KEGG   ORTHOLOGY: K20611
Entry
K20611                      KO                                     
Symbol
crtD
Name
1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase [EC:1.3.99.37]
Pathway
map00906  Carotenoid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R12708  dihydroisopentenyldehydrorhodopin:acceptor 3,4-oxidoreductase
R12709  dihydrobisanhydrobacterioruberin:acceptor 3,4-oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00906 Carotenoid biosynthesis
    K20611  crtD; 1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.99  With unknown physiological acceptors
    1.3.99.37  1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase
     K20611  crtD; 1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase
Other DBs
COG: COG1233
Genes
SHUA: PQ477_16765(crtI)
RMF: D5E69_12835(crtI)
LMAJ: GKN94_13460(crtI)
SASS: MUG09_14445(crtI)
ANF: AQPE_1616
MTH: MTH_1807
MMG: MTBMA_c03770
MWO: MWSIV6_0338(crtD)
METC: MTCT_1646
METE: tca_01745(crtN)
METK: FVF72_02665(crtI)
MTHM: FZP57_01580(crtI)
METJ: FZP68_06595(crtI)
MEME: HYG87_02230(crtI) HYG87_08505(crtI)
MZH: Mzhil_0948
MEM: Memar_0116
MSUM: OH143_07370(crtI)
MAQE: RJ40_05275(crtI)
MFK: E2N92_05475(crtI)
HAL: VNG_1684G(crtI1) VNG_1755G(crtI2)
HSL: OE_3381R(crtI1) OE_3468R(crtI2)
HANR: LJ422_06800(crtI) LJ422_07070(crtI)
HDL: HALDL1_13230
HHB: Hhub_3180(crtI)
HAGS: JT689_08130(crtI) JT689_08410(crtI)
HABO: JRZ79_06545(crtI) JRZ79_06820(crtI)
HNO: LT974_11795(crtI)
HLU: LT972_03115(crtI)
HALH: HTSR_0322(crtI)
HHSR: HSR6_0308(crtI)
HSU: HLASF_0240(crtI)
HSF: HLASA_0240(crtI)
HAHS: HSRCO_0377
SALR: FQU85_06785(crtI)
HALR: EFA46_012300(crtI)
HJE: HacjB3_05880
HDO: MUK72_08390(crtI)
HALX: M0R89_12790(crtI)
HAXZ: M0R88_12935(crtI)
HAYC: NGM10_02410(crtI)
SALI: L593_04765
SAIM: K0C01_03165(crtI) K0C01_06230(crtI)
HARA: AArcS_2785 AArcS_2862
HMA: rrnAC0321(crtI2) rrnAC1902(crtI1)
HHI: HAH_1058(crtI1) HAH_2415(crtI2)
HHN: HISP_05435 HISP_12295
HAB: SG26_04610 SG26_13105
HTA: BVU17_05180 BVU17_11750
HALJ: G9465_16515(crtI)
HSIN: KDQ40_01355(crtI) KDQ40_08200(crtI)
NPH: NP_0204A(crtI2) NP_4764A(crtD)
NMO: Nmlp_3026(crtI1) Nmlp_3576(crtI2)
NHO: HWV23_16745(crtI)
NSAL: HWV07_18225(crtI)
HUT: Huta_0318 Huta_2373
HTI: HTIA_0507 HTIA_2106
HALA: Hrd1104_01365(crtI) Hrd1104_03715(crtI)
HASV: SVXHr_1253(crtD) SVXHr_2183(crtD2)
HABN: HBNXHr_1237(crtD) HBNXHr_2179(crtD2)
HMU: Hmuk_1360 Hmuk_1684
HALZ: E5139_09960(crtI) E5139_11545(crtI)
HALL: LC1Hm_0581
HAZP: GBQ70_09955(crtI) GBQ70_11540(crtI)
HALI: BV210_13215
HSN: DV733_06795(crtI) DV733_07110(crtI)
HDS: HSR122_0174 HSR122_2630
HRR: HZS55_20285(crtI)
HPEL: HZS54_23770(crtI)
HLT: I7X12_05360(crtI) I7X12_14750(crtI)
HARC: HARCEL1_04560 HARCEL1_05665
SSAI: N0B31_09240(crtI) N0B31_19490(crtI)
HAAD: MW046_14460(crtI)
HWA: HQ_1794A(crtI2) HQ_2863A(crtD)
HWC: Hqrw_1930(crtI2) Hqrw_3257(crtD)
HVO: HVO_2528(crtI)
HALE: G3A49_16065(crtI)
HLN: SVXHx_2072(crti)
HME: HFX_2550
HGI: ABY42_12670
HLS: KU306_00320(crtI)
HBO: Hbor_10650
HAQ: DU484_15070(crtI)
HAJ: DU500_15100(crtI)
