MNG: MNEG_6875
CSL: COCSUDRAFT_59997
CVR: CHLNCDRAFT_52757
APRO: F751_2896
OLU: OSTLU_4044
OTA: OT_ostta06g01180
BPG: Bathy05g01210
MIS: MICPUN_107875
MPP: MICPUCDRAFT_27168
SCE: YOR155C(ISN1)
SEUB: DI49_4989
SPAO: SPAR_O02840
AGO: AGOS_AAR112C
ERC: Ecym_5451
KLA: KLLA0_A02365g
KMX: KLMA_30643(ISN1)
LTH: KLTH0G03036g
VPO: Kpol_363p1
ZRO: ZYRO0D11902g
CGR: 2890774(GVI51_L04081)
NCS: NCAS_0H02430(NCAS0H02430)
NDI: NDAI_0C01230(NDAI0C01230)
TPF: TPHA_0J02930(TPHA0J02930)
TBL: TBLA_0D01760(TBLA0D01760)
TGB: HG536_0A05190
TDL: TDEL_0A03650(TDEL0A03650)
KAF: KAFR_0C05230(KAFR0C05230)
KNG: KNAG_0B03860(KNAG0B03860)
ZMK: HG535_0D04680
SLUD: SCDLUD_003278
DHA: DEHA2G07414g
PIC: PICST_38342(ISN1)
PGU: PGUG_02836
SPAA: SPAPADRAFT_57719
LEL: PVL30_001403(ISN1)
LBG: 92208170(LODBEIA_P29740)
CAL: CAALFM_C101650WA(ISN1)
CTP: CTRG_04462
COT: CORT_0B10510
CDU: CD36_01520
CTEN: 18249021(ISN1)
CLU: CLUG_00750
CLUS: A9F13_17g01364
CAUR: CJI96_0000152
ASAU: 88171422(PUMCH_000353)
BNN: FOA43_001352
BBRX: BRETT_002508
OPA: HPODL_03887
YLI: 2912803(YALI2_E00241g)
NCR: NCU01945
NTE: NEUTE1DRAFT55104(NEUTE1DRAFT_55104)
SMP: 10804510(SMAC4_05391)
PAN: PODANSg040
PBEL: QC761_120720(ISN1)
PPSD: QC762_120720(ISN1)
PPSP: QC763_120720(ISN1)
PPSA: QC764_120720(ISN1)
TTT: THITE_2111481
MTM: MYCTH_2137468
CTHR: CTHT_0011740
RTHE: 98122408(VTJ83DRAFT_1589)
MGR: MGG_02955
PPEI: PpBr36_09354
PGRI: PgNI_10415
SSCK: SPSK_06243
FGR: FGSG_11629
FPU: FPSE_08202
FPOA: FPOAC1_005064(ISN1)
FVN: FVRRES_05584
FVR: FVEG_02510
FOX: FOXG_03639
NHE: NECHADRAFT_35271
FFC: NCS54_00436700
FKR: NCS57_00443400
FMU: J7337_008852(ISN1)
TRE: TRIREDRAFT_3372
TRR: M419DRAFT_140832
TATV: 25775494(TrAtP1_002038)
TASP: 36615774(ISN1)
MAW: 19249677(ISN1_1)
MAJ: MAA_03704
MBRN: 26245448(ISN1)
PCHM: VFPPC_04580
UVI: 66064914(UV8b_04136)
CMT: CCM_06504
AMUS: LMH87_001876
PLJ: 28882683(PLICBS_001308)
PTKZ: JDV02_010164(ISN1)
DCON: 63713515(DCS_00872)
VDA: VDAG_10339
CFJ: CFIO01_08488
CLUP: CLUP02_14713
CHIG: CH63R_09956
CDET: 87951070(CDEST_14570)
SAPO: SAPIO_CDS5219
PFY: PFICI_09724
SSL: SS1G_11331
BFU: BCIN_08g04420(Bcisn1)
MBE: MBM_07528
PSCO: LY89DRAFT_724295
GLZ: GLAREA_02834
ANI: ANIA_03222
AFM: AFUA_4G00970
ACT: ACLA_078090
NFI: NFIA_044530
AOR: AO090003001389
ANG: An18g01690
AFV: AFLA_000289
ALUC: AKAW2_31395S(ISN1)
ACHE: ACHE_51268S(ISN1)
APUU: APUU_80935A(ISN1)
PCS: N7525_001251
