KEGG   ORTHOLOGY: K21328
Entry
K21328                      KO                                     
Symbol
calS13, atmS13
Name
dTDP-4-amino-4,6-dideoxy-D-glucose/dTDP-4-amino-2,4-dideoxy-beta-L-xylose transaminase [EC:2.6.1.33 2.6.1.-]
Pathway
map00523  Polyketide sugar unit biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R02773  dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate aminotransferase
R11475  dTDP-4-amino-2,4-dideoxy-beta-L-xylose:2-oxoglutarate aminotransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00523 Polyketide sugar unit biosynthesis
    K21328  calS13, atmS13; dTDP-4-amino-4,6-dideoxy-D-glucose/dTDP-4-amino-2,4-dideoxy-beta-L-xylose transaminase
Enzymes [BR:ko01000]
 2. Transferases
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.33  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
     K21328  calS13, atmS13; dTDP-4-amino-4,6-dideoxy-D-glucose/dTDP-4-amino-2,4-dideoxy-beta-L-xylose transaminase
Other DBs
COG: COG0399
Genes
CTEZ: CT3_36500 CT3_36510
GEV: GSVR_04270
CSUA: IM538_21580 IM538_21585
NFS: OIE67_22410
KUT: JJ691_31610
SAQ: Sare_2034 Sare_2945
BFH: F1611_19170 F1611_19175
MJJ: PQO05_04315
HMT: MTP16_12000
HSK: H4317_15125
MHAA: Q3Y49_04760 Q3Y49_04765
CHRC: QGN23_07260 QGN23_07265
AG: AAM94797(calS13) ABC02793(atmS13)
 » show all
Reference
PMID:26289554
  Authors
Peltier-Pain P, Singh S, Thorson JS
  Title
Characterization of Early Enzymes Involved in TDP-Aminodideoxypentose Biosynthesis en Route to Indolocarbazole AT2433.
  Journal
Chembiochem 16:2141-6 (2015)
DOI:10.1002/cbic.201500365
Reference
PMID:26061967
  Authors
Singh S, Kim Y, Wang F, Bigelow L, Endres M, Kharel MK, Babnigg G, Bingman CA, Joachimiak A, Thorson JS, Phillips GN Jr
  Title
Structural characterization of AtmS13, a putative sugar aminotransferase involved in indolocarbazole AT2433 aminopentose biosynthesis.
  Journal
Proteins 83:1547-54 (2015)
DOI:10.1002/prot.24844
Reference
PMID:12183629 (calS13)
  Authors
Ahlert J, Shepard E, Lomovskaya N, Zazopoulos E, Staffa A, Bachmann BO, Huang K, Fonstein L, Czisny A, Whitwam RE, Farnet CM, Thorson JS
  Title
The calicheamicin gene cluster and its iterative type I enediyne PKS.
  Journal
Science 297:1173-6 (2002)
DOI:10.1126/science.1072105
  Sequence
[ag:AAM94797]
Reference
PMID:16873021 (atmS13)
  Authors
Gao Q, Zhang C, Blanchard S, Thorson JS
  Title
Deciphering indolocarbazole and enediyne aminodideoxypentose biosynthesis through comparative genomics: insights from the AT2433 biosynthetic locus.
  Journal
Chem Biol 13:733-43 (2006)
DOI:10.1016/j.chembiol.2006.05.009
  Sequence
[ag:ABC02793]
LinkDB

KEGG   REACTION: R11475
Entry
R11475                      Reaction                               
Name
dTDP-4-amino-2,4-dideoxy-beta-L-xylose:2-oxoglutarate aminotransferase
Definition
dTDP-4-amino-2,4-dideoxy-beta-L-xylose + 2-Oxoglutarate <=> dTDP-4-oxo-2-deoxy-beta-L-xylose + L-Glutamate
Equation
C21354 + C00026 <=> C21353 + C00025
Reaction class
RC00006  C00025_C00026
RC01514  C21353_C21354
Enzyme
2.6.1.-
Pathway
rn00523  Polyketide sugar unit biosynthesis
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.-
     R11475  dTDP-4-amino-2,4-dideoxy-beta-L-xylose + 2-Oxoglutarate <=> dTDP-4-oxo-2-deoxy-beta-L-xylose + L-Glutamate
Orthology
K21328  dTDP-4-amino-4,6-dideoxy-D-glucose/dTDP-4-amino-2,4-dideoxy-beta-L-xylose transaminase [EC:2.6.1.33 2.6.1.-]
LinkDB

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