HAER: DU502_13080(crtI)
HRA: EI982_09630(crtI) EI982_16645(crtI)
HLM: DV707_06355(crtI)
HALM: FCF25_03150(crtI)
HLA: Hlac_1897
HALP: DOS48_09165
HALB: EKH57_01630(crtI) EKH57_08510(crtI)
HEZZ: EO776_04010(crtI) EO776_05030(crtI) EO776_09980(crtI)
HALQ: Hrr1229_002465(crtI) Hrr1229_002950(crtI) Hrr1229_010285(crtI)
HSS: J7656_06535(crtI) J7656_11800(crtI) J7656_12845(crtI)
HSAI: HPS36_01735(crtI) HPS36_03195(crtI) HPS36_12055(crtI)
HAZZ: KI388_01465(crtI) KI388_02585(crtI) KI388_07990(crtI)
SRUB: C2R22_15240
HAE: halTADL_0469
HALN: B4589_011160(crtI)
HALG: HUG10_00795(crtI)
HALU: HUG12_16785(crtI)
HMP: K6T50_14385(crtI)
HRE: K6T36_14335(crtI)
HRM: K6T25_02470(crtI) K6T25_12720(crtI)
HACB: Hbl1158_06180(crtI) Hbl1158_16020(crtI)
HDF: AArcSl_1205(crtD) AArcSl_2786
HAH: Halar_2115
HTU: Htur_2704
HSAL: JMJ58_15350(crtI)
HAKZ: J0X25_02315(crtI)
NMG: Nmag_1001(crtI)
HXA: Halxa_2222
NAT: NJ7G_1612
NPE: Natpe_1081
NVR: FEJ81_05640(crtI)
NPL: FGF80_05295(crtI)
NAY: HYG81_05200(crtI)
HALY: HYG82_06630(crtI)
HJT: DVR14_14705(crtI)
HLO: J0X27_13920(crtI)
NGE: Natgr_2200
HRU: Halru_1199
SAWL: NGM29_09970(crtI)
HALV: NGM15_02175(crtI)
NOU: Natoc_1917
HLR: HALLA_16025
HLC: CHINAEXTREME08695 CHINAEXTREME13560
NAJ: B1756_14580
NAG: AArcMg_0573 AArcMg_2863
NAN: AArc1_0585 AArc1_0840
NARA: QQ977_09750(crtI)
NBG: DV706_10185(crtI)
NAS: GCU68_01890(crtI)
HDA: BB347_07035 BB347_09725
CDIV: CPM_0973
CSTY: KN1_09430
PAS: Pars_0409
POG: Pogu_1958
PYW: PYWP30_01285
CSU: CSUB_C0582
AG: BAP82509(crtD)
 » show all
Reference
PMID:25712483
  Authors
Yang Y, Yatsunami R, Ando A, Miyoko N, Fukui T, Takaichi S, Nakamura S
  Title
Complete biosynthetic pathway of the C50 carotenoid bacterioruberin from lycopene in the extremely halophilic archaeon Haloarcula japonica.
  Journal
J Bacteriol 197:1614-23 (2015)
DOI:10.1128/JB.02523-14
  Sequence
[ag:BAP82509]
LinkDB

KEGG   ENZYME: 1.3.99.37
Entry
EC 1.3.99.37                Enzyme                                 
Name
1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase;
crtD (gene name)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With unknown physiological acceptors
Sysname
dihydroisopentenyldehydrorhodopin:acceptor 3,4-oxidoreductase
Reaction(IUBMB)
(1) dihydroisopentenyldehydrorhodopin + acceptor = isopentenyldehydrorhodopin + reduced acceptor [RN:R12708];
(2) dihydrobisanhydrobacterioruberin + acceptor = bisanhydrobacterioruberin + reduced acceptor [RN:R12709]
Reaction(KEGG)
R12708 R12709
Substrate
dihydroisopentenyldehydrorhodopin [CPD:C22058];
acceptor [CPD:C00028];
dihydrobisanhydrobacterioruberin [CPD:C22060]
Product
isopentenyldehydrorhodopin [CPD:C22059];
reduced acceptor [CPD:C00030];
bisanhydrobacterioruberin [CPD:C22347]
Comment
The enzyme, isolated from the archaeon Haloarcula japonica, is involved in the biosynthesis of the C50 carotenoid bacterioruberin. In this pathway it catalyses the desaturation of the C-3,4 double bond in dihydroisopentenyldehydrorhodopin and the desaturation of the C-3',4' double bond in dihydrobisanhydrobacterioruberin.
