KEGG   ORTHOLOGY: K20077
Entry
K20077                      KO                                     
Symbol
staC
Name
flavin-dependent monooxygenase StaC [EC:1.13.12.-]
Pathway
map00404  Staurosporine biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00805  Staurosporine biosynthesis, tryptophan => staurosporine
Reaction
R11121  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00404 Staurosporine biosynthesis
    K20077  staC; flavin-dependent monooxygenase StaC
Other DBs
COG: COG0654
Genes
SRN: A4G23_00555(tfdB)
SCLF: BB341_29635
SSPO: DDQ41_30655
SPAD: DVK44_01705
SFB: CP974_02875
SMOB: J7W19_26975
SOV: QZH56_05150
KUT: JJ691_00990
SAQ: Sare_2333
MCAY: PVK37_17630
AG: BAF47693(staC)
 » show all
Reference
PMID:16967980
  Authors
Howard-Jones AR, Walsh CT
  Title
Staurosporine and rebeccamycin aglycones are assembled by the oxidative action of StaP, StaC, and RebC on chromopyrrolic acid.
  Journal
J Am Chem Soc 128:12289-98 (2006)
DOI:10.1021/ja063898m
  Sequence
[ag:BAF47693]
LinkDB

KEGG   ORTHOLOGY: K20078
Entry
K20078                      KO                                     
Symbol
staP
Name
cytochrome P450 StaP [EC:1.13.12.-]
Pathway
map00404  Staurosporine biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00805  Staurosporine biosynthesis, tryptophan => staurosporine
Reaction
R11121  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00404 Staurosporine biosynthesis
    K20078  staP; cytochrome P450 StaP
Other DBs
COG: COG2124
Genes
SRN: A4G23_00558(bioI_2)
SCLF: BB341_29670
SSPO: DDQ41_30690
SPAD: DVK44_01745
SFB: CP974_02890
SMAO: CAG99_27170
STUB: MMF93_03655
SOV: QZH56_34515
KUT: JJ691_19130
SAQ: Sare_2331
SCYT: SAMD_66600
SCYS: NIES4073_38030
BSEN: DP114_13225
BOX: DP113_13165
AG: BAC55212(staP)
 » show all
Reference
PMID:17606921
  Authors
Makino M, Sugimoto H, Shiro Y, Asamizu S, Onaka H, Nagano S
  Title
Crystal structures and catalytic mechanism of cytochrome P450 StaP that produces the indolocarbazole skeleton.
  Journal
Proc Natl Acad Sci U S A 104:11591-6 (2007)
DOI:10.1073/pnas.0702946104
  Sequence
[ag:BAC55212]
LinkDB

KEGG   REACTION: R11121
Entry
R11121                      Reaction                               
Definition
Chromopyrrolate + 2 Oxygen + 2 NADH + 3 H+ <=> K-252c + 2 CO2 + 3 H2O + 2 NAD+
Equation
C21125 + 2 C00007 + 2 C00004 + 3 C00080 <=> C21126 + 2 C00011 + 3 C00001 + 2 C00003
Reaction class
RC00001  C00003_C00004
RC03361  C21125_C21126
Enzyme
1.13.12.-
Pathway
rn00404  Staurosporine biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00805  Staurosporine biosynthesis, tryptophan => staurosporine
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.12  With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
    1.13.12.-
     R11121  Chromopyrrolate + 2 Oxygen + 2 NADH + 3 H+ <=> K-252c + 2 CO2 + 3 H2O + 2 NAD+
Orthology
K20077  flavin-dependent monooxygenase StaC [EC:1.13.12.-]
K20078  cytochrome P450 StaP [EC:1.13.12.-]
LinkDB

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