KEGG   ORTHOLOGY: K21160
Entry
K21160                      KO                                     
Symbol
sgcE2, ncsE2, kedE2
Name
enediyne biosynthesis protein E2
Pathway
map01059  Biosynthesis of enediyne antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00824  9-membered enediyne core biosynthesis, malonyl-CoA => 3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoyl-ACP => 9-membered enediyne core
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K21160  sgcE2, ncsE2, kedE2; enediyne biosynthesis protein E2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K21160  sgcE2, ncsE2, kedE2; enediyne biosynthesis protein E2
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Others
   K21160  sgcE2, ncsE2, kedE2; enediyne biosynthesis protein E2
Genes
NBR: O3I_032510
NIE: KV110_31495
NYA: LTV02_00400
NGP: LTT66_22010
NSPU: IFM12276_12590
SGR: SGR_605(unbL1)
SGB: WQO_34010
STRM: M444_38025
SCLF: BB341_26605
SPLU: LK06_002485
SRO: Sros_7003
AMD: AMED_6873
AMN: RAM_35265
AMM: AMES_6768
AMZ: B737_6768
AOI: AORI_1858
AMYY: YIM_41025
AORI: SD37_31915
SESP: BN6_39270
ACTI: UA75_19080
ACAD: UA74_18590
ALO: CRK57500
SAQ: Sare_0549
ACTN: L083_3207
AG: AAM78016(ncsE2) AFV52143(kedE2)
 » show all
Reference
PMID:12183628 (sgcE2)
  Authors
Liu W, Christenson SD, Standage S, Shen B
  Title
Biosynthesis of the enediyne antitumor antibiotic C-1027.
  Journal
Science 297:1170-3 (2002)
DOI:10.1126/science.1072110
  Sequence
[sgb:WQO_34010]
Reference
PMID:15797213 (ncsE2)
  Authors
Liu W, Nonaka K, Nie L, Zhang J, Christenson SD, Bae J, Van Lanen SG, Zazopoulos E, Farnet CM, Yang CF, Shen B
  Title
The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases.
  Journal
Chem Biol 12:293-302 (2005)
DOI:10.1016/j.chembiol.2004.12.013
  Sequence
Reference
PMID:23360970 (kedE2)
  Authors
Lohman JR, Huang SX, Horsman GP, Dilfer PE, Huang T, Chen Y, Wendt-Pienkowski E, Shen B
  Title
Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics.
  Journal
Mol Biosyst 9:478-91 (2013)
DOI:10.1039/c3mb25523a
  Sequence
LinkDB

KEGG   ORTHOLOGY: K21161
Entry
K21161                      KO                                     
Symbol
sgcE3, ncsE3, kedE3
Name
enediyne biosynthesis protein E3
Pathway
map01059  Biosynthesis of enediyne antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00824  9-membered enediyne core biosynthesis, malonyl-CoA => 3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoyl-ACP => 9-membered enediyne core
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K21161  sgcE3, ncsE3, kedE3; enediyne biosynthesis protein E3
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K21161  sgcE3, ncsE3, kedE3; enediyne biosynthesis protein E3
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Others
   K21161  sgcE3, ncsE3, kedE3; enediyne biosynthesis protein E3
Genes
LANH: KR767_19050
MAH: MEALZ_1608
MBUR: EQU24_12375
MEIN: methR_P2296
TIG: THII_0009
RUY: NOR97_17050
HOH: Hoch_0696
BHUI: LOK74_08090
PCHI: PC41400_06670
PCEL: HUB94_04220
SGR: SGR_606(unbL2)
SGB: WQO_34005
STRM: M444_38020
AMD: AMED_6872
AMN: RAM_35260
AMM: AMES_6767
AMZ: B737_6767
AOI: AORI_1833
AMYY: YIM_41020
AORI: SD37_32045
AMI: Amir_4101
SESP: BN6_39260
ACTI: UA75_19100
ACAD: UA74_18610
ALO: CRK57501
MIL: ML5_5858
ACTN: L083_3209
MAR: MAE_12740
MPK: VL20_1930
HAU: Haur_0869
AG: AAM78015(ncsE3) AFV52142(kedE3)
 » show all
Reference
PMID:12183628 (sgcE3)
  Authors
Liu W, Christenson SD, Standage S, Shen B
  Title
Biosynthesis of the enediyne antitumor antibiotic C-1027.
