KEGG   ORTHOLOGY: K18566
Entry
K18566                      KO                                     
Symbol
thnF, cmmF
Name
N-acetyltransferase [EC:2.3.1.-]
Pathway
map00332  Carbapenem biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R10745  acetyl-CoA:thienamycin N-acetyltransferase
R10746  acetyl-CoA:deacetyl-MM17880 N-acetyltransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00332 Carbapenem biosynthesis
    K18566  thnF, cmmF; N-acetyltransferase
Other DBs
COG: COG0456
Genes
SFA: Sfla_0163
STRP: F750_6858
SFIY: F0344_10130
SCT: SCAT_p0825(thnF)
SCY: SCATT_p09100
NPI: G7071_08560
Reference
PMID:18678912
  Authors
Freeman MF, Moshos KA, Bodner MJ, Li R, Townsend CA
  Title
Four enzymes define the incorporation of coenzyme A in thienamycin biosynthesis.
  Journal
Proc Natl Acad Sci U S A 105:11128-33 (2008)
DOI:10.1073/pnas.0804500105
  Sequence
[sct:SCAT_p0825]
Reference
PMID:24420617
  Authors
Li R, Lloyd EP, Moshos KA, Townsend CA
  Title
Identification and characterization of the carbapenem MM 4550 and its gene cluster in Streptomyces argenteolus ATCC 11009.
  Journal
Chembiochem 15:320-31 (2014)
DOI:10.1002/cbic.201300319
LinkDB

KEGG   REACTION: R10746
Entry
R10746                      Reaction                               
Name
acetyl-CoA:deacetyl-MM17880 N-acetyltransferase
Definition
Acetyl-CoA + Deacetylepithienamycin F <=> CoA + Epithienamycin F
Equation
C00024 + C20816 <=> C00010 + C17399
Comment
proposed pathway
not yet characterized sufficiently
Reaction class
RC00004  C00010_C00024
RC00096  C17399_C20816
Enzyme
2.3.1.-
Pathway
rn00332  Carbapenem biosynthesis
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.-
     R10746  Acetyl-CoA + Deacetylepithienamycin F <=> CoA + Epithienamycin F
Orthology
K18566  N-acetyltransferase [EC:2.3.1.-]
Reference
1  [PMID:24420617]
  Authors
Li R, Lloyd EP, Moshos KA, Townsend CA
  Title
Identification and characterization of the carbapenem MM 4550 and its gene cluster in Streptomyces argenteolus ATCC 11009.
  Journal
Chembiochem 15:320-31 (2014)
DOI:10.1002/cbic.201300319
LinkDB

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