KEGG ORTHOLOGY: K19608

ORTHOLOGY: K19608

Entry

K19608                      KO

Symbol

EVC2

Name

ellis van creveld syndrome protein 2

Pathway

map04340

Hedgehog signaling pathway

Disease

H00503

Ellis-van Creveld syndrome

H01376

Acrofacial dysostosis

H02158

Weyers acrofacial dysostosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04340 Hedgehog signaling pathway
    K19608  EVC2; ellis van creveld syndrome protein 2
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   03037 Cilium and associated proteins
    K19608  EVC2; ellis van creveld syndrome protein 2
Cilium and associated proteins [BR:ko03037]
Primary cilia and associated proteins
  EVC complex
   K19608  EVC2; ellis van creveld syndrome protein 2

Genes

HSA:	132884(EVC2)

PTR:	461676(EVC2)

PPS:	100986875(EVC2)

GGO:	101136471(EVC2)

PON:	100436741(EVC2)

PPYG:

129034924(EVC2)

NLE:	100604511(EVC2)

HMH:	116456774(EVC2)

SSYN:

129464436(EVC2)

MCC:	722758(EVC2)

MCF:	102122031(EVC2)

MTHB:

126955478

MNI:	105483923(EVC2)

CSAB:

103246396(EVC2)

CATY:

105585522(EVC2)

PANU:

101024419(EVC2)

TGE:	112625474(EVC2)

MLEU:

105555275(EVC2)

RRO:	104667565(EVC2)

RBB:	108517885 108538790(EVC2)

TFN:	117085118(EVC2)

PTEH:

111538996(EVC2)

CANG:

105507059(EVC2)

CJC:	100895988(EVC2)

SBQ:	101034030(EVC2)

CIMI:

108311636(EVC2)

ANAN:

105727215(EVC2)

CSYR:

103250089(EVC2)

MMUR:

105857374(EVC2)

LCAT:

123622138(EVC2)

PCOQ:

105825147(EVC2)

OGA:	100954867(EVC2)

MMU:	68525(Evc2)

MCAL:

110295312(Evc2)

MPAH:

110330483(Evc2)

RNO:	289711(Evc2)

MCOC:

116070490(Evc2)

ANU:	117713021(Evc2)

MUN:	110544895(Evc2)

CGE:	100751511(Evc2)

MAUA:

101836014(Evc2)

PROB:

127233705(Evc2)

PLEU:

114702080(Evc2)

MORG:

121436521(Evc2)

MFOT:

126500973

AAMP:

119822406(Evc2)

NGI:

103739553

HGL:	101718549(Evc2)

CPOC:

100731709(Evc2)

CCAN:

109695698(Evc2)

DORD:

105991334(Evc2)

DSP:	122099771(Evc2)

PLOP:

125364699(Evc2)

NCAR:

124994878

MMMA:

107139119(Evc2)

OCU:

103345886

OPI:	101516081(EVC2)

TUP:	102476441(EVC2)

GVR:	103585387(EVC2)

CFA:	611156(EVC2)

CLUD:

112653352(EVC2)

VVP:	112922526(EVC2)

VLG:	121489885(EVC2)

NPO:	129510416(EVC2)

AML:	100470784(EVC2)

UMR:	103658345(EVC2)

UAH:	113266663(EVC2)

UAR:	123775873(EVC2)

ELK:

111149087

LLV:

125093530

MPUF:

101689098(EVC2)

MNP:	132004330(EVC2)

MLK:	131826351(EVC2)

NVS:	122890551(EVC2)

ORO:	101362501(EVC2)

EJU:	114198427(EVC2)

ZCA:	113925263(EVC2)

MLX:	118010730(EVC2)

NSU:	110569733(EVC2)

FCA:	101092761(EVC2)

PYU:	121038595(EVC2)

PCOO:

112858270(EVC2)

PBG:	122479060(EVC2)

PVIV:

125164147(EVC2)

LRUF:

124520438

PTG:	102969116(EVC2)

PPAD:

109269689(EVC2)

PUC:

125922610

AJU:

106982722

HHV:	120231859(EVC2)

BTA:	280834(EVC2)

BOM:	102272780(EVC2)

BBUB:

102416477(EVC2)

BBIS:

104994280(EVC2)

CHX:	102190596(EVC2)

OAS:	101102904(EVC2)

BTAX:

128049459(EVC2)

ODA:	120862230(EVC2)

CCAD:

122428057(EVC2)

MBEZ:

129561869

SSC:	102164235(EVC2)

CFR:	102505909(EVC2)

CBAI:

105083219(EVC2)

CDK:	105085113(EVC2)

VPC:	102544998(EVC2)

