KEGG   ORTHOLOGY: K19664
Entry
K19664                      KO                                     
Symbol
carS
Name
CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase [EC:2.7.7.67]
Pathway
map00564  Glycerophospholipid metabolism
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00564 Glycerophospholipid metabolism
    K19664  carS; CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.67  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase
     K19664  carS; CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase
Other DBs
RN: R08966
COG: COG0575
Genes
MJA: MJ_1600
MFE: Mefer_0314
MVU: Metvu_1168
MFS: MFS40622_0461
MIF: Metin_0009
MJH: JH146_0423
MESG: MLAUSG7_0489(carS)
MESA: MLASG1_0023(carS)
MIG: Metig_0925
MMP: MMP1698
MMD: GYY_09365
MMAD: MMJJ_11310
MAE: Maeo_1211
MVO: Mvol_1258
MTH: MTH_832
METC: MTCT_0746
MWO: MWSIV6_1209(carS)
METE: tca_00799
MST: Msp_0385
MRU: mru_1693
MSI: Msm_0850
MEB: Abm4_0509
MMIL: sm9_1776
MEYE: TL18_07940
MOL: YLM1_1161
METH: MBMB1_0693
MFC: BRM9_1502
MCUB: MCBB_0704(carS)
MFV: Mfer_0208
MKA: MK1073(cdsA)
AFU: AF_1740
FPL: Ferp_2014
GAC: GACE_1587
GAH: GAH_00166
PFU: PF0398
PFI: PFC_01075
PHO: PH0343(PH0343)
PAB: PAB1285
PYN: PNA2_0955
PYS: Py04_0654
TKO: TK2119
TON: TON_1624
TGA: TGAM_2129
TSI: TSIB_1853
THE: GQS_07300
THA: TAM4_297
THM: CL1_1098
TLT: OCC_07371
THS: TES1_1802
TNU: BD01_1847
TEU: TEU_02180
TCQ: TIRI35C_2131(carS)
PPAC: PAP_07885
MBAR: MSBR2_0091
MBAK: MSBR3_0103
MAC: MA_3306
MMA: MM_0141
MMAC: MSMAC_2529
METM: MSMTP_1153
MTHR: MSTHT_0110
MTHE: MSTHC_0619
MHOR: MSHOH_1382
MBU: Mbur_1051
MMET: MCMEM_1528
MMH: Mmah_0606
MPY: Mpsy_1082
MTP: Mthe_1386
MCJ: MCON_1076
MHI: Mhar_2089
MHU: Mhun_1107
MLA: Mlab_0318
MEMA: MMAB1_2497
MPI: Mpet_1312
MBN: Mboo_0842
MPL: Mpal_2361
MEZ: Mtc_0822
RCI: RCIX520
HAL: VNG_2119C
HSL: OE_3954R
HHB: Hhub_3406
HALH: HTSR_0279
HHSR: HSR6_0265
HARA: AArcS_0768(cdsA)
HMA: rrnAC3084
HHI: HAH_0338
NPH: NP_0990A(carS)
NMO: Nmlp_1221
HUT: Huta_0926
HTI: HTIA_0779
HMU: Hmuk_1106
HALL: LC1Hm_0133(cdsA)
HDS: HSR122_2475(cdsA)
HWA: HQ_3230A(carS)
HWC: Hqrw_3793(carS)
HVO: HVO_0332(carS)
HME: HFX_0317(cdsA)
HLA: Hlac_0350
HDF: AArcSl_3278(carS)
HTU: Htur_2944
NMG: Nmag_0950(carS)
NAT: NJ7G_2173
SALI: L593_07400
MELU: MTLP_10280
TAC: Ta0107
TVO: TVG0192666(TVG0192666)
PTO: PTO1104
FAI: FAD_0022
CDIV: CPM_1888
MARC: AR505_1616
ABI: Aboo_1071
APE: APE_0433
ACJ: ACAM_0313
SMR: Smar_0617
IHO: Igni_0763
IIS: EYM_07025
DKA: DKAM_0148
TAG: Tagg_1160
IAG: Igag_1133
HBU: Hbut_1639
STO: STK_04650
SSO: SSO0776
SOL: Ssol_1837
SSOA: SULA_1867
SSOL: SULB_1868
SSOF: SULC_1866
SCAS: SACC_07160
SAI: Saci_0897
SID: M164_1356
SII: LD85_1487
SIH: SiH_1309
SIR: SiRe_1225
SIC: SiL_1222
MSE: Msed_2040
MCN: Mcup_0242
AHO: Ahos_0527
ACIH: HS5_18930
CSTY: KN1_17880
STEP: IC006_1260
SAHS: HS7_19950
PAI: PAE0660
PIS: Pisl_0708
PCL: Pcal_2086
PAS: Pars_2316
PYR: P186_2173
POG: Pogu_2549
TNE: Tneu_1958
CMA: Cmaq_0732
TTN: TTX_1683
TUZ: TUZN_1828
VDI: Vdis_0355
VMO: VMUT_1277
TPE: Tpen_0433
ASC: ASAC_1228
ACIA: SE86_07310
KCR: Kcr_1437
BARC: AOA65_2317
MARH: Mia14_0125
 » show all
Reference
  Authors
Jain S, Caforio A, Fodran P, Lolkema JS, Minnaard AJ, Driessen AJ
  Title
Identification of CDP-archaeol synthase, a missing link of ether lipid biosynthesis in Archaea.