PDP: PDIP_77910
POU: POX_g09358
PPSF: 300791811(PFLUO_LOCUS5823)
TMF: EYB26_009243
TRG: TRUGW13939_07393
CIM: CIMG_08882
CPW: 9696163(ISN1)
URE: UREG_02795
ABE: ARB_05991
TVE: TRV_06351
PBL: PAAG_11311(PAAG_01584)
PBN: PADG_00190
AJE: HCAG_07493
BGH: BDBG_08713
PNO: SNOG_02535
PTE: PTT_12382
PTRR: 6346767(PtrM4_147410)
BZE: COCCADRAFT_2013
BSC: COCSADRAFT_149090
BOR: COCMIDRAFT_1067
AALT: CC77DRAFT_611878
ADAC: 96081079(ACET3X_000757)
ARAB: EKO05_0004654
ZTR: MYCGRDRAFT_56200
PFJ: MYCFIDRAFT_35210
FFU: CLAFUR5_09838
CBET: CB0940_06626
BCOM: BAUCODRAFT_151081
NPA: UCRNP2_275
TML: GSTUM_00004490001
SPO: 2540344(isn1)
SOM: SOMG_01066(isn1)
RIE: OCT59_009185
PFA: PF3D7_1206100
PFD: PFDG_02232
PFH: PFHG_03990
PREI: PRSY57_1205400
PGAB: PGSY75_1206100
PLAG: 39742773(PADL01_1206500)
PKN: PKNH_1305800
PVX: PVX_084340
PCY: PCYB_131470
PMAL: PMUG01_13016100
PBRS: 92372888(MKS88_004801)
PREL: PRELSG_1304900
PCOT: PCOAH_00006900
TGO: TGME49_222710
BBES: BESB_062570
PTI: PHATRDRAFT_13606
FCY: FRACYDRAFT_263138
TPS: THAPSDRAFT_34077
AAF: AURANDRAFT_18663
PIF: PITG_13347
PSOJ: PHYSODRAFT_502616
BLAC: 94346595(CCR75_002827)
SPAR: SPRG_11168 SPRG_14401
EHX: EMIHUDRAFT_231552 EMIHUDRAFT_455795
GTT: GUITHDRAFT_163029 GUITHDRAFT_89259
 » show all
Reference
PMID:19846558
  Authors
Bogan KL, Evans C, Belenky P, Song P, Burant CF, Kennedy R, Brenner C
  Title
Identification of Isn1 and Sdt1 as glucose- and vitamin-regulated nicotinamide mononucleotide and nicotinic acid mononucleotide [corrected] 5'-nucleotidases responsible for production of nicotinamide riboside and nicotinic acid riboside.
  Journal
J Biol Chem 284:34861-9 (2009)
DOI:10.1074/jbc.M109.056689
  Sequence
[sce:YOR155C]
LinkDB

KEGG   ENZYME: 3.1.3.99
Entry
EC 3.1.3.99                 Enzyme                                 
Name
IMP-specific 5'-nucleotidase;
ISN1 (gene name)
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
Sysname
inosine 5'-phosphate phosphohydrolase
Reaction(IUBMB)
IMP + H2O = inosine + phosphate [RN:R01126]
Reaction(KEGG)
R01126
Substrate
IMP [CPD:C00130];
H2O [CPD:C00001]
Product
inosine [CPD:C00294];
phosphate [CPD:C00009]
Comment
The enzyme, isolated from the yeast Saccharomyces cerevisiae, is highly specific for inosine 5'-phosphate, and has no detectable activity with other purine and pyrimidine nucleotides. Requires divalent metals, such as Mg2+, Co2+ or Mn2+.