BACU:

103014237(EVC2)

BMUS:

118895451(EVC2)

LVE:	103083886(EVC2)

OOR:	101274587(EVC2)

DLE:	111171457(EVC2)

PCAD:

102980191(EVC2)

PSIU:

116754238(EVC2)

NASI:

112397602(EVC2)

ECB:	100069979(EVC2)

EPZ:	103562778(EVC2)

EAI:	106832492(EVC2)

MYB:	102245303(EVC2)

MYD:	102772979(EVC2)

MMYO:

118666379(EVC2)

MLF:	102443089(EVC2)

MDT:	132221644(EVC2)

PKL:	118709013(EVC2)

EFUS:

103294542(EVC2)

MNA:	107530074(EVC2)

DRO:	112316683(EVC2)

SHON:

118986997(EVC2)

AJM:	119035546(EVC2)

PDIC:

114491528(EVC2)

PHAS:

123815763(EVC2)

MMF:	118643259(EVC2)

PPAM:

129077679(EVC2)

HAI:	109392580(EVC2)

RFQ:	117022556(EVC2)

PALE:

102892455(EVC2)

PGIG:

120582858(EVC2)

PVP:	105301837(EVC2)

RAY:	107519010(EVC2)

MJV:	108405544(EVC2)

TOD:	119261294(EVC2)

SARA:

101538209(EVC2)

SETR:

126020983(EVC2)

LAV:	100655163(EVC2)

TMU:

101344058

ETF:	101651730(EVC2)

DNM:	101430793(EVC2)

MDO:	100018696(EVC2)

GAS:	123252465(EVC2)

SHR:	100921631(EVC2)

AFZ:

127542075

PCW:	110212259(EVC2)

TVP:	118852702(EVC2)

OAA:	100077378(EVC2)

GGA:	770095(EVC2)

PCOC:

116225791(EVC2)

MGP:

104909289

CJO:	107313925(EVC2)

TPAI:

128079958(EVC2)

LMUT:

125692521(EVC2)

NMEL:

110397558(EVC2)

APLA:

101804702(EVC2)

ACYG:

106035171(EVC2)

CATA:

118248389(EVC2)

AFUL:

116488884(EVC2)

TGU:	100220884(EVC2)

LSR:	110481880(EVC2)

SCAN:

103824160(EVC2)

PMOA:

120511621(EVC2)

OTC:	121335189(EVC2)

PRUF:

121348977(EVC2)

GFR:	102031743(EVC2)

FAB:	101818051(EVC2)

OMA:	130252507(EVC2)

PHI:	102104990(EVC2)

PMAJ:

107203085(EVC2)

CCAE:

111928199(EVC2)

CCW:	104690740(EVC2)

CBRC:

103625606(EVC2)

ETL:	114061463(EVC2)

ZAB:	102067473(EVC2)

ZLE:	135447049(EVC2)

ACHL:

103804446(EVC2)

SVG:	106865327(EVC2)

MMEA:

130577858(EVC2)

HRT:	120753073(EVC2)

SATI:

136360194(EVC2)

FPG:	101910663(EVC2)

FCH:	102050258(EVC2)

CCRI:

104162251(EVC2)

NNT:	104411667(EVC2)

SHAB:

115611026(EVC2)

ACUN:

113479076(EVC2)

TALA:

104358739(EVC2)

ACHC:

115339218(EVC2)

HALD:

104324536(EVC2)

HLE:	104841658(EVC2)

AGEN:

126035842

GCL:

127016058

CSTI:

104554288(EVC2)

LDI:	104340445(EVC2)

MNB:	103779216(EVC2)

DPUB:

104303591(EVC2)

AVIT:

104279518(EVC2)

BRHI:

104490116(EVC2)

EGZ:	104123277(EVC2)

NNI:	104018033(EVC2)

PCRI:

104029738(EVC2)

PCAO:

104050228(EVC2)

PADL:

103920955(EVC2)

AFOR:

103894402(EVC2)

FGA:	104076258(EVC2)

CLV:	102089807(EVC2)

MUI:	104542897(EVC2)

PGUU:

104457716(EVC2)

PLET:

104618738(EVC2)

EHS:	104508454(EVC2)

CMAC:

104476201(EVC2)

CUCA:

104062605(EVC2)

TEO:

104384583

BREG:

104639822(EVC2)

OHA:	104331093(EVC2)

ACAR:

104520375(EVC2)

CPEA:

104393601(EVC2)

CVF:	104291336(EVC2)

RTD:	128910099(EVC2)

AAM:	106498651(EVC2)

AROW:

112960488(EVC2)

NPD:	112943091(EVC2)

TGT:	104572683(EVC2)