History
EC 1.3.99.37 created 2015
Pathway
ec00906  Carotenoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K20611  1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase
Genes
SHUA: PQ477_16765(crtI)
RMF: D5E69_12835(crtI)
LMAJ: GKN94_13460(crtI)
SASS: MUG09_14445(crtI)
ANF: AQPE_1616
MTH: MTH_1807
MMG: MTBMA_c03770
MWO: MWSIV6_0338(crtD)
METC: MTCT_1646
METE: tca_01745(crtN)
METK: FVF72_02665(crtI)
MTHM: FZP57_01580(crtI)
METJ: FZP68_06595(crtI)
MEME: HYG87_02230(crtI) HYG87_08505(crtI)
MZH: Mzhil_0948
MEM: Memar_0116
MSUM: OH143_07370(crtI)
MAQE: RJ40_05275(crtI)
MFK: E2N92_05475(crtI)
HAL: VNG_1684G(crtI1) VNG_1755G(crtI2)
HSL: OE_3381R(crtI1) OE_3468R(crtI2)
HANR: LJ422_06800(crtI) LJ422_07070(crtI)
HDL: HALDL1_13230
HHB: Hhub_3180(crtI)
HAGS: JT689_08130(crtI) JT689_08410(crtI)
HABO: JRZ79_06545(crtI) JRZ79_06820(crtI)
HNO: LT974_11795(crtI)
HLU: LT972_03115(crtI)
HALH: HTSR_0322(crtI)
HHSR: HSR6_0308(crtI)
HSU: HLASF_0240(crtI)
HSF: HLASA_0240(crtI)
HAHS: HSRCO_0377
SALR: FQU85_06785(crtI)
HALR: EFA46_012300(crtI)
HJE: HacjB3_05880
HDO: MUK72_08390(crtI)
HALX: M0R89_12790(crtI)
HAXZ: M0R88_12935(crtI)
HAYC: NGM10_02410(crtI)
SALI: L593_04765
SAIM: K0C01_03165(crtI) K0C01_06230(crtI)
HARA: AArcS_2785 AArcS_2862
HMA: rrnAC0321(crtI2) rrnAC1902(crtI1)
HHI: HAH_1058(crtI1) HAH_2415(crtI2)
HHN: HISP_05435 HISP_12295
HAB: SG26_04610 SG26_13105
HTA: BVU17_05180 BVU17_11750
HALJ: G9465_16515(crtI)
HSIN: KDQ40_01355(crtI) KDQ40_08200(crtI)
NPH: NP_0204A(crtI2) NP_4764A(crtD)
NMO: Nmlp_3026(crtI1) Nmlp_3576(crtI2)
NHO: HWV23_16745(crtI)
NSAL: HWV07_18225(crtI)
HUT: Huta_0318 Huta_2373
HTI: HTIA_0507 HTIA_2106
HALA: Hrd1104_01365(crtI) Hrd1104_03715(crtI)
HASV: SVXHr_1253(crtD) SVXHr_2183(crtD2)
HABN: HBNXHr_1237(crtD) HBNXHr_2179(crtD2)
HMU: Hmuk_1360 Hmuk_1684
HALZ: E5139_09960(crtI) E5139_11545(crtI)
HALL: LC1Hm_0581
HAZP: GBQ70_09955(crtI) GBQ70_11540(crtI)
HALI: BV210_13215
HSN: DV733_06795(crtI) DV733_07110(crtI)
HDS: HSR122_0174 HSR122_2630
HRR: HZS55_20285(crtI)
HPEL: HZS54_23770(crtI)
HLT: I7X12_05360(crtI) I7X12_14750(crtI)
HARC: HARCEL1_04560 HARCEL1_05665
SSAI: N0B31_09240(crtI) N0B31_19490(crtI)
HAAD: MW046_14460(crtI)
HWA: HQ_1794A(crtI2) HQ_2863A(crtD)
HWC: Hqrw_1930(crtI2) Hqrw_3257(crtD)
HVO: HVO_2528(crtI)
HALE: G3A49_16065(crtI)
HLN: SVXHx_2072(crti)
HME: HFX_2550
HGI: ABY42_12670
HLS: KU306_00320(crtI)
HBO: Hbor_10650
HAQ: DU484_15070(crtI)
HAJ: DU500_15100(crtI)
HAER: DU502_13080(crtI)
HRA: EI982_09630(crtI) EI982_16645(crtI)
HLM: DV707_06355(crtI)
HALM: FCF25_03150(crtI)
HLA: Hlac_1897
HALP: DOS48_09165
HALB: EKH57_01630(crtI) EKH57_08510(crtI)
