KEGG   ORTHOLOGY: K20986
Entry
K20986                      KO                                     
Symbol
NUDX1
Name
geranyl diphosphate phosphohydrolase [EC:3.6.1.68]
Pathway
map00902  Monoterpenoid biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R11551  geranyl-diphosphate phosphohydrolase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00902 Monoterpenoid biosynthesis
    K20986  NUDX1; geranyl diphosphate phosphohydrolase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.6  Acting on acid anhydrides
   3.6.1  In phosphorus-containing anhydrides
    3.6.1.68  geranyl diphosphate phosphohydrolase
     K20986  NUDX1; geranyl diphosphate phosphohydrolase
Genes
FVE: 101310019 101310310
RCN: 112189710 112189741 112190176 112190349
PPER: 18792770
PMUM: 103341413
PAVI: 110757771
PDUL: 117615591 117615929 117617377 117617387
MDM: 103402740 103451694
MSYL: 126594874 126606456 126608658
PXB: 103929214 103946941
CSAV: 115698545
SHIS: 125216272
AG: AFW17224(NUDX1)
 » show all
Reference
  Authors
Magnard JL, Roccia A, Caissard JC, Vergne P, Sun P, Hecquet R, Dubois A, Hibrand-Saint Oyant L, Jullien F, Nicole F, Raymond O, Huguet S, Baltenweck R, Meyer S, Claudel P, Jeauffre J, Rohmer M, Foucher F, Hugueney P, Bendahmane M, Baudino S
  Title
PLANT VOLATILES. Biosynthesis of monoterpene scent compounds in roses.
  Journal
Science 349:81-3 (2015)
DOI:10.1126/science.aab0696
  Sequence
LinkDB

KEGG   ENZYME: 3.6.1.68
Entry
EC 3.6.1.68                 Enzyme                                 
Name
geranyl diphosphate phosphohydrolase;
NUDX1 (gene name)
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
Sysname
geranyl-diphosphate phosphohydrolase
Reaction(IUBMB)
geranyl diphosphate + H2O = geranyl phosphate + phosphate [RN:R11551]
Reaction(KEGG)
R11551
Substrate
geranyl diphosphate [CPD:C00341];
H2O [CPD:C00001]
Product
geranyl phosphate [CPD:C21203];
phosphate [CPD:C00009]
Comment
The enzyme, characterized from roses, is involved in a cytosolic pathway for the biosynthesis of free monoterpene alcohols that contribute to fragrance. In vitro the enzyme also acts on (2E,6E)-farnesyl diphosphate.
History
EC 3.6.1.68 created 2015 as EC 3.1.3.98, transferred 2016 to EC 3.6.1.68
Pathway
ec00902  Monoterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K20986  geranyl diphosphate phosphohydrolase
Genes
FVE101310019 101310310
RCN112189710 112189741 112190176 112190349
PPER18792770
PMUM103341413
PAVI110757771
PDUL117615591 117615929 117617377 117617387
MDM103402740 103451694
MSYL126594874 126606456 126608658
PXB103929214 103946941
CSAV115698545
SSPL121767850 121770971
SHIS125216272
 » show all
Reference
1  [PMID:26138978]
  Authors
Magnard JL, Roccia A, Caissard JC, Vergne P, Sun P, Hecquet R, Dubois A, Hibrand-Saint Oyant L, Jullien F, Nicole F, Raymond O, Huguet S, Baltenweck R, Meyer S, Claudel P, Jeauffre J, Rohmer M, Foucher F, Hugueney P, Bendahmane M, Baudino S
  Title
PLANT VOLATILES. Biosynthesis of monoterpene scent compounds in roses.
  Journal
Science 349:81-3 (2015)
DOI:10.1126/science.aab0696
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.6.1.68
IUBMB Enzyme Nomenclature: 3.6.1.68
ExPASy - ENZYME nomenclature database: 3.6.1.68
BRENDA, the Enzyme Database: 3.6.1.68
LinkDB

KEGG   REACTION: R11551
Entry
R11551                      Reaction                               
Name
geranyl-diphosphate phosphohydrolase
Definition
Geranyl diphosphate + H2O <=> Geranyl phosphate + Orthophosphate
Equation
Reaction class
RC00002  C00341_C21203
Enzyme
Pathway
rn00902  Monoterpenoid biosynthesis
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 3. Hydrolase reactions
  3.6  Acting on acid anhydrides
   3.6.1  In phosphorus-containing anhydrides
    3.6.1.68
     R11551  Geranyl diphosphate + H2O <=> Geranyl phosphate + Orthophosphate
Orthology
K20986  geranyl diphosphate phosphohydrolase [EC:3.6.1.68]
Other DBs
RHEA: 47947
LinkDB

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