KEGG   ORTHOLOGY: K19548
Entry
K19548                      KO                                     
Symbol
bacC
Name
dihydroanticapsin dehydrogenase [EC:1.1.1.385]
Pathway
map00998  Biosynthesis of various antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00787  Bacilysin biosynthesis, prephenate => bacilysin
Reaction
R10917  L-dihydroanticapsin:NAD+ oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00998 Biosynthesis of various antibiotics
    K19548  bacC; dihydroanticapsin dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.385  dihydroanticapsin dehydrogenase
     K19548  bacC; dihydroanticapsin dehydrogenase
Other DBs
COG: COG1028
Genes
TFT: RI844_15785
LPA: lpa_03406(phaB)
SHAI: LMH63_18985
KAI: K32_05950(fabG2) K32_25800
KOI: LV478_11255
SKT: IGS68_30855
AVM: JQX13_36925
BSU: BSU37720(bacC)
BSR: I33_3920
BSL: A7A1_0191
BSH: BSU6051_37720(bacC)
BSY: I653_18505
BSUT: BSUB_04008(bacC)
BSUL: BSUA_04008(bacC)
BSUS: Q433_20775
BSO: BSNT_10430(ywfD)
BSN: BSn5_09850
BSQ: B657_37720(bacC)
BSX: C663_3677(bacC)
BSP: U712_19010
BSS: BSUW23_18630(bacC)
BST: GYO_4158
BIT: BIS30_08575
BAY: RBAM_034910(bacC)
BAQ: BACAU_3520(bacC)
BYA: BANAU_3673(bacC)
BAMP: B938_17915(bacC)
BQY: MUS_4150(bacC3)
BAML: BAM5036_3421(bacC)
BAMA: RBAU_3629(bacC)
BAMN: BASU_3405(bacC)
BAMB: BAPNAU_3687(bacC)
BAMT: AJ82_19700
BAMY: V529_37630(bacC)
BMP: NG74_03666(gdhIV_2)
BAO: BAMF_3605(bacC)
BAZ: BAMTA208_19090(bacC)
BQL: LL3_03916(bacC)
BXH: BAXH7_03908(bacC)
BAMI: KSO_001605
BAMC: U471_36360
BAMF: U722_18650
BSIA: CWD84_01670
BVM: B9C48_17865
BHT: DIC78_12115(bacC)
BMOJ: HC660_36800(bacC)
BTEQ: G4P54_19450(bacC)
BIQ: AN935_19105
BSTR: QI003_22365(bacC)
BPU: BPUM_3422
BPUM: BW16_18170
BPUS: UP12_17615
BALT: CFN77_18075
BAER: BAE_05975
BSAF: BSL056_18715
BCAB: EFK13_19420(bacC)
BRY: M0696_19170(bacC)
BJS: MY9_3863
BACW: QR42_17170
BACP: SB24_11240
BACB: OY17_01120
BACY: QF06_17300
BACL: BS34A_40900(bacC)
BALM: BsLM_3802
BACS: AUL54_12240
BZH: NF868_15805
BAEI: RE735_02175
BGI: BGM20_13120
BMUR: ABE28_019125
PSOP: KP014_17250
PAUN: MJA45_08550
MAUU: NCTC10437_02787(cpnA_3)
MMAG: MMAD_18390(bacC)
MRF: MJO55_04500
NIE: KV110_23495
STRM: M444_35575
SPHV: F9278_21500
SDEC: L3078_20865
SXT: KPP03845_100609(bacC_1) KPP03845_106164(bacC_4)
SGK: PET44_33040
MICF: QQG74_17440
BSUE: BS3272_08590
JCY: M6B22_06160
PPIO: CE91St28_02330
NLI: G3M70_12375
ALAM: RT761_01341(bacC_5)
 » show all
Reference
PMID:15609023
  Authors
Steinborn G, Hajirezaei MR, Hofemeister J
  Title
bac genes for recombinant bacilysin and anticapsin production in Bacillus host strains.
  Journal
Arch Microbiol 183:71-9 (2005)
DOI:10.1007/s00203-004-0743-8
  Sequence
[bsu:BSU37720]
Reference
PMID:25644640
  Authors
Ozcengiz G, Ogulur I
  Title
Biochemistry, genetics and regulation of bacilysin biosynthesis and its significance more than an antibiotic.
  Journal
N Biotechnol 32:612-9 (2015)
DOI:10.1016/j.nbt.2015.01.006
LinkDB

