KEGG ORTHOLOGY: K18978

ORTHOLOGY: K18978

Entry

K18978                      KO

Symbol

gapN

Name

glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+] [EC:1.2.1.90]

Pathway

map00010

Glycolysis / Gluconeogenesis

map00030

Pentose phosphate pathway

map01100

Metabolic pathways

map01120

Microbial metabolism in diverse environments

map01200

Carbon metabolism

Module

M00308

Semi-phosphorylative Entner-Doudoroff pathway, gluconate => glycerate-3P

M00633

Semi-phosphorylative Entner-Doudoroff pathway, gluconate/galactonate => glycerate-3P

Reaction

R01058

D-glyceraldehyde 3-phosphate:NADP+ oxidoreductase

R10860

D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    K18978  gapN; glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+]
   00030 Pentose phosphate pathway
    K18978  gapN; glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+]
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.90  glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+]
     K18978  gapN; glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+]

Other DBs

COG:

COG1012

Genes

TAQU:

PFU:

PFI:

TKO:

TSI:

TLT:

TNU:

THV:	ADU37_CDS19860

TCE:	A3L02_05455

TTD:	A3L14_07265

THEM:

FPV09_07270

THEI:

K1720_01165

PPAC:

PAP_03390

HAL:	VNG_0937G(gap)

HSL:	OE_2367F(aldH3)

HANR:

HHB:

HAGS:

HABO:

HNO:	LT974_05480 LT974_09800

HLU:	LT972_07680

HANX:

ABSL23_10580

HDO:	MUK72_07355

HALX:

HAXZ:

HAYC:

HAXY:

HALI:

HSN:	DV733_08500

HAAD:

MW046_08360 MW046_16535

NMO:	Nmlp_1397(aldH2)

HRA:	EI982_02835

HALB:

EKH57_03600

HAE:	halTADL_1775

HTU:

HSAL:

HAKZ:

NMG:

NAT:

NPE:	Natpe_2432

NVR:	FEJ81_11090

NPL:	FGF80_11110

NAY:	HYG81_14030

HALY:

HYG82_00810

HJT:	DVR14_02090

HLO:	J0X27_15795

HLR:	HALLA_11300

NAJ:	B1756_06275

NAG:	AArcMg_1817

NAN:	AArc1_1866

NARA:

QQ977_10575

NBG:	DV706_13160

NAS:	GCU68_13885

HDA:	BB347_04210

APE:	APE_1786.1(gapN)

ACJ:	ACAM_1119(gapN)

SMR:

Smar_0084

SHC:	Shell_0726

DKA:

DKAM_1444

DFD:	Desfe_0067

DMU:	Desmu_1044

TAG:

Tagg_1262

TCS:	IMZ38_01220

IAG:

Igag_1780

THG:	TCELL_0871

STO:	STK_24770(gapN)

SOH:	D1869_13560

SJV:	SJAV_08420(gapN)

SSO:	SSO3194(gapN-3)

SOL:

SSOA:

SSOL:

SSOF:

SSHI:

SCAS:

SIS:	LS215_2328

SIA:	M1425_2165

SIM:	M1627_2245

SID:

M164_2168

SIY:	YG5714_2291

SIN:	YN1551_0624

SII:

SIH:

SIR:

SIC:

SULA:

SULE:

SAI:

SACN:

SACR:

SACS:

SULO:

SULL:

MSE:

MEMJ:

MCN:

MHK:	DFR87_12305

MPRU:

DFR88_11830

MTEN:

GWK48_00435

MJN:	MjAS7_2365

ABRI:

SACD:

SAZO:

CSTY:

STEP:

SMET:

RQ359_002109(gapN)

SAHS:

PAS:

POG:

CMA:

TTN:	TTX_1169(gapN)

TUZ:

TUZN_1133

VDI:

Vdis_2334

VMO:

VMUT_0605

VSO:	Vsou_22700

THF:	MA03_02735

ASC:

ASAC_1423

ACIA:

SE86_04065

CLG:	Calag_1262

FFO:	FFONT_0138

CSU:	CSUB_C0048

NAA:

Nps_02395

NAER:

MJ1_0538

AG:	CAA71651(gapN)

» show all

Reference

PMID:9497334

Authors

Brunner NA, Brinkmann H, Siebers B, Hensel R

Title

NAD+-dependent glyceraldehyde-3-phosphate dehydrogenase from Thermoproteus tenax. The first identified archaeal member of the aldehyde dehydrogenase superfamily is a glycolytic enzyme with unusual regulatory properties.

