KEGG   ORTHOLOGY: K19724
Entry
K19724            Tight     KO                                     
Symbol
dcsC
Name
O-ureido-serine racemase [EC:5.1.1.19]
Pathway
map00998  Biosynthesis of various antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00785  Cycloserine biosynthesis, arginine/serine => cycloserine
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00998 Biosynthesis of various antibiotics
    K19724  dcsC; O-ureido-serine racemase
Enzymes [BR:ko01000]
 5. Isomerases
  5.1  Racemases and epimerases
   5.1.1  Acting on amino acids and derivatives
    5.1.1.19  O-ureido-serine racemase
     K19724  dcsC; O-ureido-serine racemase
Other DBs
RN: R10488
COG: COG0253
Genes
AG: BAI70377(dcsC)
Reference
PMID:20086163
  Authors
Kumagai T, Koyama Y, Oda K, Noda M, Matoba Y, Sugiyama M
  Title
Molecular cloning and heterologous expression of a biosynthetic gene cluster for the antitubercular agent D-cycloserine produced by Streptomyces lavendulae.
  Journal
Antimicrob Agents Chemother 54:1132-9 (2010)
DOI:10.1128/AAC.01226-09
  Sequence
[ag:BAI70377]
LinkDB

KEGG   ENZYME: 5.1.1.19
Entry
EC 5.1.1.19                 Enzyme                                 
Name
O-ureido-serine racemase;
dcsC (gene name)
Class
Isomerases;
Racemases and epimerases;
Acting on amino acids and derivatives
Sysname
(2S)-2-amino-3-[(carbamoylamino)oxy]propanoate 2-epimerase
Reaction(IUBMB)
O-ureido-L-serine = O-ureido-D-serine [RN:R10488]
Reaction(KEGG)
R10488
Substrate
O-ureido-L-serine [CPD:C20639]
Product
O-ureido-D-serine [CPD:C20651]
Comment
The enzyme employs a two-base mechanism, with a thiolate-thiol pair in the active site. It participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species.
History
EC 5.1.1.19 created 2013
Pathway
ec00998  Biosynthesis of various antibiotics
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K19724  O-ureido-serine racemase
Reference
1  [PMID:20086163]
  Authors
Kumagai T, Koyama Y, Oda K, Noda M, Matoba Y, Sugiyama M
  Title
Molecular cloning and heterologous expression of a biosynthetic gene cluster for the antitubercular agent D-cycloserine produced by Streptomyces lavendulae.
  Journal
Antimicrob Agents Chemother 54:1132-9 (2010)
DOI:10.1128/AAC.01226-09
  Sequence
[ag:BAI70377]
Reference
2  [PMID:22307920]
  Authors
Dietrich D, van Belkum MJ, Vederas JC
  Title
Characterization of DcsC, a PLP-independent racemase involved in the biosynthesis of D-cycloserine.
  Journal
Org Biomol Chem 10:2248-54 (2012)
DOI:10.1039/c2ob06864h
  Sequence
[ag:BAI70377]
Other DBs
ExplorEnz - The Enzyme Database: 5.1.1.19
IUBMB Enzyme Nomenclature: 5.1.1.19
ExPASy - ENZYME nomenclature database: 5.1.1.19
BRENDA, the Enzyme Database: 5.1.1.19
LinkDB

KEGG   REACTION: R10488
Entry
R10488                      Reaction                               
Name
(2S)-2-amino-3-[(carbamoylamino)oxy]propanoate 2-epimerase
Definition
O-Ureido-L-serine <=> O-Ureido-D-serine
Equation
C20639 <=> C20651
Reaction class
RC00302  C20639_C20651
Enzyme
5.1.1.19
Pathway
rn00998  Biosynthesis of various antibiotics
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00785  Cycloserine biosynthesis, arginine/serine => cycloserine
Orthology
K19724  O-ureido-serine racemase [EC:5.1.1.19]
Other DBs
RHEA: 36710
LinkDB

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