KEGG   ORTHOLOGY: K21196
Entry
K21196                      KO                                     
Symbol
phnZ
Name
2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming) [EC:1.13.11.78]
Pathway
map00440  Phosphonate and phosphinate metabolism
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00440 Phosphonate and phosphinate metabolism
    K21196  phnZ; 2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.78  2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming)
     K21196  phnZ; 2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming)
Other DBs
RN: R10722
COG: COG4341
Genes
BFO: 118428300
BBEL: 109475006
CIN: 101242664
SCLV: 120331588
SPU: 100894127
APLC: 110978365
SKO: 100376109
PVM: 113811511
EAF: 111702628
LGI: LOTGIDRAFT_172204
MYI: 110460342
PMAX: 117323924
OBI: 106870487
OSN: 115216972
LAK: 106156700
EPA: 110244149
AMIL: 114975294
PDAM: 113683386
SPIS: 111325752
DGT: 114526236
QSU: 111995343
MAW: MAC_01243
MAJ: MAA_09260
CMT: CCM_06455
ANG: ANI_1_2760024(An02g08160)
SMIN: v1.2.002470.t1(symbB.v1.2.002470.t1)
PPT: PPS_4982
PPUH: B479_25155
PPUN: PP4_51980
PPUD: DW66_5375
PMON: X969_24605
PMOT: X970_24240
PFL: PFL_5886
PPRO: PPC_5834
PFS: PFLU_5807
PMAN: OU5_3801
PEN: PSEEN0270
PBA: PSEBR_a22
PSEM: TO66_29740
PSOS: POS17_5830
PANR: A7J50_5534
PSIL: PMA3_28680
PSEP: C4K39_3779
LHA: LHA_1529
CVI: CV_1839
CPI: Cpin_2968
MUC: MuYL_1124
SLI: Slin_3397
FAE: FAES_5432
VG: 11257372(mg458) 14445472(H012_gp541) 9925053(L432)
AG: ACU83550(phnZ)
 » show all
Reference
  Authors
Martinez A, Tyson GW, Delong EF
  Title
Widespread known and novel phosphonate utilization pathways in marine bacteria revealed by functional screening and metagenomic analyses.
  Journal
Environ Microbiol 12:222-38 (2010)
DOI:10.1111/j.1462-2920.2009.02062.x
  Sequence
LinkDB

KEGG   ORTHOLOGY: K05915
Entry
K05915            Tight     KO                                     
Symbol
phnZ1
Name
(hydroxymethyl)phosphonate/2-amino-1-hydroxyethylphosphonate dioxygenase [EC:1.13.11.89 1.13.11.78]
Pathway
map00440  Phosphonate and phosphinate metabolism
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00440 Phosphonate and phosphinate metabolism
    K05915  phnZ1; (hydroxymethyl)phosphonate/2-amino-1-hydroxyethylphosphonate dioxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.78  2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming)
     K05915  phnZ1; (hydroxymethyl)phosphonate/2-amino-1-hydroxyethylphosphonate dioxygenase
    1.13.11.89  (hydroxymethyl)phosphonate dioxygenase
     K05915  phnZ1; (hydroxymethyl)phosphonate/2-amino-1-hydroxyethylphosphonate dioxygenase
Other DBs
RN: R10722 R12451
COG: COG4341
Genes
GMR: GmarT_03180
Reference
  Authors
Gama SR, Vogt M, Kalina T, Hupp K, Hammerschmidt F, Pallitsch K, Zechel DL
  Title
An Oxidative Pathway for Microbial Utilization of Methylphosphonic Acid as a Phosphate Source.
  Journal
ACS Chem Biol 14:735-741 (2019)
DOI:10.1021/acschembio.9b00024
  Sequence
LinkDB

