KEGG ORTHOLOGY: K19754

ORTHOLOGY: K19754

Entry

K19754                      KO

Symbol

DRC1

Name

dynein regulatry complex protein 1

Disease

H00564

Primary ciliary dyskinesia

H01282

Spermatogenic failure

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   03037 Cilium and associated proteins
    K19754  DRC1; dynein regulatry complex protein 1
   04812 Cytoskeleton proteins
    K19754  DRC1; dynein regulatry complex protein 1
Cilium and associated proteins [BR:ko03037]
Motile cilia and associated proteins
  Nexin-dynein regulatory complex
   K19754  DRC1; dynein regulatry complex protein 1
Cytoskeleton proteins [BR:ko04812]
Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Dyneins
     Dynein-related proteins
      K19754  DRC1; dynein regulatry complex protein 1

Genes

HSA:	92749(DRC1)

PTR:	459082(DRC1)

PPS:	100980362(DRC1)

GGO:	101143423(DRC1)

PON:	100450913(DRC1)

NLE:	100597004(DRC1)

HMH:	116480445(DRC1)

MCC:	696596(DRC1)

MCF:	102130370(DRC1)

MTHB:

126933650

MNI:	105479911(DRC1)

CSAB:

103220634(DRC1)

CATY:

105578498(DRC1)

PANU:

101018388(DRC1)

TGE:	112604764(DRC1)

MLEU:

105534066(DRC1)

RRO:	104677896(DRC1)

RBB:	108532686(DRC1)

TFN:	117062596(DRC1)

PTEH:

111554477(DRC1)

CANG:

105517648(DRC1)

CJC:	108588274(DRC1)

SBQ:	101042964(DRC1)

CIMI:

108315895(DRC1)

CSYR:

103270593(DRC1)

MMUR:

105884368(DRC1)

LCAT:

123636695(DRC1)

PCOQ:

105816893(DRC1)

OGA:	100957110(DRC1)

MMU:	381738(Drc1)

MCAL:

110295354(Drc1)

MPAH:

110324810(Drc1)

RNO:	362712(Drc1)

MCOC:

116080534(Drc1)

ANU:	117717126(Drc1)

MUN:	110547689(Drc1)

CGE:	100759288(Drc1)

MAUA:

101822936(Drc1)

PROB:

127220063(Drc1)

PLEU:

114696527(Drc1)

MORG:

121433002 121439716

MFOT:

126492270

AAMP:

119808198(Drc1)

NGI:	103735663(Drc1)

HGL:	101697182(Drc1)

CPOC:

100729932(Drc1)

CCAN:

109699095(Drc1)

DORD:

105983589(Drc1)

DSP:	122122517(Drc1)

PLOP:

125356658(Drc1)

NCAR:

124963236

MMMA:

107137038(Drc1)

OCU:

100354262

OPI:	101532679(DRC1)

TUP:	102471093(DRC1)

GVR:

103610895

CFA:	475690(DRC1)

CLUD:

112664665(DRC1)

VVP:	112908517(DRC1)

VLG:	121490966(DRC1)

NPO:	129511006(DRC1)

AML:	100468976(DRC1)

UMR:	103671924(DRC1)

UAH:	113270844(DRC1)

UAR:	123799935(DRC1)

ELK:

111154169

LLV:

125109588

MPUF:

101688960(DRC1)

MNP:	132021203(DRC1)

MLK:	131807274(DRC1)

NVS:	122915242(DRC1)

ORO:	101363966(DRC1)

EJU:	114205919(DRC1)

ZCA:	113938654(DRC1)

MLX:	118007674(DRC1)

NSU:	110587220(DRC1)

LWW:	102746864(DRC1)

FCA:	101092351(DRC1)

PYU:	121044222(DRC1)

PCOO:

112864097(DRC1)

PBG:	122497364(DRC1)

PVIV:

125163085(DRC1)

LRUF:

124504221

PTG:	102949618(DRC1)

PPAD:

109267208(DRC1)

PUC:

125937617

AJU:

106967906

HHV:	120235825(DRC1)

BTA:	509524(DRC1)

BOM:	102287999(DRC1)

BIU:	109566311(DRC1)

BBUB:

102396715(DRC1)

BBIS:

104989056(DRC1)

CHX:	102187600(DRC1)

OAS:	101110744(DRC1)

BTAX:

128056692(DRC1)

ODA:	120851584(DRC1)

CCAD:

122441973(DRC1)

MBEZ:

129539104(DRC1)

SSC:	102159735(DRC1)

