KEGG   ORTHOLOGY: K18821
Entry
K18821                      KO                                     
Symbol
lipL
Name
lipoyl amidotransferase [EC:2.3.1.200]
Pathway
map00785  Lipoic acid metabolism
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00785 Lipoic acid metabolism
    K18821  lipL; lipoyl amidotransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.200  lipoyl amidotransferase
     K18821  lipL; lipoyl amidotransferase
Other DBs
RN: R12426
COG: COG0095
Genes
ASED: IRT44_02690
NAMP: KPF49_07155
LMO: lmo2566
LMN: LM5578_2761
LMY: LM5923_2710
LMT: LMRG_02703
LMOC: LMOSLCC5850_2570
LMOE: BN418_3034
LMOB: BN419_3048
LMOD: LMON_2581
LMOW: AX10_06905
LMOQ: LM6179_1634(lipL)
LMR: LMR479A_2694(lipL)
LMOM: IJ09_11965
LMOG: BN389_25270(lipL)
LMP: MUO_12810
LMOX: AX24_10790
LMQ: LMM7_2609
LMS: LMLG_2526
LMOK: CQ02_13025
LIN: lin2711
LWE: lwe2516(lplA)
LSG: lse_2473
LIV: LIV_2479
LGZ: NCTC10812_02569(lipL)
 » show all
Reference
  Authors
Christensen QH, Hagar JA, O'Riordan MX, Cronan JE
  Title
A complex lipoate utilization pathway in Listeria monocytogenes.
  Journal
J Biol Chem 286:31447-56 (2011)
DOI:10.1074/jbc.M111.273607
  Sequence
[lmo:lmo2566]
LinkDB

KEGG   ENZYME: 2.3.1.200
Entry
EC 2.3.1.200                Enzyme                                 
Name
lipoyl amidotransferase;
LipL (gene name, ambiguous)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
[glycine cleavage system H]-N6-lipoyl-L-lysine:[lipoyl-carrier protein]-N6-L-lysine lipoyltransferase
Reaction(IUBMB)
[glycine cleavage system H]-N6-lipoyl-L-lysine + a [lipoyl-carrier protein] = glycine cleavage system H + a [lipoyl-carrier protein]-N6-lipoyl-L-lysine [RN:R12426]
Reaction(KEGG)
R12426
Substrate
[glycine cleavage system H]-N6-lipoyl-L-lysine [CPD:C02051];
[lipoyl-carrier protein]
Product
glycine cleavage system H [CPD:C22157];
[lipoyl-carrier protein]-N6-lipoyl-L-lysine
Comment
In the bacterium Listeria monocytogenes the enzyme takes part in a pathway for scavenging of lipoic acid. The enzyme is bound to 2-oxo-acid dehydrogenases such as the pyruvate dehydrogenase complex, where it transfers the lipoyl moiety from lipoyl-[glycine cleavage system H] to the E2 subunits of the complexes.
History
EC 2.3.1.200 created 2012
Pathway
ec00785  Lipoic acid metabolism
ec01100  Metabolic pathways
Orthology
K18821  lipoyl amidotransferase
Genes
ASEDIRT44_02690
NAMPKPF49_07155
LMOlmo2566
LMNLM5578_2761
LMYLM5923_2710
LMTLMRG_02703
LMOCLMOSLCC5850_2570
LMOEBN418_3034
LMOBBN419_3048
LMODLMON_2581
LMOWAX10_06905
LMOQLM6179_1634(lipL)
LMRLMR479A_2694(lipL)
LMOMIJ09_11965
LMFLMOf2365_2538
LMCLm4b_02534
LMOGBN389_25270(lipL)
LMPMUO_12810
LMOLLMOL312_2525
LMOJLM220_21230
LMOZLM1816_15977
LMOXAX24_10790
LMHLMHCC_0030
LMQLMM7_2609
LMLlmo4a_2567
LMGLMKG_02947
LMSLMLG_2526
LMJLMOG_03020
LMWLMOSLCC2755_2572
LMXLMOSLCC2372_2630
LMZLMOSLCC2482_2571
LMONLMOSLCC2376_2459
LMOSLMOSLCC7179_2478
LMOOLMOSLCC2378_2569
LMOYLMOSLCC2479_2629
LMOTLMOSLCC2540_2600
LMOALMOATCC19117_2575
LMOKCQ02_13025
LMVY193_02875
LINlin2711
LWElwe2516(lplA)
LSGlse_2473
LIVLIV_2479
LIIJL52_13060
LIWAX25_13260
LIAJL58_13260
LIOJL53_13745
LWIUE46_02270
LGZNCTC10812_02569(lipL)
LMARLAX80_012420
 » show all
Reference
1  [PMID:21768091]
  Authors
Christensen QH, Hagar JA, O'Riordan MX, Cronan JE
  Title
A complex lipoate utilization pathway in Listeria monocytogenes.
  Journal
J Biol Chem 286:31447-56 (2011)
DOI:10.1074/jbc.M111.273607
  Sequence
[lmo:lmo2566]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.200
IUBMB Enzyme Nomenclature: 2.3.1.200
ExPASy - ENZYME nomenclature database: 2.3.1.200
BRENDA, the Enzyme Database: 2.3.1.200
LinkDB

KEGG   REACTION: R12426
Entry
R12426                      Reaction                               
Name
[glycine cleavage system H]-N6-lipoyl-L-lysine:[lipoyl-carrier protein]-L-lysine lipoyltransferase
Definition
Lipoylprotein + Lipoyl-carrier protein E2 <=> Glycine cleavage system H + Enzyme N6-(lipoyl)lysine
Equation
Enzyme
Pathway
rn00785  Lipoic acid metabolism
rn01100  Metabolic pathways
Orthology
K18821  lipoyl amidotransferase [EC:2.3.1.200]
LinkDB

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