KEGG   ORTHOLOGY: K19723
Entry
K19723            Tight     KO                                     
Symbol
dcsB
Name
Nomega-hydroxy-L-arginine amidinohydrolase [EC:3.5.3.25]
Pathway
map00998  Biosynthesis of various antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00785  Cycloserine biosynthesis, arginine/serine => cycloserine
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00998 Biosynthesis of various antibiotics
    K19723  dcsB; Nomega-hydroxy-L-arginine amidinohydrolase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.3  In linear amidines
    3.5.3.25  Nomega-hydroxy-L-arginine amidinohydrolase
     K19723  dcsB; Nomega-hydroxy-L-arginine amidinohydrolase
Other DBs
RN: R10466
COG: COG0010
Genes
AG: BAI70376(dcsB)
Reference
  Authors
Kumagai T, Koyama Y, Oda K, Noda M, Matoba Y, Sugiyama M
  Title
Molecular cloning and heterologous expression of a biosynthetic gene cluster for the antitubercular agent D-cycloserine produced by Streptomyces lavendulae.
  Journal
Antimicrob Agents Chemother 54:1132-9 (2010)
DOI:10.1128/AAC.01226-09
  Sequence
LinkDB

KEGG   ENZYME: 3.5.3.25
Entry
EC 3.5.3.25                 Enzyme                                 
Name
Nomega-hydroxy-L-arginine amidinohydrolase;
dcsB (gene name)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amidines
Sysname
Nomega-hydroxy-L-arginine amidinohydrolase
Reaction(IUBMB)
Nomega-hydroxy-L-arginine + H2O = L-ornithine + hydroxyurea [RN:R10466]
Reaction(KEGG)
R10466
Substrate
Nomega-hydroxy-L-arginine;
H2O [CPD:C00001]
Product
L-ornithine [CPD:C00077];
hydroxyurea [CPD:C07044]
Comment
The enzyme participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species.
History
EC 3.5.3.25 created 2013
Pathway
ec00998  Biosynthesis of various antibiotics
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K19723  Nomega-hydroxy-L-arginine amidinohydrolase
Reference
1  [PMID:20086163]
  Authors
Kumagai T, Koyama Y, Oda K, Noda M, Matoba Y, Sugiyama M
  Title
Molecular cloning and heterologous expression of a biosynthetic gene cluster for the antitubercular agent D-cycloserine produced by Streptomyces lavendulae.
  Journal
Antimicrob Agents Chemother 54:1132-9 (2010)
DOI:10.1128/AAC.01226-09
  Sequence
Reference
2  [PMID:22547619]
  Authors
Kumagai T, Takagi K, Koyama Y, Matoba Y, Oda K, Noda M, Sugiyama M
  Title
Heme protein and hydroxyarginase necessary for biosynthesis of D-cycloserine.
  Journal
Antimicrob Agents Chemother 56:3682-9 (2012)
DOI:10.1128/AAC.00614-12
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.5.3.25
IUBMB Enzyme Nomenclature: 3.5.3.25
ExPASy - ENZYME nomenclature database: 3.5.3.25
BRENDA, the Enzyme Database: 3.5.3.25
LinkDB

KEGG   REACTION: R10466
Entry
R10466                      Reaction                               
Name
N(omega)-hydroxy-L-arginine amidinohydrolase
Definition
N(omega)-Hydroxyarginine + H2O <=> L-Ornithine + Hydroxyurea
Equation
Reaction class
RC00024  C00077_C05933
RC03181  C05933_C07044
Enzyme
Pathway
rn00998  Biosynthesis of various antibiotics
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00785  Cycloserine biosynthesis, arginine/serine => cycloserine
Orthology
K19723  Nomega-hydroxy-L-arginine amidinohydrolase [EC:3.5.3.25]
Other DBs
RHEA: 36794
LinkDB

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