KEGG ORTHOLOGY: K20495

ORTHOLOGY: K20495

Entry

K20495                      KO

Symbol

CYP704B1

Name

long-chain fatty acid omega-monooxygenase [EC:1.14.14.80]

Pathway

map00071

Fatty acid degradation

map00073

Cutin, suberine and wax biosynthesis

map01100

Metabolic pathways

Reaction

R01348

fatty acid,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (omega-hydroxylating)

R09451

hexadecanoic acid:fatty acid omega-hydroxylase

R09452

(9Z)-octadecenoic acid,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (omega-hydroxylating)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00071 Fatty acid degradation
    K20495  CYP704B1; long-chain fatty acid omega-monooxygenase
   00073 Cutin, suberine and wax biosynthesis
    K20495  CYP704B1; long-chain fatty acid omega-monooxygenase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K20495  CYP704B1; long-chain fatty acid omega-monooxygenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.80  long-chain fatty acid omega-monooxygenase
     K20495  CYP704B1; long-chain fatty acid omega-monooxygenase
Cytochrome P450 [BR:ko00199]
Cytochrome P450, plant type
  CYP704 family
   K20495  CYP704B1; long-chain fatty acid omega-monooxygenase

Genes

ATH:	AT1G69500(CYP704B1)

ALY:

9323303

CRB:

17896290

CSAT:

104701580 104750786 104788010

EUS:	EUTSA_v10018405mg

BRP:

103831345

BNA:	106357195 106405268

BOE:

RSZ:

THJ:

CPAP:

CIT:

CIC:	CICLE_v10010274mg

PVY:

MINC:

TCC:

GRA:

GHI:	107918628 107946410

GAB:

DZI:

EGR:

GMX:

GSJ:

PVU:	PHAVU_010G126900g

VRA:

VAR:

VUN:

CCAJ:

APRC:

MTR:	11408642 11422281

TPRA:

123885362 123885455

CAM:

101510760

PSAT:

127076222

LJA:	Lj3g3v2576010.1(Lj3g3v2576010.1)

ADU:

107471687

AIP:

107621191

AHF:	112717069 112783985

LANG:

PCIN:

FVE:

RCN:

PPER:

PMUM:

PAVI:

MDM:

MSYL:

ZJU:

MNT:

CSAV:

CSV:

CMO:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

JCU:

HBR:	110647960 110672616

MESC:

POP:

PEU:

PALZ:

JRE:

CILL:

CAVE:

QSU:

QLO:

TWL:

VVI:

VRI:

SLY:

SPEN:

SOT:

SSTN:

CANN:

LBB:

NTA:	107791425 107809664

NSY:

NTO:

NAU:

INI:

ITR:

SIND:

OEU:	111381728 111403329 111403331

EGT:

SSPL:

SMIL:

APAN:

HAN:

ECAD:

LSV:

CCAV:

DCR:

CSIN:

RVL:

AEW:

BVG:

SOE:

CQI:	110706346 110712857

ATRI:

130820869

MOF:	131144911 131146455

NNU:

104598197

MING:

122077509

TSS:

122656937

PSOM:

113276881 113277819 113294044 113315034 113327834 113344306 113347695 113347697 113347700 113350438 113352775 113353311 113354302 113354495

OSA:

4331756

DOSA:

Os03t0168600-01(Os03g0168600)

OBR:

OGL:

BDI:

ATS:

TDC:	119284622 119291544

TAES:

123084791 123093296 123098566

TUA:

LPER:

LRD:

SBI:

ZMA:

SITA:

SVS:

PVIR:

PHAI:

PDA:

EGU:

MUS:

DCT:

PEQ:

AOF:

NCOL:

ATR:

SMO:	SELMODRAFT_101765 SELMODRAFT_80659(CYP704B17)

PPP:	112275480 112291140 112294808

SGRA:

EX895_002629

» show all

Reference

PMID:19700560

Authors

Dobritsa AA, Shrestha J, Morant M, Pinot F, Matsuno M, Swanson R, Moller BL, Preuss D

Title

CYP704B1 is a long-chain fatty acid omega-hydroxylase essential for sporopollenin synthesis in pollen of Arabidopsis.

Journal

Plant Physiol 151:574-89 (2009)
DOI:10.1104/pp.109.144469

Sequence

[ath:AT1G69500]

LinkDB

ENZYME: 1.14.14.80

Entry

EC 1.14.14.80               Enzyme

Name

long-chain fatty acid omega-monooxygenase;
CYP704B1 (gene name);
CYP52M1 (gene name);
CYP4A (gene name);
CYP86A (gene name)

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

long-chain fatty acid,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (omega-hydroxylating)

Reaction(IUBMB)

a long-chain fatty acid + [reduced NADPH---hemoprotein reductase] + O2 = an omega-hydroxy-long-chain fatty acid + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R12072]

Reaction(KEGG)

R12072 > R07041 R09451 R09452;
(other) R01348 R07046

Substrate

long-chain fatty acid [CPD:C00638];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]

Product

omega-hydroxy-long-chain fatty acid [CPD:C21886];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]

Comment

A cytochrome P-450 (heme thiolate) enzyme. The plant enzyme CYP704B1, which is involved in the synthesis of sporopollenin, a complex polymer found at the outer layer of spores and pollen, acts on palmitate (18:0), stearate (18:0) and oleate (18:1). The plant enzyme CYP86A1 also acts on laurate (12:0). The enzyme from the yeast Starmerella bombicola (CYP52M1) acts on C16 to C20 saturated and unsaturated fatty acids and can also hydroxylate the (omega-1) position. The mammalian enzyme CYP4A acts on laurate (12:0), myristate (14:0), palmitate (16:0), oleate (18:1), and arachidonate (20:4).

History

EC 1.14.14.80 created 2015 as EC 1.14.13.205, transferred 2018 to EC 1.14.14.80

Pathway

ec00071

Fatty acid degradation

ec00073

Cutin, suberine and wax biosynthesis

ec00590

Arachidonic acid metabolism

ec01100

Metabolic pathways

Orthology

K07422