  Journal
Chem Biol 21:1392-401 (2014)
DOI:10.1016/j.chembiol.2014.07.022
  Sequence
[afu:AF_1740]
LinkDB

KEGG   ENZYME: 2.7.7.67
Entry
EC 2.7.7.67                 Enzyme                                 
Name
CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase;
carS (gene name);
CDP-2,3-di-O-geranylgeranyl-sn-glycerol synthase;
CTP:2,3-GG-GP ether cytidylyltransferase;
CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase;
CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol synthase;
CTP:2,3-bis-O-(geranylgeranyl)-sn-glycero-1-phosphate cytidylyltransferase;
CDP-unsaturated archaeol synthase;
CDP-archaeol synthase (incorrect)
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
Sysname
CTP:2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate cytidylyltransferase
Reaction(IUBMB)
CTP + 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate = diphosphate + CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol [RN:R08966]
Reaction(KEGG)
R08966
Substrate
CTP [CPD:C00063];
2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
Product
diphosphate [CPD:C00013];
CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
Comment
This enzyme catalyses one of the steps in the biosynthesis of polar lipids in archaea, which are characterized by having an sn-glycerol 1-phosphate backbone rather than an sn-glycerol 3-phosphate backbone as is found in bacteria and eukaryotes [1]. The enzyme requires Mg2+ and K+ for maximal activity [1].
History
EC 2.7.7.67 created 2009, modified 2014
Pathway
ec00564  Glycerophospholipid metabolism
ec01110  Biosynthesis of secondary metabolites
Orthology
K19664  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase
Genes
MJAMJ_1600
MFEMefer_0314
MVUMetvu_1168
MFSMFS40622_0461
MIFMetin_0009
MJHJH146_0423
MESGMLAUSG7_0489(carS)
MESAMLASG1_0023(carS)
MIGMetig_0925
MMPMMP1698
MMQMmarC5_1708
MMXMmarC6_0973
MMZMmarC7_0973
MMDGYY_09365
MMAKMMKA1_19320
MMAOMMOS7_18130
MMADMMJJ_11310
MAEMaeo_1211
MVNMevan_1000
MVOMvol_1258
MOKMetok_0824
METFCFE53_06750
MTHMTH_832
MMGMTBMA_c12300
METCMTCT_0746
MWOMWSIV6_1209(carS)
METEtca_00799
METZMETMT2_0906
METKFVF72_07380
MTHMFZP57_05740
METJFZP68_00465
MSTMsp_0385
METBAW729_05145
MRUmru_1693
MSIMsm_0850
MEBAbm4_0509
MMILsm9_1776
MEYETL18_07940
MOLYLM1_1161
MAROMarbSA_18770
MELMetbo_1947
MEWMSWAN_0673
METHMBMB1_0693
MFCBRM9_1502
MFIDSM1535_2196
MCUBMCBB_0704(carS)
MSUBBK009_01685
METNBK008_09240
METTCIT01_01970
METOCIT02_03305
MEMEHYG87_03495
MFVMfer_0208
MKAMK1073(cdsA)
AFUAF_1740
AFGAFULGI_00019910
APOArcpr_0281
AVEArcve_0687
ASTAsulf_00219
FPLFerp_2014
GACGACE_1587
GAHGAH_00166
PFUPF0398
PFIPFC_01075
PHOPH0343(PH0343)
PABPAB1285
PYNPNA2_0955
PYAPYCH_18060
PYSPy04_0654
PYCTQ32_03610
TKOTK2119
TONTON_1624
TGATGAM_2129
TSITSIB_1853
TBATERMP_01811
THEGQS_07300
THATAM4_297
THMCL1_1098
TLTOCC_07371
THSTES1_1802
TNUBD01_1847
TEUTEU_02180
TGYX802_04005
THVADU37_CDS19710
TCHCHITON_1171
TPEPA0127_05530
