KEGG   ORTHOLOGY: K18562
Entry
K18562                      KO                                     
Symbol
thnQ, cmmQ
Name
2-oxoglutarate-dependent dioxygenase [EC:1.14.20.-]
Pathway
map00332  Carbapenem biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R10735  OA-6129-A,2-oxoglutarate:oxygen oxidoreductase (8-hydroxylating)
R13553  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00332 Carbapenem biosynthesis
    K18562  thnQ, cmmQ; 2-oxoglutarate-dependent dioxygenase
Other DBs
COG: COG5285
Genes
NJO: ABXT42_03855
DAG: PSQ19_18825
DRP: PSQ90_01635
DPV: ACE4RL_08025
SPSO: G4G27_23405
STEL: STAQ_05300
PBRU: LZC95_24850
SORG: NQZ70_08937
MTAR: DF168_01250(ectD_7) DF168_01753
AMOB: HG15A2_21170
BGOK: Pr1d_47440(ptlH_2)
TPOL: Mal48_27590
PVAR: SH412_004081
SCHL: QJS52_23730
SSPE: ACGY09_05965
SING: V5E97_08905
MUG: INP83_14890
RCG: N7E81_07850
SFA: Sfla_0152
STRP: F750_6869
SMOB: J7W19_17710
SFIY: F0344_10075
SCT: SCAT_p0836(thnQ)
SCY: SCATT_p08990
KSL: OG809_24400
KRI: OX958_24820
LEPT: JVX88_35125
LEPI: EDM05_038085
TOG: HNI00_15945
DSC: ABOD76_21605
 » show all
Reference
PMID:20017478
  Authors
Bodner MJ, Phelan RM, Freeman MF, Li R, Townsend CA
  Title
Non-heme iron oxygenases generate natural structural diversity in carbapenem antibiotics.
  Journal
J Am Chem Soc 132:12-3 (2010)
DOI:10.1021/ja907320n
Reference
PMID:21263049
  Authors
Rodriguez M, Nunez LE, Brana AF, Mendez C, Salas JA, Blanco G
  Title
Mutational analysis of the thienamycin biosynthetic gene cluster from Streptomyces cattleya.
  Journal
Antimicrob Agents Chemother 55:1638-49 (2011)
DOI:10.1128/AAC.01366-10
  Sequence
[sct:SCAT_p0836]
Reference
PMID:24420617
  Authors
Li R, Lloyd EP, Moshos KA, Townsend CA
  Title
Identification and characterization of the carbapenem MM 4550 and its gene cluster in Streptomyces argenteolus ATCC 11009.
  Journal
Chembiochem 15:320-31 (2014)
DOI:10.1002/cbic.201300319
LinkDB

KEGG   REACTION: R10415
Entry
R10415                      Reaction                               
Name
(3S,5S)-carbapenam-3-carboxylate,2-oxoglutarate:oxygen oxidoreductase (dehydrating)
Definition
(3S,5S)-Carbapenam-3-carboxylic acid + 2-Oxoglutarate + Oxygen <=> (5R)-Carbapen-2-em-3-carboxylate + Succinate + CO2 + H2O
Equation
C17367 + C00026 + C00007 <=> C06669 + C00042 + C00011 + C00001
Reaction class
RC03174  C06669_C17367
Enzyme
1.14.20.3
Pathway
rn00332  Carbapenem biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00675  Carbapenem-3-carboxylate biosynthesis, pyrroline-5-carboxylate + malonyl-CoA => carbapenem-3-carboxylate
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.20  With 2-oxoglutarate as one donor, and the other dehydrogenated
    1.14.20.3
     R10415  (3S,5S)-Carbapenam-3-carboxylic acid + 2-Oxoglutarate + Oxygen <=> (5R)-Carbapen-2-em-3-carboxylate + Succinate + CO2 + H2O
Orthology
K18315  (5R)-carbapenem-3-carboxylate synthase [EC:1.14.20.3]
Other DBs
RHEA: 36614
LinkDB

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