Journal

J Biol Chem 273:6149-56 (1998)
DOI:10.1074/jbc.273.11.6149

Sequence

[ag:CAA71651]

LinkDB

ENZYME: 1.2.1.90

Entry

EC 1.2.1.90                 Enzyme

Name

glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+];
non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (ambiguous);
GAPN

Class

Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor

Sysname

D-glyceraldehyde-3-phosphate:NAD(P)+ oxidoreductase

Reaction(IUBMB)

D-glyceraldehyde 3-phosphate + NAD(P)+ + H2O = 3-phospho-D-glycerate + NAD(P)H + 2 H+ [RN:R01058 R10860]

Reaction(KEGG)

R01058 R10860

Substrate

D-glyceraldehyde 3-phosphate [CPD:C00118];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
H2O [CPD:C00001]

Product

3-phospho-D-glycerate [CPD:C00197];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

The enzyme is part of the modified Embden-Meyerhof-Parnas pathway of the archaeon Thermoproteus tenax. cf. EC 1.2.1.9 [glyceraldehyde-3-phosphate dehydrogenase (NADP+)].

History

EC 1.2.1.90 created 2014

Pathway

ec00010

Glycolysis / Gluconeogenesis

ec00030

Pentose phosphate pathway

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K18978

glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+]

Genes

TAQU:

KDW03_05525

PFU:

PF0755

PFI:

PFC_02935

TKO:

TK0705

TSI:

TSIB_1868

TLT:

OCC_12546

TNU:

BD01_0877

THV:	ADU37_CDS19860

TCE:	A3L02_05455

TTD:	A3L14_07265

THEM:

FPV09_07270

THEI:

K1720_01165

PPAC:

PAP_03390

HAL:	VNG_0937G(gap)

HSL:	OE_2367F(aldH3)

HANR:

LJ422_03815

HHB:

Hhub_2122

HAGS:

JT689_05100

HABO:

JRZ79_03600

HNO:	LT974_05480 LT974_09800

HLU:	LT972_07680

HANX:

ABSL23_10580

HDO:	MUK72_07355

HALX:

M0R89_14390

HAXZ:

M0R88_14805

HAYC:

NGM10_01350

HAXY:

NGM07_02135

HALI:

BV210_12380

HSN:	DV733_08500

HAAD:

MW046_08360 MW046_16535

NMO:	Nmlp_1397(aldH2)

HRA:	EI982_02835

HALB:

EKH57_03600

HAE:	halTADL_1775

HTU:

Htur_1629

HSAL:

JMJ58_00455

HAKZ:

J0X25_14945

NMG:

Nmag_3488

NAT:

NJ7G_3347

NPE:	Natpe_2432

NVR:	FEJ81_11090

NPL:	FGF80_11110

NAY:	HYG81_14030

HALY:

HYG82_00810

HJT:	DVR14_02090

HLO:	J0X27_15795

HLR:	HALLA_11300

NAJ:	B1756_06275

NAG:	AArcMg_1817

NAN:	AArc1_1866

NARA:

QQ977_10575

NBG:	DV706_13160

NAS:	GCU68_13885

HDA:	BB347_04210

APE:	APE_1786.1(gapN)

ACJ:	ACAM_1119(gapN)

SMR:

Smar_0084

SHC:	Shell_0726

DKA:

DKAM_1444

DFD:	Desfe_0067

DMU:	Desmu_1044

TAG:

Tagg_1262

TCS:	IMZ38_01220

IAG:

Igag_1780

THG:	TCELL_0871

STO:	STK_24770(gapN)

SOH:	D1869_13560

SJV:	SJAV_08420(gapN)

SSO:	SSO3194(gapN-3)

SOL:

Ssol_0932

SSOA:

SULA_0965

SSOL:

SULB_0967

SSOF:

SULC_0966

SSHI:

J5U23_00303

SCAS:

SACC_31300

SIS:	LS215_2328

SIA:	M1425_2165

SIM:	M1627_2245

SID:

M164_2168

SIY:	YG5714_2291

SIN:	YN1551_0624

SII:

LD85_2431

SIH:

SiH_2110

SIR:

SiRe_2042

SIC:

SiL_2017

SULA:

BFU36_06100

SULE:

GFS03_11790

SAI:

Saci_0227

SACN:

SacN8_01100

SACR:

SacRon12I_01100

SACS:

SUSAZ_01140

SULO:

GFS33_03600

SULL:

EWF20_14560

MSE:

Msed_1298

MEMJ:

MJ1HA_1505

MCN:

Mcup_0943

MHK:	DFR87_12305

MPRU:

DFR88_11830

MTEN:

GWK48_00435

MJN:	MjAS7_2365

ABRI:

DFR85_14750

SACD:

HS1genome_1558

SAZO:

D1868_10855

CSTY:

KN1_14760

STEP:

IC006_2129

SMET:

RQ359_002109(gapN)

SAHS:

HS7_04650

PAS:

Pars_0554

POG:

Pogu_1837

CMA:

Cmaq_0979

TTN:	TTX_1169(gapN)

TUZ:

TUZN_1133

VDI:

Vdis_2334

VMO:

