KEGG   ORTHOLOGY: K18884
Entry
K18884                      KO                                     
Symbol
FGAMT
Name
4-dimethylallyltryptophan N-methyltransferase [EC:2.1.1.261]
Pathway
map00901  Indole alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00963  Chanoclavine aldehyde biosynthesis, tryptophan => chanoclavine-I aldehyde
Reaction
R10166  S-adenosyl-L-methionine:4-(3-methylbut-2-enyl)-L-tryptophan N-methyltransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00901 Indole alkaloid biosynthesis
    K18884  FGAMT; 4-dimethylallyltryptophan N-methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.261  4-dimethylallyltryptophan N-methyltransferase
     K18884  FGAMT; 4-dimethylallyltryptophan N-methyltransferase
Genes
HRJ: 124279223
FPOA: FPOAC1_004563
FVN: FVRRES_05060
FKR: NCS57_00387600
FMU: J7337_008472
MAW: 19251298(J3458_016179)
MAJ: MAA_06738
MBRN: 26246263(easF)
AMUS: LMH87_011355
PLJ: 28891802(PLICBS_004034)
PTKZ: JDV02_003061(EGT1_1)
GLZ: GLAREA_05928
AFM: AFUA_2G18060
ABE: ARB_04647
TVE: TRV_01861
AG: ACI43096(fgaMT)
 » show all
Reference
PMID:18678866
  Authors
Rigbers O, Li SM
  Title
Ergot alkaloid biosynthesis in Aspergillus fumigatus. Overproduction and biochemical characterization of a 4-dimethylallyltryptophan N-methyltransferase.
  Journal
J Biol Chem 283:26859-68 (2008)
DOI:10.1074/jbc.M804979200
  Sequence
[ag:ACI43096]
LinkDB

KEGG   ENZYME: 2.1.1.261
Entry
EC 2.1.1.261                Enzyme                                 
Name
4-dimethylallyltryptophan N-methyltransferase;
fgaMT (gene name);
easF (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:4-(3-methylbut-2-enyl)-L-tryptophan N-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 4-prenyl-L-tryptophan = S-adenosyl-L-homocysteine + 4-prenyl-L-abrine [RN:R10166]
Reaction(KEGG)
R10166
Substrate
S-adenosyl-L-methionine [CPD:C00019];
4-prenyl-L-tryptophan [CPD:C04290]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
4-prenyl-L-abrine [CPD:C20410]
Comment
The enzyme catalyses a step in the pathway leading to biosynthesis of ergot alkaloids in certain fungi.
History
EC 2.1.1.261 created 2012
Pathway
ec00901  Indole alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K18884  4-dimethylallyltryptophan N-methyltransferase
Genes
HRJ: 124279223
FPOA: FPOAC1_004563
FVN: FVRRES_05060
FKR: NCS57_00387600
FMU: J7337_008472
MAW: 19251298(J3458_016179)
MAJ: MAA_06738
MBRN: 26246263(easF)
AMUS: LMH87_011355
PLJ: 28891802(PLICBS_004034)
PTKZ: JDV02_003061(EGT1_1)
GLZ: GLAREA_05928
AFM: AFUA_2G18060
ABE: ARB_04647
TVE: TRV_01861
 » show all
Reference
1  [PMID:18678866]
  Authors
Rigbers O, Li SM
  Title
Ergot alkaloid biosynthesis in Aspergillus fumigatus. Overproduction and biochemical characterization of a 4-dimethylallyltryptophan N-methyltransferase.
  Journal
J Biol Chem 283:26859-68 (2008)
DOI:10.1074/jbc.M804979200
  Sequence
[ag:ACI43096]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.261
IUBMB Enzyme Nomenclature: 2.1.1.261
ExPASy - ENZYME nomenclature database: 2.1.1.261
BRENDA, the Enzyme Database: 2.1.1.261
LinkDB

KEGG   REACTION: R10166
Entry
R10166                      Reaction                               
Name
S-adenosyl-L-methionine:4-(3-methylbut-2-enyl)-L-tryptophan N-methyltransferase
Definition
4-(3-Methylbut-2-enyl)-L-tryptophan + S-Adenosyl-L-methionine <=> 4-Dimethylallyl-L-abrine + S-Adenosyl-L-homocysteine
Equation
C04290 + C00019 <=> C20410 + C00021
Reaction class
RC00003  C00019_C00021
RC00190  C04290_C20410
Enzyme
2.1.1.261
Pathway
rn00901  Indole alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00963  Chanoclavine aldehyde biosynthesis, tryptophan => chanoclavine-I aldehyde
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.261
     R10166  4-(3-Methylbut-2-enyl)-L-tryptophan + S-Adenosyl-L-methionine <=> 4-Dimethylallyl-L-abrine + S-Adenosyl-L-homocysteine
Orthology
K18884  4-dimethylallyltryptophan N-methyltransferase [EC:2.1.1.261]
Other DBs
RHEA: 34438
LinkDB

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