KEGG   ORTHOLOGY: K20142
Entry
K20142            Tight     KO                                     
Symbol
IDOLDH
Name
ipsdienol dehydrogenase [EC:1.1.1.386]
Pathway
map00902  Monoterpenoid biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R10918  (R)-ipsdienol:NAD+ oxidoreductase
R10919  (R)-ipsdienol:NADP+ oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00902 Monoterpenoid biosynthesis
    K20142  IDOLDH; ipsdienol dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.386  ipsdienol dehydrogenase
     K20142  IDOLDH; ipsdienol dehydrogenase
Genes
AG: AEQ59233(IDOLDH)
Reference
PMID:22101251
  Authors
Figueroa-Teran R, Welch WH, Blomquist GJ, Tittiger C
  Title
Ipsdienol dehydrogenase (IDOLDH): a novel oxidoreductase important for Ips pini pheromone production.
  Journal
Insect Biochem Mol Biol 42:81-90 (2012)
DOI:10.1016/j.ibmb.2011.10.009
  Sequence
[ag:AEQ59233]
LinkDB

KEGG   ENZYME: 1.1.1.386
Entry
EC 1.1.1.386                Enzyme                                 
Name
ipsdienol dehydrogenase;
IDOLDH
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(R)-ipsdienol:NAD(P)+ oxidoreductase
Reaction(IUBMB)
(R)-ipsdienol + NAD(P)+ = ipsdienone + NAD(P)H + H+ [RN:R10918 R10919]
Reaction(KEGG)
R10918 R10919
Substrate
(R)-ipsdienol [CPD:C20943];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
ipsdienone [CPD:C20944];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme is involved in pheromone production by the pine engraver beetle, Ips pini.
History
EC 1.1.1.386 created 2015
Pathway
ec00902  Monoterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K20142  ipsdienol dehydrogenase
Reference
1  [PMID:22101251]
  Authors
Figueroa-Teran R, Welch WH, Blomquist GJ, Tittiger C
  Title
Ipsdienol dehydrogenase (IDOLDH): a novel oxidoreductase important for Ips pini pheromone production.
  Journal
Insect Biochem Mol Biol 42:81-90 (2012)
DOI:10.1016/j.ibmb.2011.10.009
  Sequence
[ag:AEQ59233]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.386
IUBMB Enzyme Nomenclature: 1.1.1.386
ExPASy - ENZYME nomenclature database: 1.1.1.386
BRENDA, the Enzyme Database: 1.1.1.386
LinkDB

KEGG   REACTION: R10918
Entry
R10918                      Reaction                               
Name
(R)-ipsdienol:NAD+ oxidoreductase
Definition
(R)-Ipsdienol + NAD+ <=> Ipsdienone + NADH + H+
Equation
C20943 + C00003 <=> C20944 + C00004 + C00080
Comment
NADP+ (see R10919)
Reaction class
RC00001  C00003_C00004
RC00241  C20943_C20944
Enzyme
1.1.1.386
Pathway
rn00902  Monoterpenoid biosynthesis
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.386
     R10918  (R)-Ipsdienol + NAD+ <=> Ipsdienone + NADH + H+
Orthology
K20142  ipsdienol dehydrogenase [EC:1.1.1.386]
Other DBs
RHEA: 45123
LinkDB

KEGG   REACTION: R10919
Entry
R10919                      Reaction                               
Name
(R)-ipsdienol:NADP+ oxidoreductase
Definition
(R)-Ipsdienol + NADP+ <=> Ipsdienone + NADPH + H+
Equation
C20943 + C00006 <=> C20944 + C00005 + C00080
Comment
NAD+ (see R10918)
Reaction class
RC00001  C00005_C00006
RC00241  C20943_C20944
Enzyme
1.1.1.386
Pathway
rn00902  Monoterpenoid biosynthesis
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.386
     R10919  (R)-Ipsdienol + NADP+ <=> Ipsdienone + NADPH + H+
Orthology
K20142  ipsdienol dehydrogenase [EC:1.1.1.386]
Other DBs
RHEA: 45119
LinkDB

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