KEGG   ORTHOLOGY: K20679
Entry
K20679            Tight     KO                                     
Symbol
fdtA
Name
TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase [EC:5.3.2.3]
Pathway
map00523  Polyketide sugar unit biosynthesis
map00541  O-Antigen nucleotide sugar biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01250  Biosynthesis of nucleotide sugars
Reaction
R09904  dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose:dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose isomerase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00541 O-Antigen nucleotide sugar biosynthesis
    K20679  fdtA; TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase
  09109 Metabolism of terpenoids and polyketides
   00523 Polyketide sugar unit biosynthesis
    K20679  fdtA; TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase
Enzymes [BR:ko01000]
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.2  Interconverting keto- and enol-groups
    5.3.2.3  TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose-forming)
     K20679  fdtA; TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase
Genes
AG: AAS55720(fdtA)
Reference
PMID:12740380
  Authors
Pfoestl A, Hofinger A, Kosma P, Messner P
  Title
Biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactose in Aneurinibacillus thermoaerophilus L420-91T.
  Journal
J Biol Chem 278:26410-7 (2003)
DOI:10.1074/jbc.M300858200
  Sequence
[ag:AAS55720]
LinkDB

KEGG   ENZYME: 5.3.2.3
Entry
EC 5.3.2.3                  Enzyme                                 
Name
TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose-forming);
dTDP-6-deoxy-hex-4-ulose isomerase;
TDP-6-deoxy-hex-4-ulose isomerase;
FdtA
Class
Isomerases;
Intramolecular oxidoreductases;
Interconverting keto- and enol-groups
Sysname
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose:dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose isomerase
Reaction(IUBMB)
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose = dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose [RN:R09904]
Reaction(KEGG)
R09904
Substrate
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose [CPD:C11907]
Product
dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose [CPD:C19960]
Comment
The enzyme is involved in the biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactose. Four moieties of alpha-D-rhamnose and two moities of 3-acetamido-3,6-dideoxy-alpha-D-galactose form the repeating unit of the glycan chain in the S-layer of the bacterium Aneurinibacillus thermoaerophilus.
History
EC 5.3.2.3 created 2011
Pathway
ec00523  Polyketide sugar unit biosynthesis
ec00541  O-Antigen nucleotide sugar biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K20679  TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase
Reference
1  [PMID:12740380]
  Authors
Pfoestl A, Hofinger A, Kosma P, Messner P
  Title
Biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactose in Aneurinibacillus thermoaerophilus L420-91T.
  Journal
J Biol Chem 278:26410-7 (2003)
DOI:10.1074/jbc.M300858200
  Sequence
[ag:AAS55720]
Reference
2  [PMID:17459872]
  Authors
Davis ML, Thoden JB, Holden HM
  Title
The x-ray structure of dTDP-4-keto-6-deoxy-D-glucose-3,4-ketoisomerase.
  Journal
J Biol Chem 282:19227-36 (2007)
DOI:10.1074/jbc.M702529200
  Sequence
[ag:AAS55720]
Other DBs
ExplorEnz - The Enzyme Database: 5.3.2.3
IUBMB Enzyme Nomenclature: 5.3.2.3
ExPASy - ENZYME nomenclature database: 5.3.2.3
BRENDA, the Enzyme Database: 5.3.2.3
LinkDB

KEGG   REACTION: R09904
Entry
R09904                      Reaction                               
Name
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose:dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose isomerase
Definition
dTDP-4-oxo-6-deoxy-D-glucose <=> dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose
Equation
C11907 <=> C19960
Reaction class
RC01513  C11907_C19960
Enzyme
5.3.2.3
Pathway
rn00523  Polyketide sugar unit biosynthesis
rn00541  O-Antigen nucleotide sugar biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01250  Biosynthesis of nucleotide sugars
Brite
Enzymatic reactions [BR:br08201]
 5. Isomerase reactions
  5.3  Intramolecular oxidoreductases
   5.3.2  Interconverting keto- and enol-groups
    5.3.2.3
     R09904  dTDP-4-oxo-6-deoxy-D-glucose <=> dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose
Orthology
K20679  TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase [EC:5.3.2.3]
Other DBs
RHEA: 31838
LinkDB

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