HEZZ: EO776_04010(crtI) EO776_05030(crtI) EO776_09980(crtI)
HALQ: Hrr1229_002465(crtI) Hrr1229_002950(crtI) Hrr1229_010285(crtI)
HSS: J7656_06535(crtI) J7656_11800(crtI) J7656_12845(crtI)
HSAI: HPS36_01735(crtI) HPS36_03195(crtI) HPS36_12055(crtI)
HAZZ: KI388_01465(crtI) KI388_02585(crtI) KI388_07990(crtI)
SRUB: C2R22_15240
HAE: halTADL_0469
HALN: B4589_011160(crtI)
HALG: HUG10_00795(crtI)
HALU: HUG12_16785(crtI)
HMP: K6T50_14385(crtI)
HRE: K6T36_14335(crtI)
HRM: K6T25_02470(crtI) K6T25_12720(crtI)
HACB: Hbl1158_06180(crtI) Hbl1158_16020(crtI)
HDF: AArcSl_1205(crtD) AArcSl_2786
HAH: Halar_2115
HTU: Htur_2704
HSAL: JMJ58_15350(crtI)
HAKZ: J0X25_02315(crtI)
NMG: Nmag_1001(crtI)
HXA: Halxa_2222
NAT: NJ7G_1612
NPE: Natpe_1081
NVR: FEJ81_05640(crtI)
NPL: FGF80_05295(crtI)
NAY: HYG81_05200(crtI)
HALY: HYG82_06630(crtI)
HJT: DVR14_14705(crtI)
HLO: J0X27_13920(crtI)
NGE: Natgr_2200
HRU: Halru_1199
SAWL: NGM29_09970(crtI)
HALV: NGM15_02175(crtI)
NOU: Natoc_1917
HLR: HALLA_16025
HLC: CHINAEXTREME08695 CHINAEXTREME13560
NAJ: B1756_14580
NAG: AArcMg_0573 AArcMg_2863
NAN: AArc1_0585 AArc1_0840
NARA: QQ977_09750(crtI)
NBG: DV706_10185(crtI)
NAS: GCU68_01890(crtI)
HDA: BB347_07035 BB347_09725
CDIV: CPM_0973
CSTY: KN1_09430
PAS: Pars_0409
POG: Pogu_1958
PYW: PYWP30_01285
CSU: CSUB_C0582
 » show all
Reference
1  [PMID:25712483]
  Authors
Yang Y, Yatsunami R, Ando A, Miyoko N, Fukui T, Takaichi S, Nakamura S
  Title
Complete biosynthetic pathway of the C50 carotenoid bacterioruberin from lycopene in the extremely halophilic archaeon Haloarcula japonica.
  Journal
J Bacteriol 197:1614-23 (2015)
DOI:10.1128/JB.02523-14
  Sequence
[ag:BAP82509]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.99.37
IUBMB Enzyme Nomenclature: 1.3.99.37
ExPASy - ENZYME nomenclature database: 1.3.99.37
BRENDA, the Enzyme Database: 1.3.99.37
LinkDB

KEGG   REACTION: R12709
Entry
R12709                      Reaction                               
Name
dihydrobisanhydrobacterioruberin:acceptor 3,4-oxidoreductase
Definition
Dihydrobisanhydrobacterioruberin + Acceptor <=> Bisanhydrobacterioruberin + Reduced acceptor
Equation
C22060 + C00028 <=> C22347 + C00030
Reaction class
RC01970  C22060_C22347
Enzyme
1.3.99.37
Pathway
rn00906  Carotenoid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.3  Acting on the CH-CH group of donors
   1.3.99  With unknown physiological acceptors
    1.3.99.37
     R12709  Dihydrobisanhydrobacterioruberin + Acceptor <=> Bisanhydrobacterioruberin + Reduced acceptor
Orthology
K20611  1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase [EC:1.3.99.37]
LinkDB

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