KEGG   ENZYME: 1.13.11.78
Entry
EC 1.13.11.78               Enzyme                                 
Name
2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming);
phnZ (gene name)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
2-amino-1-hydroxyethylphosphonate:oxygen 1-oxidoreductase (glycine-forming)
Reaction(IUBMB)
(2-amino-1-hydroxyethyl)phosphonate + O2 = glycine + phosphate [RN:R10722]
Reaction(KEGG)
R10722
Substrate
(2-amino-1-hydroxyethyl)phosphonate [CPD:C05678];
O2 [CPD:C00007]
Product
glycine [CPD:C00037];
phosphate [CPD:C00009]
Comment
Requires Fe2+. The enzyme, characterized from a marine bacterium, is involved in a 2-aminoethylphosphonate degradation pathway.
History
EC 1.13.11.78 created 2014
Pathway
ec00440  Phosphonate and phosphinate metabolism
ec01100  Metabolic pathways
Orthology
K05915  (hydroxymethyl)phosphonate/2-amino-1-hydroxyethylphosphonate dioxygenase
K21196  2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming)
Genes
BFO118428300
BBEL109475006
CIN101242664
SCLV120331588
SPU100894127
APLC110978365
SKO100376109
PVM113811511
EAF111702628
LGILOTGIDRAFT_172204
MYI110460342
PMAX117323924
OBI106870487
OSN115216972
LAK106156700
NVE116601128 5509073
EPA110244149
AMIL114975294
PDAM113683386
SPIS111325752
DGT114526236
QSU111995343
SSCKSPSK_02742 SPSK_09841
FVRFVEG_07744
MAWMAC_01243
MAJMAA_09260
CMTCCM_06455
PLJVFPFJ_04692 VFPFJ_10444
PSCOLY89DRAFT_642787
NFINFIA_065140
ANGANI_1_2760024(An02g08160)
PCSPc22g12750
TMFPMAA_015640
ZTRMYCGRDRAFT_104600 MYCGRDRAFT_96870
BCOMBAUCODRAFT_309643 BAUCODRAFT_37034
MRRMoror_5309
MBRMONBRDRAFT_9769
SREPTSG_05670
ACANACA1_131370 ACA1_196720
SMINv1.2.002470.t1(symbB.v1.2.002470.t1)
EHXEMIHUDRAFT_205428
PALCA0T30_00550
PPGPputGB1_5187
PPTPPS_4982
PPUHB479_25155
PPUNPP4_51980
PPUDDW66_5375
PMONX969_24605
PMOTX970_24240
PMOSO165_021700
PPJRK21_05378
PMOLCLJ08_11285
PFLPFL_5886
PPRCPFLCHA0_c58400
PPROPPC_5834
PFNHZ99_16105
PFOPfl01_5365
PFSPFLU_5807
PFCPflA506_5099
PPZH045_19430
PMANOU5_3801
PTVAA957_16045
PVRPverR02_29745
PAZOAYR47_05215
POIBOP93_24745
PRXHRH33_25590
PFWPF1751_v1c52220
PFFPFLUOLIPICF709865
PFXA7318_25715
PENPSEEN0270
PBAPSEBR_a22
PPUUPputUW4_05161
PSVPVLB_01395
PSKU771_30045
PCHEY04_31220
PCZPCL1606_03280
PCPJM49_01920
PFZAV641_01230
PSEMTO66_29740
PSECCCOS191_0283
PPSYAOC04_21410
PSOSPOS17_5830
PKRAYO71_01700
PFKPFAS1_12830
PANRA7J50_5534
PSILPMA3_28680
PYMAK972_0124
PKEDLD99_27310
PUMHGP31_29605
PPSHG5J76_04200
PGYAWU82_08025
PATAJWU58_02255
PZEHU754_028605
PMOEHV782_027640
PSEPC4K39_3779
PVWHU752_030920
PTRTHU722_0028015
PXAKSS93_00650
PSAMHU731_014145
PTZHU718_028860
PSHHHU773_026560
PXNHU772_023530
PANHHU763_023215
PFAKKSS94_01295
PMAMKSS90_01415
PAZEKSS91_27370
PORYEJA05_26835
PTKEXN22_02675
PIEHU724_026755
PWYHU734_001945
PXIJ5O05_16035
ALGAQULUS_23780
LHALHA_1529
LCDclem_07260
LLG44548918_01854
LCJNCTC11976_01455
FHACDV26_02630
NCUF0U83_10385
CVICV_1839
CVCBKX93_22430
CHROCXB49_13150
CHRIDK842_16370
CHRBDK843_21895
GMRGmarT_03180
CPICpin_2968
NKONiako_2712
PSEGD3H65_26340
PGINFRZ67_07390
FLCKJS93_18225
FLVKJS94_02230
PCMAY601_2093
MUPA0256_23040
MUCMuYL_1124
MGOTMgSA37_00812
MUHHYN43_027925
MGINFRZ54_02780
MGKFSB76_24850
MRUBDEO27_029700
MGOSDIU38_031875
CMRCycma_1724
CAMUCA2015_1630
SLISlin_3397
SRDSD10_19030
SMONAWR27_04710
SPIRCWM47_32850
SPIKEXU85_08700
SPIBG8759_17555
STAEHNV11_07495
SRHOHH216_12685
RHOZGXP67_25885
RSIRunsl_4009
RUNDR864_01355
RUPDTQ70_11150
EOLEmtol_0956
FAEFAES_5432
FIBA6C57_02290
ALSDJ013_20145
HYZAXW84_22205
HNVDDQ68_03200
CHKD4L85_03505
 » show all
Reference
1  [PMID:22564006]
  Authors
McSorley FR, Wyatt PB, Martinez A, DeLong EF, Hove-Jensen B, Zechel DL
  Title
PhnY and PhnZ comprise a new oxidative pathway for enzymatic cleavage of a carbon-phosphorus bond.
  Journal
J Am Chem Soc 134:8364-7 (2012)
DOI:10.1021/ja302072f
Reference
2  [PMID:24198335]
  Authors
Worsdorfer B, Lingaraju M, Yennawar NH, Boal AK, Krebs C, Bollinger JM Jr, Pandelia ME
  Title
Organophosphonate-degrading PhnZ reveals an emerging family of HD domain mixed-valent diiron oxygenases.
  Journal
Proc Natl Acad Sci U S A 110:18874-9 (2013)
DOI:10.1073/pnas.1315927110
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.78
IUBMB Enzyme Nomenclature: 1.13.11.78
ExPASy - ENZYME nomenclature database: 1.13.11.78
BRENDA, the Enzyme Database: 1.13.11.78
LinkDB

KEGG   REACTION: R10722
Entry
R10722                      Reaction                               
Name
2-amino-1-hydroxyethylphosphonate:oxygen 1-oxidoreductase (glycine-forming)
Definition
(2-Amino-1-hydroxyethyl)phosphonate + Oxygen <=> Glycine + Orthophosphate
Equation
Reaction class
RC03261  C00037_C05678
Enzyme
Pathway
rn00440  Phosphonate and phosphinate metabolism
rn01100  Metabolic pathways
Orthology
K05915  (hydroxymethyl)phosphonate/2-amino-1-hydroxyethylphosphonate dioxygenase [EC:1.13.11.89 1.13.11.78]
K21196  2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming) [EC:1.13.11.78]
Other DBs
RHEA: 41447
LinkDB

DBGET integrated database retrieval system