KEGG   ENZYME: 1.1.1.385
Entry
EC 1.1.1.385                Enzyme                                 
Name
dihydroanticapsin dehydrogenase;
BacC;
ywfD (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
L-dihydroanticapsin:NAD+ oxidoreductase
Reaction(IUBMB)
L-dihydroanticapsin + NAD+ = L-anticapsin + NADH + H+ [RN:R10917]
Reaction(KEGG)
R10917
Substrate
L-dihydroanticapsin [CPD:C20940];
NAD+ [CPD:C00003]
Product
L-anticapsin [CPD:C20941];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, characterized from the bacterium Bacillus subtilis, is involved in the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin.
History
EC 1.1.1.385 created 2015
Pathway
ec00998  Biosynthesis of various antibiotics
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K19548  dihydroanticapsin dehydrogenase
Genes
TFT: RI844_15785
LPA: lpa_03406(phaB)
SHAI: LMH63_18985
KAI: K32_05950(fabG2) K32_25800
KOI: LV478_11255
SKT: IGS68_30855
AVM: JQX13_36925
BSU: BSU37720(bacC)
BSR: I33_3920
BSL: A7A1_0191
BSH: BSU6051_37720(bacC)
BSY: I653_18505
BSUT: BSUB_04008(bacC)
BSUL: BSUA_04008(bacC)
BSUS: Q433_20775
BSO: BSNT_10430(ywfD)
BSN: BSn5_09850
BSQ: B657_37720(bacC)
BSX: C663_3677(bacC)
BSP: U712_19010
BSS: BSUW23_18630(bacC)
BST: GYO_4158
BIT: BIS30_08575
BAY: RBAM_034910(bacC)
BAQ: BACAU_3520(bacC)
BYA: BANAU_3673(bacC)
BAMP: B938_17915(bacC)
BQY: MUS_4150(bacC3)
BAML: BAM5036_3421(bacC)
BAMA: RBAU_3629(bacC)
BAMN: BASU_3405(bacC)
BAMB: BAPNAU_3687(bacC)
BAMT: AJ82_19700
BAMY: V529_37630(bacC)
BMP: NG74_03666(gdhIV_2)
BAO: BAMF_3605(bacC)
BAZ: BAMTA208_19090(bacC)
BQL: LL3_03916(bacC)
BXH: BAXH7_03908(bacC)
BAMI: KSO_001605
BAMC: U471_36360
BAMF: U722_18650
BSIA: CWD84_01670
BVM: B9C48_17865
BHT: DIC78_12115(bacC)
BMOJ: HC660_36800(bacC)
BTEQ: G4P54_19450(bacC)
BIQ: AN935_19105
BSTR: QI003_22365(bacC)
BPU: BPUM_3422
BPUM: BW16_18170
BPUS: UP12_17615
BALT: CFN77_18075
BAER: BAE_05975
BSAF: BSL056_18715
BCAB: EFK13_19420(bacC)
BRY: M0696_19170(bacC)
BJS: MY9_3863
BACW: QR42_17170
BACP: SB24_11240
BACB: OY17_01120
BACY: QF06_17300
BACL: BS34A_40900(bacC)
BALM: BsLM_3802
BACS: AUL54_12240
BZH: NF868_15805
BAEI: RE735_02175
BGI: BGM20_13120
BMUR: ABE28_019125
PSOP: KP014_17250
PAUN: MJA45_08550
MAUU: NCTC10437_02787(cpnA_3)
MMAG: MMAD_18390(bacC)
MRF: MJO55_04500
NIE: KV110_23495
STRM: M444_35575
SPHV: F9278_21500
SDEC: L3078_20865
SXT: KPP03845_100609(bacC_1) KPP03845_106164(bacC_4)
SGK: PET44_33040
MICF: QQG74_17440
BSUE: BS3272_08590
JCY: M6B22_06160
PPIO: CE91St28_02330
NLI: G3M70_12375
ALAM: RT761_01341(bacC_5)
 » show all
Reference
1  [PMID:23317005]
  Authors
Parker JB, Walsh CT
  Title
Action and timing of BacC and BacD in the late stages of biosynthesis of the dipeptide antibiotic bacilysin.
  Journal
Biochemistry 52:889-901 (2013)
DOI:10.1021/bi3016229
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.385
IUBMB Enzyme Nomenclature: 1.1.1.385
ExPASy - ENZYME nomenclature database: 1.1.1.385
BRENDA, the Enzyme Database: 1.1.1.385
LinkDB

KEGG   REACTION: R10917
Entry
R10917                      Reaction                               
Name
L-dihydroanticapsin:NAD+ oxidoreductase
Definition
L-Dihydroanticapsin + NAD+ <=> L-Anticapsin + NADH + H+
Equation
C20940 + C00003 <=> C20941 + C00004 + C00080
Reaction class
RC00001  C00003_C00004
RC00154  C20940_C20941
Enzyme
1.1.1.385
Pathway
rn00998  Biosynthesis of various antibiotics
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00787  Bacilysin biosynthesis, prephenate => bacilysin
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.385
     R10917  L-Dihydroanticapsin + NAD+ <=> L-Anticapsin + NADH + H+
Orthology
K19548  dihydroanticapsin dehydrogenase [EC:1.1.1.385]
Other DBs
RHEA: 44631
LinkDB

DBGET integrated database retrieval system