KEGG   ORTHOLOGY: K19566
Entry
K19566            Tight     KO                                     
Symbol
elmGT
Name
8-demethyltetracenomycin C L-rhamnosyltransferase [EC:2.4.1.331]
Pathway
map01057  Biosynthesis of type II polyketide products
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00784  Elloramycin biosynthesis, 8-demethyltetracenomycin C => elloramycin A
Reaction
R10955  dTDP-beta-L-rhamnose:8-demethyltetracenomycin-C alpha-L-rhamnosyltransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K19566  elmGT; 8-demethyltetracenomycin C L-rhamnosyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K19566  elmGT; 8-demethyltetracenomycin C L-rhamnosyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.331  8-demethyltetracenomycin C L-rhamnosyltransferase
     K19566  elmGT; 8-demethyltetracenomycin C L-rhamnosyltransferase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Glycosyltransferase
   K19566  elmGT; 8-demethyltetracenomycin C L-rhamnosyltransferase
Other DBs
CAZy: GT1
Genes
AG: CAP12607(elmGT)
Reference
PMID:11306350
  Authors
Blanco G, Patallo EP, Brana AF, Trefzer A, Bechthold A, Rohr J, Mendez C, Salas JA
  Title
Identification of a sugar flexible glycosyltransferase from Streptomyces olivaceus, the producer of the antitumor polyketide elloramycin.
  Journal
Chem Biol 8:253-63 (2001)
DOI:10.1016/S1074-5521(01)00010-2
  Sequence
[ag:CAP12607]
LinkDB

KEGG   ENZYME: 2.4.1.331
Entry
EC 2.4.1.331                Enzyme                                 
Name
8-demethyltetracenomycin C L-rhamnosyltransferase;
elmGT
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
dTDP-beta-L-rhamnose:8-demethyltetracenomycin C 3-alpha-L-rhamnosyltransferase
Reaction(IUBMB)
dTDP-beta-L-rhamnose + 8-demethyltetracenomycin C = dTDP + 8-demethyl-8-alpha-L-rhamnosyltetracenomycin C [RN:R10955]
Reaction(KEGG)
R10955
Substrate
dTDP-beta-L-rhamnose [CPD:C03319];
8-demethyltetracenomycin C [CPD:C12379]
Product
dTDP [CPD:C00363];
8-demethyl-8-alpha-L-rhamnosyltetracenomycin C [CPD:C20974]
Comment
Isolated from Streptomyces olivaceus Tu2353. Involved in elloramycin biosynthesis. In vitro it can also utilize other 6-deoxy D- or L-hexoses.
History
EC 2.4.1.331 created 2014
Pathway
ec01057  Biosynthesis of type II polyketide products
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K19566  8-demethyltetracenomycin C L-rhamnosyltransferase
Reference
1  [PMID:11306350]
  Authors
Blanco G, Patallo EP, Brana AF, Trefzer A, Bechthold A, Rohr J, Mendez C, Salas JA
  Title
Identification of a sugar flexible glycosyltransferase from Streptomyces olivaceus, the producer of the antitumor polyketide elloramycin.
  Journal
Chem Biol 8:253-63 (2001)
DOI:10.1016/S1074-5521(01)00010-2
  Sequence
[ag:CAP12607]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.331
IUBMB Enzyme Nomenclature: 2.4.1.331
ExPASy - ENZYME nomenclature database: 2.4.1.331
BRENDA, the Enzyme Database: 2.4.1.331
LinkDB

KEGG   REACTION: R10955
Entry
R10955                      Reaction                               
Name
dTDP-beta-L-rhamnose:8-demethyltetracenomycin-C alpha-L-rhamnosyltransferase
Definition
dTDP-L-rhamnose + 8-Demethyltetracenomycin C <=> dTDP + 8-Demethyl-8-alpha-L-rhamnosyltetracenomycin C
Equation
C03319 + C12379 <=> C00363 + C20974
Reaction class
RC00005  C00363_C03319
RC00171  C12379_C20974
Enzyme
2.4.1.331
Pathway
rn01057  Biosynthesis of type II polyketide products
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00784  Elloramycin biosynthesis, 8-demethyltetracenomycin C => elloramycin A
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.331
     R10955  dTDP-L-rhamnose + 8-Demethyltetracenomycin C <=> dTDP + 8-Demethyl-8-alpha-L-rhamnosyltetracenomycin C
Orthology
K19566  8-demethyltetracenomycin C L-rhamnosyltransferase [EC:2.4.1.331]
Other DBs
RHEA: 42851
LinkDB

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