KEGG   ORTHOLOGY: K21178
Entry
K21178                      KO                                     
Symbol
sgcD4
Name
O-methyltransferase [EC:2.1.1.-]
Pathway
map01059  Biosynthesis of enediyne antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00826  C-1027 benzoxazolinate moiety biosynthesis, chorismate => benzoxazolinyl-CoA
Reaction
R11364  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K21178  sgcD4; O-methyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K21178  sgcD4; O-methyltransferase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Methylase
   K21178  sgcD4; O-methyltransferase
Other DBs
COG: COG2890
Genes
SGB: WQO_33900
STRM: M444_37940
STIR: DDW44_31335
SNIG: HEK616_06680
SGK: PET44_34950
SHAU: K9S39_23505
STTN: BSL84_16275
AGLA: OIE69_33905
KRI: OX958_06495
NEC: KGD82_25075
AGRA: AGRA3207_006081
ACIR: OG979_40580
ACTQ: OG417_10575
SRO: Sros_6962 Sros_6986
NGN: LCN96_24245
AMOG: QRX60_04250
ACYN: ORV05_12860
ACOR: LCL61_34870
PSDS: K1T35_38085
ACTU: Actkin_05245(dnrK)
UME: RM788_02115
ASIC: Q0Z83_092910
 » show all
Reference
PMID:12183628
  Authors
Liu W, Christenson SD, Standage S, Shen B
  Title
Biosynthesis of the enediyne antitumor antibiotic C-1027.
  Journal
Science 297:1170-3 (2002)
DOI:10.1126/science.1072110
  Sequence
[sgb:WQO_33900]
Reference
PMID:18182490
  Authors
Van Lanen SG, Lin S, Shen B
  Title
Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism.
  Journal
Proc Natl Acad Sci U S A 105:494-9 (2008)
DOI:10.1073/pnas.0708750105
LinkDB

KEGG   REACTION: R11364
Entry
R11364                      Reaction                               
Definition
3,4-Dihydro-7-hydroxy-2-methylene-3-oxo-2H-1,4-benzoxazine-5-carboxylate <=> 3,4-Dihydro-7-methoxy-2-methylene-3-oxo-2H-1,4-benzoxazine-5-carboxylic acid
Equation
C21307 <=> C11468
Comment
methyltransferase
incomplete reaction
Reaction class
RC00392  C11468_C21307
Enzyme
2.1.1.-
Pathway
rn01059  Biosynthesis of enediyne antibiotics
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00826  C-1027 benzoxazolinate moiety biosynthesis, chorismate => benzoxazolinyl-CoA
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.-
     R11364  3,4-Dihydro-7-hydroxy-2-methylene-3-oxo-2H-1,4-benzoxazine-5-carboxylate <=> 3,4-Dihydro-7-methoxy-2-methylene-3-oxo-2H-1,4-benzoxazine-5-carboxylic acid
Orthology
K21178  O-methyltransferase [EC:2.1.1.-]
LinkDB

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