KEGG   ORTHOLOGY: K19567
Entry
K19567            Tight     KO                                     
Symbol
elmMI
Name
8-demethyl-8-alpha-L-rhamnosyltetracenomycin-C 2'-O-methyltransferase [EC:2.1.1.305]
Pathway
map01057  Biosynthesis of type II polyketide products
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00784  Elloramycin biosynthesis, 8-demethyltetracenomycin C => elloramycin A
Reaction
R10956  S-adenosyl-L-methionine:8-demethyl-8-alpha-L-rhamnosyltetracenomycin-C 2'-O-methyltransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K19567  elmMI; 8-demethyl-8-alpha-L-rhamnosyltetracenomycin-C 2'-O-methyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K19567  elmMI; 8-demethyl-8-alpha-L-rhamnosyltetracenomycin-C 2'-O-methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.305  8-demethyl-8-alpha-L-rhamnosyltetracenomycin-C 2'-O-methyltransferase
     K19567  elmMI; 8-demethyl-8-alpha-L-rhamnosyltetracenomycin-C 2'-O-methyltransferase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Methylase
   K19567  elmMI; 8-demethyl-8-alpha-L-rhamnosyltetracenomycin-C 2'-O-methyltransferase
Genes
AG: CAP12606(elmMI)
Reference
PMID:11376004
  Authors
Patallo EP, Blanco G, Fischer C, Brana AF, Rohr J, Mendez C, Salas JA
  Title
Deoxysugar methylation during biosynthesis of the antitumor polyketide elloramycin by Streptomyces olivaceus. Characterization of three methyltransferase genes.
  Journal
J Biol Chem 276:18765-74 (2001)
DOI:10.1074/jbc.M101225200
  Sequence
[ag:CAP12606]
LinkDB

KEGG   ENZYME: 2.1.1.305
Entry
EC 2.1.1.305                Enzyme                                 
Name
8-demethyl-8-alpha-L-rhamnosyltetracenomycin-C 2'-O-methyltransferase;
ElmMI
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:8-demethyl-8-alpha-L-rhamnosyltetracenomycin-C 2'-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 8-demethyl-8-alpha-L-rhamnosyltetracenomycin C = S-adenosyl-L-homocysteine + 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)tetracenomycin C [RN:R10956]
Reaction(KEGG)
R10956
Substrate
S-adenosyl-L-methionine [CPD:C00019];
8-demethyl-8-alpha-L-rhamnosyltetracenomycin C [CPD:C20974]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)tetracenomycin C [CPD:C20975]
Comment
The enzyme from the bacterium Streptomyces olivaceus is involved in the biosynthesis of the polyketide elloramycin.
History
EC 2.1.1.305 created 2014
Pathway
ec01057  Biosynthesis of type II polyketide products
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K19567  8-demethyl-8-alpha-L-rhamnosyltetracenomycin-C 2'-O-methyltransferase
Reference
1  [PMID:11376004]
  Authors
Patallo EP, Blanco G, Fischer C, Brana AF, Rohr J, Mendez C, Salas JA
  Title
Deoxysugar methylation during biosynthesis of the antitumor polyketide elloramycin by Streptomyces olivaceus. Characterization of three methyltransferase genes.
  Journal
J Biol Chem 276:18765-74 (2001)
DOI:10.1074/jbc.M101225200
  Sequence
[ag:CAP12606]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.305
IUBMB Enzyme Nomenclature: 2.1.1.305
ExPASy - ENZYME nomenclature database: 2.1.1.305
BRENDA, the Enzyme Database: 2.1.1.305
LinkDB

KEGG   REACTION: R10956
Entry
R10956                      Reaction                               
Name
S-adenosyl-L-methionine:8-demethyl-8-alpha-L-rhamnosyltetracenomycin-C 2'-O-methyltransferase
Definition
S-Adenosyl-L-methionine + 8-Demethyl-8-alpha-L-rhamnosyltetracenomycin C <=> S-Adenosyl-L-homocysteine + 8-Demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)tetracenomycin C
Equation
C00019 + C20974 <=> C00021 + C20975
Reaction class
RC00003  C00019_C00021
RC00466  C20974_C20975
Enzyme
2.1.1.305
Pathway
rn01057  Biosynthesis of type II polyketide products
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00784  Elloramycin biosynthesis, 8-demethyltetracenomycin C => elloramycin A
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.305
     R10956  S-Adenosyl-L-methionine + 8-Demethyl-8-alpha-L-rhamnosyltetracenomycin C <=> S-Adenosyl-L-homocysteine + 8-Demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)tetracenomycin C
Orthology
K19567  8-demethyl-8-alpha-L-rhamnosyltetracenomycin-C 2'-O-methyltransferase [EC:2.1.1.305]
LinkDB

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