KEGG   ORTHOLOGY: K18572
Entry
K18572                      KO                                     
Symbol
cmmT, thnT
Name
putative pantetheine hydrolase [EC:3.5.1.-]
Pathway
map00332  Carbapenem biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R10752  OA-6129-C amidohydrolase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00332 Carbapenem biosynthesis
    K18572  cmmT, thnT; putative pantetheine hydrolase
Genes
SVL: Strvi_1091
SRC: M271_19995
SMAL: SMALA_4678
SSOI: I1A49_27460
SFA: Sfla_0149
SBH: SBI_06476
STRP: F750_6873
STRE: GZL_05239
SLD: T261_4855
SLC: SL103_03245
STRC: AA958_12395
SNR: SNOUR_24315
SALU: DC74_3658
SALL: SAZ_19425
SAUO: BV401_27245
SGV: B1H19_17705
SLAU: SLA_0668
SALJ: SMD11_4013
STRO: STRMOE7_16705
SDX: C4B68_09180
SRK: FGW37_13420
SBY: H7H31_12390
SRIM: CP984_23825
SPLA: CP981_16410
SDW: K7C20_15705
SAUH: SU9_013890
SANU: K7396_21145
SINE: KI385_19480
SNIG: HEK616_01090
STUD: STRTU_004160
SENG: OJ254_12085
SANT: QR300_17855
SYUN: MOV08_24490
SOV: QZH56_21390
SFIY: F0344_10060
SHAU: K9S39_26120
STRZ: OYE22_12140
SLUO: PS467_25305
SRPA: HEP86_17395
SCT: SCAT_p0839(thnT)
SCY: SCATT_p08960
ABRY: NYE86_19405
 » show all
Reference
PMID:18678912
  Authors
Freeman MF, Moshos KA, Bodner MJ, Li R, Townsend CA
  Title
Four enzymes define the incorporation of coenzyme A in thienamycin biosynthesis.
  Journal
Proc Natl Acad Sci U S A 105:11128-33 (2008)
DOI:10.1073/pnas.0804500105
  Sequence
[sct:SCAT_p0839]
Reference
PMID:24420617
  Authors
Li R, Lloyd EP, Moshos KA, Townsend CA
  Title
Identification and characterization of the carbapenem MM 4550 and its gene cluster in Streptomyces argenteolus ATCC 11009.
  Journal
Chembiochem 15:320-31 (2014)
DOI:10.1002/cbic.201300319
LinkDB

KEGG   REACTION: R10752
Entry
R10752                      Reaction                               
Name
OA-6129-C amidohydrolase
Definition
OA-6129 C + H2O <=> Deacetylepithienamycin F + Pantothenate
Equation
C20814 + C00001 <=> C20816 + C00864
Comment
proposed pathway
not yet characterized sufficiently
Reaction class
RC00090  C00864_C20814
RC00096  C20814_C20816
Enzyme
3.5.1.-
Pathway
rn00332  Carbapenem biosynthesis
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 3. Hydrolase reactions
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.1  In linear amides
    3.5.1.-
     R10752  OA-6129 C + H2O <=> Deacetylepithienamycin F + Pantothenate
Orthology
K18572  putative pantetheine hydrolase [EC:3.5.1.-]
Reference
1  [PMID:24420617]
  Authors
Li R, Lloyd EP, Moshos KA, Townsend CA
  Title
Identification and characterization of the carbapenem MM 4550 and its gene cluster in Streptomyces argenteolus ATCC 11009.
  Journal
Chembiochem 15:320-31 (2014)
DOI:10.1002/cbic.201300319
LinkDB

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