CFR:	102508150(DRC1)

CBAI:

105063856(DRC1)

CDK:	105098514(DRC1)

VPC:	102540842(DRC1)

BACU:

103003927(DRC1)

BMUS:

118906460(DRC1)

LVE:	103087892(DRC1)

OOR:	101288125(DRC1)

DLE:	111174984(DRC1)

PCAD:

102995808(DRC1)

PSIU:

116764356(DRC1)

NASI:

112412765(DRC1)

ECB:	100071349(DRC1)

EPZ:	103546458(DRC1)

EAI:	106832679(DRC1)

MYB:	102262105(DRC1)

MYD:	102774581(DRC1)

MMYO:

118669203(DRC1)

MLF:	102434113(DRC1)

PKL:	118717219(DRC1)

EFUS:

103283152(DRC1)

MNA:	107534784(DRC1)

DRO:	112298106(DRC1)

SHON:

119001415(DRC1)

AJM:	119050448(DRC1)

PDIC:

114500074(DRC1)

PHAS:

123822551(DRC1)

MMF:	118631003(DRC1)

PPAM:

129065068(DRC1)

HAI:	109391393(DRC1)

RFQ:	117033463(DRC1)

PALE:

102890229(DRC1)

PGIG:

120621872(DRC1)

PVP:	105289752(DRC1)

RAY:	107505204(DRC1)

MJV:	108391184(DRC1)

TOD:	119259470(DRC1)

SARA:

101554960(DRC1)

SETR:

126024284(DRC1)

LAV:	100671944(DRC1)

TMU:

101358756

ETF:	101650269(DRC1)

DNM:	101442364(DRC1)

MDO:	100030821(DRC1)

GAS:	123233522(DRC1)

SHR:	100933482(DRC1)

AFZ:

127548768

PCW:	110206506(DRC1)

OAA:	100078391(DRC1)

GGA:	422009(DRC1)

PCOC:

116235627(DRC1)

MGP:	100539548(DRC1)

CJO:	107312417(DRC1)

TPAI:

128084886(DRC1)

LMUT:

125689766(DRC1)

NMEL:

110396140(DRC1)

APLA:

101789971(DRC1)

ACYG:

106038097(DRC1)

CATA:

118256524(DRC1)

AFUL:

116487523(DRC1)

TGU:	105760434(DRC1)

LSR:

110477397

SCAN:

108963710(DRC1)

PMOA:

120503434(DRC1)

OTC:	121339188(DRC1)

PRUF:

121360476(DRC1)

FAB:	101805829(DRC1)

PHI:

102099545

PMAJ:

107199106

CCAE:

111927476(DRC1)

CBRC:

103611215(DRC1)

ACHL:

103810671(DRC1)

SVG:	106860375(DRC1)

FPG:	101922247(DRC1)

FCH:	102047543(DRC1)

CLV:	102093328(DRC1)

EGZ:	104132027(DRC1)

NNI:	104014766(DRC1)

PCRI:

104038255(DRC1)

PLET:

104622228(DRC1)

EHS:	104507122(DRC1)

PCAO:

104039810(DRC1)

ACUN:

113478852(DRC1)

TALA:

104361676(DRC1)

PADL:

103913291(DRC1)

AFOR:

103902400(DRC1)

ACHC:

115351215(DRC1)

HALD:

104313123(DRC1)

HLE:	104841504(TRIM35)

AGEN:

126046706

GCL:

127014575

CCRI:

104165351(DRC1)

CSTI:

104553114(DRC1)

CMAC:

104481081(DRC1)

BREG:

104631851(DRC1)

FGA:	104075539(DRC1)

GSTE:

104257452(DRC1)

LDI:	104340324(DRC1)

MNB:	103768344(DRC1)

OHA:	104330705(DRC1)

NNT:	104403527(DRC1)

SHAB:

115609969 115609992

DPUB:

104306751(DRC1)

CVF:	104295691(DRC1)

RTD:	128907538(DRC1)

CUCA:

104061816(DRC1)

TEO:	104369946(DRC1)

BRHI:

104493292(DRC1)

AAM:	106488012(DRC1)

AROW:

112966666(DRC1)

NPD:	112948789(DRC1)

TGT:	104568499(DRC1)

DNE:	112984275(DRC1)

SCAM:

104154088(DRC1)

ASN:	102385708(DRC1)

AMJ:	102577086(DRC1)

CPOO:

109312066(DRC1)

PSS:	102457352(DRC1)

CMY:	102939697(DRC1)

CCAY:

