KEGG   ORTHOLOGY: K19727
Entry
K19727            Tight     KO                                     
Symbol
dcsG
Name
O-ureido-D-serine cyclo-ligase [EC:6.3.3.5]
Pathway
map00998  Biosynthesis of various antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00785  Cycloserine biosynthesis, arginine/serine => cycloserine
Reaction
R10470  O-ureido-D-serine cyclo-ligase (D-cycloserine-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00998 Biosynthesis of various antibiotics
    K19727  dcsG; O-ureido-D-serine cyclo-ligase
Enzymes [BR:ko01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.3  Cyclo-ligases
    6.3.3.5  O-ureido-D-serine cyclo-ligase
     K19727  dcsG; O-ureido-D-serine cyclo-ligase
Other DBs
COG: COG0189
Genes
AG: BAI70381(dcsG)
Reference
PMID:20086163
  Authors
Kumagai T, Koyama Y, Oda K, Noda M, Matoba Y, Sugiyama M
  Title
Molecular cloning and heterologous expression of a biosynthetic gene cluster for the antitubercular agent D-cycloserine produced by Streptomyces lavendulae.
  Journal
Antimicrob Agents Chemother 54:1132-9 (2010)
DOI:10.1128/AAC.01226-09
  Sequence
[ag:BAI70381]
LinkDB

KEGG   ENZYME: 6.3.3.5
Entry
EC 6.3.3.5                  Enzyme                                 
Name
O-ureido-D-serine cyclo-ligase;
dcsG (gene name)
Class
Ligases;
Forming carbon-nitrogen bonds;
Cyclo-ligases
Sysname
O-ureido-D-serine cyclo-ligase (D-cycloserine-forming)
Reaction(IUBMB)
O-ureido-D-serine + ATP + H2O = D-cycloserine + CO2 + NH3 + ADP + phosphate [RN:R10470]
Reaction(KEGG)
R10470
Substrate
O-ureido-D-serine [CPD:C20651];
ATP [CPD:C00002];
H2O [CPD:C00001]
Product
D-cycloserine [CPD:C08057];
CO2 [CPD:C00011];
NH3 [CPD:C00014];
ADP [CPD:C00008];
phosphate [CPD:C00009]
Comment
The enzyme participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species.
History
EC 6.3.3.5 created 2013
Pathway
ec00998  Biosynthesis of various antibiotics
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K19727  O-ureido-D-serine cyclo-ligase
Reference
1  [PMID:20086163]
  Authors
Kumagai T, Koyama Y, Oda K, Noda M, Matoba Y, Sugiyama M
  Title
Molecular cloning and heterologous expression of a biosynthetic gene cluster for the antitubercular agent D-cycloserine produced by Streptomyces lavendulae.
  Journal
Antimicrob Agents Chemother 54:1132-9 (2010)
DOI:10.1128/AAC.01226-09
  Sequence
[ag:BAI70381]
Reference
2  [PMID:23529730]
  Authors
Uda N, Matoba Y, Kumagai T, Oda K, Noda M, Sugiyama M
  Title
Establishment of an in vitro D-cycloserine-synthesizing system by using O-ureido-L-serine synthase and D-cycloserine synthetase found in the biosynthetic pathway.
  Journal
Antimicrob Agents Chemother 57:2603-12 (2013)
DOI:10.1128/AAC.02291-12
  Sequence
[ag:BAI70381]
Other DBs
ExplorEnz - The Enzyme Database: 6.3.3.5
IUBMB Enzyme Nomenclature: 6.3.3.5
ExPASy - ENZYME nomenclature database: 6.3.3.5
BRENDA, the Enzyme Database: 6.3.3.5
LinkDB

KEGG   REACTION: R10470
Entry
R10470                      Reaction                               
Name
O-ureido-D-serine cyclo-ligase (D-cycloserine-forming)
Definition
O-Ureido-D-serine + ATP + H2O <=> Cycloserine + CO2 + Ammonia + ADP + Orthophosphate
Equation
C20651 + C00002 + C00001 <=> C08057 + C00011 + C00014 + C00008 + C00009
Reaction class
RC00002  C00002_C00008
RC03170  C08057_C20651
Enzyme
6.3.3.5
Pathway
rn00998  Biosynthesis of various antibiotics
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00785  Cycloserine biosynthesis, arginine/serine => cycloserine
Brite
Enzymatic reactions [BR:br08201]
 6. Ligase reactions
  6.3  Forming carbon-nitrogen bonds
   6.3.3  Cyclo-ligases
    6.3.3.5
     R10470  O-Ureido-D-serine + ATP + H2O <=> Cycloserine + CO2 + Ammonia + ADP + Orthophosphate
Orthology
K19727  O-ureido-D-serine cyclo-ligase [EC:6.3.3.5]
Other DBs
RHEA: 36714
LinkDB

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