KEGG   ORTHOLOGY: K19546
Entry
K19546                      KO                                     
Symbol
bacA
Name
prephenate decarboxylase [EC:4.1.1.100]
Pathway
map00998  Biosynthesis of various antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00787  Bacilysin biosynthesis, prephenate => bacilysin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00998 Biosynthesis of various antibiotics
    K19546  bacA; prephenate decarboxylase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.100  prephenate decarboxylase
     K19546  bacA; prephenate decarboxylase
Other DBs
RN: R10934
COG: COG0077
Genes
BSU: BSU37740(bacA)
BSR: I33_3922
BSL: A7A1_0193
BSH: BSU6051_37740(bacA)
BSY: I653_18515
BSUT: BSUB_04010(bacA)
BSUL: BSUA_04010(bacA)
BSUS: Q433_20785
BSO: BSNT_10432
BSN: BSn5_09860
BSQ: B657_37740(bacA)
BSX: C663_3679(bacA)
BSS: BSUW23_18640(bacA)
BST: GYO_4160
BAQ: BACAU_3522(bacA)
BYA: BANAU_3675(bacA)
BAMP: B938_17925(bacA)
BQY: MUS_4152(bacA)
BAML: BAM5036_3423(bacA)
BAMA: RBAU_3631(bacA)
BAMN: BASU_3407(bacA)
BAMB: BAPNAU_3689(bacA)
BAMT: AJ82_19710
BAMY: V529_37650(bacA)
BAO: BAMF_3607(bacA)
BAZ: BAMTA208_19100(bacA)
BQL: LL3_03918(bacA)
BXH: BAXH7_03910(bacA)
BAMI: KSO_001595
BAMC: U471_36380
BAMF: U722_18660
BMOJ: HC660_36820(bacA)
BTEQ: G4P54_19460(bacA)
BPU: BPUM_3420
BPUM: BW16_18160
BPUS: UP12_17605
BJS: MY9_3866
BACW: QR42_17160
BACP: SB24_11230
BACB: OY17_01130
BACY: QF06_17310
BACL: BS34A_40920(bacA)
BALM: BsLM_3804
 » show all
Reference
  Authors
Mahlstedt SA, Walsh CT
  Title
Investigation of anticapsin biosynthesis reveals a four-enzyme pathway to tetrahydrotyrosine in Bacillus subtilis.
  Journal
Biochemistry 49:912-23 (2010)
DOI:10.1021/bi9021186
  Sequence
[bsu:BSU37740]
Reference
  Authors
Ozcengiz G, Ogulur I
  Title
Biochemistry, genetics and regulation of bacilysin biosynthesis and its significance more than an antibiotic.
  Journal
N Biotechnol 32:612-9 (2015)
DOI:10.1016/j.nbt.2015.01.006
LinkDB

KEGG   ENZYME: 4.1.1.100
Entry
EC 4.1.1.100                Enzyme                                 
Name
prephenate decarboxylase;
BacA;
AerD;
SalX;
non-aromatizing prephenate decarboxylase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
prephenate carboxy-lyase (3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate-forming)
Reaction(IUBMB)
prephenate = 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate + CO2 [RN:R10934]
Reaction(KEGG)
R10934
Substrate
prephenate [CPD:C00254]
Product
3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate [CPD:C20953];
CO2 [CPD:C00011]
Comment
The enzyme, characterized from the bacterium Bacillus subtilis, is involved in the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. The enzyme isomerizes only the pro-R double bond in prephenate.
History
EC 4.1.1.100 created 2015
Pathway
ec00998  Biosynthesis of various antibiotics
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K19546  prephenate decarboxylase
Genes
BSUBSU37740(bacA)
BSRI33_3922
BSLA7A1_0193
BSHBSU6051_37740(bacA)
BSYI653_18515
BSUTBSUB_04010(bacA)
BSULBSUA_04010(bacA)
BSUSQ433_20785
BSOBSNT_10432
BSNBSn5_09860
BSQB657_37740(bacA)
BSXC663_3679(bacA)
BSPU712_19020
BSSBSUW23_18640(bacA)
BSTGYO_4160
BAYRBAM_034930
BAQBACAU_3522(bacA)
BYABANAU_3675(bacA)
BAMPB938_17925(bacA)
BQYMUS_4152(bacA)
BAMLBAM5036_3423(bacA)
BAMARBAU_3631(bacA)
BAMNBASU_3407(bacA)
BAMBBAPNAU_3689(bacA)
BAMTAJ82_19710
BAMYV529_37650(bacA)
BMPNG74_03668
BAOBAMF_3607(bacA)
BAZBAMTA208_19100(bacA)
BQLLL3_03918(bacA)
BXHBAXH7_03910(bacA)
BAMIKSO_001595
BAMCU471_36380
BAMFU722_18660
BSIACWD84_01660
BVMB9C48_17875
BHTDIC78_12105
BMOJHC660_36820(bacA)
BTEQG4P54_19460(bacA)
BIQAN935_19115
BPUBPUM_3420
BPUMBW16_18160
BPUSUP12_17605
BJSMY9_3866
BACWQR42_17160
BACPSB24_11230
BACBOY17_01130
BACYQF06_17310
BACLBS34A_40920(bacA)
BALMBsLM_3804
BALTCFN77_18065
BACSAUL54_12230
BSAFBSL056_18705
BITBIS30_08585
BGIBGM20_13130
BMURABE28_019115
PSOPKP014_17420
SPHVF9278_21515
SCOECP976_00065
AFLOHEQ12_06185
 » show all
Reference
1  [PMID:20052993]
  Authors
Mahlstedt SA, Walsh CT
  Title
Investigation of anticapsin biosynthesis reveals a four-enzyme pathway to tetrahydrotyrosine in Bacillus subtilis.
  Journal
Biochemistry 49:912-23 (2010)
DOI:10.1021/bi9021186
Reference
2  [PMID:20863139]
  Authors
Mahlstedt S, Fielding EN, Moore BS, Walsh CT
  Title
Prephenate decarboxylases: a new prephenate-utilizing enzyme family that performs nonaromatizing decarboxylation en route to diverse secondary metabolites.
  Journal
Biochemistry 49:9021-3 (2010)
DOI:10.1021/bi101457h
Reference
3  [PMID:22483065]
  Authors
Parker JB, Walsh CT
  Title
Olefin isomerization regiochemistries during tandem action of BacA and BacB on prephenate in bacilysin biosynthesis.
  Journal
Biochemistry 51:3241-51 (2012)
DOI:10.1021/bi300254u
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.100
IUBMB Enzyme Nomenclature: 4.1.1.100
ExPASy - ENZYME nomenclature database: 4.1.1.100
BRENDA, the Enzyme Database: 4.1.1.100
LinkDB

KEGG   REACTION: R10934
Entry
R10934                      Reaction                               
Name
prephenate carboxy-lyase (3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate-forming)
Definition
Prephenate <=> 3-[(4R)-4-Hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate + CO2
Equation
Reaction class
RC03316  C00254_C20953
Enzyme
Pathway
rn00998  Biosynthesis of various antibiotics
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00787  Bacilysin biosynthesis, prephenate => bacilysin
Orthology
K19546  prephenate decarboxylase [EC:4.1.1.100]
Other DBs
RHEA: 33502
LinkDB

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