  Journal
Science 297:1170-3 (2002)
DOI:10.1126/science.1072110
  Sequence
[sgb:WQO_34005]
Reference
PMID:15797213 (ncsE3)
  Authors
Liu W, Nonaka K, Nie L, Zhang J, Christenson SD, Bae J, Van Lanen SG, Zazopoulos E, Farnet CM, Yang CF, Shen B
  Title
The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases.
  Journal
Chem Biol 12:293-302 (2005)
DOI:10.1016/j.chembiol.2004.12.013
  Sequence
Reference
PMID:23360970 (kedE3)
  Authors
Lohman JR, Huang SX, Horsman GP, Dilfer PE, Huang T, Chen Y, Wendt-Pienkowski E, Shen B
  Title
Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics.
  Journal
Mol Biosyst 9:478-91 (2013)
DOI:10.1039/c3mb25523a
  Sequence
LinkDB

KEGG   ORTHOLOGY: K21162
Entry
K21162                      KO                                     
Symbol
sgcE4, ncsE4, kedE4
Name
enediyne biosynthesis protein E4
Pathway
map01059  Biosynthesis of enediyne antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00824  9-membered enediyne core biosynthesis, malonyl-CoA => 3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoyl-ACP => 9-membered enediyne core
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K21162  sgcE4, ncsE4, kedE4; enediyne biosynthesis protein E4
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K21162  sgcE4, ncsE4, kedE4; enediyne biosynthesis protein E4
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Others
   K21162  sgcE4, ncsE4, kedE4; enediyne biosynthesis protein E4
Genes
LANH: KR767_19060
XBA: C7S18_10370 C7S18_17060
PMAO: PMYSY11_0486
SWD: Swoo_1678
SPSW: Sps_03706
SMAI: EXU30_03455
SBK: SHEWBE_3492
SAES: HBH39_12035
SPSH: FM037_10050
SSEM: JYB85_11785
ASP: AOR13_475
SDE: Sde_2997
SAGA: M5M_16680
LLO: LLO_3253
TIG: THII_0010
THIP: N838_16205
TBN: TBH_C0179
HCH: HCH_01486
NTU: NTH_01684
PHL: KKY_3572
HDI: HDIA_0904
SIL: SPO0859
DSH: Dshi_2002
PGD: Gal_03764
CID: P73_2894
MAGQ: MGMAQ_3276
SFU: Sfum_1617
MXA: MXAN_7127
BMX: BMS_1273
SGR: SGR_607(unbV)
SGB: WQO_34000
STRM: M444_38015
AMD: AMED_6871
AMN: RAM_35255
AMM: AMES_6766
AMZ: B737_6766
AOI: AORI_1834
AMYY: YIM_41015
AORI: SD37_32040
SESP: BN6_39250
ACTI: UA75_19095
ACAD: UA74_18605
ALO: CRK57502
MIL: ML5_5857
ACTN: L083_3235
CAI: Caci_6360
MAR: MAE_12730
MPK: VL20_1931
NSPH: BDGGKGIB_04550(rsxD)
RCA: Rcas_1882
MRB: Mrub_1750
RBA: RB11088
PSL: Psta_1247
LLH: I41_23630
CPI: Cpin_6727
CPRV: CYPRO_2340
SALI: L593_05865
HMU: Hmuk_1747
HALL: LC1Hm_1003
AG: AAM78014(ncsE4) AFV52141(kedE4)
 » show all
Reference
PMID:12183628 (sgcE4)
  Authors
Liu W, Christenson SD, Standage S, Shen B
  Title
Biosynthesis of the enediyne antitumor antibiotic C-1027.
  Journal
Science 297:1170-3 (2002)
DOI:10.1126/science.1072110
  Sequence
[sgb:WQO_34000]
Reference
PMID:15797213 (ncsE4)
  Authors
Liu W, Nonaka K, Nie L, Zhang J, Christenson SD, Bae J, Van Lanen SG, Zazopoulos E, Farnet CM, Yang CF, Shen B
  Title
The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases.
  Journal
Chem Biol 12:293-302 (2005)
DOI:10.1016/j.chembiol.2004.12.013
  Sequence
Reference
PMID:23360970 (kedE4)
  Authors
Lohman JR, Huang SX, Horsman GP, Dilfer PE, Huang T, Chen Y, Wendt-Pienkowski E, Shen B
  Title
Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics.