DNE:	112996479(EVC2)

SCAM:

104151394(EVC2)

ASN:	102381038(EVC2)

AMJ:	102560472(EVC2)

CPOO:

109322205(EVC2)

GGN:	109303922(EVC2)

PSS:	102459168(EVC2)

CMY:	102931616(EVC2)

CCAY:

125636180(EVC2)

DCC:	119854671(EVC2)

CPIC:

101949072(EVC2)

TST:	117878014(EVC2)

CABI:

116831749(EVC2)

MRV:	120406111(EVC2)

HCG:	128328225(EVC2)

GJA:	107122652(EVC2)

STOW:

125439764(EVC2)

EMC:	129343458(EVC2)

XLA:	108698024(evc2.L)

XTR:	100495651(evc2)

NPR:	108796357(EVC2)

RTEM:

120924440(EVC2)

BBUF:

120990357(EVC2)

BGAR:

122929136(EVC2)

MUO:	115461405(EVC2)

GSH:	117362653(EVC2)

SRX:	107744002(evc2)

CAUA:

CGIB:

PTET:

LROH:

OMC:

PPRM:

RKG:

MAMB:

CIDE:

CERY:

TDW:

MANU:

IPU:

IFU:

PHYP:

113528304(evc2)

SMEO:

TFD:

TVC:

TRN:

CMAO:

EEE:	113574028(evc2)

TRU:	494348(evc2)

TFS:

130524193

TNG:	GSTEN00020779G001

LCO:	104927934(evc2)

NCC:	104961958(evc2)

TBEN:

117486560

CGOB:

115008460(evc2)

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:	116687377(evc2)

PFLV:

114554236(evc2)

GAT:

PPUG:

AFB:

CLUM:

PSWI:

MSAM:

SCHU:

CUD:

ALAT:

MZE:	101477337(evc2)

ONL:	100704947(evc2)

OAU:

116326518

OLA:	101155424(evc2)

OML:

112144826

CSAI:

133448854

XMA:	102236822(evc2)

XCO:	114135756(evc2)

XHE:	116710194(evc2)

PRET:

103464959(evc2)

PFOR:

103139546(evc2)

PLAI:

106957340(evc2)

PMEI:

106928893(evc2)

GAF:

122834243

PPRL:

129358231

CVG:	107097280(evc2)

CTUL:

119780117

GMU:

124857496

NFU:	107385511(evc2)

KMR:

108239896

ALIM:

106518381(evc2)

NWH:

119412232

AOCE:

111583165(evc2)

MCEP:

125006543

CSEM:

103386250(evc2)

POV:	109629383(evc2)

SSEN:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:	111221792(evc2)

SLAL:

111670959(evc2)

XGL:

120807105

HCQ:	109522535(evc2)

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

110172947(evc2)

MALB:

109955956(evc2)

BSPL:

114855527

SJO:

128355815

SASA:

106565205

STRU:

115208282(evc2)

OTW:

112214309

OMY:

110493980

OGO:

124002673

ONE:	115142768(evc2)

OKI:	109892098(evc2)

OKE:

118389007

SALP:

111962424(evc2)

SNH:

120064110

CCLU:

121575522 121578029

ELS:	105016757(evc2)

SFM:	108924158(evc2)

PKI:	111837697(evc2)

AANG:

118232166

LOC:	102692398(evc2)

PSPA:

121330109

ARUT:

117408524

LCM:	102350576(EVC2)

CMK:

RTP:

CPLA:

HOC:

LERI:

BFO:

BBEL:

SPU:

APLC:

SKO:

LGI:	LOTGIDRAFT_229882

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

MYI:

PMAX:

MMER:

OBI:

LAK:	106157035 106179092

NVE:

EPA:

ATEN:

AMIL:

PDAM:

SPIS:

DGT:

Reference

PMID:25311364

Authors

Ginns EI, Galdzicka M, Elston RC, Song YE, Paul SM, Egeland JA

Title

Disruption of sonic hedgehog signaling in Ellis-van Creveld dwarfism confers protection against bipolar affective disorder.

Journal

Mol Psychiatry 20:1212-8 (2015)
DOI:10.1038/mp.2014.118

Reference

PMID:24582806

Authors

Pusapati GV, Hughes CE, Dorn KV, Zhang D, Sugianto P, Aravind L, Rohatgi R

Title

EFCAB7 and IQCE regulate hedgehog signaling by tethering the EVC-EVC2 complex to the base of primary cilia.

Journal

Dev Cell 28:483-96 (2014)
DOI:10.1016/j.devcel.2014.01.021

Sequence

[hsa:132884]

LinkDB

DBGET integrated database retrieval system