KEGG   ORTHOLOGY: K20611
Entry
K20611                      KO                                     
Symbol
crtD
Name
1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase [EC:1.3.99.37]
Pathway
map00906  Carotenoid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00906 Carotenoid biosynthesis
    K20611  crtD; 1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.99  With unknown physiological acceptors
    1.3.99.37  1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase
     K20611  crtD; 1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase
Other DBs
RN: R12708 R12709
COG: COG1233
Genes
RMF: D5E69_12835(crtI)
MTH: MTH_1807
MMG: MTBMA_c03770
METC: MTCT_1646
MWO: MWSIV6_0338(crtD)
METE: tca_01745(crtN)
METK: FVF72_02665(crtI)
MTHM: FZP57_01580(crtI)
METJ: FZP68_06595(crtI)
MEME: HYG87_02230(crtI) HYG87_08505(crtI)
HAL: VNG_1684G(crtI1) VNG_1755G(crtI2)
HSL: OE_3381R(crtI1) OE_3468R(crtI2)
HHB: Hhub_3180(crtI)
HAGS: JT689_08130(crtI) JT689_08410(crtI)
HABO: JRZ79_06545(crtI) JRZ79_06820(crtI)
HNO: LT974_11795(crtI)
HLU: LT972_03115(crtI)
HANR: LJ422_06800(crtI) LJ422_07070(crtI)
HALH: HTSR_0322(crtI)
HHSR: HSR6_0308(crtI)
HSU: HLASF_0240(crtI)
HSF: HLASA_0240(crtI)
SALR: FQU85_06785(crtI)
HALR: EFA46_012300(crtI)
HAAD: MW046_14460(crtI)
HALX: M0R89_12790(crtI)
HMA: rrnAC0321(crtI2) rrnAC1902(crtI1)
HHI: HAH_1058(crtI1) HAH_2415(crtI2)
HALJ: G9465_16515(crtI)
HSIN: KDQ40_01355(crtI) KDQ40_08200(crtI)
NPH: NP_0204A(crtI2) NP_4764A(crtD)
NMO: Nmlp_3026(crtI1) Nmlp_3576(crtI2)
NHO: HWV23_16745(crtI)
NSAL: HWV07_18225(crtI)
HALA: Hrd1104_01365(crtI) Hrd1104_03715(crtI)
HALZ: E5139_09960(crtI) E5139_11545(crtI)
HALL: LC1Hm_0581
HAZP: GBQ70_09955(crtI) GBQ70_11540(crtI)
HSN: DV733_06795(crtI) DV733_07110(crtI)
HRR: HZS55_20285(crtI)
HPEL: HZS54_23770(crtI)
HLT: I7X12_05360(crtI) I7X12_14750(crtI)
HDO: MUK72_08390(crtI)
HWA: HQ_1794A(crtI2) HQ_2863A(crtD)
HWC: Hqrw_1930(crtI2) Hqrw_3257(crtD)
HVO: HVO_2528(crtI)
HME: HFX_2550
HALE: G3A49_16065(crtI)
HAQ: DU484_15070(crtI)
HAJ: DU500_15100(crtI)
HAER: DU502_13080(crtI)
HRA: EI982_09630(crtI) EI982_16645(crtI)
HLM: DV707_06355(crtI)
HALM: FCF25_03150(crtI)
HLA: Hlac_1897
HALB: EKH57_01630(crtI) EKH57_08510(crtI)
HEZZ: EO776_04010(crtI) EO776_05030(crtI) EO776_09980(crtI)
HSS: J7656_06535(crtI) J7656_11800(crtI) J7656_12845(crtI)
HSAI: HPS36_01735(crtI) HPS36_03195(crtI) HPS36_12055(crtI)
HAZZ: KI388_01465(crtI) KI388_02585(crtI) KI388_07990(crtI)
HALN: B4589_011160(crtI)
HALG: HUG10_00795(crtI)
HALU: HUG12_16785(crtI)
HMP: K6T50_14385(crtI)
HRE: K6T36_14335(crtI)
HRM: K6T25_02470(crtI) K6T25_12720(crtI)
HACB: Hbl1158_06180(crtI) Hbl1158_16020(crtI)
HTU: Htur_2704
HJT: DVR14_14705(crtI)
HALY: HYG82_06630(crtI)
HSAL: JMJ58_15350(crtI)
HLO: J0X27_13920(crtI)
HAKZ: J0X25_02315(crtI)
NMG: Nmag_1001(crtI)
NAT: NJ7G_1612
NVR: FEJ81_05640(crtI)
NPL: FGF80_05295(crtI)
NAY: HYG81_05200(crtI)
SALI: L593_04765
SAIM: K0C01_03165(crtI) K0C01_06230(crtI)
NBG: DV706_10185(crtI)
NAS: GCU68_01890(crtI)
CDIV: CPM_0973
CSTY: KN1_09430
PAS: Pars_0409
POG: Pogu_1958
AG: BAP82509(crtD)
 » show all
Reference
  Authors
Yang Y, Yatsunami R, Ando A, Miyoko N, Fukui T, Takaichi S, Nakamura S
  Title
Complete biosynthetic pathway of the C50 carotenoid bacterioruberin from lycopene in the extremely halophilic archaeon Haloarcula japonica.