  Journal
Mol Biosyst 9:478-91 (2013)
DOI:10.1039/c3mb25523a
  Sequence
LinkDB

KEGG   ORTHOLOGY: K21163
Entry
K21163                      KO                                     
Symbol
sgcE5, ncsE5, kedE5
Name
enediyne biosynthesis protein E5
Pathway
map01059  Biosynthesis of enediyne antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00824  9-membered enediyne core biosynthesis, malonyl-CoA => 3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoyl-ACP => 9-membered enediyne core
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K21163  sgcE5, ncsE5, kedE5; enediyne biosynthesis protein E5
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K21163  sgcE5, ncsE5, kedE5; enediyne biosynthesis protein E5
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Others
   K21163  sgcE5, ncsE5, kedE5; enediyne biosynthesis protein E5
Genes
LANH: KR767_19065
MAH: MEALZ_1606(unbU)
MBUR: EQU24_12385
MEIN: methR_P2298
TIG: THII_0011
DAR: Daro_4058
EAA: I862_02175
BBT: BBta_7863
AOL: S58_72740
BRO: BRAD285_7692
HOH: Hoch_0694
BPUM: BW16_02230
BMEG: BG04_2489
PSAB: PSAB_23820
SGR: SGR_608(unbU)
SGB: WQO_33995
STRM: M444_38010
AMD: AMED_6870
AMN: RAM_35250
AMM: AMES_6765
AMZ: B737_6765
AOI: AORI_1835
AMYY: YIM_41010
AORI: SD37_32035
SESP: BN6_39240
ACTI: UA75_19090
ACAD: UA74_18600
ALO: CRK57503
MIL: ML5_5850
ACTN: L083_3234
CAI: Caci_6359
MAR: MAE_12850
MPK: VL20_1919
PLS: VT03_11610(rsxD)
LRS: PX52LOC_00384(rsxD)
FTJ: FTUN_8499
ULI: ETAA1_04370(rsxD)
ABAS: ACPOL_5989
GBA: J421_4030
CPRV: CYPRO_2339
AG: AAM78013(ncsE5) AFV52140(kedE5)
 » show all
Reference
PMID:12183628 (sgcE5)
  Authors
Liu W, Christenson SD, Standage S, Shen B
  Title
Biosynthesis of the enediyne antitumor antibiotic C-1027.
  Journal
Science 297:1170-3 (2002)
DOI:10.1126/science.1072110
  Sequence
[sgb:WQO_33995]
Reference
PMID:15797213 (ncsE5)
  Authors
Liu W, Nonaka K, Nie L, Zhang J, Christenson SD, Bae J, Van Lanen SG, Zazopoulos E, Farnet CM, Yang CF, Shen B
  Title
The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases.
  Journal
Chem Biol 12:293-302 (2005)
DOI:10.1016/j.chembiol.2004.12.013
  Sequence
Reference
PMID:23360970 (kedE5)
  Authors
Lohman JR, Huang SX, Horsman GP, Dilfer PE, Huang T, Chen Y, Wendt-Pienkowski E, Shen B
  Title
Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics.
  Journal
Mol Biosyst 9:478-91 (2013)
DOI:10.1039/c3mb25523a
  Sequence
LinkDB

KEGG   ORTHOLOGY: K21164
Entry
K21164                      KO                                     
Symbol
sgcE7, ncsE7, kedE7
Name
enediyne biosynthesis protein E7
Pathway
map01059  Biosynthesis of enediyne antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00824  9-membered enediyne core biosynthesis, malonyl-CoA => 3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoyl-ACP => 9-membered enediyne core
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K21164  sgcE7, ncsE7, kedE7; enediyne biosynthesis protein E7
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K21164  sgcE7, ncsE7, kedE7; enediyne biosynthesis protein E7
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Others
   K21164  sgcE7, ncsE7, kedE7; enediyne biosynthesis protein E7
Other DBs
COG: COG2124
Genes
PRAG: EKN56_15110
CSER: CCO03_03245
CODO: LAD35_12920
DRG: H9K76_13975 H9K76_15125
STAR: G3545_08030
PSTI: SOO65_12315
MYW: BVC93_22290
MRH: MycrhN_0267
MMUC: C1S78_027390
MKR: MKOR_30620
MABB: MASS_2078
SGR: SGR_611
SGB: WQO_33980
STRM: M444_37990
LMOI: VV02_06570
SRO: Sros_6996
AMD: AMED_6869
AMN: RAM_35245
AMM: AMES_6764
AMZ: B737_6764
AOI: AORI_1836
AMYY: YIM_41005
AORI: SD37_32030
AMI: Amir_4102
SESP: BN6_39230
ACTI: UA75_19085
ACAD: UA74_18595
ALO: CRK57504
SAQ: Sare_0554
ACTN: L083_3213
CAI: Caci_6371
AG: AAM78009(ncsE7) AFV52138(kedE7)
 » show all
Reference
PMID:12183628 (sgcE7)
  Authors
Liu W, Christenson SD, Standage S, Shen B
  Title
Biosynthesis of the enediyne antitumor antibiotic C-1027.
