KEGG   ORTHOLOGY: K21181
Entry
K21181                      KO                                     
Symbol
sgcC4, mdpC4
Name
MIO-dependent L-tyrosine 2,3-aminomutase [EC:5.4.3.6]
Pathway
map01059  Biosynthesis of enediyne antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00827  C-1027 beta-amino acid moiety biosynthesis, tyrosine => 3-chloro-4,5-dihydroxy-beta-phenylalanyl-PCP
M00828  Maduropeptin beta-hydroxy acid moiety biosynthesis, tyrosine => 3-(4-hydroxyphenyl)-3-oxopropanoyl-PCP
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K21181  sgcC4, mdpC4; MIO-dependent L-tyrosine 2,3-aminomutase
Enzymes [BR:ko01000]
 5. Isomerases
  5.4  Intramolecular transferases
   5.4.3  Transferring amino groups
    5.4.3.6  tyrosine 2,3-aminomutase
     K21181  sgcC4, mdpC4; MIO-dependent L-tyrosine 2,3-aminomutase
Other DBs
RN: R11366
COG: COG2986
GO: 0050368
Genes
SGB: WQO_33885
SALU: DC74_7947
SALL: SAZ_41030
STRM: M444_37815
STIR: DDW44_31245(cmdF)
SSPO: DDQ41_30915(cmdF)
SVD: CP969_01715(cmdF)
AJA: AJAP_16300(cmdF)
AAB: A4R43_37260
AMYY: YIM_40825
APRE: CNX65_24635(cmdF)
ACTI: UA75_18110
ACAD: UA74_17585
AHG: AHOG_16435
ACTA: C1701_26515(cmdF)
ALO: CRK59451
SAQ: Sare_2092
PFLA: Pflav_004690(hutH_1)
RPOR: RHAB15C_0000911
AG: ABY66005(mdpC4)
 » show all
Reference
PMID:12183628 (sgcC4)
  Authors
Liu W, Christenson SD, Standage S, Shen B
  Title
Biosynthesis of the enediyne antitumor antibiotic C-1027.
  Journal
Science 297:1170-3 (2002)
DOI:10.1126/science.1072110
  Sequence
[sgb:WQO_33885]
Reference
PMID:17918933 (mdpC4)
  Authors
Van Lanen SG, Oh TJ, Liu W, Wendt-Pienkowski E, Shen B
  Title
Characterization of the maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis.
  Journal
J Am Chem Soc 129:13082-94 (2007)
DOI:10.1021/ja073275o
  Sequence
[ag:ABY66005]
Reference
PMID:23034235
  Authors
Lohman JR, Shen B
  Title
4-methylideneimidazole-5-one-containing aminomutases in enediyne biosynthesis.
  Journal
Methods Enzymol 516:299-319 (2012)
DOI:10.1016/B978-0-12-394291-3.00007-1
LinkDB

KEGG   ENZYME: 5.4.3.6
Entry
EC 5.4.3.6                  Enzyme                                 
Name
tyrosine 2,3-aminomutase;
tyrosine alpha,beta-mutase
Class
Isomerases;
Intramolecular transferases;
Transferring amino groups
Sysname
L-tyrosine 2,3-aminomutase
Reaction(IUBMB)
L-tyrosine = 3-amino-3-(4-hydroxyphenyl)propanoate [RN:R00739]
Reaction(KEGG)
R00739 > R11366
Substrate
L-tyrosine [CPD:C00082]
Product
3-amino-3-(4-hydroxyphenyl)propanoate [CPD:C04368]
Comment
Requires ATP.
History
EC 5.4.3.6 created 1976
Pathway
ec00350  Tyrosine metabolism
ec01059  Biosynthesis of enediyne antibiotics
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K21181  MIO-dependent L-tyrosine 2,3-aminomutase
Genes
SGB: WQO_33885
SALU: DC74_7947
SALL: SAZ_41030
STRM: M444_37815
STIR: DDW44_31245(cmdF)
SSPO: DDQ41_30915(cmdF)
SVD: CP969_01715(cmdF)
AJA: AJAP_16300(cmdF)
AAB: A4R43_37260
AMYY: YIM_40825
APRE: CNX65_24635(cmdF)
ACTI: UA75_18110
ACAD: UA74_17585
AHG: AHOG_16435
ACTA: C1701_26515(cmdF)
ALO: CRK59451
SAQ: Sare_2092
PFLA: Pflav_004690(hutH_1)
RPOR: RHAB15C_0000911
 » show all
Reference
1  [PMID:5021987]
  Authors
Kurylo-Borowska Z, Abramsky T.
  Title
Biosynthesis of  -tyrosine.
  Journal
Biochim Biophys Acta 264:1-10 (1972)
DOI:10.1016/0304-4165(72)90110-9
Other DBs
ExplorEnz - The Enzyme Database: 5.4.3.6
IUBMB Enzyme Nomenclature: 5.4.3.6
ExPASy - ENZYME nomenclature database: 5.4.3.6
BRENDA, the Enzyme Database: 5.4.3.6
CAS: 9073-38-5
LinkDB

KEGG   REACTION: R11366
Entry
R11366                      Reaction                               
Name
L-tyrosine 2,3-aminomutase
Definition
L-Tyrosine <=> (S)-beta-Tyrosine
Equation
C00082 <=> C21308
Reaction class
RC00366  C00082_C21308
Enzyme
5.4.3.6
Pathway
rn01059  Biosynthesis of enediyne antibiotics
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00827  C-1027 beta-amino acid moiety biosynthesis, tyrosine => 3-chloro-4,5-dihydroxy-beta-phenylalanyl-PCP
M00828  Maduropeptin beta-hydroxy acid moiety biosynthesis, tyrosine => 3-(4-hydroxyphenyl)-3-oxopropanoyl-PCP
Orthology
K21181  MIO-dependent L-tyrosine 2,3-aminomutase [EC:5.4.3.6]
LinkDB

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