125634810(DRC1)

DCC:	119853525(DRC1)

CPIC:

101950348(DRC1)

CABI:

116835635(DRC1)

MRV:	120399998(DRC1)

ACS:	100559501(drc1)

ASAO:

132761694(DRC1)

PVT:	110089590(DRC1)

SUND:

121929607(DRC1)

PBI:	103051167(DRC1)

PMUR:

107289052(DRC1)

CTIG:

120309123(DRC1)

TSR:	106555521(DRC1)

PGUT:

117667677(DRC1)

APRI:

131188836(DRC1)

PTEX:

113446344(DRC1)

NSS:	113414521(DRC1)

VKO:	123033617(DRC1)

PMUA:

114593440(DRC1)

PRAF:

128411601(DRC1)

ZVI:	118082544(DRC1)

HCG:	128324867(DRC1)

GJA:	107126256(DRC1)

STOW:

125444675(DRC1)

EMC:	129335070(DRC1)

XLA:	379530(drc1.L)

XTR:	100494062(drc1)

NPR:	108802783(DRC1)

RTEM:

120936207(DRC1)

BBUF:

120997137(DRC1)

BGAR:

122935645(DRC1)

MUO:	115467014(DRC1)

GSH:	117351835 117356524(DRC1)

DRE:	100034551(drc1)

SRX:	107726498 107726629

SANH:

107696151 107698403

SGH:	107555624 107602748

CCAR:

109059054(drc1) 109083802

CAUA:

113062987 113120806

CGIB:

127938866 127984509

PTET:

122325532(drc1)

LROH:

127183480(drc1)

OMC:	131527702(drc1)

PPRM:

120493648(drc1)

RKG:	130103208(drc1)

MAMB:

125278167(drc1)

CIDE:

127502308

MASI:

127425583

TROS:

130566436(drc1)

TDW:	130433870(drc1)

MANU:

129430090(drc1)

IPU:	108266160 108268164 108268170

IFU:	128609197 128610357 128610411

PHYP:

113524999(drc1)

SMEO:

124383218(drc1)

TFD:	113639761 113639956

TVC:	132849984 132849985

AMEX:

103046744

CMAO:

118815915(drc1)

EEE:	113588484(drc1)

CHAR:

105901453(drc1)

TRU:	101072942(drc1)

TFS:	130516614(drc1)

TNG:	GSTEN00023102G001

LCO:	109141304(drc1)

NCC:	104966130(drc1)

TBEN:

117492763(drc1)

CGOB:

115003904(drc1)

PGEO:

117439899(drc1)

GACU:

117555818(drc1)

EMAC:

134877155(drc1)

ELY:

117259753

EFO:

125880938

SLUC:

116066215(drc1)

ECRA:

117961476(drc1)

ESP:	116706033(drc1)

PFLV:

114573552(drc1)

GAT:	120830932(drc1)

PPUG:

119219197(drc1)

AFB:	129107583(drc1)

CLUM:

117739022(drc1)

PSWI:

130198688(drc1)

MSAM:

119909159(drc1)

SCHU:

122863163(drc1)

CUD:	121520935(drc1)

ALAT:

119012317(drc1)

MZE:	101481899(drc1)

ONL:	102081769(drc1)

OAU:	116310768(drc1)

OLA:	101155737(drc1)

OML:	112158085(drc1)

CSAI:

133457878(drc1)

XMA:	102232827(drc1)

XCO:	114154750(drc1)

XHE:	116729884(drc1)

PRET:

103470598(drc1)

PFOR:

103147205(drc1)

PLAI:

106949587(drc1)

PMEI:

106933184(drc1)

GAF:

122827821

PPRL:

129372906(drc1)

GMU:	124865889(drc1)

NFU:

107377528

KMR:	108233420(drc1)

ALIM:

106518638(drc1)

NWH:	119418247(drc1)

AOCE:

111587289

CSEM:

103380978(drc1) 103390507

POV:	109636185(drc1)

SSEN:

122778806 122783861

HHIP:

117758554(drc1)

HSP:	118099133(drc1)

SMAU:

118290115(drc1)

LCF:

108883121

SDU:	111235850(drc1)

SLAL:

111658322(drc1)

XGL:	120789129(drc1)

HCQ:	109517896 109531027(drc1)

SSCV:

125981709

SBIA:

133514033(drc1)

PEE:	133415701 133417169

PTAO:

133467216 133468294(drc1)

MALB:

109962105 109973676

BSPL:

114850123(drc1)

SJO:	128376842(drc1)