History
EC 3.1.3.99 created 2016
Pathway
ec00230  Purine metabolism
ec01100  Metabolic pathways
Orthology
K18550  IMP and pyridine-specific 5'-nucleotidase
Genes
CJF: 131041906
SMO: SELMODRAFT_103387 SELMODRAFT_413967 SELMODRAFT_415743 SELMODRAFT_99737
PPP: 112282666 112283810 112286598 112287728 112291556 112292774
CRE: CHLRE_04g225750v5
VCN: VOLCADRAFT_105288
MNG: MNEG_6875
CSL: COCSUDRAFT_59997
CVR: CHLNCDRAFT_52757
APRO: F751_2896
OLU: OSTLU_4044
OTA: OT_ostta06g01180
BPG: Bathy05g01210
MIS: MICPUN_107875
MPP: MICPUCDRAFT_27168
SCE: YOR155C(ISN1)
SEUB: DI49_4989
SPAO: SPAR_O02840
AGO: AGOS_AAR112C
ERC: Ecym_5451
KLA: KLLA0_A02365g
KMX: KLMA_30643(ISN1)
LTH: KLTH0G03036g
VPO: Kpol_363p1
ZRO: ZYRO0D11902g
CGR: 2890774(GVI51_L04081)
NCS: NCAS_0H02430(NCAS0H02430)
NDI: NDAI_0C01230(NDAI0C01230)
TPF: TPHA_0J02930(TPHA0J02930)
TBL: TBLA_0D01760(TBLA0D01760)
TGB: HG536_0A05190
TDL: TDEL_0A03650(TDEL0A03650)
KAF: KAFR_0C05230(KAFR0C05230)
KNG: KNAG_0B03860(KNAG0B03860)
ZMK: HG535_0D04680
SLUD: SCDLUD_003278
DHA: DEHA2G07414g
PIC: PICST_38342(ISN1)
PGU: PGUG_02836
SPAA: SPAPADRAFT_57719
LEL: PVL30_001403(ISN1)
LBG: 92208170(LODBEIA_P29740)
CAL: CAALFM_C101650WA(ISN1)
CTP: CTRG_04462
COT: CORT_0B10510
CDU: CD36_01520
CTEN: 18249021(ISN1)
CLU: CLUG_00750
CLUS: A9F13_17g01364
CAUR: CJI96_0000152
ASAU: 88171422(PUMCH_000353)
BNN: FOA43_001352
BBRX: BRETT_002508
OPA: HPODL_03887
YLI: 2912803(YALI2_E00241g)
NCR: NCU01945
NTE: NEUTE1DRAFT55104(NEUTE1DRAFT_55104)
SMP: 10804510(SMAC4_05391)
PAN: PODANSg040
PBEL: QC761_120720(ISN1)
PPSD: QC762_120720(ISN1)
PPSP: QC763_120720(ISN1)
PPSA: QC764_120720(ISN1)
TTT: THITE_2111481
MTM: MYCTH_2137468
CTHR: CTHT_0011740
RTHE: 98122408(VTJ83DRAFT_1589)
MGR: MGG_02955
PPEI: PpBr36_09354
PGRI: PgNI_10415
SSCK: SPSK_06243
FGR: FGSG_11629
FPU: FPSE_08202
FPOA: FPOAC1_005064(ISN1)
FVN: FVRRES_05584
FVR: FVEG_02510
FOX: FOXG_03639
NHE: NECHADRAFT_35271
FFC: NCS54_00436700
FKR: NCS57_00443400
FMU: J7337_008852(ISN1)
TRE: TRIREDRAFT_3372
TRR: M419DRAFT_140832
TATV: 25775494(TrAtP1_002038)
TASP: 36615774(ISN1)
MAW: 19249677(ISN1_1)
MAJ: MAA_03704
MBRN: 26245448(ISN1)
PCHM: VFPPC_04580
UVI: 66064914(UV8b_04136)
CMT: CCM_06504
AMUS: LMH87_001876
PLJ: 28882683(PLICBS_001308)
PTKZ: JDV02_010164(ISN1)
DCON: 63713515(DCS_00872)
VDA: VDAG_10339
CFJ: CFIO01_08488
CLUP: CLUP02_14713
CHIG: CH63R_09956
CDET: 87951070(CDEST_14570)
SAPO: SAPIO_CDS5219
PFY: PFICI_09724
SSL: SS1G_11331
BFU: BCIN_08g04420(Bcisn1)
MBE: MBM_07528
PSCO: LY89DRAFT_724295
GLZ: GLAREA_02834
ANI: ANIA_03222
AFM: AFUA_4G00970
ACT: ACLA_078090
NFI: NFIA_044530
AOR: AO090003001389
ANG: An18g01690
AFV: AFLA_000289
ALUC: AKAW2_31395S(ISN1)
ACHE: ACHE_51268S(ISN1)
APUU: APUU_80935A(ISN1)
PCS: N7525_001251
PDP: PDIP_77910
POU: POX_g09358
PPSF: 300791811(PFLUO_LOCUS5823)
TMF: EYB26_009243
TRG: TRUGW13939_07393
CIM: CIMG_08882
CPW: 9696163(ISN1)
URE: UREG_02795
ABE: ARB_05991
TVE: TRV_06351
PBL: PAAG_11311(PAAG_01584)
PBN: PADG_00190
AJE: HCAG_07493
BGH: BDBG_08713
PNO: SNOG_02535
PTE: PTT_12382
PTRR: 6346767(PtrM4_147410)
BZE: COCCADRAFT_2013