  Journal
J Bacteriol 197:1614-23 (2015)
DOI:10.1128/JB.02523-14
  Sequence
LinkDB

KEGG   ENZYME: 1.3.99.37
Entry
EC 1.3.99.37                Enzyme                                 
Name
1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase;
crtD (gene name)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With unknown physiological acceptors
Sysname
dihydroisopentenyldehydrorhodopin:acceptor 3,4-oxidoreductase
Reaction(IUBMB)
(1) dihydroisopentenyldehydrorhodopin + acceptor = isopentenyldehydrorhodopin + reduced acceptor [RN:R12708];
(2) dihydrobisanhydrobacterioruberin + acceptor = bisanhydrobacterioruberin + reduced acceptor [RN:R12709]
Reaction(KEGG)
R12708 R12709
Substrate
dihydroisopentenyldehydrorhodopin [CPD:C22058];
acceptor [CPD:C00028];
dihydrobisanhydrobacterioruberin [CPD:C22060]
Product
isopentenyldehydrorhodopin [CPD:C22059];
reduced acceptor [CPD:C00030];
bisanhydrobacterioruberin [CPD:C22347]
Comment
The enzyme, isolated from the archaeon Haloarcula japonica, is involved in the biosynthesis of the C50 carotenoid bacterioruberin. In this pathway it catalyses the desaturation of the C-3,4 double bond in dihydroisopentenyldehydrorhodopin and the desaturation of the C-3',4' double bond in dihydrobisanhydrobacterioruberin.
History
EC 1.3.99.37 created 2015
Pathway
ec00906  Carotenoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K20611  1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase
Genes
RMFD5E69_12835(crtI)
MTHMTH_1807
MMGMTBMA_c03770
METCMTCT_1646
MWOMWSIV6_0338(crtD)
METEtca_01745(crtN)
METKFVF72_02665(crtI)
MTHMFZP57_01580(crtI)
METJFZP68_06595(crtI)
MEMEHYG87_02230(crtI) HYG87_08505(crtI)
MZHMzhil_0948
MEMMemar_0116
HALVNG_1684G(crtI1) VNG_1755G(crtI2)
HSLOE_3381R(crtI1) OE_3468R(crtI2)
HDLHALDL1_13230
HHBHhub_3180(crtI)
HAGSJT689_08130(crtI) JT689_08410(crtI)
HABOJRZ79_06545(crtI) JRZ79_06820(crtI)
HNOLT974_11795(crtI)
HLULT972_03115(crtI)
HANRLJ422_06800(crtI) LJ422_07070(crtI)
HJEHacjB3_05880
HALHHTSR_0322(crtI)
HHSRHSR6_0308(crtI)
HSUHLASF_0240(crtI)
HSFHLASA_0240(crtI)
SALRFQU85_06785(crtI)
HALREFA46_012300(crtI)
HARAAArcS_2785 AArcS_2862
HAADMW046_14460(crtI)
HALXM0R89_12790(crtI)
HMArrnAC0321(crtI2) rrnAC1902(crtI1)
HHIHAH_1058(crtI1) HAH_2415(crtI2)
HHNHISP_05435 HISP_12295
HABSG26_04610 SG26_13105
HTABVU17_05180 BVU17_11750
HALJG9465_16515(crtI)
HSINKDQ40_01355(crtI) KDQ40_08200(crtI)
NPHNP_0204A(crtI2) NP_4764A(crtD)
NMONmlp_3026(crtI1) Nmlp_3576(crtI2)
NHOHWV23_16745(crtI)
NSALHWV07_18225(crtI)
HUTHuta_0318 Huta_2373
HTIHTIA_0507 HTIA_2106
HALAHrd1104_01365(crtI) Hrd1104_03715(crtI)
HMUHmuk_1360 Hmuk_1684
HALZE5139_09960(crtI) E5139_11545(crtI)
HALLLC1Hm_0581
HAZPGBQ70_09955(crtI) GBQ70_11540(crtI)
HALIBV210_13215
HSNDV733_06795(crtI) DV733_07110(crtI)
HDSHSR122_0174 HSR122_2630
