KEGG   ORTHOLOGY: K19546
Entry
K19546                      KO                                     
Symbol
bacA
Name
prephenate decarboxylase [EC:4.1.1.100]
Pathway
map00998  Biosynthesis of various antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00787  Bacilysin biosynthesis, prephenate => bacilysin
Reaction
R10934  prephenate carboxy-lyase (3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00998 Biosynthesis of various antibiotics
    K19546  bacA; prephenate decarboxylase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.100  prephenate decarboxylase
     K19546  bacA; prephenate decarboxylase
Other DBs
COG: COG0077
Genes
DAQ: DAQ1742_03406(bacA)
DIC: Dpoa569_001039
DLC: O1Q98_16235
LPA: lpa_03409
BSU: BSU37740(bacA)
BSR: I33_3922
BSL: A7A1_0193
BSH: BSU6051_37740(bacA)
BSY: I653_18515
BSUT: BSUB_04010(bacA)
BSUL: BSUA_04010(bacA)
BSUS: Q433_20785
BSO: BSNT_10432
BSN: BSn5_09860
BSQ: B657_37740(bacA)
BSX: C663_3679(bacA)
BSP: U712_19020
BSS: BSUW23_18640(bacA)
BST: GYO_4160
BIT: BIS30_08585
BAY: RBAM_034930
BAQ: BACAU_3522(bacA)
BYA: BANAU_3675(bacA)
BAMP: B938_17925(bacA)
BQY: MUS_4152(bacA)
BAML: BAM5036_3423(bacA)
BAMA: RBAU_3631(bacA)
BAMN: BASU_3407(bacA)
BAMB: BAPNAU_3689(bacA)
BAMT: AJ82_19710
BAMY: V529_37650(bacA)
BMP: NG74_03668
BAO: BAMF_3607(bacA)
BAZ: BAMTA208_19100(bacA)
BQL: LL3_03918(bacA)
BXH: BAXH7_03910(bacA)
BAMI: KSO_001595
BAMC: U471_36380
BAMF: U722_18660
BSIA: CWD84_01660
BVM: B9C48_17875
BHT: DIC78_12105
BMOJ: HC660_36820(bacA)
BTEQ: G4P54_19460(bacA)
BIQ: AN935_19115
BSTR: QI003_22375(bacA)
BPU: BPUM_3420
BPUM: BW16_18160
BPUS: UP12_17605
BALT: CFN77_18065
BAER: BAE_05965
BSAF: BSL056_18705
BCAB: EFK13_19430(bacA)
BRY: M0696_19180(bacA)
BJS: MY9_3866
BACW: QR42_17160
BACP: SB24_11230
BACB: OY17_01130
BACY: QF06_17310
BACL: BS34A_40920(bacA)
BALM: BsLM_3804
BACS: AUL54_12230
BZH: NF868_15795
BAEI: RE735_02185
BGI: BGM20_13130
BMUR: ABE28_019115
PSOP: KP014_17420
STRM: M444_35590
SPHV: F9278_21515
SCOE: CP976_00065
SDEC: L3078_20880
SXT: KPP03845_106161(bacA)
SGK: PET44_33055
LEPT: JVX88_12410
MAR: MAE_56560
MPK: VL20_295
MVZ: myaer102_28820
PAGH: NIES204_06210(aerD)
PPSU: NO713_02126(aerD)
PRUN: PCC7821_03672(aerD)
MPRO: BJP34_16215
HBQ: QI031_25715
NSP: BMF81_03788(bacA_2)
NSPH: BDGGKGIB_04044(suoD)
AFLO: HEQ12_06185
SCYS: NIES4073_42240
 » show all
Reference
PMID:20052993
  Authors
Mahlstedt SA, Walsh CT
  Title
Investigation of anticapsin biosynthesis reveals a four-enzyme pathway to tetrahydrotyrosine in Bacillus subtilis.
  Journal
Biochemistry 49:912-23 (2010)
DOI:10.1021/bi9021186
  Sequence
[bsu:BSU37740]
Reference
PMID:25644640
  Authors
Ozcengiz G, Ogulur I
  Title
Biochemistry, genetics and regulation of bacilysin biosynthesis and its significance more than an antibiotic.
  Journal
N Biotechnol 32:612-9 (2015)
DOI:10.1016/j.nbt.2015.01.006
LinkDB