TPIEA7C91_04030
TGGA3K92_00075
TCEA3L02_07560
TBSA3L01_08940
THHCDI07_08925
TSLA3L11_02440
TTDA3L14_00005
TPRFA3L09_01895
TRLA3L10_08420
TPAFA3L08_01940
THYA3L12_04655
TICFH039_00555
TCQTIRI35C_2131(carS)
THEMFPV09_08795
PPACPAP_07885
MBAMbar_A3516
MBYMSBRM_2321
MBWMSBRW_1219
MBARMSBR2_0091
MBAKMSBR3_0103
MACMA_3306
MMAMM_0141
MMAZMmTuc01_0153
MMJMSMAS_1191
MMACMSMAC_2529
MVCMSVAZ_2285
MEKMSKOL_2290
MLSMSLAZ_1594
METMMSMTP_1153
MEFMSWH1_1030
MEQMSWHS_1101
MSJMSSAC_1616
MSZMSSIH_1212
MSWMSSIT_1269
MTHRMSTHT_0110
MTHEMSTHC_0619
MHORMSHOH_1382
MFZAOB57_001935
MBUMbur_1051
MMETMCMEM_1528
MELOJ7W08_06450
MMHMmah_0606
MHAZBHR79_00340
MEVMetev_0876
MZHMzhil_0625
MPYMpsy_1082
MZIHWN40_03105
MHZMetho_1973
MTPMthe_1386
MCJMCON_1076
MHIMhar_2089
MHUMhun_1107
MRTJKHC33_08590
MLAMlab_0318
MEMMemar_1002
MBGBN140_1933
MEMAMMAB1_2497
MCHKMchiMG62_11260
MPIMpet_1312
MBNMboo_0842
MFOMetfor_2119
MPLMpal_2361
MPDMCP_0607 MCP_2595
MEZMtc_0822
RCIRCIX520
HALVNG_2119C
HSLOE_3954R
HDLHALDL1_15495
HHBHhub_3406
HAGSJT689_09865
HABOJRZ79_08245
HNOLT974_13850
HLULT972_00880
HANRLJ422_08515
HJEHacjB3_01055
HALHHTSR_0279
HHSRHSR6_0265
HSUHLASF_0224
HSFHLASA_0224
SALRFQU85_05585
HALREFA46_002575
HARAAArcS_0768(cdsA)
HAADMW046_03900
HALXM0R89_06980
HMArrnAC3084
HHIHAH_0338
HHNHISP_01775
HABSG26_09585
HTABVU17_01625
HALJG9465_01085
HSINKDQ40_11990
NPHNP_0990A(carS)
NMONmlp_1221
NHOHWV23_06655
NSALHWV07_08100
HUTHuta_0926
HTIHTIA_0779
HALAHrd1104_08500
HMUHmuk_1106
HALZE5139_08705
HALLLC1Hm_0133(cdsA)
HAZPGBQ70_08700
HALIBV210_09040
HSNDV733_03100
HDSHSR122_2475(cdsA)
HRRHZS55_01305
HPELHZS54_07860
HLTI7X12_13735
HARCHARCEL1_02255
HDOMUK72_04835
HWAHQ_3230A(carS)
HWCHqrw_3793(carS)
HVOHVO_0332(carS)
HMEHFX_0317(cdsA)
HGIABY42_01495
HALEG3A49_01875
HBOHbor_28390
HAQDU484_04905
HAJDU500_05345
HAERDU502_02315
HRAEI982_11225
HLMDV707_02600
HALMFCF25_08475
HLAHlac_0350
HALPDOS48_01325
HALBEKH57_10365
HEZZEO776_01060
HALQHrr1229_005880
HSSJ7656_00110
HSAIHPS36_05630
HAZZKI388_14745
HAEhalTADL_3310
HALNB4589_009605
HALGHUG10_18095
HALUHUG12_18125
HMPK6T50_13235
HREK6T36_13150
HRMK6T25_03505
HACBHbl1158_05070
HDFAArcSl_3278(carS)
HAHHalar_3075
HTUHtur_2944
HDABB347_08885
HJTDVR14_13190
HALYHYG82_09930
HSALJMJ58_13715
HLOJ0X27_13495
HAKZJ0X25_01340
NMGNmag_0950(carS)
HXAHalxa_2276
NATNJ7G_2173
NPENatpe_0776
NVRFEJ81_04030
NPLFGF80_06785
NAYHYG81_06965
NGENatgr_2464
HRUHalru_2249
NOUNatoc_2624
SALIL593_07400
SAIMK0C01_05575
HLRHALLA_07340
HLCCHINAEXTREME09215
NAJB1756_13205
NAGAArcMg_2879
NANAArc1_0823
NBGDV706_10730
NASGCU68_01330
MELUMTLP_10280
MEAMMU439_04885
TACTa0107
TVOTVG0192666(TVG0192666)
PTOPTO1104
FACFACI_IFERC01G0999
FAIFAD_0022
CDIVCPM_1888
TARTALC_00225
MAXMMALV_02110
MERMMINT_01920
MEARMpt1_c12490
MARCAR505_1616
ABIAboo_1071
ACFAciM339_1212
APEAPE_0433
ACJACAM_0313
SMRSmar_0617
SHCShell_0178
IHOIgni_0763
IISEYM_07025
DKADKAM_0148
DFDDesfe_0223
DMUDesmu_0699
TAGTagg_1160
IAGIgag_1133