SASA:

106571766(drc1)

STRU:

115174466(drc1)

OTW:	112232963(drc1)

OMY:	110529885(drc1)

OGO:	123991014(drc1)

ONE:	115108016(drc1)

OKI:	109900987(drc1)

OKE:	118398389(drc1)

SALP:

111954554(drc1)

SNH:	120023928(drc1)

CCLU:

121552289(drc1)

ELS:	105030556(drc1) 106024746

SFM:	108921093 108935924

PKI:	111851534(drc1)

AANG:

118230698(drc1)

LOC:	102688496(drc1)

PSPA:

121317476(drc1)

ARUT:

117410982(drc1)

PSEX:

120525743(drc1)

LCM:	102358568(DRC1)

CMK:	103183134(drc1)

CPLA:

122540458(drc1)

HOC:	132808141(drc1)

LERI:

129697158(drc1)

PMRN:

116946587(DRC1)

LRJ:	133352860(DRC1)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

AJC:

SKO:

DME:	Dmel_CG10958(CG10958)

DER:

6550308

DSE:

6620169

DSI:	Dsimw501_GD16879(Dsim_GD16879)

DYA:	Dyak_GE15761

DAN:

6503988

DSR:	110179721 110185296

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI14361

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:	119669085 119671109

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

109424536 115255851 115255853 115269399

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

DSM:

NPT:

NLO:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_207386

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:	105380151 105394930

PGW:	126370859 126373563

CCRN:

123300387

API:	100160150 100572937

DNX:

AGS:

RMD:

ACOO:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM127190

TPAL:

ZNE:

CSEC:

BROR:

IEL:

DPX:	DAPPUDRAFT_101154

DMK:

PJA:

PCHN:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

EAF:

LSM:

TCF:

PPOI:

CSCU:

PMEO:

HRO:	HELRODRAFT_188640

LGI:	LOTGIDRAFT_225997

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:	124273051 124273054

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:	106152050 106169860

SMM:	Smp_135670

SHX:	MS3_00011040(DRC1)

OVI:	T265_08736

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

TAD:	TRIADDRAFT_50537

AQU:

100639912

SMO:	SELMODRAFT_420977 SELMODRAFT_450597

PPP:

112286166

VCN:	VOLCADRAFT_81425

MNG:	MNEG_12945

MIS:	MICPUN_67523

MPP:	MICPUCDRAFT_48895(JGI:MicpuC2_48895)

MBR:	MONBRDRAFT_32581

SRE:	PTSG_05992

PFA:	PF3D7_1403400

PFH:	PFHG_00417

PGAB:

PGSY75_1403400

PYO:	PY17X_1041000

PCB:	PCHAS_1039400

PBE:	PBANKA_1038600

PVV:	PVVCY_1004400

PKN:	PKNH_1354700

PVX:	PVX_086265

PCY:	PCYB_135310

PMAL:

PMUG01_13054900

PREL:

PRELSG_1347600

TGO:	TGME49_267875

TET:	TTHERM_01345750

PTM:	GSPATT00008103001 GSPATT00024309001

SMIN:

v1.2.005535.t1(symbB.v1.2.005535.t1)

TPS:	THAPS_10929

AAF:	AURANDRAFT_32588

PIF:	PITG_19516

PSOJ:

PHYSODRAFT_351042

SPAR:

SPRG_00427

EHX:	EMIHUDRAFT_63754

GTT:	GUITHDRAFT_159902 GUITHDRAFT_56998

TBR:	Tb10.6k15.2670

TBG:	TbgDal_X9650

TCR:	506247.380

LMA:	LMJF_36_6590

LIF:	LINJ_36_6900

LDO:	LDBPK_366900

LMI:	LMXM_36_6590

LBZ:	LBRM_35_6950

LPAN:

LPMP_356780

TVA:	TVAG_2v0507810 TVAG_2v0577840

GLA:	GL50803_0016237

» show all

Reference

PMID:23354437

Authors

Wirschell M, Olbrich H, Werner C, Tritschler D, Bower R, Sale WS, Loges NT, Pennekamp P, Lindberg S, Stenram U, Carlen B, Horak E, Kohler G, Nurnberg P, Nurnberg G, Porter ME, Omran H

Title

The nexin-dynein regulatory complex subunit DRC1 is essential for motile cilia function in algae and humans.

Journal

Nat Genet 45:262-8 (2013)
DOI:10.1038/ng.2533

Sequence

[hsa:92749]

LinkDB

DBGET integrated database retrieval system