KEGG   ORTHOLOGY: K21055
Entry
K21055                      KO                                     
Symbol
E3.1.3.103
Name
3-deoxy-D-glycero-D-galacto-nononate 9-phosphatase [EC:3.1.3.103]
Pathway
map00520  Amino sugar and nucleotide sugar metabolism
map01100  Metabolic pathways
map01250  Biosynthesis of nucleotide sugars
Reaction
R11440  3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate-9-phosphate 9-phosphohydrolase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00520 Amino sugar and nucleotide sugar metabolism
    K21055  E3.1.3.103; 3-deoxy-D-glycero-D-galacto-nononate 9-phosphatase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.103  3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphatase
     K21055  E3.1.3.103; 3-deoxy-D-glycero-D-galacto-nononate 9-phosphatase
Genes
HSH: NHP194022_04600
HAIL: ASB7_00190
SDIA: QU667_10080
STIM: H1B31_05900
BPAA: K7I13_00560
SBU: SpiBuddy_2424
BTH: BT_1713
BTHO: Btheta7330_01303 Btheta7330_02993
BCEL: BcellWH2_03094
BIS: DXK01_006205
BEG: INE88_01922
BSTE: K6V31_10245
DDB: E7747_08105
BVS: BARVI_00425
ANF: AQPE_2134
SHT: KO02_22670
CAMU: CA2015_3636
MSAA: QYS49_14175 QYS49_22710
CLIT: OQ292_15535
RSR: T7867_13005
FAX: FUAX_28070
FAZ: M0M57_00270
ASL: Aeqsu_2922
AIC: JK629_04870
SMIS: LDL76_16000
SINH: LS482_08945
FBE: FF125_10320
LUY: QZH61_06935
HWS: RNZ46_07200
MGEL: G5B37_10200
PTAN: CRYO30217_01042
 » show all
Reference
PMID:18804026
  Authors
Wang L, Lu Z, Allen KN, Mariano PS, Dunaway-Mariano D
  Title
Human symbiont Bacteroides thetaiotaomicron synthesizes 2-keto-3-deoxy-D-glycero-D- galacto-nononic acid (KDN).
  Journal
Chem Biol 15:893-7 (2008)
DOI:10.1016/j.chembiol.2008.08.005
  Sequence
[bth:BT_1713]
LinkDB

KEGG   ENZYME: 3.1.3.103
Entry
EC 3.1.3.103                Enzyme                                 
Name
3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphatase;
3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate-9-phosphate phosphatase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
Sysname
3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate 9-phosphohydrolase
Reaction(IUBMB)
3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate 9-phosphate + H2O = 3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate + phosphate [RN:R11440]
Reaction(KEGG)
R11440
Substrate
3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate 9-phosphate [CPD:C21383];
H2O [CPD:C00001]
Product
3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate [CPD:C20934];
phosphate [CPD:C00009]
Comment
The enzyme, characterized from the bacterium Bacteroides thetaiotaomicron, is part of the biosynthesis pathway of the sialic acid 3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate (Kdn). Kdn is abundant in extracellular glycoconjugates of lower vertebrates such as fish and amphibians, but is also found in the capsular polysaccharides of bacteria that belong to the Bacteroides genus.
History
EC 3.1.3.103 created 2016
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
ec01100  Metabolic pathways
Orthology
K21055  3-deoxy-D-glycero-D-galacto-nononate 9-phosphatase
Genes
HSH: NHP194022_04600
HAIL: ASB7_00190
SDIA: QU667_10080
STIM: H1B31_05900
BPAA: K7I13_00560
SBU: SpiBuddy_2424
BTH: BT_1713
BTHO: Btheta7330_01303 Btheta7330_02993
BCEL: BcellWH2_03094
BIS: DXK01_006205
BEG: INE88_01922
BSTE: K6V31_10245
DDB: E7747_08105
BVS: BARVI_00425
ANF: AQPE_2134
SHT: KO02_22670
CAMU: CA2015_3636
MSAA: QYS49_14175 QYS49_22710
CLIT: OQ292_15535
RSR: T7867_13005
FAX: FUAX_28070
FAZ: M0M57_00270
ASL: Aeqsu_2922
AIC: JK629_04870
SMIS: LDL76_16000
SINH: LS482_08945
FBE: FF125_10320
LUY: QZH61_06935
HWS: RNZ46_07200
MGEL: G5B37_10200
PTAN: CRYO30217_01042
 » show all
Reference
1  [PMID:18804026]
  Authors
Wang L, Lu Z, Allen KN, Mariano PS, Dunaway-Mariano D
  Title
Human symbiont Bacteroides thetaiotaomicron synthesizes 2-keto-3-deoxy-D-glycero-D- galacto-nononic acid (KDN).
  Journal
Chem Biol 15:893-7 (2008)
DOI:10.1016/j.chembiol.2008.08.005
  Sequence
[bth:BT_1713]
Reference
2  [PMID:18986982]
  Authors
Lu Z, Wang L, Dunaway-Mariano D, Allen KN
  Title
Structure-function analysis of 2-keto-3-deoxy-D-glycero-D-galactonononate-9-phosphate phosphatase defines specificity elements in type C0 haloalkanoate dehalogenase family members.
  Journal
J Biol Chem 284:1224-33 (2009)
DOI:10.1074/jbc.M807056200
  Sequence
[bth:BT_1713]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.103
IUBMB Enzyme Nomenclature: 3.1.3.103
ExPASy - ENZYME nomenclature database: 3.1.3.103
BRENDA, the Enzyme Database: 3.1.3.103
LinkDB

KEGG   REACTION: R11440
Entry
R11440                      Reaction                               
Name
3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate-9-phosphate 9-phosphohydrolase
Definition
3-Deoxy-D-glycero-D-galacto-non-2-ulopyranosonate 9-phosphate + H2O <=> 3-Deoxy-D-glycero-D-galacto-non-2-ulopyranosonate + Orthophosphate
Equation
C21383 + C00001 <=> C20934 + C00009
Reaction class
RC00017  C20934_C21383
Enzyme
3.1.3.103
Pathway
rn00520  Amino sugar and nucleotide sugar metabolism
rn01100  Metabolic pathways
rn01250  Biosynthesis of nucleotide sugars
Brite
Enzymatic reactions [BR:br08201]
 3. Hydrolase reactions
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.103
     R11440  3-Deoxy-D-glycero-D-galacto-non-2-ulopyranosonate 9-phosphate + H2O <=> 3-Deoxy-D-glycero-D-galacto-non-2-ulopyranosonate + Orthophosphate
Orthology
K21055  3-deoxy-D-glycero-D-galacto-nononate 9-phosphatase [EC:3.1.3.103]
Other DBs
RHEA: 49219
LinkDB

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