KEGG   ORTHOLOGY: K20514
Entry
K20514            Tight     KO                                     
Symbol
DC1
Name
phyllocladan-16alpha-ol/copalyl diphosphate synthase [EC:4.2.3.45 5.5.1.12]
Pathway
map00904  Diterpenoid biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R06298  (+)-copalyl-diphosphate lyase (decyclizing)
R09686  (+)-copalyl-diphosphate diphosphate-lyase (phyllocladan-16alpha-ol-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00904 Diterpenoid biosynthesis
    K20514  DC1; phyllocladan-16alpha-ol/copalyl diphosphate synthase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.3  Acting on phosphates
    4.2.3.45  phyllocladan-16alpha-ol synthase
     K20514  DC1; phyllocladan-16alpha-ol/copalyl diphosphate synthase
 5. Isomerases
  5.5  Intramolecular lyases
   5.5.1  Intramolecular lyases (only sub-subclass identified to date)
    5.5.1.12  copalyl diphosphate synthase
     K20514  DC1; phyllocladan-16alpha-ol/copalyl diphosphate synthase
Other DBs
GO: 0050559
Genes
AG: BAG30961(PaDC1)
Reference
PMID:18391465
  Authors
Toyomasu T, Niida R, Kenmoku H, Kanno Y, Miura S, Nakano C, Shiono Y, Mitsuhashi W, Toshima H, Oikawa H, Hoshino T, Dairi T, Kato N, Sassa T
  Title
Identification of diterpene biosynthetic gene clusters and functional analysis of labdane-related diterpene cyclases in Phomopsis amygdali.
  Journal
Biosci Biotechnol Biochem 72:1038-47 (2008)
DOI:10.1271/bbb.70790
  Sequence
[ag:BAG30961]
LinkDB

KEGG   ENZYME: 4.2.3.45
Entry
EC 4.2.3.45                 Enzyme                                 
Name
phyllocladan-16alpha-ol synthase;
PaDC1
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
(+)-copalyl-diphosphate diphosphate-lyase (phyllocladan-16alpha-ol-forming)
Reaction(IUBMB)
(+)-copalyl diphosphate + H2O = phyllocladan-16alpha-ol + diphosphate [RN:R09686]
Reaction(KEGG)
R09686
Substrate
(+)-copalyl diphosphate [CPD:C11901];
H2O [CPD:C00001]
Product
phyllocladan-16alpha-ol [CPD:C19817];
diphosphate [CPD:C00013]
Comment
The adjacent gene PaDC2 codes EC 5.5.1.12 copalyl diphosphate synthase.
History
EC 4.2.3.45 created 2009
Pathway
ec00904  Diterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K20514  phyllocladan-16alpha-ol/copalyl diphosphate synthase
Reference
1  [PMID:18391465]
  Authors
Toyomasu T, Niida R, Kenmoku H, Kanno Y, Miura S, Nakano C, Shiono Y, Mitsuhashi W, Toshima H, Oikawa H, Hoshino T, Dairi T, Kato N, Sassa T
  Title
Identification of diterpene biosynthetic gene clusters and functional analysis of labdane-related diterpene cyclases in Phomopsis amygdali.
  Journal
Biosci Biotechnol Biochem 72:1038-47 (2008)
DOI:10.1271/bbb.70790
  Sequence
[ag:BAG30961]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.45
IUBMB Enzyme Nomenclature: 4.2.3.45
ExPASy - ENZYME nomenclature database: 4.2.3.45
BRENDA, the Enzyme Database: 4.2.3.45
LinkDB

KEGG   REACTION: R09686
Entry
R09686                      Reaction                               
Name
(+)-copalyl-diphosphate diphosphate-lyase (phyllocladan-16alpha-ol-forming)
Definition
Copalyl diphosphate + H2O <=> Phyllocladan-16alpha-ol + Diphosphate
Equation
C11901 + C00001 <=> C19817 + C00013
Reaction class
RC02602  C11901_C19817
Enzyme
4.2.3.45
Pathway
rn00904  Diterpenoid biosynthesis
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.2  Carbon-oxygen lyases
   4.2.3  Acting on phosphates
    4.2.3.45
     R09686  Copalyl diphosphate + H2O <=> Phyllocladan-16alpha-ol + Diphosphate
Orthology
K20514  phyllocladan-16alpha-ol/copalyl diphosphate synthase [EC:4.2.3.45 5.5.1.12]
Other DBs
RHEA: 26433
LinkDB

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