  Journal
Science 297:1170-3 (2002)
DOI:10.1126/science.1072110
  Sequence
[sgb:WQO_33980]
Reference
PMID:15797213 (ncsE7)
  Authors
Liu W, Nonaka K, Nie L, Zhang J, Christenson SD, Bae J, Van Lanen SG, Zazopoulos E, Farnet CM, Yang CF, Shen B
  Title
The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases.
  Journal
Chem Biol 12:293-302 (2005)
DOI:10.1016/j.chembiol.2004.12.013
  Sequence
Reference
PMID:23360970 (kedE7)
  Authors
Lohman JR, Huang SX, Horsman GP, Dilfer PE, Huang T, Chen Y, Wendt-Pienkowski E, Shen B
  Title
Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics.
  Journal
Mol Biosyst 9:478-91 (2013)
DOI:10.1039/c3mb25523a
  Sequence
LinkDB

KEGG   ORTHOLOGY: K21165
Entry
K21165                      KO                                     
Symbol
sgcE8, ncsE8, kedE8
Name
enediyne biosynthesis protein E8
Pathway
map01059  Biosynthesis of enediyne antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00824  9-membered enediyne core biosynthesis, malonyl-CoA => 3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoyl-ACP => 9-membered enediyne core
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K21165  sgcE8, ncsE8, kedE8; enediyne biosynthesis protein E8
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K21165  sgcE8, ncsE8, kedE8; enediyne biosynthesis protein E8
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Others
   K21165  sgcE8, ncsE8, kedE8; enediyne biosynthesis protein E8
Genes
PSEP: C4K39_4983
SGR: SGR_601
SGB: WQO_33965
STRM: M444_37975
SPLU: LK06_002540
STIR: DDW44_31440
SGZ: C0216_12080
SSPO: DDQ41_30970
SFY: GFH48_34880
SBAT: G4Z16_02205
SRO: Sros_6993
AMD: AMED_6868
AMN: RAM_35240
AMM: AMES_6763
AMZ: B737_6763
AOI: AORI_1837
AMYY: YIM_41000
AORI: SD37_32025
SESP: BN6_39210
ACTI: UA75_19105
ACAD: UA74_18615
SAQ: Sare_0547
ACTN: L083_3205
CAI: Caci_6377
AG: AAM78006(ncsE8) AFV52136(kedE8)
 » show all
Reference
PMID:12183628 (sgcE8)
  Authors
Liu W, Christenson SD, Standage S, Shen B
  Title
Biosynthesis of the enediyne antitumor antibiotic C-1027.
  Journal
Science 297:1170-3 (2002)
DOI:10.1126/science.1072110
  Sequence
[sgb:WQO_33965]
Reference
PMID:15797213 (ncsE8)
  Authors
Liu W, Nonaka K, Nie L, Zhang J, Christenson SD, Bae J, Van Lanen SG, Zazopoulos E, Farnet CM, Yang CF, Shen B
  Title
The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases.
  Journal
Chem Biol 12:293-302 (2005)
DOI:10.1016/j.chembiol.2004.12.013
  Sequence
Reference
PMID:23360970 (kedE8)
  Authors
Lohman JR, Huang SX, Horsman GP, Dilfer PE, Huang T, Chen Y, Wendt-Pienkowski E, Shen B
  Title
Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics.