KEGG   ENZYME: 4.1.1.100
Entry
EC 4.1.1.100                Enzyme                                 
Name
prephenate decarboxylase;
BacA;
AerD;
SalX;
non-aromatizing prephenate decarboxylase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
prephenate carboxy-lyase (3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate-forming)
Reaction(IUBMB)
prephenate = 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate + CO2 [RN:R10934]
Reaction(KEGG)
R10934
Substrate
prephenate [CPD:C00254]
Product
3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate [CPD:C20953];
CO2 [CPD:C00011]
Comment
The enzyme, characterized from the bacterium Bacillus subtilis, is involved in the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. The enzyme isomerizes only the pro-R double bond in prephenate.
History
EC 4.1.1.100 created 2015
Pathway
ec00998  Biosynthesis of various antibiotics
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K19546  prephenate decarboxylase
Genes
DAQ: DAQ1742_03406(bacA)
DIC: Dpoa569_001039
DLC: O1Q98_16235
LPA: lpa_03409
BSU: BSU37740(bacA)
BSR: I33_3922
BSL: A7A1_0193
BSH: BSU6051_37740(bacA)
BSY: I653_18515
BSUT: BSUB_04010(bacA)
BSUL: BSUA_04010(bacA)
BSUS: Q433_20785
BSO: BSNT_10432
BSN: BSn5_09860
BSQ: B657_37740(bacA)
BSX: C663_3679(bacA)
BSP: U712_19020
BSS: BSUW23_18640(bacA)
BST: GYO_4160
BIT: BIS30_08585
BAY: RBAM_034930
BAQ: BACAU_3522(bacA)
BYA: BANAU_3675(bacA)
BAMP: B938_17925(bacA)
BQY: MUS_4152(bacA)
BAML: BAM5036_3423(bacA)
BAMA: RBAU_3631(bacA)
BAMN: BASU_3407(bacA)
BAMB: BAPNAU_3689(bacA)
BAMT: AJ82_19710
BAMY: V529_37650(bacA)
BMP: NG74_03668
BAO: BAMF_3607(bacA)
BAZ: BAMTA208_19100(bacA)
BQL: LL3_03918(bacA)
BXH: BAXH7_03910(bacA)
BAMI: KSO_001595
BAMC: U471_36380
BAMF: U722_18660
BSIA: CWD84_01660
BVM: B9C48_17875
BHT: DIC78_12105
BMOJ: HC660_36820(bacA)
BTEQ: G4P54_19460(bacA)
BIQ: AN935_19115
BSTR: QI003_22375(bacA)
BPU: BPUM_3420
BPUM: BW16_18160
BPUS: UP12_17605
BALT: CFN77_18065
BAER: BAE_05965
BSAF: BSL056_18705
BCAB: EFK13_19430(bacA)
BRY: M0696_19180(bacA)
BJS: MY9_3866
BACW: QR42_17160
BACP: SB24_11230
BACB: OY17_01130
BACY: QF06_17310
BACL: BS34A_40920(bacA)
BALM: BsLM_3804
BACS: AUL54_12230
BZH: NF868_15795
BAEI: RE735_02185
BGI: BGM20_13130
BMUR: ABE28_019115
PSOP: KP014_17420
STRM: M444_35590
SPHV: F9278_21515
SCOE: CP976_00065
SDEC: L3078_20880
SXT: KPP03845_106161(bacA)
SGK: PET44_33055
LEPT: JVX88_12410
MAR: MAE_56560
MPK: VL20_295
MVZ: myaer102_28820
PAGH: NIES204_06210(aerD)
PPSU: NO713_02126(aerD)
PRUN: PCC7821_03672(aerD)
MPRO: BJP34_16215
HBQ: QI031_25715
NSP: BMF81_03788(bacA_2)
NSPH: BDGGKGIB_04044(suoD)
AFLO: HEQ12_06185
SCYS: NIES4073_42240
 » show all
Reference
1  [PMID:20052993]
  Authors
Mahlstedt SA, Walsh CT
  Title
Investigation of anticapsin biosynthesis reveals a four-enzyme pathway to tetrahydrotyrosine in Bacillus subtilis.
  Journal
Biochemistry 49:912-23 (2010)
DOI:10.1021/bi9021186
Reference
2  [PMID:20863139]
  Authors
Mahlstedt S, Fielding EN, Moore BS, Walsh CT
  Title
Prephenate decarboxylases: a new prephenate-utilizing enzyme family that performs nonaromatizing decarboxylation en route to diverse secondary metabolites.
  Journal
Biochemistry 49:9021-3 (2010)
DOI:10.1021/bi101457h
Reference
3  [PMID:22483065]
  Authors
Parker JB, Walsh CT
  Title
Olefin isomerization regiochemistries during tandem action of BacA and BacB on prephenate in bacilysin biosynthesis.
  Journal
Biochemistry 51:3241-51 (2012)
DOI:10.1021/bi300254u
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.100
IUBMB Enzyme Nomenclature: 4.1.1.100
ExPASy - ENZYME nomenclature database: 4.1.1.100
BRENDA, the Enzyme Database: 4.1.1.100
LinkDB

KEGG   REACTION: R10934
Entry
R10934                      Reaction                               
Name
prephenate carboxy-lyase (3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate-forming)
Definition
Prephenate <=> 3-[(4R)-4-Hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate + CO2
Equation
C00254 <=> C20953 + C00011
Reaction class
RC03316  C00254_C20953
Enzyme
4.1.1.100
Pathway
rn00998  Biosynthesis of various antibiotics
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00787  Bacilysin biosynthesis, prephenate => bacilysin
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.100
     R10934  Prephenate <=> 3-[(4R)-4-Hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate + CO2
Orthology
K19546  prephenate decarboxylase [EC:4.1.1.100]
Other DBs
RHEA: 33502
LinkDB

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