BSC: COCSADRAFT_149090
BOR: COCMIDRAFT_1067
AALT: CC77DRAFT_611878
ADAC: 96081079(ACET3X_000757)
ARAB: EKO05_0004654
ZTR: MYCGRDRAFT_56200
PFJ: MYCFIDRAFT_35210
FFU: CLAFUR5_09838
CBET: CB0940_06626
BCOM: BAUCODRAFT_151081
NPA: UCRNP2_275
TML: GSTUM_00004490001
SPO: 2540344(isn1)
SOM: SOMG_01066(isn1)
RIE: OCT59_009185
PFA: PF3D7_1206100
PFD: PFDG_02232
PFH: PFHG_03990
PREI: PRSY57_1205400
PGAB: PGSY75_1206100
PLAG: 39742773(PADL01_1206500)
PKN: PKNH_1305800
PVX: PVX_084340
PCY: PCYB_131470
PMAL: PMUG01_13016100
PBRS: 92372888(MKS88_004801)
PREL: PRELSG_1304900
PCOT: PCOAH_00006900
TGO: TGME49_222710
BBES: BESB_062570
PTI: PHATRDRAFT_13606
FCY: FRACYDRAFT_263138
TPS: THAPSDRAFT_34077
AAF: AURANDRAFT_18663
PIF: PITG_13347
PSOJ: PHYSODRAFT_502616
BLAC: 94346595(CCR75_002827)
SPAR: SPRG_11168 SPRG_14401
EHX: EMIHUDRAFT_231552 EMIHUDRAFT_455795
GTT: GUITHDRAFT_163029 GUITHDRAFT_89259
 » show all
Reference
1  [PMID:8141771]
  Authors
Itoh R
  Title
Purification and some properties of an IMP-specific 5'-nucleotidase from yeast.
  Journal
Biochem J 298 Pt 3:593-8 (1994)
DOI:10.1042/bj2980593
Reference
2  [PMID:12735798]
  Authors
Itoh R, Saint-Marc C, Chaignepain S, Katahira R, Schmitter JM, Daignan-Fornier B
  Title
The yeast ISN1 (YOR155c) gene encodes a new type of IMP-specific 5'-nucleotidase.
  Journal
BMC Biochem 4:4 (2003)
DOI:10.1186/1471-2091-4-4
  Sequence
[sce:YOR155C]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.99
IUBMB Enzyme Nomenclature: 3.1.3.99
ExPASy - ENZYME nomenclature database: 3.1.3.99
BRENDA, the Enzyme Database: 3.1.3.99
CAS: 9027-73-0
LinkDB

KEGG   REACTION: R01126
Entry
R01126                      Reaction                               
Name
inosine 5'-monophosphate phosphohydrolase
Definition
IMP + H2O <=> Inosine + Orthophosphate
Equation
C00130 + C00001 <=> C00294 + C00009
Reaction class
RC00017  C00130_C00294
Enzyme
3.1.3.5         3.1.3.99        3.1.3.-
Pathway
rn00230  Purine metabolism
rn01100  Metabolic pathways
rn01232  Nucleotide metabolism
Module
M00958  Adenine ribonucleotide degradation, AMP => Urate
Brite
Enzymatic reactions [BR:br08201]
 3. Hydrolase reactions
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.5
     R01126  IMP + H2O <=> Inosine + Orthophosphate
    3.1.3.99
     R01126  IMP + H2O <=> Inosine + Orthophosphate
    3.1.3.-
     R01126  IMP + H2O <=> Inosine + Orthophosphate
IUBMB reaction hierarchy [BR:br08202]
 3. Hydrolase reactions
  3.1.3.5
   R07297  5'-Ribonucleotide <=> Ribonucleoside
    R01126  IMP <=> Inosine
Orthology
K01081  5'-nucleotidase [EC:3.1.3.5]
K02566  5'-nucleotidase [EC:3.1.3.5]
K03787  5'/3'-nucleotidase [EC:3.1.3.5 3.1.3.6]
K08693  2',3'-cyclic-nucleotide 2'-phosphodiesterase / 3'-nucleotidase / 5'-nucleotidase [EC:3.1.4.16 3.1.3.6 3.1.3.5]
K11751  5'-nucleotidase / UDP-sugar diphosphatase [EC:3.1.3.5 3.6.1.45]
K18550  IMP and pyridine-specific 5'-nucleotidase [EC:3.1.3.99 3.1.3.-]
K19970  5'-nucleotidase [EC:3.1.3.5]
K20881  GMP/IMP 5'-nucleotidase [EC:3.1.3.-]
Other DBs
RHEA: 27721
LinkDB

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