HRRHZS55_20285(crtI)
HPELHZS54_23770(crtI)
HLTI7X12_05360(crtI) I7X12_14750(crtI)
HARCHARCEL1_04560 HARCEL1_05665
HDOMUK72_08390(crtI)
HWAHQ_1794A(crtI2) HQ_2863A(crtD)
HWCHqrw_1930(crtI2) Hqrw_3257(crtD)
HVOHVO_2528(crtI)
HMEHFX_2550
HGIABY42_12670
HALEG3A49_16065(crtI)
HBOHbor_10650
HAQDU484_15070(crtI)
HAJDU500_15100(crtI)
HAERDU502_13080(crtI)
HRAEI982_09630(crtI) EI982_16645(crtI)
HLMDV707_06355(crtI)
HALMFCF25_03150(crtI)
HLAHlac_1897
HALPDOS48_09165
HALBEKH57_01630(crtI) EKH57_08510(crtI)
HEZZEO776_04010(crtI) EO776_05030(crtI) EO776_09980(crtI)
HALQHrr1229_002465(crtI) Hrr1229_002950(crtI) Hrr1229_010285(crtI)
HSSJ7656_06535(crtI) J7656_11800(crtI) J7656_12845(crtI)
HSAIHPS36_01735(crtI) HPS36_03195(crtI) HPS36_12055(crtI)
HAZZKI388_01465(crtI) KI388_02585(crtI) KI388_07990(crtI)
SRUBC2R22_15240
HAEhalTADL_0469
HALNB4589_011160(crtI)
HALGHUG10_00795(crtI)
HALUHUG12_16785(crtI)
HMPK6T50_14385(crtI)
HREK6T36_14335(crtI)
HRMK6T25_02470(crtI) K6T25_12720(crtI)
HACBHbl1158_06180(crtI) Hbl1158_16020(crtI)
HDFAArcSl_1205(crtD) AArcSl_2786
HAHHalar_2115
HTUHtur_2704
HDABB347_07035 BB347_09725
HJTDVR14_14705(crtI)
HALYHYG82_06630(crtI)
HSALJMJ58_15350(crtI)
HLOJ0X27_13920(crtI)
HAKZJ0X25_02315(crtI)
NMGNmag_1001(crtI)
HXAHalxa_2222
NATNJ7G_1612
NPENatpe_1081
NVRFEJ81_05640(crtI)
NPLFGF80_05295(crtI)
NAYHYG81_05200(crtI)
NGENatgr_2200
HRUHalru_1199
NOUNatoc_1917
SALIL593_04765
SAIMK0C01_03165(crtI) K0C01_06230(crtI)
HLRHALLA_16025
HLCCHINAEXTREME08695 CHINAEXTREME13560
NAJB1756_14580
NAGAArcMg_0573 AArcMg_2863
NANAArc1_0585 AArc1_0840
NBGDV706_10185(crtI)
NASGCU68_01890(crtI)
CDIVCPM_0973
CSTYKN1_09430
PASPars_0409
POGPogu_1958
PYWPYWP30_01285
CSUCSUB_C0582
 » show all
Reference
1  [PMID:25712483]
  Authors
Yang Y, Yatsunami R, Ando A, Miyoko N, Fukui T, Takaichi S, Nakamura S
  Title
Complete biosynthetic pathway of the C50 carotenoid bacterioruberin from lycopene in the extremely halophilic archaeon Haloarcula japonica.
  Journal
J Bacteriol 197:1614-23 (2015)
DOI:10.1128/JB.02523-14
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.3.99.37
IUBMB Enzyme Nomenclature: 1.3.99.37
ExPASy - ENZYME nomenclature database: 1.3.99.37
BRENDA, the Enzyme Database: 1.3.99.37
LinkDB

KEGG   REACTION: R12709
Entry
R12709                      Reaction                               
Name
dihydrobisanhydrobacterioruberin:acceptor 3,4-oxidoreductase
Definition
Dihydrobisanhydrobacterioruberin + Acceptor <=> Bisanhydrobacterioruberin + Reduced acceptor
Equation
Reaction class
RC01970  C22060_C22347
Enzyme
Pathway
rn00906  Carotenoid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K20611  1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase [EC:1.3.99.37]
LinkDB

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