THGTCELL_0129
HBUHbut_1639
PFMPyrfu_0189
PDLPyrde_0508
STOSTK_04650
SOHD1869_02140
SSOSSO0776
SOLSsol_1837
SSOASULA_1867
SSOLSULB_1868
SSOFSULC_1866
SSHIJ5U23_02626
SCASSACC_07160
SAISaci_0897
SACNSacN8_04345
SACRSacRon12I_04335
SACSSUSAZ_04095
SISLS215_1460
SIAM1425_1364
SIMM1627_1414
SIDM164_1356
SIYYG5714_1358
SINYN1551_1483
SIILD85_1487
SIHSiH_1309
SIRSiRe_1225
SICSiL_1222
SULABFU36_02225
SULEGFS03_07630
SULOGFS33_13035
SULLEWF20_03665
MSEMsed_2040
MCNMcup_0242
MHKDFR87_08285
MPRUDFR88_07960
MTENGWK48_03550
MJNMjAS7_0341
AHOAhos_0527
AMANB6F84_06305
ABRIDFR85_08305
ASULDFR86_05365
AAMBD1866_10330
ACIHHS5_18930
SACDHS1genome_0971
SAZOD1868_01445
CSTYKN1_17880
STEPIC006_1260
SAHSHS7_19950
PAIPAE0660
PISPisl_0708
PCLPcal_2086
PASPars_2316
PYRP186_2173
POGPogu_2549
TNETneu_1958
PYWPYWP30_02210
CMACmaq_0732
TTNTTX_1683
TUZTUZN_1828
VDIVdis_0355
VMOVMUT_1277
TPETpen_0433
THBN186_03185
TCBTCARB_1702
THFMA03_07865
THELIG193_05470
ASCASAC_1228
ACIASE86_07310
CLGCalag_1169
FFOFFONT_1088
CSUCSUB_C0502
KCRKcr_1437
BARCAOA65_2317
MARHMia14_0125
FLTSv326_0532
MIYMicr_00207
LOKILokiarch_20290 Lokiarch_25840
PSYTDSAG12_00452 DSAG12_02845
AGWQT03_C0001G0925
 » show all
Reference
1  [PMID:10960477]
  Authors
Morii H, Nishihara M, Koga Y
  Title
CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase in the methanogenic archaeon Methanothermobacter thermoautotrophicus.
  Journal
J Biol Chem 275:36568-74 (2000)
DOI:10.1074/jbc.M005925200
Reference
2  [PMID:12562787]
  Authors
Morii H, Koga Y
  Title
CDP-2,3-Di-O-geranylgeranyl-sn-glycerol:L-serine O-archaetidyltransferase (archaetidylserine synthase) in the methanogenic archaeon Methanothermobacter thermautotrophicus.
  Journal
J Bacteriol 185:1181-9 (2003)
DOI:10.1128/JB.185.4.1181-1189.2003
Reference
3  [PMID:25219966]
  Authors
Jain S, Caforio A, Fodran P, Lolkema JS, Minnaard AJ, Driessen AJ
  Title
Identification of CDP-archaeol synthase, a missing link of ether lipid biosynthesis in Archaea.
  Journal
Chem Biol 21:1392-401 (2014)
DOI:10.1016/j.chembiol.2014.07.022
  Sequence
[afu:AF_1740]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.67
IUBMB Enzyme Nomenclature: 2.7.7.67
ExPASy - ENZYME nomenclature database: 2.7.7.67
BRENDA, the Enzyme Database: 2.7.7.67
CAS: 329791-09-5
LinkDB

KEGG   REACTION: R08966
Entry
R08966                      Reaction                               
Name
CTP:2,3-bis-O-(geranylgeranyl)-sn-glycerol-1-phosphate cytidylyltransferase
Definition
CTP + 2,3-Bis-O-(geranylgeranyl)glycerol 1-phosphate <=> Diphosphate + CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol
Equation
Reaction class
RC00002  C04638_C18059
Enzyme
Pathway
rn00564  Glycerophospholipid metabolism
rn01110  Biosynthesis of secondary metabolites
Orthology
K19664  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase [EC:2.7.7.67]
Other DBs
RHEA: 25693
LinkDB

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