  Journal
Mol Biosyst 9:478-91 (2013)
DOI:10.1039/c3mb25523a
  Sequence
LinkDB

KEGG   ORTHOLOGY: K21166
Entry
K21166                      KO                                     
Symbol
sgcE9, ncsE9, kedE9
Name
enediyne biosynthesis protein E9
Pathway
map01059  Biosynthesis of enediyne antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00824  9-membered enediyne core biosynthesis, malonyl-CoA => 3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoyl-ACP => 9-membered enediyne core
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K21166  sgcE9, ncsE9, kedE9; enediyne biosynthesis protein E9
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K21166  sgcE9, ncsE9, kedE9; enediyne biosynthesis protein E9
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Others
   K21166  sgcE9, ncsE9, kedE9; enediyne biosynthesis protein E9
Other DBs
COG: COG2303
Genes
SGR: SGR_600
SGB: WQO_33960
STRM: M444_37970
SPLU: LK06_002545
STIR: DDW44_31435
SGZ: C0216_12085
SSPO: DDQ41_30965
SFY: GFH48_34885
SBAT: G4Z16_02210
SLON: LGI35_02875
SRO: Sros_6992
AMD: AMED_6867
AMN: RAM_35235
AMM: AMES_6762
AMZ: B737_6762
AOI: AORI_1838
AMYY: YIM_40995(choA2)
AORI: SD37_32020
SESP: BN6_39200
ACTI: UA75_19110
ACAD: UA74_18620
AHG: AHOG_16625(choA)
ALO: CRK57510
ACTU: Actkin_03734(choD_1)
SAQ: Sare_0546
ACTN: L083_3206
CAI: Caci_6378
AG: AAM78005(ncsE9) AFV52135(kedE9)
 » show all
Reference
PMID:12183628 (sgcE9)
  Authors
Liu W, Christenson SD, Standage S, Shen B
  Title
Biosynthesis of the enediyne antitumor antibiotic C-1027.
  Journal
Science 297:1170-3 (2002)
DOI:10.1126/science.1072110
  Sequence
[sgb:WQO_33960]
Reference
PMID:15797213 (ncsE9)
  Authors
Liu W, Nonaka K, Nie L, Zhang J, Christenson SD, Bae J, Van Lanen SG, Zazopoulos E, Farnet CM, Yang CF, Shen B
  Title
The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases.
  Journal
Chem Biol 12:293-302 (2005)
DOI:10.1016/j.chembiol.2004.12.013
  Sequence
Reference
PMID:23360970 (kedE9)
  Authors
Lohman JR, Huang SX, Horsman GP, Dilfer PE, Huang T, Chen Y, Wendt-Pienkowski E, Shen B
  Title
Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics.
  Journal
Mol Biosyst 9:478-91 (2013)
DOI:10.1039/c3mb25523a
  Sequence
LinkDB

KEGG   ORTHOLOGY: K21167
Entry
K21167                      KO                                     
Symbol
sgcE11, ncsE11, kedE11
Name
enediyne biosynthesis protein E11
Pathway
map01059  Biosynthesis of enediyne antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00824  9-membered enediyne core biosynthesis, malonyl-CoA => 3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoyl-ACP => 9-membered enediyne core
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K21167  sgcE11, ncsE11, kedE11; enediyne biosynthesis protein E11
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K21167  sgcE11, ncsE11, kedE11; enediyne biosynthesis protein E11
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Others
   K21167  sgcE11, ncsE11, kedE11; enediyne biosynthesis protein E11
Genes
SGR: SGR_599
SGB: WQO_33950
STRM: M444_37960
SPLU: LK06_002535
STIR: DDW44_31425
SGZ: C0216_12095
SSPO: DDQ41_30960
SDRZ: NEH16_31870
SGK: PET44_34930
SFIY: F0344_34750
SRO: Sros_6990
AMD: AMED_6865
AMN: RAM_35225
AMM: AMES_6760
AMZ: B737_6760
AOI: AORI_6954
AMYY: YIM_40975
AORI: SD37_05930
SESP: BN6_39350
ACTI: UA75_19055
ACAD: UA74_18565
SAQ: Sare_0559
ACTN: L083_3208
CAI: Caci_6381
AG: AAM78004(ncsE11) AFV52131(kedE11)
 » show all
Reference
PMID:12183628 (sgcE11)
  Authors
Liu W, Christenson SD, Standage S, Shen B
  Title
Biosynthesis of the enediyne antitumor antibiotic C-1027.
  Journal
Science 297:1170-3 (2002)
DOI:10.1126/science.1072110
  Sequence
[sgb:WQO_33950]
Reference
PMID:15797213 (ncsE11)
  Authors
Liu W, Nonaka K, Nie L, Zhang J, Christenson SD, Bae J, Van Lanen SG, Zazopoulos E, Farnet CM, Yang CF, Shen B
  Title
The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases.
  Journal
Chem Biol 12:293-302 (2005)
DOI:10.1016/j.chembiol.2004.12.013
  Sequence
Reference
PMID:23360970 (kedE11)
  Authors
Lohman JR, Huang SX, Horsman GP, Dilfer PE, Huang T, Chen Y, Wendt-Pienkowski E, Shen B
  Title
Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics.
  Journal
Mol Biosyst 9:478-91 (2013)
DOI:10.1039/c3mb25523a
  Sequence
LinkDB

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