KEGG   ORTHOLOGY: K19725
Entry
K19725            Tight     KO                                     
Symbol
dcsD
Name
O-ureido-L-serine/cysteine synthase [EC:2.6.99.3 2.5.1.47]
Pathway
map00998  Biosynthesis of various antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00785  Cycloserine biosynthesis, arginine/serine => cycloserine
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00998 Biosynthesis of various antibiotics
    K19725  dcsD; O-ureido-L-serine/cysteine synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.47  cysteine synthase
     K19725  dcsD; O-ureido-L-serine/cysteine synthase
  2.6  Transferring nitrogenous groups
   2.6.99  Transferring other nitrogenous groups
    2.6.99.3  O-ureido-L-serine synthase
     K19725  dcsD; O-ureido-L-serine/cysteine synthase
Other DBs
RN: R10461
COG: COG0031
GO: 0004124
Genes
AG: BAI70378(dcsD)
Reference
  Authors
Kumagai T, Koyama Y, Oda K, Noda M, Matoba Y, Sugiyama M
  Title
Molecular cloning and heterologous expression of a biosynthetic gene cluster for the antitubercular agent D-cycloserine produced by Streptomyces lavendulae.
  Journal
Antimicrob Agents Chemother 54:1132-9 (2010)
DOI:10.1128/AAC.01226-09
  Sequence
LinkDB

KEGG   ENZYME: 2.6.99.3
Entry
EC 2.6.99.3                 Enzyme                                 
Name
O-ureido-L-serine synthase;
dcsD (gene name)
Class
Transferases;
Transferring nitrogenous groups;
Transferring other nitrogenous groups
Sysname
O-acetyl-L-serine:hydroxyurea 2-amino-2-carboxyethyltransferase
Reaction(IUBMB)
O-acetyl-L-serine + hydroxyurea = O-ureido-L-serine + acetate [RN:R10461]
Reaction(KEGG)
R10461
Substrate
O-acetyl-L-serine [CPD:C00979];
hydroxyurea [CPD:C07044]
Product
O-ureido-L-serine [CPD:C20639];
acetate [CPD:C00033]
Comment
The enzyme participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species. Also catalyses EC 2.5.1.47, cysteine synthase.
History
EC 2.6.99.3 created 2013
Pathway
ec00998  Biosynthesis of various antibiotics
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K19725  O-ureido-L-serine/cysteine synthase
Reference
1  [PMID:20086163]
  Authors
Kumagai T, Koyama Y, Oda K, Noda M, Matoba Y, Sugiyama M
  Title
Molecular cloning and heterologous expression of a biosynthetic gene cluster for the antitubercular agent D-cycloserine produced by Streptomyces lavendulae.
  Journal
Antimicrob Agents Chemother 54:1132-9 (2010)
DOI:10.1128/AAC.01226-09
  Sequence
Reference
2  [PMID:23529730]
  Authors
Uda N, Matoba Y, Kumagai T, Oda K, Noda M, Sugiyama M
  Title
Establishment of an in vitro D-cycloserine-synthesizing system by using O-ureido-L-serine synthase and D-cycloserine synthetase found in the biosynthetic pathway.
  Journal
Antimicrob Agents Chemother 57:2603-12 (2013)
DOI:10.1128/AAC.02291-12
Other DBs
ExplorEnz - The Enzyme Database: 2.6.99.3
IUBMB Enzyme Nomenclature: 2.6.99.3
ExPASy - ENZYME nomenclature database: 2.6.99.3
BRENDA, the Enzyme Database: 2.6.99.3
LinkDB

KEGG   REACTION: R10461
Entry
R10461                      Reaction                               
Name
O-acetyl-L-serine:hydroxyurea 2-amino-2-carboxyethyltransferase
Definition
O-Acetyl-L-serine + Hydroxyurea <=> O-Ureido-L-serine + Acetate
Equation
Reaction class
RC00020  C00033_C00979
RC03179  C07044_C20639
Enzyme
Pathway
rn00998  Biosynthesis of various antibiotics
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00785  Cycloserine biosynthesis, arginine/serine => cycloserine
Orthology
K19725  O-ureido-L-serine/cysteine synthase [EC:2.6.99.3 2.5.1.47]
Other DBs
RHEA: 36266
LinkDB

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