KEGG   ORTHOLOGY: K18562
Entry
K18562                      KO                                     
Symbol
thnQ, cmmQ
Name
2-oxoglutarate-dependent dioxygenase [EC:1.14.20.-]
Pathway
map00332  Carbapenem biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R10415  (3S,5S)-carbapenam-3-carboxylate,2-oxoglutarate:oxygen oxidoreductase (dehydrating)
R10735  OA-6129-A,2-oxoglutarate:oxygen oxidoreductase (8-hydroxylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00332 Carbapenem biosynthesis
    K18562  thnQ, cmmQ; 2-oxoglutarate-dependent dioxygenase
Genes
DAG: PSQ19_18825
DRP: PSQ90_01635
GYJ: AADW23_08005 AADW23_10430
STEL: STAQ_05300
PAUU: E8A73_036665
PSPN: L1F29_23765
SFA: Sfla_0152
STRP: F750_6869
SMOB: J7W19_17710
SFIY: F0344_10075
SCT: SCAT_p0836(thnQ)
SCY: SCATT_p08990
RHAL: LQF10_09425
KSL: OG809_24400
KRI: OX958_24820
LEPT: JVX88_35125
TOG: HNI00_15945
TSIN: OXH18_17685
PUO: RZN69_18375
MTAR: DF168_01250(ectD_7) DF168_01753 DF168_02179(ectD_10)
AMOB: HG15A2_21170
BGOK: Pr1d_47440(ptlH_2)
GFM: Enr17x_01500(ptlH)
GAW: V144x_19550
TPOL: Mal48_27590 Mal48_34080(ptlH_2)
PVAR: SH412_004081
RCG: N7E81_07850
 » show all
Reference
PMID:20017478
  Authors
Bodner MJ, Phelan RM, Freeman MF, Li R, Townsend CA
  Title
Non-heme iron oxygenases generate natural structural diversity in carbapenem antibiotics.
  Journal
J Am Chem Soc 132:12-3 (2010)
DOI:10.1021/ja907320n
Reference
PMID:21263049
  Authors
Rodriguez M, Nunez LE, Brana AF, Mendez C, Salas JA, Blanco G
  Title
Mutational analysis of the thienamycin biosynthetic gene cluster from Streptomyces cattleya.
  Journal
Antimicrob Agents Chemother 55:1638-49 (2011)
DOI:10.1128/AAC.01366-10
  Sequence
[sct:SCAT_p0836]
Reference
PMID:24420617
  Authors
Li R, Lloyd EP, Moshos KA, Townsend CA
  Title
Identification and characterization of the carbapenem MM 4550 and its gene cluster in Streptomyces argenteolus ATCC 11009.
  Journal
Chembiochem 15:320-31 (2014)
DOI:10.1002/cbic.201300319
LinkDB

KEGG   REACTION: R10735
Entry
R10735                      Reaction                               
Name
OA-6129-A,2-oxoglutarate:oxygen oxidoreductase (8-hydroxylating)
Definition
OA-6129 A + 2-Oxoglutarate + Oxygen <=> OA-6129 B2 + Succinate + CO2
Equation
C20813 + C00026 + C00007 <=> C17374 + C00042 + C00011
Comment
proposed pathway
not yet characterized sufficiently
Reaction class
RC01525  C17374_C20813
Enzyme
1.14.20.-
Pathway
rn00332  Carbapenem biosynthesis
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.20  With 2-oxoglutarate as one donor, and the other dehydrogenated
    1.14.20.-
     R10735  OA-6129 A + 2-Oxoglutarate + Oxygen <=> OA-6129 B2 + Succinate + CO2
Orthology
K18562  2-oxoglutarate-dependent dioxygenase [EC:1.14.20.-]
Reference
1  [PMID:24420617]
  Authors
Li R, Lloyd EP, Moshos KA, Townsend CA
  Title
Identification and characterization of the carbapenem MM 4550 and its gene cluster in Streptomyces argenteolus ATCC 11009.
  Journal
Chembiochem 15:320-31 (2014)
DOI:10.1002/cbic.201300319
LinkDB

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