VMUT_0605

VSO:	Vsou_22700

THF:	MA03_02735

ASC:

ASAC_1423

ACIA:

SE86_04065

CLG:	Calag_1262

FFO:	FFONT_0138

CSU:	CSUB_C0048

NAA:

Nps_02395

NAER:

MJ1_0538

» show all

Reference

1 [PMID:9497334]

Authors

Brunner NA, Brinkmann H, Siebers B, Hensel R

Title

Journal

J Biol Chem 273:6149-56 (1998)
DOI:10.1074/jbc.273.11.6149

Sequence

[ag:CAA71651]

Reference

2 [PMID:11354453]

Authors

Brunner NA, Siebers B, Hensel R

Title

Role of two different glyceraldehyde-3-phosphate dehydrogenases in controlling the reversible Embden-Meyerhof-Parnas pathway in Thermoproteus tenax: regulation on protein and transcript level.

Journal

Extremophiles 5:101-9 (2001)
DOI:10.1007/s007920100181

Sequence

[ag:CAA71651]

Reference

3 [PMID:11842090]

Authors

Pohl E, Brunner N, Wilmanns M, Hensel R

Title

The crystal structure of the allosteric non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase from the hyperthermophilic archaeum Thermoproteus tenax.

Journal

J Biol Chem 277:19938-45 (2002)
DOI:10.1074/jbc.M112244200

Sequence

[ag:CAA71651]

Reference

4 [PMID:15288789]

Authors

Lorentzen E, Hensel R, Knura T, Ahmed H, Pohl E

Title

Structural Basis of allosteric regulation and substrate specificity of the non-phosphorylating glyceraldehyde 3-Phosphate dehydrogenase from Thermoproteus tenax.

Journal

J Mol Biol 341:815-28 (2004)
DOI:10.1016/j.jmb.2004.05.032

Sequence

[ag:CAA71651]

Other DBs

ExplorEnz - The Enzyme Database:

1.2.1.90

IUBMB Enzyme Nomenclature:

1.2.1.90

ExPASy - ENZYME nomenclature database:

1.2.1.90

BRENDA, the Enzyme Database:

1.2.1.90

LinkDB

REACTION: R01058

Entry

R01058                      Reaction

Name

D-glyceraldehyde 3-phosphate:NADP+ oxidoreductase

Definition

D-Glyceraldehyde 3-phosphate + NADP+ + H2O <=> 3-Phospho-D-glycerate + NADPH + H+

Equation

C00118 + C00006 + C00001 <=> C00197 + C00005 + C00080

Reaction class

RC00001

C00005_C00006

RC00242

C00118_C00197

Enzyme

1.2.1.9 1.2.1.90

Pathway

rn00010

Glycolysis / Gluconeogenesis

rn00030

Pentose phosphate pathway

rn01100

Metabolic pathways

rn01120

Microbial metabolism in diverse environments

rn01200

Carbon metabolism

Module

M00308

Semi-phosphorylative Entner-Doudoroff pathway, gluconate => glycerate-3P

M00633

Semi-phosphorylative Entner-Doudoroff pathway, gluconate/galactonate => glycerate-3P

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.9
     R01058  D-Glyceraldehyde 3-phosphate + NADP+ + H2O <=> 3-Phospho-D-glycerate + NADPH + H+
    1.2.1.90
     R01058  D-Glyceraldehyde 3-phosphate + NADP+ + H2O <=> 3-Phospho-D-glycerate + NADPH + H+

Orthology

K00131

glyceraldehyde-3-phosphate dehydrogenase (NADP+) [EC:1.2.1.9]

K18978

glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+] [EC:1.2.1.90]

Other DBs

RHEA:

14672

LinkDB

REACTION: R10860

Entry

R10860                      Reaction

Name

D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase

Definition

D-Glyceraldehyde 3-phosphate + NAD+ + H2O <=> 3-Phospho-D-glycerate + NADH + H+

Equation

C00118 + C00003 + C00001 <=> C00197 + C00004 + C00080

Reaction class

RC00001

C00003_C00004

RC00242

C00118_C00197

Enzyme

1.2.1.90

Pathway

rn00010

Glycolysis / Gluconeogenesis

rn00030

Pentose phosphate pathway

rn01100

Metabolic pathways

rn01120

Microbial metabolism in diverse environments

rn01200

Carbon metabolism

Module

M00308

Semi-phosphorylative Entner-Doudoroff pathway, gluconate => glycerate-3P

M00633

Semi-phosphorylative Entner-Doudoroff pathway, gluconate/galactonate => glycerate-3P

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.90
     R10860  D-Glyceraldehyde 3-phosphate + NAD+ + H2O <=> 3-Phospho-D-glycerate + NADH + H+

Orthology

K18978

glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+] [EC:1.2.1.90]

Other DBs

RHEA:

42763

LinkDB

DBGET integrated database retrieval system