KEGG   ORTHOLOGY: K21329
Entry
K21329                      KO                                     
Symbol
calE10
Name
aminosugar N-oxygenase [EC:1.14.15.-]
Pathway
map00523  Polyketide sugar unit biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R11468  dTDP-4-amino-4,6-dideoxy-D-glucose:reduced-ferredoxin:oxygen oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00523 Polyketide sugar unit biosynthesis
    K21329  calE10; aminosugar N-oxygenase
Other DBs
COG: COG2124
Genes
ACIR: OG979_40495
SAQ: Sare_2024
AG: AAM94800(calE10)
Reference
PMID:12183629
  Authors
Ahlert J, Shepard E, Lomovskaya N, Zazopoulos E, Staffa A, Bachmann BO, Huang K, Fonstein L, Czisny A, Whitwam RE, Farnet CM, Thorson JS
  Title
The calicheamicin gene cluster and its iterative type I enediyne PKS.
  Journal
Science 297:1173-6 (2002)
DOI:10.1126/science.1072105
  Sequence
[ag:AAM94800]
Reference
PMID:19055330
  Authors
Johnson HD, Thorson JS
  Title
Characterization of CalE10, the N-oxidase involved in calicheamicin hydroxyaminosugar formation.
  Journal
J Am Chem Soc 130:17662-3 (2008)
DOI:10.1021/ja807557a
LinkDB

KEGG   REACTION: R11468
Entry
R11468                      Reaction                               
Name
dTDP-4-amino-4,6-dideoxy-D-glucose:reduced-ferredoxin:oxygen oxidoreductase
Definition
dTDP-4-amino-4,6-dideoxy-D-glucose + Reduced ferredoxin + Oxygen <=> dTDP-4-hydroxyamino-4,6-dideoxy-alpha-D-glucose + Oxidized ferredoxin + H2O
Equation
C04268 + C00138 + C00007 <=> C21348 + C00139 + C00001
Reaction class
RC03446  C04268_C21348
Enzyme
1.14.15.-
Pathway
rn00523  Polyketide sugar unit biosynthesis
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.-
     R11468  dTDP-4-amino-4,6-dideoxy-D-glucose + Reduced ferredoxin + Oxygen <=> dTDP-4-hydroxyamino-4,6-dideoxy-alpha-D-glucose + Oxidized ferredoxin + H2O
Orthology
K21329  aminosugar N-oxygenase [EC:1.14.15.-]
LinkDB

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